Delving into the Latest Updates on Kookmin University with Synapse

概览

疾病领域	数量

感染	2

排名前五的药物类型	数量

化学药	2

排名前五的靶点	数量

SARS-CoV-1 Nsp13(SARS冠状病毒Nsp13蛋白)	2

关联

3

项与 Kookmin University 相关的药物

Myricetin

杨梅黄酮

靶点

SARS-CoV-1 Nsp13

作用机制

SARS-CoV-1 Nsp13 agonists

在研机构

Kookmin University

原研机构

Kookmin University

在研适应症

严重急性呼吸综合征

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Scutellarein

野黄芩素

靶点

SARS-CoV-1 Nsp13

作用机制

SARS-CoV-1 Nsp13抑制剂

在研机构

Kookmin University

原研机构

Kookmin University

在研适应症

严重急性呼吸综合征

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

SKL2001

靶点

CTNNB

作用机制

CTNNB 激动剂

在研机构-

原研机构

Kookmin University

在研适应症-

非在研适应症-

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

1

项与 Kookmin University 相关的临床试验

KCT0005380

/ CompletedN/AIIT

Clinical research for Human Centric Lighting

开始日期2019-06-13

申办/合作机构

Kookmin University

100 项与 Kookmin University 相关的临床结果

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0 项与 Kookmin University 相关的专利（医药）

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8,997

项与 Kookmin University 相关的文献（医药）

2025-07-01·Bioresource Technology

Enzyme cascades for high-yield conversion of d-xylose into d-ribose by overcoming equilibrium constraints and enhancing selectivity

Article

作者: Park, Yong-Cheol ; Kim, Dong Hyun ; Kim, Kyoung Heon ; Lee, Ja Hyun ; Kim, Doyeon ; Kim, Yoonjoo

d-Ribose is essential for critical cellular functions and the synthesis of antiviral nucleosides. However, traditional chemical synthesis and fermentation methods of d-ribose production suffer from low yields and inefficient resource utilization. Here, we present a highly efficient enzymatic cascade strategy that utilizes selective phosphorylation and dephosphorylation processes, coupled with ATP regeneration to convert d-xylose into d-ribose with high yield. By optimizing this enzyme cascade, we achieved a substantial increase in d-ribose yield from 23.4 % to 93.5 % mol/mol, effectively overcoming the equilibrium limitations of sugar conversion processes. Notably, our approach allows for the selective conversion of d-xylose to d-ribose in lignocellulosic hydrolysates, even in the presence of d-glucose. This work demonstrates the highly efficient enzymatic conversion of d-xylose into d-ribose offering a competitive alternative to existing chemical synthesis methods. Our findings provide a novel approach to cellulosic biomass valorization and represent a significant contribution to the field of biorefinery.

2025-06-01·Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Browning of inguinal white adipose tissue by the novel lignan (−)-secoisolariciresinol 4-O-methyl ether attenuates diet-induced obesity through mitochondrial and peroxisomal activation

Article

作者: Kwak, Hyun Jeong ; Park, Woo Yong ; Song, Gahee ; Choe, Seong-Kyu ; Kim, Beomsu ; Um, Jae-Young ; Jung, Se Jin ; Kim, Yong-Il ; Kim, Jin-Hyung ; Park, Ja Yeon ; Jiao, Wenjun ; Lee, Jong-Hyun

Studies indicate that the induction and activation of brown and beige adipocytes, which can enhance energy expenditure, may be beneficial for managing obesity and its associated diseases. This study investigated whether a novel lignan (-)-secoisolariciresinol 4-O-methyl ether (S4M) obtained from arctigenin inhibited diet-induced obesity by the browning of white adipose tissue (WAT). S4M treatment inhibited adipogenesis and lipid accumulation in white-induced 3T3-L1 adipocytes and in zebrafish embryonic development. Moreover, S4M treatment promoted browning in white adipocytes by increasing TOM20, UCP1, and PGC1α protein levels and consequently upregulating the mitochondrial content. S4M treatment significantly promoted mitochondrial fission by increasing the expression of DRP1. Furthermore, it enhanced peroxisomal biogenesis and function by inducing PEX13, ACOX1, and catalase. Mdivi-1, a mitochondrial dynamics inhibitor, diminished the browning effect of white adipocytes by the S4M treatment. This study found that S4M treatment inhibited weight gain in high-fat diet-induced obese mice, decreased the weight of WAT, and increased the abundance and function of mitochondria and peroxisomes in inguinal WAT, suggesting that S4M treatment could increase energy expenditure. The results suggest that S4M has potential as a therapeutic agent for combating obesity and its associated metabolic disorders.

2025-05-06·Proceedings of the 4th International Workshop on Real-time and IntelliGent Edge computing

Selective Layer Acceleration with Data-parallel Architecture for DNN Inference Throughput Maximization

作者: Kim, Jaehyuck ; Ahn, Sol ; Kim, Jong-Chan ; Roh, Seungwoo

100 项与 Kookmin University 相关的药物交易

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100 项与 Kookmin University 相关的转化医学

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2025年05月07日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

2

1

其他

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当前项目

药物(靶点)	适应症	全球最高研发状态

杨梅黄酮 ( SARS-CoV-1 Nsp13 )	严重急性呼吸综合征更多	临床前
野黄芩素 ( SARS-CoV-1 Nsp13 )	严重急性呼吸综合征更多	临床前
SKL2001 ( CTNNB )	-	无进展