Exploration of Biomarkers for AFP-PIVKA-II Double-Negative Cases in Hepatocellular Carcinoma - Exploration of Biomarkers for AFP-PIVKA-II Double-Negative Cases in Hepatocellular Carcinoma

开始日期2023-01-17

申办/合作机构

Tottori University

JPRN-UMIN000050248

/ RecruitingN/AIIT

Research for cardiac rehabilitation under remote supervision - Cardiac rehabilitation under remote supervision

开始日期2023-01-01

申办/合作机构

Tottori University

JPRN-UMIN000046699

/ CompletedN/AIIT

Effects of Mindfulness Meditation Intervention on Mindlessness and Interpersonal Attitudes. - Effects of Mindfulness Meditation Intervention on Mindlessness and Interpersonal Attitudes.

开始日期2022-02-07

申办/合作机构

Tottori University

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27,957

项与 Tottori University 相关的文献（医药）

2025-12-31·GM Crops & Food

Development of transgenic wheat plants withstand salt stress via the MDAR1 gene

Article

作者: Hassanein, Sameh E. ; Ramadan, Ahmed M. ; Saleh, Osama M. ; Fahmy, Eman M. ; Eltayeb, Amin E. ; Hassan, Sabah M. ; Abdel-Tawab, Fatthy M. ; Al-Saud, Najla B. S. ; Bahieldin, Ahmed ; Alameldin, Hussien. F. ; Eissa, Hala F. ; Abdel Azeiz, Ahmed Z. ; Abdelsattar, Mohamed ; Ali, Hani M. ; Mohamed, Nermin G.

In light of the fact that climate change has emerged as one of the difficulties confronting the global food system, researchers are obligated to work toward developing fundamental crops, particularly wheat, to combat environmental stress, including drought and salt. In the present study, genetic engineering was used to transfer the Arabidopsis MDAR1 gene, which controls the buildup of ascorbic acid (AsA) to make bread wheat less likely to be sensitive to salt stress. The biolistic bombardment was used to transfer cDNA from the Arabidopsis thaliana plant that encodes MDAR1 into Bobwhite 56 cultivar wheat plants. A molecular investigation was performed on six different transgenic lines to confirm the integration of the transgene, the copy number, and the expression of the transgene. There were one to three copies of the transgene, and there was no association found between the number of copies of the transgene and All the data generated or analyzed during this study are included in this published article [and its supplementary information files].the presence of its expression. Compared to plants that were not transgenic, the amount of ascorbic acid (AsA) that accumulated in the transgenic plants was twice as high. ROS concentrations are significantly lower in transgenic plants compared to non-transgenic plants under both control and salt stress conditions, effectively reducing oxidative stress. By cultivating transgenic T2 plants in a greenhouse, we were able to determine whether they were able to tolerate the potentially damaging effects of salt stress (200 mm). The study concluded that transgenic wheat plants that consistently expressed the MDAR1 gene become tolerant to salt stress with improvement in growth characteristics.

2025-08-01·Journal of Engineering and Science in Medical Diagnostics and Therapy

Effect of the Cell Orientation Angle on the Nucleus of a Cultured Vascular Smooth Muscle Cell Subjected to Uniaxial Stretching: A Finite Element Analysis

作者: Uehara, Shoma ; Tamura, Atsutaka ; Tanabe, Yasuhiro ; Nagayama, Kazuaki

AbstractThe media, a primary layer of the aortic wall, is rich in smooth muscle cells (SMCs) that regulate the vessel diameter and maintain the mechanical balance of the aortic ring in vivo. Embedded in the medial extracellular matrix, SMCs adapt to their surrounding mechanical environment via cyclic stretch during vascular contraction and relaxation. Thus, the circumferential stress that constantly acts on the hypertensive aorta is expected to further increase with increasing blood pressure (hypertension), resulting in a thickened medial wall. This thickening is considered an active biomechanical response of SMCs to maintain constant circumferential stress, ensuring homeostasis. Therefore, understanding how external forces or mechanical stimuli acting on SMCs are transmitted through intracellular components is crucial. Nuclei may sense mechanical changes through stress fibers (SFs) and focal adhesions (FAs). However, limited quantitative information exists regarding the mechanical contributions of SFs and FAs to whole-cell mechanical events, such as the response to uniaxial stretching. In this study, we developed a finite element model of a cultured vascular SMC with contractile SFs anchored on a silicone substrate via FAs and applied uniaxial stretching to investigate the mechanotransduction pathways in SMCs. We revealed that the initial orientation angle of the cell relative to the stretching direction strongly correlated with the resultant magnitude of the biomechanical forces acting on the nuclei surface exerted by the SFs.

2025-07-01·The Journal of Physiological Sciences

Changes in adrenoceptor expression level contribute to the cellular plasticity of glioblastoma cells

Article

作者: Peña, Tirso ; Katayama, Haruyoshi ; Fujimura, Atsushi ; Huang, Rongsheng ; Uneda, Atsuhito ; Chin, Vanessa D ; Masumoto, Toshio ; Otani, Yusuke ; Asaka, Yutaro ; Ando, Teruhiko ; Itano, Takuto

Glioblastoma cells are known to regulate their cellular plasticity in response to their surrounding microenvironment, but it is not fully understood what factors contribute to the cells' changing plasticity. Here, we found that glioblastoma cells alter the expression level of adrenoreceptors depending on their differentiation stage. Catecholamines are abundant in the central nervous system, and we found that noradrenaline, in particular, enhances the stemness of glioblastoma cells and promotes the dedifferentiation potential of already differentiated glioblastoma cells. Antagonist and RNAi experiments revealed that signaling through α1D-adrenoreceptor is important for noradrenaline action on glioblastoma cells. We also found that high α1D-adrenoreceptor expression was associated with poor prognosis in patients with gliomas. These data suggest that glioblastoma cells increase the expression level of their own adrenoreceptors to alter the surrounding tumor microenvironment favorably for survival. We believe that our findings will contribute to the development of new therapeutic strategies for glioblastoma.

项与 Tottori University 相关的新闻（医药）

2024-11-14

·drugs

Continuous Psychological Distress in Pregnancy Increases Offspring Risk for Epilepsy

THURSDAY, Nov. 14, 2024 -- Continuous moderate-level maternal psychological distress throughout pregnancy is associated with a heightened risk for epilepsy among offspring, according to a study published online Nov. 13 in PLOS ONE . Yuto Arai, M.D., from Tottori University in Yonago, Japan, and colleagues evaluated the association between six-item Kessler Psychological Distress Scale (K6) scores and epilepsy among children aged 1 to 3 years. The analysis included data from 97,484 children divided into six groups based on K6 scores of two ranges during the first and second halves of pregnancy. The researchers found that a maternal K6 score ≥5 at both the first and second half of pregnancy was associated with epilepsy diagnosis ratios among 1-, 2-, and 3-year-old children in both univariate and multivariate analyses (odds ratios, 1.7, 1.6, and 1.6, respectively). "In conclusion, the present study found that continuous moderate-level maternal psychological distress from the first to the second half of pregnancy was associated with epilepsy among 1-, 2-, and 3-year-old children," the authors write. "As previously reported, additional risk factors include artificial milk nutrition, low birth weight, and chromosomal abnormalities. Therefore, environmental adjustments to promote relaxation in pregnant women are needed to prevent the development of epilepsy in their offspring." Abstract/Full Text Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

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