更新于：2024-11-01

SERT x D4 receptor x D2 receptor x 5-HT2A receptor

更新于：2024-11-01

基本信息

关联

项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的药物

Citalopram Hydrobromide/Pipamperone Hydrochloride

氢溴酸西酞普兰/盐酸匹泮哌隆

靶点

5-HT2A receptor x D2 receptor x D4 receptor x SERT

作用机制

5-HT2A receptor拮抗剂 [+3]

在研机构-

原研机构

PharmaNeuroBoost NV

在研适应症-

非在研适应症

重度抑郁症

最高研发阶段无进展

首次获批国家/地区-

首次获批日期1800-01-20

项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的临床试验

NCT01312922 / Completed临床3期

Pipamperone/Citalopram (PNB01) Versus Citalopram (CIT) and Versus Pipamperone (PIP) in the Treatment of Moderate to Severe Major Depressive Disorder (MDD): a Randomized, Double-blind Phase III Study of 10 Weeks

The overall objective of this trial is to demonstrate clinically relevant superior antidepressant efficacy of the fixed dose combination PNB01 (low dose pipamperone and citalopram) over reference antidepressant treatment with citalopram alone, and a low dose of psychoactive pipamperone alone in patients with moderate to severe Major Depressive Disorder.
This study was specifically designed to assess patient related outcome (PRO) parameters using an Interactive Voice Response System (IVRS) via telephone.

开始日期2011-09-01

申办/合作机构

PharmaNeuroBoost NV

100 项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的临床结果

登录后查看更多信息

100 项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的转化医学

登录后查看更多信息

0 项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的专利（医药）

登录后查看更多信息

项与 SERT x D4 receptor x D2 receptor x 5-HT2A receptor 相关的文献（医药）

2017-01-01·The Spanish Journal of Psychology4区 · 心理学

A Potential Role of the 5-HTTLPR Polymorphism in Self-Reported Executive Functioning

4区 · 心理学

Article

作者: Lezheiko, Tatyana ; Korovaitseva, Galina ; Golimbet, Vera ; Alfimova, Margarita V

AbstractIntense effort is directed toward searching for associations between genes and neuropsychological measures of executive functions. In contrast, the impact of genetic polymorphisms on self-rating of everyday executive functioning has not been investigated so far. This study was designed to test associations of self-reported executive functioning, measured with the Behavior Rating Inventory of Executive Function (BRIEF-A), with dopaminergic and serotoninergic genes in non-clinical population and to assess impact of neuropsychological and personality characteristics on these associations. One hundred healthy adults completed the BRIEF-A, personality inventories SPQ-74, STAI, MMPI, and neuropsychological tests for executive functions. Polymorphisms in theDRD4, COMT, DRD2, HTR2A, andSLC6A4genes were genotyped. We revealed a significant main effect of theSLC6A4’s 5-HTTLPR polymorphism on BRIEF-A scores (F= 2.21,P= .018, η2= .24). Among the BRIEF-A measures, the genotype effect was significant for the Plan/Organize (F= 7.34,P= .008, η2= .07) and Task Monitor scales (F= 4.33,P= .04, η2= .04), and the Metacognition index (F= 4.21,P= .043, η2= .04). Carriers of the short allele reported fewer problems than homozygotes for the long allele. Correlations of the BRIEF-A measures with neuropsychological variables were weak, while those with personality characteristics were strong, with trait anxiety being the most powerful predictor of the BRIEF-A scores. However, the relationship between the 5-HTTLPR and BRIEF-A scores remained significant when trait anxiety was controlled for. The results suggest a potential role of the 5-HTTLPR in self-reported everyday task planning and monitoring.

2013-04-01·Journal of Neural Transmission4区 · 医学

Genetics of impulse control disorders in Parkinson’s disease

4区 · 医学

Review

作者: Florence Cormier ; Jean-Christophe Corvol ; Julia Muellner

Impulse control disorders (ICD) have been recognised in Parkinson's disease (PD) as adverse effects of dopamine replacement therapy, particularly with dopamine agonists. Although virtually all PD patients are treated with dopaminergic drugs, only a minority will develop hyperdopaminergic states, suggesting predisposing and/or protecting factors. The age at onset, the sex and the dose or type of dopaminergic drugs have been identified as clinical predictive factors. Recent genetic studies have investigated associations between ICD and polymorphisms of genes involved in the dopamine metabolism pathway (COMT, DAT), dopamine receptors (DRD1, DRD2, DRD3, DRD4), serotonin receptors and its transporter (HTR2A, 5HTT), and glutamate receptors (GRIN2B). Although validation in larger and independent cohorts is needed, the results from these studies give us some insights into the pathophysiology of hyperdopaminergic states and may be useful, at term, in personalising antiparkinsonian treatment in clinical practice.

2009-06-01·Genes, Brain and Behavior3区 · 心理学

Investigation of 17 candidate genes for personality traits confirms effects of the HTR2A gene on novelty seeking

3区 · 心理学

Article

作者: A. Ellgas ; A. Heck ; R. Lieb ; H. Pfister ; F. Holsboer ; S. Lucae ; B. Müller-Myhsok ; M. Ising ; B. Pütz ; M. Uhr ; D. Roeske

Genes involved in serotonergic and dopaminergic neurotransmission have been hypothesized to affect different aspects of personality, but findings from genetic association studies did not provide conclusive results so far. In previous studies, however, only one or a few polymorphisms within single genes were investigated neglecting the possibility that the genetic associations might be more complex comprising several genes or gene regions. To overcome this limitation, we performed an extended genetic association study analyzing 17 serotonergic (SLC6A4, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, HTR6, MAOA, TPH1, TPH2) and dopaminergic genes (SLC6A3, DRD2, DRD3, DRD4, COMT, MAOA, TH, DBH), which have been previously reported to be implicated with personality traits.One hundred and ninety‐five single nucleotide polymorphisms (SNPs) within these genes were genotyped with the Illumina BeadChip technology (HumanHap300, Human‐1) in a sample of 366 mentally healthy Caucasians. Additionally, we tried to replicate our results in an independent sample of further 335 Caucasians. Personality traits in both samples were assessed with the German version of Cloninger's Tridimensional Personality Questionnaire.From 30 SNPs showing associations at a nominal level of significance, two intronic SNPs, rs2770296 and rs927544, both located in the HTR2A gene, withstood correction for multiple testing. These SNPs were associated with the personality trait novelty seeking. The effect of rs927544 could be replicated for the novelty seeking subscale extravagance, and the same SNP was also associated with extravagance inthe combined samples.Our results show that HTR2A polymorphisms modulate facets of novelty seeking behaviour in healthy adults suggesting that serotonergic neurotransmission is involved in this phenotype.