Delving into the Latest Updates on Jawaharlal Nehru Centre For Advanced Scientific Research with Synapse

概览

疾病领域	数量

感染	4
内分泌与代谢疾病	1

排名前五的药物类型	数量

化学药	4
小分子化药	1

排名前五的靶点	数量

β-lactamase(β-内酰胺酶)	2
EP300(组蛋白乙酰转移酶p300)	1

关联

5

项与 Jawaharlal Nehru Centre For Advanced Scientific Research 相关的药物

VanNHdipi

靶点

β-lactamase

作用机制

β-lactamase抑制剂 [+2]

在研机构

Jawaharlal Nehru Centre For Advanced Scientific Research

原研机构

Jawaharlal Nehru Centre For Advanced Scientific Research

在研适应症

革兰氏阳性细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

LTK-14A

靶点

EP300

作用机制

EP300抑制剂

在研机构

Jawaharlal Nehru Centre For Advanced Scientific Research

原研机构

Jawaharlal Nehru Centre For Advanced Scientific Research

在研适应症

肥胖

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

VanQAmC10

靶点-

作用机制

细菌生物膜抑制剂

在研机构

Central Drug Research Institute [+1]

原研机构

Central Drug Research Institute [+1]

在研适应症

碳青霉烯类耐药鲍曼不动杆菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

100 项与 Jawaharlal Nehru Centre For Advanced Scientific Research 相关的临床结果

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0 项与 Jawaharlal Nehru Centre For Advanced Scientific Research 相关的专利（医药）

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6,247

项与 Jawaharlal Nehru Centre For Advanced Scientific Research 相关的文献（医药）

2025-05-01·Applied Catalysis B: Environment and Energy

Coke-free propane dehydrogenation over ultra-stable metal-free BCN catalyst

作者: Singh, Abhishek K. ; Eswaramoorthy, Muthusamy ; Agarwal, Sakshi ; Ahamed, Momin

Non-oxidative propane dehydrogenation (PDH) is one of the most important on-purpose techniques for bridging the supply-demand gap of propylene.Pt and Cr-based catalysts are the com. catalysts for the PDH process.However, the high cost of Pt, environmental impact of Cr, and rapid catalyst deactivation which requires frequent regeneration resulting in CO₂ emissions are some of the major challenges.Here we report a metal-free borocarbonitride (BCN) catalyst that exhibits exceptional catalytic activity and stability.The as-synthesized catalyst achieved a propane conversion of 17.8% with 94% propylene selectivity at 600 °C.Time-onstream (TOS) stability test at 600 °C shows that BCN retains its initial activity even after 400 h in a single run.The stable nature of active sites and insignificant coke formation rates are believed to be the reasons for such performance.Based on exptl. characterizations and DFT calculations, we propose that quinone functional groups are the active site and catalyst regeneration happens via the release of a hydrogen mol.

2025-03-17·Journal of Physics: Condensed Matter

Investigation of magnetic and transport properties of GdSbSe

Article

作者: Gautam, Aarti ; Sundaresan, A ; Kant Mishra, Prabuddha ; Kumar Ganguli, Ashok ; Banerjee, Souvik

AbstractWe report the detailed investigation of the magnetic, transport, and magnetocaloric effects (MCEs) of GdSbSe by magnetic susceptibility

χ(T)

, isothermal magnetization M(H), resistivity

ρ(T,H)

, and heat capacity

Cp(T)

measurements, crystallizing in the ZrSiS-type tetragonal crystal system with space group P4/nmm. Temperature-dependent magnetic susceptibility measurements revealed long-range antiferromagnetic ordering with two additional magnetic anomalies below Néel temperature (

TN≈8.6

K), corroborated through magnetocaloric and specific heat studies. Isothermal magnetization measurements unveil hidden metamagnetic signatures through a clear deviation from linearity. In addition, the enhanced value of the Sommerfeld coefficient (γ = 152(5) mJ mol−1 K2) suggests strong electronic correlations in GdSbSe. The entropy of magnetization derived from magnetic isotherms unfolds the field-induced transition from Inverse MCE to Conventional MCE. The detailed transport properties indicate a semimetallic behavior, strongly coupled with magnetic order. Furthermore, the linear field dependence of MR in the high-field region anticipate the possibility of Dirac-like dispersion. Deviations from Kohler’s rule and non-linear Hall resistivity suggest the multiband nature of GdSbSe.

2025-01-16·The Journal of Physical Chemistry C

One-Dimensional Indium(III) Halide Double Perovskites (CH₃NH₃)₂NaInX₆ (X = Cl, Br) and Their Antimony(III)-Induced High Photoluminescence

作者: Pati, Swapan K. ; Sharma, Mayank ; Shreeraksha, Madhukara ; Vishwajith, Nagale S. ; Prasad, Ajay J. ; Vishnoi, Pratap

Low-dimensional In(III) halide perovskites have become one of the most attractive classes of light-emitting materials due to their tunable and high photoluminescence efficiency.However, their synthesis is still a challenge.Here, we report two novel Na(I)-In(III) halide double perovskite-related compounds (MA)₂NaInCl₆ and (MA)₂NaInBr₆ and their Sb³⁺-doped counterparts.Both compounds crystallize in one-dimensional (1D) face-sharing chain structures with a trigonal P3̅m1 symmetry. (MA)₂NaInCl₆ and (MA)₂NaInBr₆ show wide and direct band gaps of 5.3 and 3.9 eV, resp.While both materials are nonemissive in their pristine forms, 5% Sb³⁺-doped (MA)₂NaInCl₆ and (MA)₂NaInBr₆ show green (555 nm) and yellow (585 nm) emission with the photoluminescence quantum yields of 13.8 and 53.6%, resp.For (MA)₂NaInBr₆, a PLQY of 67.64% was achieved with 1% Sb doping.Variable-temperature PL studies and d. functional theory calculations indicate that the Sb³⁺ ion introduces self-trapped excitonic (STE) states, which are responsible for the high-efficiency PL emission.Our findings significantly expand the scope of halide double perovskites to low-dimensional photoluminescent In(III)-based metal halide perovskites.

100 项与 Jawaharlal Nehru Centre For Advanced Scientific Research 相关的药物交易

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100 项与 Jawaharlal Nehru Centre For Advanced Scientific Research 相关的转化医学

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2025年01月31日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

5

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当前项目

药物(靶点)	适应症	全球最高研发状态

LTK-14A ( EP300 )	肥胖更多	临床前
Dipi-Van ( β-lactamase )	革兰氏阳性细菌感染更多	临床前
VanNHdipi ( β-lactamase )	革兰氏阳性细菌感染更多	临床前
VanQAmC10	碳青霉烯类耐药鲍曼不动杆菌感染更多	临床前
AAV-qC10	细菌感染更多	临床前