The Column Group’s drug R&D team, known as TCG Labs Soleil, has been busy churning out new portfolio companies since it unveiled with a
$400 million-plus fund
in February.
And on Tuesday, one of its startups announced its first cross-border deal — a licensing pact for an en vogue modality developed by a biotech in China, one of the industry’s hottest R&D regions.
Soleil’s Juri Biosciences snagged the exclusive global license to a KLK2- and CD3-targeting T cell engager from EpimAb Biotherapeutics, according to the companies. The Shanghai-based startup will get up to $210 million in upfront payments and biobucks. The details of the terms were kept under wraps.
The tie-up is at least the 19th China-to-US biopharma deal so far in 2025, according to an
Endpoints News
tally. Drug giants like Pfizer, Merck, AstraZeneca and AbbVie are all collaborating with Chinese biotechs on China-grown assets, as are scrappier outfits backed by Western investors like Ouro Medicines and Verdiva Bio.
EpimAb has also benefited from the growing interest in China’s biotech sector. The company, which disclosed a
$120 million Series C
in 2021, has forged deals with
Almirall
,
Vignette Bio
,
Candid Therapeutics
and
Medigene
.
In a statement, EpimAb CEO Chengbin Wu said the deal with Juri “further validated” its T cell engager platform. The platform once focused on immunology and hematology but has now expanded into solid tumors.
With Juri’s help, EpimAb’s unnamed T cell engager will “soon” be clinically investigated for metastatic prostate cancer, Soleil CEO and TCG Labs managing partner Jin-Long Chen said in an interview.
The asset targets kallikrein-related peptidase 2, or KLK2, which is expressed in prostate tissues and has “very, very limited expression in healthy tissues,” Chen said.
“If you can get that really specific target where you can achieve a good therapeutic index, you get this really long durability efficacy, which is so unique for the T cell engager mechanism,” Soleil chief scientific officer Josh Lichtman said. “With this very specific profile, the combinations with other oncology approaches, including ADCs, chemotherapies, and in prostate cancer specifically, androgen receptor modulators, is very promising.”
Guiding the Juri team will be scientific advisor Charles Sawyers, who directs the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center in New York. He
co-discovered
the prostate cancer treatment marketed as Xtandi.
Juri is part of Soleil’s broad portfolio of about 10 companies, according to COO Lucinda Quan. The Column Group last year announced the launch of TCG Labs Soleil, with a mission to pair TCG’s venture funding with an R&D lab that creates single-asset companies and takes them to clinical proof of concept before handing them off to larger biopharmas that can take them to market.
So far, Soleil’s apparatus spans a wide range of therapeutic categories, including cardiovascular, autoimmune and cancer.