The preparation process of Zhongjiefeng dropping pills was optimized by orthogonal test.The optimal preparation process was: ratio of drug-PEG 4000-PEG 6000-water was 1:1.7:0.3:0.3, melting temperature was 80°C, dropping temperature was 85°C, refrigerant was Me silicon oil, cooling temperature was 1-5°C.Under such conditions, the surface of dropping pill was smooth, the size was similar.The preparation process was convenient and feasible, and quality indexes accorded with the requirement.