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Assessment of Safety and Immunogenicity of Intradermal Electroporation of tetwtCEA DNA in Patients With Colorectal Cancer
The purpose of this study is to evaluate the safety and immunogenicity of a CEA DNA immunisation approach in patients with colorectal cancer. The DNA plasmid, tetwtCEA, encodes wild type human CEA fused to a tetanus toxoid T helper epitope. The vaccine will be delivered using an intradermal electroporation device, Derma Vax (Cyto Pulse Sciences). The following will be assessed:
The efficiency of priming immunological responses to CEA by intradermal administration of CEA DNA in combination with electroporation.
The efficiency of boosting immunological responses to CEA by intradermal administration of CEA DNA in combination with electroporation in subjects already vaccinated with CEA DNA.
GM-CSF will be administered to half of the subjects primed with CEA DNA in combination with electroporation and any possible adjuvant effects of GM-CSF will be evaluated.
DNA Vaccine Coding for the Rhesus Prostate Specific Antigen (rhPSA) and Electroporation in Patients With Relapsed Prostate Cancer. A Phase I/II Study
This study will assess the feasibility and safety of vaccination with increasing doses of xenogenic DNA administered intradermally in combination with electroporation in patients with relapse of prostate cancer. The DNA encodes prostate specific antigen (PSA) from Rhesus Macaque (Macaca mulatta), a protein that is 89% homologous to human PSA. The study will also assess the safety and functionality of the DERMA VAX™ (Cyto Pulse Sciences) DNA vaccine delivery system.
100 项与 Cyto Pulse Sciences, Inc. 相关的临床结果
0 项与 Cyto Pulse Sciences, Inc. 相关的专利(医药)
2012-04-30·Journal of Instrumentation
Sensitivity of an image plate system in the XUV (60 eV < E < 900 eV)
作者: Failor, B. H. ; Gullikson, E. M. ; Link, N. G. ; Riordan, J. C. ; Wilson, B. C.
Phosphor imaging plates (IPs) have been calibrated and proven useful for quant. x-ray imaging in the 1 to over 1000 keV energy range. In this paper we report on calibration measurements made at XUV energies in the 60 to 900 eV energy range using beamline 6.3.2 at the Advanced Light Source at Lawrence Berkeley National Laboratory We measured a sensitivity of ∼25 ± 15 counts/pJ over the stated energy range which is compatible with the sensitivity of Si photodiodes that are used for time-resolved measurements. Our measurements at 900 eV are consistent with the measurements made by Meadowcroft et al. at ∼1 keV.
100 项与 Cyto Pulse Sciences, Inc. 相关的药物交易
100 项与 Cyto Pulse Sciences, Inc. 相关的转化医学