Objective: To establish a method for the determination of 8 residual organic solvents in tolterodine tartrate by capillary GC. Methods: The determination of methanol, ethanol, acetonitrile, acetone, Et acetate, trichloromethane and THF in tolterodine tartrate dissolved in the solution of N,N-dimethylformamide-water (1 : 4) was carried out on a CP-sil 5CB (60.0 m × 0.32 mm, 5 μm) column. The inlet temperature was 200 degree and the FID detector temperature was 250 degree. The flow rate of carrier gas was 1.2 mL·min-1. The column temperature was 120 degree. The headspace vial temperature was 85 degree and the time was 30 min. The determination of pyridine in tolterodine tartrate dissolved in the solution of dimethylsulfoxide-sodium hydroxide (17 : 13) was carried out on an HP-1 (30.0 m × 0.53 mm, 5 μm) column. The inlet temperature was 220 degree and the FID detector temperature was 250 degree. The column temperature was 80 degree. The flow rate of carrier gas was 3.0 mL·min-1. The headspace vial temperature was 85 degree and the time was 30 min. Results: All peaks could be separated from each other under the chromatog. conditions. The linearity of the eight solvents was fairly good (r>0.999). The average recovery was ranged from 86.0% to 100.2% with RSD of 1.7%-3.5% (n = 9). The limit of detection was 0.63, 0.43, 0.30, 0.18, 0.079, 0.36, 0.18 and 0.89 μg·ml-1, resp. Conclusion: The methods could be applied in the determination of the eight residual organic solvents in tolterodine tartrate.