Scorpion Therapeutics, Inc.

Series C led by Lightspeed Venture Partners and Ascenta Capital with participation from top-tier new investor syndicate and existing investors Funding will advance distinctive pipeline of targeted radiopharmaceuticals through clinical studies across multiple tumors with high unmet patient need Growing portfolio will be supported by continued investment in discovery capabilities and expansion of manufacturing and isotope supply partnerships BOSTON and VANCOUVER, BC, Oct. 23, 2024 /PRNewswire/ -- Alpha-9 Oncology Inc. (Alpha-9 or the Company), a clinical stage company developing radiopharmaceuticals to meaningfully improve the treatment of people living with cancer, today announced an oversubscribed $175 million Series C financing to support the progression of its pipeline. The financing was led by Lightspeed Venture Partners and Ascenta Capital. A selected syndicate of new investors – General Catalyst, a16z Bio + Health, RA Capital Management, Janus Henderson Investors, Delos Capital, Digitalis Ventures, Lumira Ventures and a healthcare fund managed by abrdn Inc. – joined the round, in addition to existing investors Frazier Life Sciences, Longitude Capital, Nextech Invest, BVF Partners LP, and Samsara BioCapital. Shelley Chu, head of Lightspeed Venture Partners' healthcare team and Evan Rachlin, cofounder and managing partner of Ascenta Capital will join the Company's Board of Directors. Alpha-9 has built a diversified portfolio of clinical and discovery assets across both validated and novel targets. The Series C will fund human studies for the clinical stage assets and advancement of discovery stage assets to clinic-ready development candidates. Furthermore, the Series C will fund expanded R&D capabilities and continued investment in CMC and supply chain. "Over the last few years, Alpha-9 has built a leading radiopharmaceutical company with a deep pipeline and robust infrastructure," said Alpha-9 CEO, David Hirsch, MD, PhD. "The Series C is an exciting, significant milestone for us and will greatly accelerate our growth. We are thrilled to have the backing of a top-tier investor syndicate who share our belief in the potential of radiopharmaceuticals." "Alpha-9 is developing a differentiated portfolio that includes multiple radiopharmaceuticals with first-in-class and best-in-class potential," said Shelley Chu, head of Lightspeed Venture Partners' healthcare team. "We are impressed with the team's progress to date and are proud to support the advancement of these programs." Alpha-9's approach to designing bespoke molecules is systematic and data-driven. The Company has a differentiated toolbox of binders, linkers, chelators and radioisotopes – elements that each play an integral role in radiopharmaceutical development. Alpha-9 designs each component of the radiopharmaceutical for optimal selectivity, stability and payload delivery. The Alpha-9 approach is rigorous, fast and capital efficient, generating best-in-class compounds for rapid clinical development. "We have been following this space for a long time. What differentiated Alpha-9 was its effective approach to molecule design as well as its thoughtful strategy on infrastructure expansion," said Evan Rachlin, MD, managing partner of Ascenta Capital. "We are pleased to support the Company's continued progress as it strives to deliver on the promise of radiopharmaceuticals." To support its endeavors, Alpha-9 has purpose-built research facilities in Vancouver, which were completed last year and have been operating at scale. These facilities help to accelerate drug development by streamlining discovery processes. Alpha-9 has also partnered with isotope suppliers and CDMOs to support its ongoing clinical trials. Alpha-9's commitment to continue building robust infrastructure and world class capabilities underscores the company's mission to provide effective treatments for patients worldwide. About Alpha-9 Oncology Alpha-9 Oncology Inc. is a clinical stage radiopharmaceutical company developing differentiated and highly targeted radiopharmaceuticals with the potential to meaningfully improve the treatment of people living with cancer. Applying proprietary technologies and deep foundational expertise, Alpha-9 is on the forefront of engineering bespoke radiopharmaceuticals that are optimized to selectively deliver radiation to tumor sites while minimizing off-target effects. Alpha-9 is advancing a robust pipeline of novel radiopharmaceuticals with a systematic approach to molecule design that offers broad potential for expansion into several validated oncology targets. For more information, please visit . About Lightspeed Venture Partners Lightspeed Venture Partners is a multi-stage venture capital firm focused on accelerating disruptive innovations and trends in the Enterprise, Healthcare, Consumer and Fintech sectors. Over the past two decades, the Lightspeed team has backed hundreds of entrepreneurs and helped build more than 500 companies globally including biotechnology companies such as Abata, Ancora, Diagonal, Enlaza, Forty Seven, Personalis, Pheon, Teneobio, Triana, Scorpion, Seismic, Ultima Genomics, Xaira, ZagBio, and more. Lightspeed and its global team currently manage $25B in AUM across the Lightspeed platform, with investment professionals and advisors in the U.S., Europe, India, Israel, and Southeast Asia. For more information, please visit . About Ascenta Capital Ascenta Capital is a biotech venture fund, co-founded in 2023 by Dr. Evan Rachlin and Dr. Lorence Kim. The fund is focused on a concentrated portfolio of investments in multi-product companies. For more information about Ascenta Capital, visit . Notice Regarding Forward-Looking Statements: This news release contains forward-looking statements within the meaning of the U.S. Private Securities Litigation Reform Act of 1995 and forward-looking information within the meaning of applicable Canadian securities laws (collectively, "forward-looking statements"). The words "may", "will", "potential", "believes" and "if" are intended to identify forward-looking statements, although not all forward-looking statements contain such terms. You are cautioned that such statements are subject to a multitude of risks and uncertainties that could cause actual results, future circumstances, or events to differ materially from those projected in the forward-looking statements. These risks include but are not limited to: those associated with the success of research and development programs, the ability to raise additional funding, and the need to obtain regulatory approval. Forward-looking statements are made as of the date hereof and Alpha-9 disclaims any intention and has no obligation or responsibility, except as required by law, to update or revise any forward-looking statements, whether as a result of new information, future events, or otherwise. SOURCE Alpha-9 Oncology, Inc. WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

PFL-241/STX-241是一种高选择性的第四代表皮生长因子受体（EGFR）抑制剂，有潜力成为同类产品中的佼佼者 这是Scorpion Therapeutics正在开发的两个EGFR项目之一 法国卡斯特尔和波士顿 2024年10月9日 /美通社/ -- 在肿瘤学领域具有全球影响力的Pierre Fabre Laboratories，以及致力于通过重新定义精准医学的前沿来改善癌症患者生活的创新临床阶段肿瘤学公司Scorpion Therapeutics, Inc.（简称“Scorpion”），今天宣布，在一项Ⅰ/Ⅱ期、首次人体剂量递增、剂量优化和剂量扩展试验中，首位患者已经开始接受给药。 该临床试验评估了PFL-241/STX-241，这是一种高度分化、口服生物利用度高、高选择性的酪氨酸激酶抑制剂（TKI），靶向表皮生长因子受体（EGFR）外显子19或21突变以及共存的C797S突变，C797S是一种已知的对第 三 代EGFR抑制剂的耐药机制。 PFL-241/STX-241的Ⅰ/Ⅱ期临床试验是一项开放标签、多中心的研究，旨在评估PFL-241/STX-241作为单药治疗在局部晚期或转移性非小细胞肺癌（NSCLC）患者中的安全性、耐受性、药代动力学（PK）、药效学（PD）以及初步的临床疗效，这些患者带有EGFR外显子19或21的突变，并且存在共发的C797S突变。 NSCLC是最常见的肺癌形式，EGFR突变是其最常见的疾病驱动因素之一，其发生率可高达38%，具体取决于地理位置 1、2、3 。 “我们非常期待开始对PFL-241/STX-241进行临床评估，这是我们的突变选择性第四代EGFR抑制剂，一个具有独特特性的分子，我们相信它有潜力成为对现有靶向治疗产生耐药性的患者的最佳治疗选择。” Pierre Fabre Laboratories医疗护理研究和开发部门负责人Francesco Hofmann表示。 “这项临床试验的启动彰显了我们团队与Scorpion Therapeutics之间坚实的合作伙伴关系，以及我们在其中的积极参与和执行力度。我们期待展示这种靶向治疗如何为患者带来潜在的益处。” PDF： https://mma.prnewswire.com/media/2525480/Pierre_Fabre_Laboratories.pdf Pierre Fabre Laboratories媒体联系人： Laure Bregeon-Sgandurra Pierre Fabre Laboratories Laure.sgandurra@pierre-fabre.com Scorpion Therapeutics联系人： 媒体联系人： Ethan Metelenis Precision AQ ethan.metelenis@precisionaq.com 投资者联系人： Emiley Demick Precision AQ emiley.demick@precisionaq.com

PFL-241/STX-241 is a highly selective, and potentially best-in-class fourth generation epidermal growth factor receptor (“EGFR”) inhibitor One of two EGFR programs being developed with Scorpion Therapeutics CASTRES, France & BOSTON, MA, USA I October 08, 2024 I Pierre Fabre Laboratories, a global player in oncology, and Scorpion Therapeutics, Inc. (“Scorpion”), a pioneering clinical-stage oncology company dedicated to transforming the lives of cancer patients by redefining the frontier of precision medicine, today announced that the first patient has been dosed in a Phase I/II, first-in-human dose-escalation, dose-optimization and dose-expansion trial. This clinical trial evaluates PFL-241/STX-241, a highly differentiated, orally bioavailable, highly selective tyrosine kinase inhibitor (“TKI”) targeting epidermal growth factor receptor (“EGFR”) Exon 19 or 21 mutations with the co-occurring C797S mutation, a known resistance mechanism to 3 rd generation EGFR inhibitors. The PFL-241/STX-241 Phase I/II trial is an open label, multi-center study that aims to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and preliminary clinical efficacy of PFL-241/STX-241 as a monotherapy in patients with locally advanced or metastatic non-small cell lung cancer (“NSCLC”) harboring EGFR Exon 19 or 21 mutations with the co-occurring C797S mutation. NSCLC is the most common form of lung cancer and EGFR mutations are one of its most common disease drivers, occurring in up to 38 percent of tumors, depending on geography 1,2,3 . “We are eager to begin the clinical evaluation of PFL-241/STX-241, our mutant-selective 4 th generation EGFR inhibitor, a molecule with differentiated properties that we believe has the potential to become a best-in-class therapeutic option for patients developing resistance to current targeted therapy,” said Francesco Hofmann, Head of Research and Development for Medical Care at Pierre Fabre Laboratories. “The initiation of this clinical trial highlights our team’s engagement and execution in strong partnership with Scorpion Therapeutics, and we look forward to demonstrating how patients could potentially benefit from this targeted therapy.” PFL-241/STX-241 is an oral treatment designed to selectively inhibit the C797S resistance mutation co-occurring with EGFR exon 19 deletion or exon 21 mutation (“double mutant”). Those “double mutants” are emerging as an on-target resistance mechanism in a subset of NSCLC patients. Most recent data suggest that the C797S mutation emerges in approximately 12.5% 4-8 of patients undergoing therapy with 3 rd generation EGFR inhibitors.There are currently no approved therapeutic options for patients who develop this “double mutant” EGFR NSCLC. “The initiation of the second clinical trial in partnership with Pierre Fabre Laboratories is an important milestone as we work together to enable the rapid, global advancement of our next-generation EGFR inhibitors for difficult-to-treat NSCLC patients,” said Mark Chao, M.D., Ph.D., Chief Medical Officer of Scorpion. “PFL-241/STX-241 is a novel, CNS-penetrant and highly potent and selective treatment option for patients who develop ‘double mutant’ disease for which there is currently no approved treatment, and it’s a pleasure to partner with Pierre Fabre Laboratories, a company who shares our commitment to bringing innovative treatments to this underserved patient population. We look forward to demonstrating how PFL-241/STX-241’s differentiated preclinical profile translates into clinical benefit for patients.” About Pierre Fabre Laboratories R&D pipeline Pierre Fabre Laboratories has expanded its efforts in precision oncology by adding several assets to its R&D pipeline. In partnership with Scorpion Therapeutics, PFL-241/STX-241 and PFL-721/STX-721, two mutant-selective EGFR inhibitors, will be developed for the treatment of EGFR-driven non-small cell lung cancer (NSCLC) patients. Through the acquisition of Vertical Bio, PFL-002/VERT-002 will undergo clinical testing in solid tumours driven by MET genetic alterations. More recently, the pan-RAF inhibitor exarafenib was acquired from Kinnate Biopharma with the aim to expand targeted therapy options for RAS/RAF-driven solid tumours. These new additions to its clinical development portfolio complement Pierre Fabre Laboratories’ existing precision oncology portfolio targeting BRAF, MEK, HER2, with encorafenib, binimetinib and neratinib, respectively. About Pierre Fabre Laboratories Pierre Fabre Laboratories is one of Europe’s leading pharmaceutical companies. For over 40 years, it has established itself as an international player in oncology, mastering the entire value chain from R&D to marketing. Its portfolio of oncology specialties covers colorectal, breast, lung and skin cancers, as well as certain hematologic malignancies and precancerous dermatological conditions such as actinic keratosis. In 2023, its oncology revenue amounted to nearly 500 million euros, over 90% of which was generated outside France. In 2023, Pierre Fabre Laboratories posted 2.83 billion euros in revenue, 70% of which came from international sales in 120 countries. Its portfolio includes several international brands and medical franchises such as Pierre Fabre Oncologie, Pierre Fabre Dermatologie, Pierre Fabre Pharma Care, Eau Thermale Avène, Ducray, A-Derma, Klorane, René Furterer and Même Cosmetics. Historically based in the southwest of France and manufacturing 95% of its products in France, Pierre Fabre Laboratories employs over 10 000 people worldwide. Its annual R&D budget amounts to nearly 200 million euros, of which about 50% is dedicated to targeted therapies in oncology and 40% to skin health and care solutions. Pierre Fabre Laboratories’ majority shareholder (86%) is the eponymous Foundation, which is recognized by the French government as being a public–interest foundation. This capital structure guarantees the company’s independence and long-term vision. Dividends paid to the Pierre Fabre Foundation enable it to design and finance healthcare-access programs in developing countries. Employees are the company’s secondary shareholder, through an international employee shareholding plan. Pierre Fabre Laboratories’ sustainability policy has been assessed by the independent AFNOR Certification body and has been awarded the “Exemplary” level of its CSR label (ISO 26 000 standard for sustainable development). For more information, visit www.pierre-fabre.com , @PierreFabreGroup About Scorpion Therapeutics Scorpion is a pioneering clinical-stage oncology company redefining the frontier of precision medicine to deliver optimized and transformational therapies for larger populations of patients with cancer. Scorpion has built a proprietary and fully-integrated platform of the most advanced technologies across cancer biology, medicinal chemistry, and data sciences, with the goal of consistently and rapidly creating exquisitely selective small molecule compounds against an unprecedented spectrum of targets. Scorpion aims to leverage its platform to advance a broad pipeline of wholly-owned, optimized compounds across three target categories: best-in-class molecules targeting validated oncogene targets; first-in-class molecules for previously undruggable targets; and first-in-class molecules for novel cancer targets. For more information, visit www.scorpiontx.com . SOURCE: Scorpion Therapeutics