Instituto Ramón y Cajal de Investigación Sanitaria (Instituto Ramón y Cajal de Investigación Sanitaria)

概览

关联

1

项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的药物

L-165041

靶点

PPARδ

作用机制

PPARδ激动剂

在研机构-

原研机构

Merck & Co., Inc.

在研适应症-

非在研适应症

高脂血症 [+1]

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

1

项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的临床试验

ISRCTN11587056

/ CompletedN/A

Surgery first and Invisalign. A comparative assessment of periodontal health and quality of life in postsurgical orthodontic treatment with Invisalign or traditional fixed appliances: a randomized controlled trial

开始日期2016-05-01

申办/合作机构

Instituto Ramón y Cajal de Investigación Sanitaria

100 项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的临床结果

登录后查看更多信息

0 项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的专利（医药）

登录后查看更多信息

384

项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的文献（医药）

2025-06-01·Experimental Eye Research

P2 component latency of fVEP as a bioindicator for clinical and diagnostic use in visual pathologies

Article

作者: Liao, Fei ; Wang, Ting ; Liu, Haitao ; de la Villa, Pedro ; Germain, Francisco

PURPOSEThe signaling of flash visual evoked potential (fVEP) derives from the retina, but how retinal activity influences fVEP remains unclear. This work aimed to decipher the specific retinal kinetic contributions to fVEP response.METHODSMonocular and simultaneous recordings of flash VEP and electroretinogram were performed. Healthy and adult mice C57BL/6J were used. The right eye was injected intravitreally with 1 μL of PBS containing 25 mM APB, 10 mM Bicuculline, 30 mM DNQX, 100 mM Glutamate, 100 mM GABA, 5 mM TPMPA, or 25 mM HEPES. The left eye was injected with 1 μL of PBS and then wore an opaque patch. The amplitude and latency of fVEP were analyzed in detail.RESULTSIn the control group, at light intensity ≤0.1 cd·s/m², four robust components of the fVEP recordings, N1, P1, N2, and P2, were identified in dark adaptation conditions. After administration reagents, N1 and P1 components were abolished by APB, Bicuculline, DNQX or TPMPA, but were preserved by GABA/Glutamate or HEPES. Notably, N2 and P2 components were always kept. The latency and amplitude of fVEP were shown to be stimulus-dependent. Nevertheless, the amplitude showed greater inter-individual variability than latency.CONCLUSIONN1 and P1 components are strongly related to rod photoreceptor activity and/or the level of horizontal cell excitation. Latency, rather than fVEP amplitude, could be a good biomarker for clinical and diagnostic purposes, particularly the P2 latency in the rod-driven scotopic response.

2025-04-01·Endoscopy

Single-use gastroscopes: evolution, revolution, or involution?

Article

作者: Rodriguez de Santiago, Enrique ; Pohl, Heiko

2025-04-01·Actas Dermo-Sifiliográficas

[[Artículo traducido]]Revisión sistemática sobre suplementos dietéticos en la prevención y/o tratamiento de la queratosis actínica y el campo de cancerización

Review

作者: Longo, C ; Pellacani, G ; de Troya, M ; Peris, K ; de Galvez, M V ; Rodríguez-Luna, A ; Calzavara-Pinton, P ; Juarranz, Á ; Zamarrón, A ; Gilaberte, Y ; González, Salvador

BACKGROUNDActinic keratoses (AKs) are chronic, recurrent precancerous lesions primarily induced by long-term sun exposure, commonly found on sun-exposed areas such as the face, neck, hands, forearms, and lower legs. AKs are prevalent, affecting millions worldwide, and pose a significant risk of transforming into invasive squamous cell carcinomas (SCCs).OBJECTIVEThis systematic review aims to update the scientific evidence on the role of oral bioactives, nutraceuticals, or dietary supplements in the treatment of AKs and field cancerization, while evaluating their safety and efficacy profile.METHODSA review plan was pre-registered in the PROSPERO database (CRD42023485985). Following the PRISMA guidelines, we identified, selected, and included relevant studies. We screened a total of 234 articles, thoroughly reviewed 38 full texts, and ultimately included 21 articles published from 2013 through 2023 for analysis.RESULTSThe selected studies were categorized into 3 groups based on the chemical nature of the supplements: polyphenols (11 studies), vitamins (8 studies), and others (2 studies). The studies included preclinical (9) and clinical (12) studies. Clinical trials have demonstrated the efficacy profile of polyphenolic supplements, such as Polypodium leucotomos extract (PLE) and others in improving skin health and reducing the risk of skin cancers. Preclinical studies highlighted the protective effects of polyphenols against UV-induced damage and neoplastic transformation. Vitamin supplementation studies revealed mixed results, with clear data showing benefits in reducing the risk of precancerous lesions and skin cancers after nicotinamide (NAM) treatment, while others did not demonstrate significant protective effects.CONCLUSIONSThe review confirms the efficacy of polyphenols in preventing and treating AKs and related skin conditions. However, the role of vitamins and other supplements requires further investigation due to inconsistent and/or scarce findings. Future clinical trials should focus on diverse populations at higher risk of skin cancer and explore new ingredients as well as combinations of various ingredients to optimize therapeutic applications.

100 项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的药物交易

登录后查看更多信息

100 项与 Instituto Ramón y Cajal de Investigación Sanitaria 相关的转化医学

登录后查看更多信息