在符合NRTI停药标准并进入NRTI停药监测期(NDMP)的受试者中,BRII-179+PEG-IFNα组中保持HBsAg清除的受试者百分比高于安慰剂+PEG-IFNα组(全分析集[FAS]中19.3% vs 12.3%)。从EOT(FAS中26.3% vs 19.3%)到NRTI停药后至少24周或EOT后36周(即数据截止日期),BRII-179+PEG-IFNα组的总体HBsAg清除率改善趋势持续维持。NRTI停药的受试者均不需要接受NRTI再治疗。
NRTI停药后至少24周时,与安慰剂+PEG-IFNα组相比,BRII-179+PEG-IFNα组保持HBsAg清除的受试者中HBsAb ≥ 100 IU/L的受试者比例更高(FAS中36.4% vs 14.3%)。
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