预约演示

更新于：2025-01-23

SERT x D4 receptor x D2 receptor x 5-HT2A receptor

更新于：2025-01-23

基本信息

关联

项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的药物

Citalopram Hydrobromide/Pipamperone Hydrochloride

氢溴酸西酞普兰/盐酸匹泮哌隆

靶点

5-HT2A receptor x D2 receptor x D4 receptor x SERT

作用机制

5-HT2A receptor拮抗剂 [+3]

在研机构-

原研机构

PharmaNeuroBoost NV

在研适应症-

非在研适应症

重度抑郁症

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的临床试验

NCT01312922

/ Completed临床3期

Pipamperone/Citalopram (PNB01) Versus Citalopram (CIT) and Versus Pipamperone (PIP) in the Treatment of Moderate to Severe Major Depressive Disorder (MDD): a Randomized, Double-blind Phase III Study of 10 Weeks

The overall objective of this trial is to demonstrate clinically relevant superior antidepressant efficacy of the fixed dose combination PNB01 (low dose pipamperone and citalopram) over reference antidepressant treatment with citalopram alone, and a low dose of psychoactive pipamperone alone in patients with moderate to severe Major Depressive Disorder.
This study was specifically designed to assess patient related outcome (PRO) parameters using an Interactive Voice Response System (IVRS) via telephone.

开始日期2011-09-01

申办/合作机构

PharmaNeuroBoost NV

100 项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的临床结果

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100 项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的转化医学

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0 项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的专利（医药）

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项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的文献（医药）

2017-01-01·The Spanish Journal of Psychology4区 · 心理学

A Potential Role of the 5-HTTLPR Polymorphism in Self-Reported Executive Functioning

4区 · 心理学

Article

作者: Lezheiko, Tatyana ; Korovaitseva, Galina ; Golimbet, Vera ; Alfimova, Margarita V

AbstractIntense effort is directed toward searching for associations between genes and neuropsychological measures of executive functions. In contrast, the impact of genetic polymorphisms on self-rating of everyday executive functioning has not been investigated so far. This study was designed to test associations of self-reported executive functioning, measured with the Behavior Rating Inventory of Executive Function (BRIEF-A), with dopaminergic and serotoninergic genes in non-clinical population and to assess impact of neuropsychological and personality characteristics on these associations. One hundred healthy adults completed the BRIEF-A, personality inventories SPQ-74, STAI, MMPI, and neuropsychological tests for executive functions. Polymorphisms in theDRD4, COMT, DRD2, HTR2A, andSLC6A4genes were genotyped. We revealed a significant main effect of theSLC6A4’s 5-HTTLPR polymorphism on BRIEF-A scores (F= 2.21,P= .018, η2= .24). Among the BRIEF-A measures, the genotype effect was significant for the Plan/Organize (F= 7.34,P= .008, η2= .07) and Task Monitor scales (F= 4.33,P= .04, η2= .04), and the Metacognition index (F= 4.21,P= .043, η2= .04). Carriers of the short allele reported fewer problems than homozygotes for the long allele. Correlations of the BRIEF-A measures with neuropsychological variables were weak, while those with personality characteristics were strong, with trait anxiety being the most powerful predictor of the BRIEF-A scores. However, the relationship between the 5-HTTLPR and BRIEF-A scores remained significant when trait anxiety was controlled for. The results suggest a potential role of the 5-HTTLPR in self-reported everyday task planning and monitoring.

2017-01-01·The Journal of Sexual Medicine

Paraphilic Sexual Offenders Do Not Differ from Control Subjects with Respect to Dopamine- and Serotonin-Related Genetic Polymorphisms

Article

作者: Klimkiewicz, Anna ; Brower, Kirk ; Krasowska, Aleksandra ; Jakima, Sławomir ; Łoczewska, Agata ; Podgórska, Anna ; Płoski, Rafał ; Kopera, Maciej ; Bugaj, Marcin ; Szejko, Natalia ; Wojnar, Marcin ; Markuszewski, Leszek ; Michalska, Aneta ; Majewska, Aleksandra ; Sołowiej, Małgorzata ; Jakubczyk, Andrzej

AbstractIntroductionRape and pedophilic child molestation are the most commonly convicted sexual offenses in Poland. Recent studies have suggested a possible genetic contribution toward pathologic sexual interests and behaviors.AimTo analyze and compare functional polymorphisms of genes associated with the activity of the serotonin and dopamine systems in a group of paraphilic sexual offenders and control subjects.MethodsThe study sample (n = 97) consisted of two groups: paraphilic sexual offenders (65 pedophilic child molesters and 32 rapists) and controls (n = 76). Genetic polymorphisms previously associated with behavioral control, addictive behaviors, and sexual functions were chosen for analyses. Specifically, functional polymorphisms in dopamine receptors genes (DRD1, DRD2, DRD4), catechol-O-methyltransferase gene (COMT), dopamine transporter gene (DAT), serotonin transporter gene (SLC6A4), serotonin type 2A receptor gene (5HTR2A), tryptophan hydroxylase 2 gene (TPH2), monoamine oxidase A gene (MAOA), and brain-derived neurotrophic factor gene (BDNF) were analyzed.Main Outcome MeasuresAn association between a history of sexual offense and the distribution of genotypes and alleles in the analyzed polymorphisms.ResultsOur results found no association between a history of sexual offense and the distribution of genotypes or alleles in the analyzed polymorphisms.ConclusionAlthough these results are limited by the small sample and are exploratory, they highlight a novel approach to sample selection in a population that is difficult to access and study. Future research should include larger samples and other relevant polymorphisms to advance this field of study.

2013-04-01·Journal of Neural Transmission4区 · 医学

Genetics of impulse control disorders in Parkinson’s disease

4区 · 医学

Review

作者: Florence Cormier ; Jean-Christophe Corvol ; Julia Muellner

Impulse control disorders (ICD) have been recognised in Parkinson's disease (PD) as adverse effects of dopamine replacement therapy, particularly with dopamine agonists. Although virtually all PD patients are treated with dopaminergic drugs, only a minority will develop hyperdopaminergic states, suggesting predisposing and/or protecting factors. The age at onset, the sex and the dose or type of dopaminergic drugs have been identified as clinical predictive factors. Recent genetic studies have investigated associations between ICD and polymorphisms of genes involved in the dopamine metabolism pathway (COMT, DAT), dopamine receptors (DRD1, DRD2, DRD3, DRD4), serotonin receptors and its transporter (HTR2A, 5HTT), and glutamate receptors (GRIN2B). Although validation in larger and independent cohorts is needed, the results from these studies give us some insights into the pathophysiology of hyperdopaminergic states and may be useful, at term, in personalising antiparkinsonian treatment in clinical practice.

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