A multi-center, Randomized, Double-blind, Parallel Phase III Clinical Trial to Evaluate the efficacy and safety of Triple combination therapy of Amlodipine/Valsartan/Rosuvastatin in Paients with Dyslipidemia and Hypertension
A randomized, open-label, single dose, crossover clinical study to compare the pharmacokinetic characteristics and the safety between Tenelitin tablet 20 mg and Tenelia tablet 20 mg in healthy adult subjects
Biopharmaceutical studies of 1,2-ethanediol ester and 1,4-butanediol ester of flurbiprofen
作者: Rho, Jae Il ; Lee, Wan Ha
Prodrugs of flurbiprofen, its 1,2-ethanediol ester and 1,4-butanediol ester were prepared and their biopharmaceutical studies were performed. The prodrugs showed high stability in simulated gastric fluid, simulated intestinal fluid and pancreatin-saturated solution Pharmacokinetic parameters of the prodrugs were similar to those of their parent drug. However they showed less acute toxicity and gastric irritation and higher anti-inflammatory and analgesic effects.