Data to include insights from 12 indications from more than 15 CAR T centers in US and Europe
Kyverna to host a press conference on June 14 at 5pm CEST
EMERYVILLE, Calif., June 7, 2024 /PRNewswire/ -- Kyverna Therapeutics, Inc. (Kyverna), a patient-centered, clinical-stage biopharmaceutical company focused on developing cell therapies for patients suffering from autoimmune diseases, announced today that it will host a sponsored symposium to present the largest and most diverse set of data to date from a cohort of 50 patients treated with the CAR in KYV-101, an autologous, fully human anti-CD19 CAR T-cell immunotherapy. The data support the differentiated safety profile of the CAR in various indications, including a 30-patient data set that spans >28 day follow-up in various autoimmune disease patients with early efficacy data. A 12-month follow-up of the first patient treated with KYV-101 for myasthenia gravis will also be presented. The symposium titled "Anti-CD19 CAR T-Cell Therapy in Rheumatologic Autoimmune Diseases and Beyond" will take place on June 14, 2024, from 8:15 a.m. to 9:30 a.m. CEST. The symposium will offer insights on the ongoing clinical trials and named-patient initiatives from leading experts in rheumatology and neurology, including: Dr. Richard Furie, Northwell Health, USA
A press conference will be hosted later in the day featuring Georg Schett, M.D., vice president of research at the Friedrich-Alexander-University in Erlangen, Germany, and Peter A. Merkel, M.D., M.P.H. Both are members of Kyverna's Scientific Advisory Board. Additionally, Kyverna will showcase two posters on Wednesday, June 12 focusing on the preclinical development of KYV-201 - the Company's allogeneic product candidate - and proteomic markers associated with CAR T therapeutic response in autoimmune diseases, respectively. Kyverna will also set up an exhibit at EULAR (booth E22-23) to serve as a meeting point for interested healthcare practitioners and patient advocates.
KYV-101 is currently being evaluated in sponsored, open-label, Phase 1/2 and Phase 2 trials of KYV-101 in the United States and Germany across two broad areas of autoimmune disease: rheumatology and neurology. With 50 patients treated so far with the CAR in KYV-101 in both oncological and autoimmune conditions at more than 15 locations in Europe and the U.S., we believe that the differentiated properties of KYV-101 are critical for the potential success of CAR T cells as autoimmune disease therapies. KYV-101 is also being evaluated in investigator-initiated trials for multiple indications in multiple geographies. Forward-Looking Statements
Statements in this press release about future expectations, plans and prospects, as well as any other statements regarding matters that are not historical facts, may constitute "forward-looking statements." The words, without limitation, "anticipate," "believe," "continue," "could," "estimate," "expect," "intend," "may," "plan," "potential," "predict," "project," "should," "target," "will," "would" and similar expressions are intended to identify forward-looking statements, although not all forward-looking statements contain these or similar identifying words. Forward-looking statements in this press release include, without limitation, those related to: the potential of cell therapies in rheumatological and neurological B cell-driven autoimmune diseases and rising interests related thereto; Kyverna's goals to develop certain paradigm-shifting treatment options; Kyverna's beliefs about the differentiated safety profile and other properties of KYV-101; and Kyverna's clinical trials. Actual results may differ materially from those indicated by such forward-looking statements as a result of various important factors, including: uncertainties related to market conditions, and other factors discussed in the "Risk Factors" section of Kyverna's most recent Annual Report on Form 10-K and Quarterly Reports on Form 10-Q that Kyverna has filed or may subsequently file with the U.S. Securities and Exchange Commission. Any forward-looking statements contained in this press release are based on the current expectations of Kyverna's management team and speak only as of the date hereof, and Kyverna specifically disclaims any obligation to update any forward-looking statement, whether as a result of new information, future events or otherwise. For more information, please visit https://kyvernatx.com.
1. Brudno et al., Nature Medicine 2020; 26:270-280.
Consort Partners for Kyverna