MacroGenics investigates three patient deaths in Phase 2 prostate cancer drug trial
2024-05-10
临床结果临床2期抗体药物偶联物
MacroGenics reported on Thursday afternoon that three patients died in a mid-stage trial of its antibody-drug conjugate for prostate cancer. Two participants died due to pneumonitis and the third died from a pleural effusion.
The biotech’s shares $MGNX plummeted 66% to $4.91 premarket on Friday.
A total of five patients died in the trial, although two of the deaths were deemed unrelated to vobramitamab duocarmazine, also dubbed vobra duo. All but one patient in the trial had a treatment-emergent adverse event and 33.5% experienced a grade 3 or higher event.
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来源: EndPoints
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