D1 receptor x D2 receptor x μ opioid receptor x 5-HT2 receptor

The goal of this [clinical trial] is to [evaluate the safety and efficacy of olanzapine-samidorphan tablets] in [adults with schizophrenia]. The main question[s] it aims to answer are:
* [question 1] Olanzapine-samidorphan significantly mitigate weight gain better than olanzapine.
* [question 2] Olanzapine- samidorphan and olanzapine have similar antipsychotic efficacy.

This clinical lactation study is to provide information regarding the PK and amount of OLZ/SAM in breast milk and estimated infant exposure.

To compare changes in body mass index (BMI) Z-score following treatment with OLZ/SAM vs olanzapine