别名 60 kDa chaperonin、60 kDa heat shock protein, mitochondrial、Chaperonin 60 + [11] |
简介 Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:1346131, PubMed:11422376). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). |
靶点 |
作用机制 Hsp60调节剂 [+1] |
在研机构 |
在研适应症 |
非在研适应症- |
最高研发阶段临床申请 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
开始日期2017-03-01 |
申办/合作机构- |
开始日期2014-03-25 |
申办/合作机构- |