YES1

Fort Lee, NJ, Oct. 23, 2024 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced upcoming scientific presentations for NXP900 at the 2024 AACR-NCI-EORTC on Molecular Targets and Cancer Therapeutics (October 23-25, 2024, Barcelona, Spain). Titles and Presenters Presentation Details Title NXP900, a novel YES1/SRC kinase inhibitor in phase 1 dose escalation, demonstrates potent synergy with ALK inhibitors in ALK resistant cell lines Presenter Asier Unciti-Broceta University of Edinburgh Scottland, UK Session Title Combination Therapies Session Type Poster Session Date / Time October 24th, 2024 09:00 - 17:30 CET Title A multi-omics approach to identify biomarkers of response to the novel and selective SRC/YES1 inhibitor NXP900 Presenter Ben King University of Edinburgh Scottland, UK Session Title Cancer Genomics Session Type Poster Session Date / Time October 25th, 2024 09:00 - 15:00 CET About Nuvectis Pharma, Inc. Nuvectis Pharma, Inc. is a biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology. The Company is currently developing two clinical-stage drug candidates, NXP800 and NXP900. NXP800 is an oral small molecule GCN2 activator currently in a Phase 1b clinical trial for the treatment for platinum resistant, ARID1a-mutated ovarian carcinoma and in an Investigator-sponsored clinical trial for the treatment of cholangiocarcinoma. The U.S. Food and Drug Administration granted Fast Track Designation to the NXP800 development program in platinum resistant, ARID1a-mutated ovarian carcinoma, and Orphan Drug Designations for the treatment of cholangiocarcinoma and ARID1a-deficient ovarian, fallopian tube, and primary peritoneal cancers. NXP900 is an oral small molecule inhibitor of the SRC Family of Kinases (SFK), including SRC and YES1. NXP900 has a unique mechanism of action in that it inhibits both the catalytic and scaffolding functions of the SRC kinase thereby providing complete shutdown of the signaling pathway. NXP900 is currently in a Phase 1a dose escalation study Forward Looking Statements Certain statements in this presentation constitute “forward-looking statements" within the meaning of the federal securities laws, which statements are subject to substantial risks and uncertainties. All statements, other than statements of historical fact, contained in this press release are forward-looking statements. Forward-looking statements contained in this press release may be identified by the use of words such as "anticipate," "believe," "contemplate," "could," "estimate," "expect," "intend," "seek," "may," "might," "plan," "potential," "predict," "project," "target," "aim," "should," "will," "would," or the negative of these words or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements are based on Nuvectis Pharma, Inc.'s current expectations, estimates, and projections about future events and trends that we believe may affect our business, financial condition, results of operations, prospects, business strategy, and financial needs. The outcome of the events described in these forward-looking statements are subject to inherent uncertainties, risks, assumptions, market and other conditions, and other factors that are difficult to predict and include statements regarding the potential benefits of the Orphan Drug Designation granted to NXP800, the preclinical and the Phase 1a data generated to date for NXP800 and the clinical expectations for the NXP800 Phase 1b study, including statements regarding NXP800's mechanism of action and its potential ability to become a therapeutic option for the treatment of platinum-resistant, ARID1a-mutated ovarian carcinoma, cholangiocarcinoma, and potentially other cancer indications, and the timing for this study. Further, certain forward-looking statements are based on assumptions as to future events that may not prove to be accurate. These and other risks and uncertainties are subject to market and other conditions and described more fully in the section titled "Risk Factors" in our 2Q 2024 Form 10-Q and our other public filings with the Securities and Exchange Commission ("SEC"). However, these risks are not exhaustive and new risks and uncertainties emerge from time to time, and it is not possible for us to predict all risks and uncertainties that could have an impact on the forward looking statements contained in this press release or other filings with the SEC. Any forward-looking statements contained in this press release speak only as of the date of this press release. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward looking statements contained herein to reflect any change in our expectations or any changes in events, conditions or circumstances on which any such statement is based, except as may be required by law, and we claim the protection of the safe harbor for forward-looking statements contained in the Private Securities Litigation Reform Act of 1995. Company ContactRon BentsurChairman, Chief Executive Officer and President 201-614-3151rbentsur@nuvectis.com Media Relations ContactChristopher M. Calabrese LifeSci Advisors Tel: 917-680-5608ccalabrese@lifesciadvisors.com

Fort Lee, NJ , Oct. 07, 2024 (GLOBE NEWSWIRE) -- Nuvectis Pharma, Inc. (NASDAQ: NVCT) ("Nuvectis" or the "Company"), a clinical-stage biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology, today announced that management will participate in a panel discussion on innovative therapies for solid tumors at the 3rd Annual ROTH Healthcare Opportunities Conference taking place on October 9, 2024 in New York, NY. Event Annual ROTH Healthcare Opportunities Conference Panel Title Innovative Therapies for Solid Tumors Date and Time October 9, 2024, 12:30 pm ET About Nuvectis Pharma, Inc. Nuvectis Pharma, Inc. is a biopharmaceutical company focused on the development of innovative precision medicines for the treatment of serious conditions of unmet medical need in oncology. The Company is currently developing two clinical-stage drug candidates, NXP800 and NXP900. NXP800 is an oral small molecule GCN2 activator currently in a Phase 1b clinical trial for the treatment for platinum resistant, ARID1a-mutated ovarian carcinoma and in an Investigator-sponsored clinical trial for the treatment of cholangiocarcinoma. The U.S. Food and Drug Administration granted Fast Track Designation to the NXP800 development program in platinum resistant, ARID1a-mutated ovarian carcinoma, and Orphan Drug Designation for the treatment of cholangiocarcinoma and ARID1a-deficient ovarian, fallopian tube, and primary peritoneal cancers. NXP900 is an oral small molecule inhibitor of the SRC Family of Kinases (SFK), including SRC and YES1. NXP900 has a unique mechanism of action in that it inhibits both the catalytic and scaffolding functions of the SRC kinase thereby providing complete shutdown of the signaling pathway. NXP900 is currently in a Phase 1a dose escalation study. Company ContactRon BentsurChairman, Chief Executive Officer and President201-614-3151rbentsur@nuvectis.com Media Relations ContactChristopher M. CalabreseLifeSci AdvisorsTel: 917-680-5608ccalabrese@lifesciadvisors.com

LONDON--( BUSINESS WIRE )-- Summit Therapeutics’ Breakthrough with Ivonescimab The recent breakthrough with Summit Therapeutics’ Ivonescimab (SMT112) reverberated not just in the medical industry but also across the markets. In its Phase 3 trial conducted in China, Ivonescimab shattered expectations, reducing the risk of disease progression or death by 49% compared to Merck’s Keytruda (pembrolizumab). With a nearly doubled median progression-free survival—11.14 months versus Keytruda’s 5.82 months—this result shook the foundations of the NSCLC treatment landscape. The market responded swiftly: Summit’s stock skyrocketed as investors rushed to back what now appeared to be a potential "Keytruda slayer." In contrast, Merck’s stock (NYSE: MRK) faced a dip as fears spread that its reign in NSCLC could be under real threat. Just days after the trial news, Summit announced a $235 million private placement, led by insiders and prominent biopharma institutional investors. This dramatic move further solidified the belief that Summit is gearing up for a monumental push to capture a larger share of the oncology market. Ivonescimab’s success and the subsequent capital raise underscore the shifting dynamics in NSCLC, with Summit poised to potentially reshape the standard of care. The stakes have never been higher, and the market is keenly watching what could be the start of a new era in cancer treatment. The Need for Innovation in NSCLC Treatment The excitement around Ivonescimab highlights a critical and growing need in NSCLC: addressing treatment resistance. While immunotherapies like Keytruda have transformed the treatment of certain cancers, the challenge of resistance looms large. Many patients eventually stop responding to these therapies, leading to cancer progression. Ivonescimab’s dual-targeting mechanism is an attempt to solve this problem, offering a more robust attack on the cancer’s survival pathways. However, Ivonescimab seems to only address the subgroup of NSCLC patients that have PD-L1 expression which still leaves significant additional subgroups within NSCLC that in need of improved treatment and outcomes. The treatment landscape for NSCLC is evolving rapidly, driven by the increasing recognition that overcoming resistance mechanisms is essential for achieving durable patient outcomes. While drugs like Ivonescimab, with its dual inhibition of PD-1 and VEGF, have made significant strides, they are not a panacea. Resistance to therapies in NSCLC, particularly in areas of EGFR and ALK resistance, remains a major challenge, as cancer cells find alternative survival pathways to evade treatment. This creates a critical need for therapies like NXP900, which target different molecular mechanisms, such as the SRC/YES1 kinase pathways. By addressing these alternative resistance pathways, NXP900 could not only complement existing treatments like EGFR and ALK inhibitors, but also might provide new options for patients who have exhausted standard therapies. Nuvectis Pharma's focus on these underexplored avenues positions it to potentially fill the gaps left by current therapies, offering a more comprehensive approach to battling resistant NSCLC. Nuvectis Pharma and NXP900: A Key Player Tackling Resistance Nuvectis Pharma’s NXP900, represents a novel approach to addressing the resistance challenges in NSCLC and other cancers. Unlike Ivonescimab, which focuses on immune evasion and angiogenesis, NXP900 seeks to target EGFR and ALK resistance by utilizing its ability to inhibit SRC/YES1 kinases, critical drivers of cancer cell survival and growth. This distinction positions NXP900 not as a competitor to Ivonescimab, but as another important player that could address different aspects of treatment resistance. NXP900’s mechanism seems particularly compelling because it inhibits both the catalytic and scaffolding functions of SRC and YES1, which are involved in key signaling pathways that enable cancer to evade standard therapies. In preclinical studies, NXP900 has shown potent activity against NSCLC models that have developed resistance to standard treatments like EGFR inhibitors (e.g., osimertinib) and ALK inhibitors (e.g., alectinib). This places NXP900 in a strong position to offer a solution for patients who have run out of treatment options after developing resistance to current therapies. What’s more, NXP900 has demonstrated synergistic effects when used in combination with existing treatments, such as AstraZeneca's osimertinib (Tagrisso), a widely used EGFR inhibitor. In preclinical studies, the combination of NXP900 and osimertinib significantly enhanced anti-tumor activity, successfully reversing resistance in models where osimertinib alone had become ineffective. This suggests that NXP900 could prolong the effectiveness of osimertinib in patients whose cancer has adapted to evade treatment, offering a promising strategy to combat resistance and improve long-term outcomes. From Summit Therapeutics to Nuvectis Pharma: Overcoming Resistance Targeting Well-Defined Subsets Both Ivonescimab and NXP900 reflect a broader movement in oncology towards targeting cancer's resilience. Ivonescimab’s dual inhibition of PD-1 and VEGF and NXP900’s kinase inhibition strategy both aim to outmaneuver cancer’s ability to develop. These subgroups are not competitive with one another as they address large but different subgroups within NSCLS. Thus these two drug candidates seem to be a part of a broader strategy that reflects the ongoing innovation in the field of cancer treatment. While Ivonescimab’s early success suggests that it could disrupt the current standard of care in NSCLC, NXP900 could represent another critical piece of the puzzle, especially for patients who no longer respond to therapies like osimertinib or alectinib. Both therapies focus on the unmet need for more durable and comprehensive cancer treatments that target multiple mechanisms of resistance. The Road Ahead for NXP900: Early Promise, Future Potential Nuvectis Pharma’s NXP900 is still in the early stages of clinical development, currently undergoing Phase 1 trials. These trials are designed to evaluate the safety and pharmacokinetics of the drug, but early results have been promising. In preclinical studies, NXP900 has shown strong anti-tumor activity, particularly in NSCLC models resistant to standard therapies. If these findings hold true in clinical trials, NXP900 could become a significant player in the NSCLC treatment landscape. In addition to its potential in NSCLC, NXP900 is being explored for use in other cancers, including squamous cell carcinomas, where SRC/YES1 pathways play a significant role in tumor development. The versatility of NXP900 could make it a valuable asset not only in lung cancer but across a range of tumor types, expanding its market potential significantly. Beyond NXP900, Nuvectis’ more advanced candidate, NXP800 has shown promise, particularly in targeting ARID1a-mutated cancers, such as ovarian and endometrial cancers, further broadening the company’s pipeline and potential impact in oncology. Looking Ahead: Keeping a Close Eye on Nuvectis Pharma Summit Therapeutics’ success with Ivonescimab has demonstrated that there is a hunger in the oncology field for therapies that can tackle the challenge of resistance in NSCLC. While Summit’s Ivonescimab has captured the spotlight for now, Nuvectis Pharma’s NXP900 is quietly positioning itself as another promising contender in this space. By addressing kinase-driven resistance, NXP900 offers another innovative targeted therapy approach being tackled. As clinical trials progress, NXP900 has the potential to capture significant attention, particularly if it can demonstrate efficacy in patients who have developed resistance to other treatments. With a strong foundation in preclinical data and a growing interest in therapies that target cancer’s survival mechanisms, Nuvectis Pharma (NASDAQ: NVCT) is one to watch closely as the battle against NSCLC continues to evolve. PESG Research is a digital commentary brand, offering coverage and exploration into companies and sectors in the fields of Pharma, BioTech, Sustainability, and several other innovative industries. Read our previous report on Pioneering RNAi Technology in the Fight Against KRAS-Driven Cancers . >> Subscribe for more Updates from PESG Research * * * This report is for informational purposes only and is not intended to serve as medical, pharmacological, financial, investment or any form of professional advice, recommendation or endorsement. Please review the full documentation detailing financial compensation disclosures and disclaimers the text is subject to. We are a digital brand and are compensated to publish and syndicate commentary and exploration into innovative companies and industries and are thus subject to conflicts of interest as detailed in the full documentation. [ https://justpaste.it/fcm9n/pdf ] www.pesgresearch.com