Oxymatrine has pos. inotropic action, neg. chronotropic action, and neg. automatic action, so it possesses a braod-spectrum antiarrhythmic effect. Oxymatrine has the protective actions against myocardial injuries induced by coronary artery stricture-induced ischemia, ischemia/reperfusion, isoproterenol, adriamycin, infection and immunization, Oxymatrine can block to occurrence and development of myocardial hypertrophy and fibrosis. The basic mechanisms of cardioprotective effect of oxymatrine are antioxidation, anti-inflammation, immunodepression, and down-regulating the expression of mineralocorticoid(aldosterone)receptor, thus activating Nrf2/HO-1 pathway, and inhibiting the expression of TGF-β1 and its I type receptor, therefore blocking backward signaling pathways of JNK/STAT, MAPK/Smad2/3, and Notch, to decrease myocardial apoptosis, and prevent myocardial injury and collagen synthesis, so to express the attenuating effects of myocardial hypertrophy and fibrosis.