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非在研适应症- |
最高研发阶段批准上市 |
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首次获批日期2000-07-31 |
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非在研适应症- |
最高研发阶段临床3期 |
首次获批国家/地区- |
首次获批日期1800-01-20 |
二甲双胍格列本脲片在中国健康受试者中进行的单中心、随机、开放、单次(空腹/餐后)口服给药、两制剂、两序列、两周期、交叉的人体生物等效性试验
主要目的:观察中国健康受试者在空腹/餐后状态下单次口服受试制剂二甲双胍格列本脲片(规格:500mg/2.5mg)和参比制剂二甲双胍格列本脲片(商品名:Glucovance®;规格:500mg/2.5mg;持证商:Merck SANTE S.A.S)后的药代动力学特征,评价两种制剂在空腹/餐后状态下的生物等效性。
次要目的:观察受试制剂二甲双胍格列本脲片和参比制剂二甲双胍格列本脲片(Glucovance®)在中国健康受试者中的安全性。
Efficacy and Safety of the Oral Combined Therapy Glimepiride / Vildagliptin / Metformin in Patients With Type 2 Diabetes With Dual Treatment Failure
Phase IIIb, randomized, multicenter, double-blind, prospective study to evaluate the efficacy and safety of a daily fixed-dose combination of glimepiride / vildagliptin / metformin in patients with type 2 diabetes with a history of dual treatment failure and combined or individual oral antidiabetics with SGLT2 / Metformin, Biguanide / Sulfonylurea, Sulfonylurea / iDPP4 or Biguanide / iDPP4. To evaluate the changes in the percentage of HbA1c at 3 and 6 months with regard to their baseline measurement.
A Prospective, Randomized Open-Label Phase II Study of the Safety and Tolerability of Metformin in Combination With Standard Antimicrobial Treatment of Pulmonary Tuberculosis in People With TB and Co-infected With HIV
The METHOD study will examine whether adding metformin to standard antibiotic treatment for tuberculosis (TB) in people with HIV is safe and well tolerated. The study will also test if adding metformin clears the infection more quickly and with less lung damage. When enrolled, participants will have an equal chance of being in the group that takes standard TB medicines alone or in the group that also takes metformin. Participants will have a chance to be put on either: 1) standard TB medicines (isoniazid, rifampicin, ethambutol and pyrazinamide for two months, continuing isoniazid and rifampin for four more months) only; or 2) the same standard TB medicines plus metformin. Participants randomized to the metformin arm will take metformin for eleven weeks, starting one week after starting the standard TB medicines. In addition to monitoring for side effects, all participants will have studies of drug levels and lung and immune function.
100 项与 PRKAB1 x SUR1 相关的临床结果
100 项与 PRKAB1 x SUR1 相关的转化医学
0 项与 PRKAB1 x SUR1 相关的专利(医药)