Objective: To develop a method for the determination of five residual organic solvents in olanzapine. Methods: The residual organic solvents including methanol, dichloromethane, ethanol, triethylamine and toluene were quant. determined by GC, and nitrogen was the carrier gas. Results: Five residual organic solvents were completely separated The linear range of methanol was 0.030 7-0.614 0 mg/mL (r = 1), the linear range of ethanol was 0.0519-1.0380 mg/mL (r = 0.9997), the linear range of dichloromethane was 0.0057-0.1148 mg/mL (r = 0.9999), the linear range of triethylamine was 0.051 36-1.027 2 mg/mL (r = 0.9999), the linear range of toluene was 0.0095-0.1900 mg/mL (r = 0.9999). The theor. plates of five organic solvents were much more than 5000, the separation of the organic solvents was more than 2.0, the separation of the measured solvent and solvent blank was more than 2.0, system suitability and system precision are required. The RSDs of precision of six residual organic solvents were less than 5%, the average recovery rates of the preparation were in the range of 90%-100%. The RSDs of recovery were less than 2.0%. Conclusion: The method is simple, sensitive, accurate and can be used for the quality control of olanzapine.