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疾病领域	数量

肿瘤	1

排名前五的药物类型	数量

小分子化药	1

排名前五的靶点	数量

CLK1	1

关联

2

项与 Politechnika Gdanska 相关的药物

Clk1 inhibitor (Ahram Canadian University)

靶点

CLK1

作用机制

CLK1 抑制剂

在研机构

Politechnika Gdanska

原研机构

Ahram Canadian University

在研适应症

肺癌

非在研适应症-

最高研发阶段临床前

首次获批国家/地区-

首次获批日期-

C-1305

靶点

Top II

作用机制

Top II抑制剂

在研机构-

原研机构

Politechnika Gdanska

在研适应症-

非在研适应症

肿瘤

最高研发阶段无进展

首次获批国家/地区-

首次获批日期-

100 项与 Politechnika Gdanska 相关的临床结果

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0 项与 Politechnika Gdanska 相关的专利（医药）

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17,580

项与 Politechnika Gdanska 相关的文献（医药）

2025-02-01·Bioelectrochemistry

Unlocking the electrochemical performance of glassy carbon electrodes by surface engineered, sustainable chitosan membranes

Article

作者: Olejnik, Adrian ; Smułka, Agata ; Ryl, Jacek ; Ossowski, Tadeusz ; Zieliński, Artur ; Cieślik, Mateusz

Chitosan coatings, derived from crustacean shell waste, possess inherent biocompatibility and biodegradability, rendering them suitable for various biomedical and environmental applications, including electrochemical biosensing. Its amine and hydroxyl functional groups offer abundant sites for chemical modifications to boost the charge transfer kinetics and provide excellent adhesion, enabling the construction of robust electrode-coating interfaces for electroanalysis. This study explores the role of electrostatically-driven chemical interactions and crosslinking density originating from different chitosan (Cs) and glutaraldehyde (Ga) concentrations in this aspect. Studying anionic ([Fe(CN)₆]^3-/4-), neutral (FcDM^0/+), and cationic ([Ru(NH₃)₆]^2+/3+) redox probes highlights the influence of Coulombic interactions with chitosan chains containing positively-charged pathways, calculated by DFT analysis. Our study reveals how a proper Ch-to-Ga ratio has a superior influence on the cross-linking efficacy and resultant charge transfer kinetics, which is primarily boosted by up to 20× analyte preconcentration increase, due to electrostatically-driven migration of negatively charged ferrocyanide ions toward positively charged chitosan hydrogel. Notably the surface engineering approach allows for a two-orders of magnitude enhancement in [Fe(CN)₆]^4- limit of detection, from 0.1 µM for bare GCE down to even 0.2 nM upon an adequate hydrogel modification.

2025-01-01·Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy

Gold(III) complexes with chloride and cyanopyridines: Facilitated hydrolysis of nitrile ligand to amide and antibacterial activity

Article

作者: Malik, Magdalena ; Gutmańska, Karolina ; Ejnik, Maciej ; Gudat, Dietrich ; Bruździak, Piotr ; Dołęga, Anna ; Brillowska-Dąbrowska, Anna ; Ciborska, Anna

A range of novel simple gold(III) compounds has been synthesized in their monocrystalline form, including two previously unknown chloro-complexes of Au³⁺ with 2-cyanopyridine or 3-cyanopyridine, respectively. Our investigations have revealed the intricate nature of the reaction between 2-cyanopyridine and tetrachloroauric acid, yielding at least three distinct products. The main product, obtained in high yield, is a salt featuring a tetrachloroauric anion and a pyridinium cation stabilized by a hydrogen bond to a further 2-cyanopyridine molecule. Moreover, we observed the in-situ formation of a 2-cyanopyridine-AuCl₃ complex, which undergoes hydrolysis of the nitrile bond to yield a picolinamide-Au(III) complex. The complexes were characterized by IR and Raman spectroscopies, NMR spectroscopy, and single-crystal XRD studies. Additional computational studies were conducted to explain unusual spectral features, the observed disparities in the complexation reactions of the three isomeric cyanopyridine ligands and the distinct reactivity of the complex with 2-cyanopyridine. Based on these studies, we propose a mechanism for the catalyzed hydrolysis of the nitrile bond within the Au(III) complex. Finally, we assessed the antimicrobial efficacy of the synthesized gold(III) complexes against a spectrum of bacteria and fungi.

2025-01-01·Talanta

Elucidating charge transfer process and enhancing electrochemical performance of laser-induced graphene via surface engineering with sustainable hydrogel membranes: An electrochemist's perspective

Article

作者: Khodadadiyazdi, Mohsen ; Saeb, Mohammad Reza ; Ryl, Jacek ; Pierpaoli, Mattia ; Smułka, Agata ; Khodadadi Yazdi, Mohsen ; Olejnik, Adrian ; Kramek, Agnieszka ; Bogdanowicz, Robert ; Manohar, Aiswarya

Laser-induced graphene (LIG) has emerged as a promising solvent-free strategy for producing highly porous, 3D graphene structures, particularly for electrochemical applications. However, the unique character of LIG and hydrogel membrane (HM) coated LIG requires accounting for the specific conditions of its charge transfer process. This study investigates electron transfer kinetics and the electroactive surface area of LIG electrodes, finding efficient kinetics for the [Fe(CN)₆]^3-/4- redox process, with a high rate constant of 4.89 x 10^-3 cm/s. The impact of polysaccharide HM coatings (cationic chitosan, neutral agarose and anionic sodium alginate) on LIG's charge transfer behavior is elucidated, considering factors like ohmic drop across porous LIG and Coulombic interactions/permeability affecting diffusion coefficient (D), estimated from amperometry.It was found that D of redox species is lower for HM-coated LIGs, and is the lowest for chitosan HM. Chitosan coating results in increased capacitive share in the total current while does not apparently reduce Faradaic current. Experimental findings are supported by ab-initio calculations showing an electrostatic potential map's negative charge distribution upon chitosan chain protonation, having an effect in over a two-fold redox current increase upon switching the pH from 7.48 to 1.73. This feature is absent for other studied HMs. It was also revealed that the chitosan's band gap was reduced to 3.07 eV upon acetylation, due to the introduction of a new LUMO state. This study summarizes the operating conditions enhanced by HM presence, impacting redox process kinetics and presenting unique challenges for prospective LIG/HM systems' electrochemical applications.

100 项与 Politechnika Gdanska 相关的药物交易

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100 项与 Politechnika Gdanska 相关的转化医学

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