Delving into the Latest Updates on Quaid-i-Azam University with Synapse

概览

疾病领域	数量

感染	2

排名前五的药物类型	数量

小分子化药	2

排名前五的靶点	数量

α-淀粉酶	2

关联

3

项与 Quaid-i-Azam University 相关的药物

Pyrimidine linked acyl thiourea derivatives 6j(Quaid-I-Azam University)

靶点

α-淀粉酶

作用机制

α-淀粉酶抑制剂

在研机构

Quaid-i-Azam University

原研机构

Quaid-i-Azam University

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Pyrimidine linked acyl thiourea derivatives 6g(Quaid-I-Azam University)

靶点

α-淀粉酶

作用机制

α-淀粉酶抑制剂

在研机构

Quaid-i-Azam University

原研机构

Quaid-i-Azam University

在研适应症

细菌感染

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

Kisspeptin-10

靶点-

作用机制-

在研机构-

原研机构

Mass General Brigham, Inc.

在研适应症-

非在研适应症

不孕

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

10

项与 Quaid-i-Azam University 相关的临床试验

ChiCTR2200065420

/ SuspendedN/AIIT

Using mHealth solution to improve self-management, medication adherence and quality of life in type 2 diabetic patients

开始日期2022-11-15

申办/合作机构

Quaid-i-Azam University

[+1]

IRCT20220516054875N1

/ Suspended临床1/2期IIT

Exploring the pharmacist's intervention for precluding the factors effecting medication adherence in Chronic Obstructive Pulmonary Diseases (COPD) following GOLD (Global Initiative for Chronic Obstructive Lungs diseases) guidelines in Pakistan

开始日期2022-06-01

申办/合作机构

Quaid-i-Azam University

ACTRN12622000996763

/ CompletedN/AIIT

Pharmacist-led Intervention for Disease and Risk Management in Patients with Ischemic Heart Disease

开始日期2022-01-03

申办/合作机构

Quaid-i-Azam University

100 项与 Quaid-i-Azam University 相关的临床结果

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0 项与 Quaid-i-Azam University 相关的专利（医药）

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19,381

项与 Quaid-i-Azam University 相关的文献（医药）

2025-12-31·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Sandstone reservoir modeling based on rock physics characterization for hydrocarbon resource potential in Southern Pakistan

作者: Mughal, Muhammad Rizwan ; Akhter, Gulraiz

In the development and production of hydrocarbons as natural energy sources, it is necessary to predict the lithol. and fluid type as the essential building blocks of reservoir modeling.This study aims to discriminate the reservoir litho-fluid classes for the prediction of hydrocarbon resource potential in the gas prone reservoir (C-sand interval) of Sawan area, Southern Pakistan.Initially, model-based inversion technique is applied for the estimation of acoustic impedance (P-impedance) values within the reservoir C-sand interval.Inversion results provided a reasonable estimate of P-impedance in term of its spatial variations, and geo-statistically derived effective porosity highlighted a hydrocarbon-saturated sand channel within reservoir at targeted depth level.At the second stage, rock physics characterization created a useful distinction between litho-fluid classes in the cross-plot of elastic properties within C-sand interval at well locations.The probability d. functions (PDFs) are then computed to extract litho-fluid classes from inversion results within the Bayesian framework.Finally, the extraction of most probable facies and gas sand probability volumes identified that the gas sand channel passing through the Sawan-01, Sawan-07, and Sawan-08 well is majorly responsible for the gas accumulation in the area.Furthermore, the calibration of these estimates with inversion, geo-statistics, and rock physics anal. indicates a good match with each other for prediction of hydrocarbon resource potential in the area under investigation.

2025-12-31·Energy Sources, Part A: Recovery, Utilization, and Environmental Effects

Engine characteristics study on beef tallow biodiesel produced by ethanol based co-solvent transesterification

作者: Palani, Shalini ; Mohanam, Anand ; Saeed, Muhammad ; Thangavelu, Lakshmanan ; Munir, Mamoona ; Srinivasan, Gokul Raghavendra ; Jambulingam, Ranjitha

This present study looks at the engine characteristics of beef tallow biodiesel (tallow Me Et ester) produced using methanol-ethanol-based co-solvent transesterification.From combustion characteristics, TMEE reported increased mean peak in-cylinder pressure (5.992 ± 1.34 MPa) and heat release rate (HRR) (61.52 ± 1.28 kJ/m³.deg) than TME on account of its higher cetane number and fuel bound oxygen content; however, TEE exhibited increased mean in-cylinder pressure (1.75%) and HRR (2.14%) than TMEE sample.Likewise, TEE exhibited superior fuel consumption (SFC) rate (on average, 2.67%) and brake thermal efficiency (BTE)(on average, 3.53%) than TMEE; while, TMEE displayed reduced SFC (on average, 11.43%) and increased BTE (on average, 12.46%) than TME in view of its increased calorific value contributed by TEEs in it.Besides, emission characteristics reported reduced CO emission level and exhaust HC concentrations (on average, 10% and 7.1%, resp.); along with slightly increased CO₂ and NO_X emissions (on average, 4.79% and 5.82%, resp.), in case of TMEE when compared to TME.Here, reduced emission characteristics of TEE, followed by TMEE were because of their high oxygen content and increased cetane number contributed by the Et esters available in them; which also signified the completeness of their combustion.

2025-12-01·Molecular Biology Reports

Molecular and computational analysis of a novel pathogenic variant in emopamil-binding protein (EBP) involved in cholesterol biosynthetic pathway causing a rare male EBP disorder with neurologic defects (MEND syndrome)

Article

作者: Houlden, Henry ; Rahman, Fatima ; Efthymiou, Stephanie ; Naeem, Muhammad ; Maqbool, Shazia ; Ahmad, Riaz ; Bibi, Hadiba

AbstractBackgroundMale EBP disorder with neurologic defects (MEND syndrome) is an extremely rare disorder with a prevalence of less than 1/1,000,000 individuals worldwide. It is inherited as an X-linked recessive disorder caused by impaired sterol biosynthesis due to nonmosaic hypomorphic EBP variants. MEND syndrome is characterized by variable clinical manifestations including intellectual disability, short stature, scoliosis, digital abnormalities, cataracts, and dermatologic abnormalities. The goal of this study was to investigate the disease-causing variants in a family of two patients affected with MEND syndrome.MethodsThe genomic DNA of the two patients with MEND syndrome was subjected to whole exome sequencing to identify disease-causing variants. Segregation of the identified variant was tested through Sanger sequencing. Several in-silico tools were used to evaluate the pathogenicity of the variant. Protein’s 3D structure analysis systems were used to predict the impact of the identified variant on the binding and function of the mutated EBP protein including AlphaFold, PyMOL, AutoDock, ChimeraX and Discovery Studio.ResultsA novel pathogenic missense EBP variant NM_006579.3:c.556T > C (Trp186Arg) was found segregating in the affected family. In-silico analysis and molecular docking results supported the pathogenicity of the identified variant.ConclusionOur study expands the mutation spectrum of EBP and adds to the restricted reports of MEND patients. It strengthens the body of evidence that supports the role of EBP in the MEND syndrome phenotype. To our knowledge, this is the first report of this disorder from Pakistan.

100 项与 Quaid-i-Azam University 相关的药物交易

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100 项与 Quaid-i-Azam University 相关的转化医学

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2025年01月24日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床前

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当前项目

药物(靶点)	适应症	全球最高研发状态

Pyrimidine linked acyl thiourea derivatives 6g(Quaid-I-Azam University) ( α-淀粉酶 )	细菌感染更多	临床前
Pyrimidine linked acyl thiourea derivatives 6j(Quaid-I-Azam University) ( α-淀粉酶 )	细菌感染更多	临床前
Kisspeptin-10	-	无进展