2区 · 医学
Article
作者: Abdulla, Salim ; Mbaga, Thabiti A. ; Shekalaghe, Seif A. ; Ali, Ali Mohamed ; Mtoro, Ali T. ; Hamad, Ali ; Lweno, Omar N. ; Denti, Paolo ; Milando, Florence A. ; Mkindi, Catherine ; Simon, Beatus ; Gausi, Kamunkhwala ; Bakari, Bakari M. ; Kassim, Kamaka R. ; Jongo, Said A. ; Juma, Omar A. ; Penny, Melissa A. ; Gwandu, Conrad H.
The combination antimalarial therapy of artemisinin-naphthoquine (ART-NQ) was developed as a single-dose therapy, aiming to improve adherence relative to the multiday schedules of other artemisinin combination therapies. The pharmacokinetics of ART-NQ has not been well characterized, especially in children. A pharmacokinetic study was conducted in adults and children over 5 years of age (6 to 10, 11 to 17, and ≥18 years of age) with uncomplicated malaria in Tanzania.