Dietary Supplementation With Biobran/MGN-3 Increases Innate Resistance Against Viral Infections That Cause Influenza-like Illnesses in Elderly Subjects: a Randomized, Double-blind, Placebo-controlled Clinical Trial
Influenza is a seasonally-epidemic viral infection causing 3-5 million severe illnesses and up to approximately 500,000 annual deaths around the world. Influenza-like illnesses (ILI) is a simple constellation of symptoms and signs that was introduced to capture influenza cases in surveillance system. The elderly are more susceptible to cancers and viral infections including influenza infection and complications that was attributed to the phenomenon of immunosenescence or age-associated decline of immune system activity. Biobran/MGN3 is a natural nutritional supplement that was shown to exhibit potent immunomodulator effect such as enhancement of natural killer cell (NKC) activity and up-regulating the production of cytokines such as tumor necrosis factor-α (TNF- α), interferon-gamma (IFN-γ) and -lambda (IFN-λ). The protective effect of Biobran/MGN-3 against viral infection such hepatitis C virus (HCV) and human immunodeficiency virus (HIV) as well as several cancer types has been previously reported in experimental animal models and humans. The objective of the current study was to investigate the effect of Biobran/MGN-3 on some innate immune system components and the incidence of ILI in the older adult population. The studied innate immune system included NKC activity and the expressions of intracellular viral nucleic acid sensors such as retinoic acid-inducible gene 1 (RIG-1), melanoma differentiation-associated protein 5 (MDA5) and some of their downstream signals such as ISG15 and MX1.
Clinical Study of a Biological Response Modifier (Arabinoxylan Rice Bran/MGN-3/Biobran) With Interferon-Alpha for the Treatment of Hepatitis C Infection
Current treatments for Hepatitis C virus (HCV) have severe side effects and are very expensive. There is a need to explore effective natural therapies against HCV that are less toxic and more cost-effective. 37 chronic HCV infected patients were randomized into two groups and treated with PEG interferon plus ribavirin for the first group or Biobran, an arabinoxylan from rice bran (1 g/day) for the second group. Viremia level, liver enzymes, γ-interferon (IFN-γ) levels in serum, and toxicity were checked before and three months after treatment.
Development of functional food (BioBran) produced from rice bran
作者: Kato, Hisayoshi ; Zhu, Xia
A review. Rice bran is considered to be inedible and is hence discarded, but using it as the raw material on which enzymic processing is done, the food ingredient biobran is made, which has varied bioactive properties, as revealed by studies done so far. In this paper, the concept of this development and its bioactive nature, as well as recent discussions on this topic are presented.
2008-10-31·Food Style 21
Possibilities of functional foods with immunomodulatory effect
作者: Kawakami, Satoshi
A review discussing (1) Biobran (MGN-3) and arabinoxylan from rice bran, (2) life style and immunity, (3) immune system, (4) gut associated lymphatic system (GALT), (5) enhanced human natural killer cell activity by arabinoxylan from rice bran and (6) suppression of immune hypersensitivity by arabinoxylan from rice bran.
2005-02-28·Food Style 21
The development of phyto-kefiran and study of its dietary function
作者: Maeda, Hiroaki
A review discussing production of kefiran from Lactobacillus kefiranofaciens from kefir, and physiol. effects of kefiran, e.g. blood glucose-lowering effect, intestine-conditioning effect, anti-hypertensive effect, and anti-arteriosclerotic effect for its application in health food material is provided.