Objective: To increase the content of the newly added indicator of salvianolic acid B on the premise of ensuring the contents of sodium danshensu and protocatechuic aldehyde according to the quality standards of Danshen drip liquid Methods: To optimize the parameters of the process of alkali treatment through orthogonal experiment Results: The optimized alkali treatment condition was A2B2 (pH 7.0∼7.5, boiling for 30 mins). Conclusion: The optimized condition of A2B2 can reduce the over-degradation of salvianolic acid B, thus the relatively high content of salvianolic acid B in Danshen drip liquid can be obtained.