Zhejiang Jinhua CONBA Bio-Pharm Co., Ltd.

The objective of this paper is to the preparation and formulation investigation of asiaticoside orally disintegrating tablets.Prepare the tablets by using asiaticoside as principal drug and starch as disintegrating agent; establish the quality control method including character, disintegration, assay etc.Results show that the asiaticoside orally disintegrating tablets prepared met technol. requirements.The assay of asiaticoside was determined by HPLC, average recovery rate and RSD were 100.7% and 1.01% (n=9) resp.It was concluded that the preparation technol. is feasible and testing method is convenient and accurate.

OBJECTIVE To prepare sevelamer carbonate into dispersible tablets and to screen its optimal prescription to solve the problems of dysphagia and abnormal esophagus caused by conventional tablets in patients.METHODS According to the characteristics of excipients, the dispersible tablets were prepared with crosslinked polyvinylpyrrolidone(PVPP) as disintegrating agent, microcrystalline cellulose as excipient, povidone K-30 as adhesive, magnesium stearate as lubricant and aspartame and lemon essence as flavoring agents.The prescription was screened through DOE design with the dispersion uniformity and dissolution as indicators.RESULTS The optimal prescription was screened as the active pharmaceutical ingredient particle size of(D90) was 15.0 μm, the proportions of PVPP and magnesium stearate were 45.0% and 0.6% resp.CONCLUSION For the prepared sevelamer carbonate dispersible tablets, the formulation is reasonable, the process is feasible and the quality meets the requirement of the specification.

Preparation and quality control of diammonium glycyrrhizinate enteric-coated micropill were studied.Diammonium glycyrrhizinate enteric-coated micropill was prepared by extrusion-spheronization method, and the formula was optimized by orthogonal test.Acid tolerance rate and drug release were determined by HPLC.The optimal formula was: microcrystalline cellulose 15%, hydroxypropyl methylcellulose 4%, Eudragit L30-D55 18%.The linear range of diammonium glycyrrhizinate was 10-500 μg/mL.The acid tolerance rate and drug release accorded with the requirement.So the formula and preparation of diammonium glycyrrhizinate enteric-coated micropill were suitable.