An Open-label, Multicenter, Randomized Clinical Trial for Malnutrition After Nonphysiological Reconstruction of the Upper Gastrointestinal Tract: Washed Microbiota Transplantation Via Mid-gut Tube Versus Colonic Transendoscopic Enteral Tube

This is a prospective, randomized, multicenter study to evaluate WMT in improving nutritional status in malnourished patients who underwent nonphysiological reconstruction of the upper gastrointestinal tract. In this multicenter trial, sixty-two patients will be enrolled in forteen Chinese sites. Participants will be randomized at a ratio of 1:1 to receive three WMTs through either mid-gut tube or colonic TET. After WMT, each participant will receive free diet plus home enteral nutrition. Home enteral nutrition should last for 2 months at home, with blood, urine and stool samples taken and stored at baseline and 2 months after WMT.

开始日期2024-10-20

申办/合作机构

兰州大学

[+9]

ChiCTR2400087572 / SuspendedN/AIIT

Clinical efficacy and safety of Gushuling in the treatment of diabetes patients with osteoporosis: a randomized controlled trial

开始日期2024-08-02

申办/合作机构

安徽中医药大学

NCT06331923 / RecruitingN/AIIT

Assessing the Effectiveness of Continuous Glucose Monitoring Compared With Conventional Monitoring in Enhancing Surgical Outcomes for Diabetic Patients: A Multi-center, Pragmatic, Randomized Controlled Trial in China

The goal of this multi-center, pragmatic, randomized controlled trial is to assess the effectiveness of continuous glucose monitoring (CGM) compared with conventional monitoring in enhancing surgical outcomes for diabetic patients. The main questions it aims to answer are:
To assess the effectiveness of CGM compared with conventional monitoring in reducing the comprehensive complication index (CCI) for patients with diabetes or impaired glucose tolerance (IGT) within 30 days after surgery.
To analyze the impact of different age groups, types of surgery, preoperative levels of HbA1c, and preoperative 24h glycemic variations on the improvement of surgical outcomes under the CGM model.
Participants will receive CGM prescribed by the attending physician for at least 6 hours before surgery. Glucose monitoring should be continued until the 7th day after surgery or discharge.
The investigators will compare conventional monitoring group to see if CGM could reduce the CCIs for patients with diabetes or impaired glucose tolerance within 30 days after surgery.

开始日期2024-04-12

申办/合作机构

北京清华长庚医院

[+20]

100 项与安徽中医药大学相关的临床结果

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0 项与安徽中医药大学相关的专利（医药）

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项与安徽中医药大学相关的文献（医药）

2025-01-01·Food Chemistry

Characterization of cooked off-flavor volatile sulfur-containing compounds in green tea and their thermal inhibition via (−)-epigallocatechin gallate

Article

作者: Yao, Xin ; Tang, Jun ; Zhai, Xiaoting ; Zhang, Yanyan ; Zhang, Guoyu ; Wan, Xiaochun ; Yu, Jieyao ; Li, Yangyang

Cooked note is an undesired flavor in green tea, while the key odorants and inhibition mechanisms were unknown. Here, volatiles of four green tea samples and two thermal reaction models of methionine-glucose and methional were assessed using gas chromatography‑sulfur chemiluminescence detector and two dimensional gas chromatography-time-of-flight mass spectrometry. Nonvolatiles of reaction models were determined using ultra performance liquid chromatography-Q-Exactive orbitrap mass spectrometry. Four cooked smelling sulfur-containing odorants including dimethyl trisulfide, dimethyl sulfide, diethyl disulfide, and methanethiol having odor activity values > 1 were characterized in tea samples. Aroma addition tests confirmed dimethyl trisulfide (> 0.4 μg/L) as a reliable predictor of the cooked note. Seven sulfur-containing odorants were detected in reaction models. The addition of (-)-epigallocatechin gallate depleted glucose and interrupted the reaction, thus reduced sulfur-containing odorants' amounts. The study provides a novel insight on targeted strategic guidance for mitigating cooked off-flavor during the thermal processing of green tea production.

2025-01-01·Journal of Molecular Structure

Efficient removal of fluoride from water by CaO/Ca12Al14O33/Ca5Al6O14 composites: Performance and mechanism

作者: Jia, Yong ; Ma, Dong ; Zhang, Yong-Xing ; Ni, Jia

CaO/Ca₁₂Al₁₄O₃₃/Ca₅Al₆O₁₄ composites were synthesized through calcination of Ca-Al layered double hydroxides (CaAl-LDHs).The structures of the CaAl-LDHs and the composites were characterized by X-ray diffraction (XRD), SEM (SEM) and nitrogen adsorption-desorption isotherms.Batch experiments were carried out to study the influence of various exptl. parameters such as initial fluoride concentration, contact time, pH and the coexisting anions on the adsorption of fluoride.The fluoride adsorption follows the Freundlich isotherm model.With the World Health Organization (WHO) guideline of 1.5 mg L^-1, the adsorption capacity was 52.78 mg g^-1.The kinetic data were fitted to the pseudo-second-order model.The change of pH (3-10) has almost no influence on the fluoride removal.High concentration of the coexisted sulfate, carbonate and phosphate anions slightly inhibited the fluoride removal.The fluoride removal mechanism study suggested that CaO transformed into CaF₂ after fluoride adsorption, which play key roles in fluoride removal.The hydrolysis of Ca₁₂Al₁₄O₃₃ and Ca₅Al₆O₁₄ resulted the formation of Ca₃Al₂(OH)₁₂.Fluoride anions participated in this hydrolysis process and resulted in the formation of Ca₃Al₂(OH)_12-xF_x, which was revealed by XRD, XPS anal. (XPS) and SEM elemental mapping images.

2025-01-01·Journal of Ethnopharmacology

Transcriptomics analysis reveals the effect of Pulsatilla decoction butanol extract on endoplasmic reticulum and peroxisome function of Candida albicans in hyphal state

Article

作者: Qiu, Wei ; Chu, Faqiong ; Wang, Changzhong ; Shao, Jing ; Li, Can ; Zang, Long ; Wu, Daqiang ; Wu, Hui ; Wang, Tianming

ETHNOPHARMACOLOGICAL RELEVANCEThe traditional Chinese medicine formula known as Pulsatilla decoction was utilized to treat conditions such as bacterial dysentery, ulcerative colitis, and fungal infections like vulvovaginal candidiasis (VVC) caused by Candida albicans (C. albicans). In our prior research, it was shown that the n-butanol extract from Pulsatilla Decoction (BEPD) exhibited effective inhibition of C. albicans. Nevertheless, the exact mechanism by which BEPD hinders hyphal growth, a critical virulence factor of C. albicans, remains unclear.AIM OF THE STUDYIn the present study, the inhibitory effect and mechanism of the BEPD on C. albicans hyphal growth was predicted by transcriptome analysis, and further verified by in vitro and in vivo experiments.MATERIALS AND METHODSThe BEPD was prepared and C. albicans was cultured to induce the hyphal state. Transcriptome analysis was conducted to predict the significant difference in enrichment genes and signaling pathways in the inhibitory effect of BEPD on C. albicans hyphae. Various methods, such as spot assay, time-growth curve analysis, Confocal laser scanning microscope (CLSM), scanning electron microscope (SEM), transmission electron microscope (TEM), flow cytometry, and spectrophotometer, were used to assess the effect of BEPD on hyphal structure and growth activity, lipid peroxidation level, peroxidase (CAT) activity, superoxide dismutase (SOD) activity, and apoptosis of C. albicans. Reverse transcription quantitative polymerase chain reaction (RT-qPCR) was employed to examine the expression levels of genes associated with endoplasmic reticulum and peroxisome function. The VVC model was employed to evaluate the influence of BEPD on the growth of C. albicans hyphae in vivo.RESULTThe growth of C. albicans hyphae on solid culture media was significantly inhibited by BEPD. CLSM showed that the length of C. albicans hyphae was decreased and their vitality was lowered. SEM indicated that the hyphae of C. albicans were fractured, while TEM revealed damage to the organelles within the cells. GO enrichment and KEGG pathways analysis from transcriptomic data demonstrated that BEPD effectively suppressed the functioning of the endoplasmic reticulum and peroxisomes in C. albicans hyphae. RT-qPCR verified the decreased expression of genes associated with endoplasmic reticulum and peroxisome function by BEPD. Investigation of the endoplasmic reticulum revealed that BEPD elevated levels of reactive oxygen species (ROS) and apoptosis, indicating endoplasmic reticulum stress, as well as malondialdehyde (MDA), a marker of oxidative stress. Additionally, BEPD was shown to lower the activities of catalase (CAT) and superoxide dismutase (SOD). In animal trials, BEPD effectively hindered the growth of C. albicans hyphae in the vaginas of mice with VVC, thus reducing immune inflammatory damage to the vaginal mucosa of these mice.CONCLUSIONThis study demonstrates that BEPD has an inhibitory effect on hyphae, which are an important virulence factor of C. albicans. This effect may be related to BEPD's inhibitory effect on endoplasmic reticulum (ER) and peroxisome function. The findings suggest that BEPD could potentially play a therapeutic role in C. albicans infectious diseases by inhibiting hyphae.

项与安徽中医药大学相关的新闻（医药）

2024-09-18

·药研网

复星医药执行总裁辞职

近日，上海复星医药（集团）股份有限公司发布公告，公司董事会收到李胜利先生的书面辞职函，因个人原因，李胜利先生向董事会申请辞去执行总裁职务。李胜利先生自2024年9月13日起不再担任本公司执行总裁职务。董事会对李胜利先生任职本公司高级管理人员期间的工作表示感谢。李胜利先生，1973年1月出生，于2004年4月加入本集团，于2018年1月至2020年1月任本公司总裁助理，于2020年1月至2021年3月任本公司副总裁，于2021年3月起任本公司高级副总裁。加入本集团前，李胜利先生曾于徐州恩华药业集团有限责任公司任职。李胜利先生1996年毕业于安徽中医药大学医学临床专业专科，于2011年12月获上海交通大学工商管理硕士学位。 End 声明：本公众号所有发文章(包括原创及转载文章)系出于传递更多信息之目的，且注明来源和作者。本公众号欢迎分享朋友圈或大群，谢绝媒体或机构未经授权以任何形式转载至其他平台。转载/商务/投稿 | 联系微信 wfj_GM 商务合作稿件征集点击了解详情往期回顾 1 5月| 20家药企裁员（附名单） 2 18亿美元，ADC又出海! 宜联生物宣布新授权 3 2024 ASCO| 默沙东/科伦TROP2 ADC、信达、礼新CLDN18.2 ADC数据公布

高管变更ASCO会议抗体药物偶联物

2024-07-29

·药渡

新书上架丨《纳米药物代谢动力学》

与传统药物相比，纳米药物递送系统显示出更多纳米药物代谢动力学和药效学优势，如改善溶解度、提高生物利用度、减轻不良反应、透过血脑屏障等。纳米药物能够提高难溶性药物的有效性、安全性和耐受性，在药物递送系统中发挥非常重要和独特的作用。由于纳米药物展现出许多新的药剂学、药物效应动力学、药代动力学等特征，为很多重大疾病的治疗提供了新机会，带来新的解决方案，对人类健康产生了重要影响，因此，将一些难溶性或细胞毒性较强的药物设计成可以工业化生产的纳米药物制剂具有重要的意义，纳米药物近年来发展非常迅猛。1995年美国食品药品监督管理局批准第一例纳米药物——盐酸多柔比星脂质体Doxil®进入临床以来，近30年全球已批准上市纳米药物 100多个，超过 2000个纳米药物正在进行临床研究。纳米药物代谢动力学是借助于动力学原理，研究纳米药物体内吸收、分布、代谢和排泄的动态变化规律及其体内时量-时效关系，并用数学模型加以定量描述的一门科学。纳米药物的药效和毒性与其在体内的纳米药物代谢动力学行为是密切相关的，研究纳米药物代谢动力学，可以揭示纳米药物的原理与科学内涵，为优化纳米药物的临床给药方案提供理论基础，阐明纳米药物的体内代谢机制，揭示纳米药物量-效关系、时-效关系，提高纳米药物的安全性。在由安徽中医药大学陈卫东教授主编、安徽中医药大学王雷副教授和中国科学院上海药物研究所张继稳研究员副主编的《纳米药物代谢动力学》一书中，该书编写团队从纳米药物理化性质、结构，纳米药物吸收、分布、代谢、清除和排泄等药物代谢的基本过程讨论其药代动力学，深入、全面、系统地研究和总结了纳米药物的生理药物动力学、纳米药物代谢动力学的不同分析方法、结合药物和游离药物药代动力学的研究方法、纳米药物结构与药代动力学，并简要介绍已上市纳米药物的临床药代动力学研究。想了解更多，请参阅《纳米药物代谢动力学》。目录 ← 左右滑动查看更多 → 试读章节 ← 左右滑动查看更多 → 作者简介陈卫东安徽中医药大学教授，主任药师，博士生导师，安徽省学术和技术带头人，安徽省第十三批“115”产业创新团队带头人。主要从事药物代谢动力学、药剂学、临床药学等方面研究。牵头成立安徽省药学会药物代谢专业委员会，牵头申请获批安徽中医药大学“药代动力学”硕士学位点。兼任中国药理学会药物代谢专业委员会副主任委员、安徽省质谱学会副理事长、安徽省药学会常务理事等。主持国家自然科学基金面上项目、“重大新药创制”国家科技重大专项、国家中药标准化项目、安徽省科技重大专项、安徽省中央引导地方科技发展专项等20 余项。在 Hepatology、Acta Pharmaceutica Sinica B、Chemical Engineering Journal、Theranostics、Drug Metabolism and Disposition 等期刊发表 SCI 论文 80 余篇，发表中文核心期刊论文 100 余篇，主编、副主编教材和专著 8 部。获安徽省自然科学奖1 项，申请及授权专利 20 余项。购书方式长按识别下方二维码或点击“阅读原文”购买~ 《纳米药物代谢动力学》陈卫东（主编）定价：180 折扣价：147.00 系列图书推荐点击图片了解图书详情 *以上内容包含广告发货及发票说明发货说明：商品付款后，工作日48小时内发货，节假日不发货，顺延至工作日正常发货。发票说明：药渡书店图书下单7天内可以提供开票服务，下单时备注下发票抬头、税号及接收邮箱信息（三者缺一不可），则可在确认收货无误后我方提供增值税电子版普通发票。联系我们：任何问题请联系010-82826195-8036、18600036371 戳“阅读原文”一键购买图书

核酸药物医药出海

2023-08-29

·生物谷

Nature子刊：张智/陶文娟团队揭示压力通过大脑调节胃功能的神经机制

有意思的是，研究团队还发现急性应激模型小鼠的这条环路活性增加，下调该环路的活性可缓解急性应激导致的胃功能障碍。总的来说，该研究揭示了脑-胃轴驱动应激导致胃功能障碍的新机制中国科学技术大学生命科学与医学部张智团队和安徽医科大学基础医学院陶文娟团队合作，在 Nature Metabolism 期刊发表了题为：Brain regulation of gastric dysfunction induced by stress 的研究论文。该研究揭示了应激（压力）导致胃功能障碍的神经机制——DRN5-HT→DMVACh→胃神经环路驱动应激相关的胃功能障碍，激活该回路可逆转慢性应激诱导的小鼠胃功能障碍，这一发现为大脑调控胃的神经回路基础提供了新见解。为探索脑-胃之间的结构连接，研究团队在胃部注射逆行示踪染料，在大脑的迷走神经运动背核（DMV）追踪到信号。综合运用在体电生理、深部钙成像、神经调控等研究手段发现，投射到胃的DMV乙酰胆碱能神经元（DMVACh）接受应激相关的中缝背核5-羟色胺能神经元（DRN5-HT）支配，慢性应激后活性显著降低。此外，DRN5-HT在慢性应激后活性也显著降低，特异调控DRN5-HT→DMVACh→胃神经环路活性可缓解慢性应激导致的胃功能障碍。有意思的是，研究团队还发现急性应激模型小鼠的这条环路活性增加，下调该环路的活性可缓解急性应激导致的胃功能障碍。总的来说，该研究揭示了脑-胃轴驱动应激导致胃功能障碍的新机制，不仅为应激性胃病的发病机理提出了新的理论，也为进一步探索大脑和外周器官的交互作用提供了新思路。中国科学技术大学博士研究生董婉莹和黄继业、唐皓迪博士（现就职于四川大学华西医院）、朱霞副研究员为论文共同第一作者，中国科学技术大学张智教授和安徽医科大学基础医学院陶文娟副教授为共同通讯作者，合作者还包括中国科学技术大学附属第一医院神经内科张艳教授课题组、安徽中医药大学王海涛教授课题组等。