Delving into the Latest Updates on University of Miyazaki with Synapse

Evaluating the relaxation effects of Shikuwasa (Citrus depressa Hayata) essential oil inhalation in young female adults: study protocol for a randomised controlled trial - Clinical trial to investigate the relaxation effects of Shikuwasa (Citrus depressa Hayata) essential oil inhalation

开始日期2024-04-01

申办/合作机构

University of Miyazaki

JPRN-UMIN000052811

/ CompletedN/AIIT

Investigation of the feasibility of measuring electrical conductivity with paper-based microfluidic chips using blood samples - Investigation of the feasibility of measuring electrical conductivity with paper-based microfluidic chips using blood samples

开始日期2023-12-15

申办/合作机构

University of Miyazaki

[+1]

JPRN-UMIN000052702

/ Recruiting临床3期IIT

An evaluation of the efficacy of internet-delivered cognitive therapy for social anxiety disorder (iCT-SAD) in Japan: a randomised controlled trial - An evaluation of the efficacy of internet-delivered cognitive therapy for social anxiety disorder (iCT-SAD) in Japan: a randomised controlled trial

开始日期2023-12-01

申办/合作机构

University of Miyazaki

100 项与 University of Miyazaki 相关的临床结果

登录后查看更多信息

0 项与 University of Miyazaki 相关的专利（医药）

登录后查看更多信息

15,153

项与 University of Miyazaki 相关的文献（医药）

2025-05-01·Journal of Photochemistry and Photobiology A: Chemistry

Heat trapping with restricted energy dissipation in polyfluorinated supra molecular environment: Wavelength dependency of energy deposition

作者: Nakazato, Ryosuke ; Shiragami, Tsutomu ; Inoue, Haruo ; Tachibana, Hiroshi ; Ramakrishnan, Vivek ; Iwata, Yuki ; Nabetani, Yu

Following our previous report on the heat trapping in organic/inorganic hybrid compound with bilayer structure formed by cationic polyfluorinated surfactant containing azobenzene moiety (C3F-Azo-C6H) in the interlayer of cation-exchangeable synthetic clay (Smecton SA: SSA) nanosheets having been probed by a temperature sensing Rhodamine B (RhB) upon excitation by a fixed wavelength of visible light, a systematic study of the effect of wavelength dependency for the excitation was carried out to get deeper insight into the heat trapping.Evident wavelength effect of excitation on the temperature elevation was observedAmong three components in the fluorescence lifetime (τ₁, τ₂, τ₃) of RhB, the local temperatures T₁, T₂ deduced from τ₁, τ₂ exhibited a systematic temperature elevation upon excitation of RhB with a shorter wavelength of visible light (570-520 nm).Estimation of the energy stored against the energy input indicated that an excess energy initially deposited at Franck-Condon state is retained in a limited number of local modes during the fluorescence lifetime through a pretty slow intramol. vibrational relaxation (IVR) in the interlayer.Structural anal. by TD-DFT calculation strongly suggested that all the local modes within RhB are classified into four groups (I-IV), which well coincides with the prediction by a comparison anal. in respect to the energy stored against the energy input to rationalize that the IVR of RhB for τ₁ component (T₁) in the interlayer is limited among the local mode groups I (#1-10)-II (#11-21) and τ₂ component (T₂) being restricted up to group III (# 22-36).The systematic study revealed that the hybrid compound C3F-Azo-C6H/SSA provides a unique microenvironment having gaseous/vacuum-like atm. to a mol. incorporated in the narrow gap space sandwiched by neighboring C3F-Azo-C6H mols. in the interlayer to allow an inherently slow IVR.

2025-03-01·Journal of Food Composition and Analysis

Effect of seasons and fishing ban period on umami-related and functional components of greeneye (Chlorophthalmus albatrossis) from Japanese coast

作者: Imagawa, Takumi ; Uchida, Katsuhisa ; Tanaka, Ryusuke ; Taoka, Yousuke ; Horie, Ryohei

Greeneye (Chlorophthalmus albatrossis) is a small fish with a mild white flesh and texture that can be eaten with bones.In this study, we aimed to clarify the effect of season and fishing ban period of greeneyes in terms of umami-related and functional component values by analyzing their chem. components.Greeneyes from the Japanese coast were analyzed between March 2023 (spring) and Feb. 2024 (winter), excluding the fishing ban period on June 2023.Free amino acids and nucleic acid-related substances were analyzed as components associated with umami-related components.The free amino acid level was the highest (3619.13 ± 719.54 μg/g wet sample) in the spring before the fishing ban, while the inosine monophosphate level in autumn was the highest (3884.28 ± 666.56 μg/g wet sample).Therefore, the umami taste was higher in spring and autumn.The levels of functional components (lipid content, fatty acids, vitamin E, and imidazole dipeptides) increased following the implementation of the fishing ban.Calcium levels were approx. 5 mg/g sample, with no significant differences observed in all seasons; the level was comparable to other fish consumed with bones or alternative high-calcium food sources.In conclusion, greeneyes can be considered a stable source of calcium and fish throughout the year, with varying umami-related and functional components depending on the season.

2025-02-01·Pathology - Research and Practice

Loss of tumor cell surface hepatocyte growth factor activator inhibitor-1 predicts worse prognosis in esophageal squamous cell carcinoma

Article

作者: Sato, Yuichiro ; Fukushima, Tsuyoshi ; Ikenoue, Makoto ; Yamamoto, Koji ; Kataoka, Hiroaki ; Kiwaki, Takumi ; Umekita, Yoshiko ; Kawaguchi, Makiko ; Takeno, Shinsuke

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is an epithelial type-1 transmembrane protease inhibitor that regulates the pericellular activities of hepatocyte growth factor activator and type-2 transmembrane serine proteases. It is strongly expressed in the stratified squamous epithelium and functions on the cell surface. We previously reported that the cell surface immunoreactivity of HAI-1 was reduced at the invasion front of oral squamous cell carcinoma. In this study, we investigate the relationship between cell surface HAI-1 (csHAI-1) and prognosis of esophageal squamous cell carcinoma (ESCC) after surgery. The effect of HAI-1 knockdown on cultured ESCC cells was also analyzed in vitro. HAI-1 exhibited distinct cell surface immunoreactivity in normal esophageal epithelium. In contrast, alterations in HAI-1 immunoreactivity were frequent in cancer cells, which exhibited aberrant intracytoplasmic localization and decreased cell surface immunoreactivity. The preservation of csHAI-1 immunoreactivity was a sign of a well-differentiated phenotype of ESCC cells. The decreased csHAI-1 was associated with shorter overall survival (OS) and disease-free survival (DFS) in the patients. In 55 cases of early (T1) ESCC cases, decreased csHAI-1 also predicted poor OS and DFS. The loss of HAI-1 enhanced migration and invasion of ESCC cells in vitro. These results suggest that the decreased cell surface immunoreactivity of HAI-1 is associated with a less differentiated phenotype and worse prognosis in ESCC. The cell surface-localized HAI-1 may serve as a promising marker for predicting recurrence and prognosis of ESCC.

100 项与 University of Miyazaki 相关的药物交易

登录后查看更多信息

100 项与 University of Miyazaki 相关的转化医学

登录后查看更多信息

组织架构

使用我们的机构树数据加速您的研究。

登录

或

查看完整样例数据

管线布局

2025年02月01日管线快照

管线布局中药物为当前组织机构及其子机构作为药物机构进行统计，早期临床1期并入临床1期，临床1/2期并入临床2期，临床2/3期并入临床3期

临床2期

2

其他

登录后查看更多信息

当前项目

药物(靶点)	适应症	全球最高研发状态

Pegylated adrenomedullin	溃疡性结肠炎更多	临床2期
重组人肾上腺髓质素(University of Miyazaki) ( ADMR )	溃疡性结肠炎更多	临床2期
JNASE-7001 ( GLP-1R )	2型糖尿病更多	无进展
R723 ( JAK2 )	肿瘤更多	无进展