'New data presented at #ATS2023 : INV-202 induces #WeightLoss and reduces airway hyperreactivity (mouse model of #Obese #Asthma) #CB1 #Inversago'
In an oral presentation, Carolyn R. Morris, PhD, Faculty Scientist, University of Vermont, Burlington, VT will discuss results from a proof-of-concept study designed to test the efficacy of INV-202 in a mouse model of obese asthma for direct effects on the airway and weight loss. INV-202, Inversago’s lead drug candidate, is a potential first-in-class, peripheral CB1r blocker, being developed to treat metabolic disorder complications.
“INV-202 is being developed for the treatment of metabolic disorder complications, and this preclinical data demonstrates its potential to also address the large unmet need in asthma complicated by obesity,” added Glenn Crater MD, Chief Medical Officer of Inversago.
Presentation Details:
Abstract Title: Cannabinoid Receptor 1 Inverse Agonist, INV-202, Induces Weight Loss and Reduces Airway Hyperreactivity in a Mouse Model of Obese Asthma
Presenter: Carolyn R. Morris, PhD, Faculty Scientist, University of Vermont, Burlington, VT
Session: B15 - ASTHMA: HOT OFF THE PRESS FROM THE BENCH TO THE CLINIC
Date and Time: Monday, May 22, 2023, 9:00 - 11:00 AM ET
About INV-202
INV-202 is a small molecule CB1r blocker being developed for the potential treatment of a range of cardiometabolic conditions, including diabetic kidney disease. It is specifically designed to preferentially block CB1 receptors in peripheral tissues such as the kidneys, gastro-intestinal tract, liver, pancreas, adipose tissues, muscles, lungs and other organs. The therapeutic effects of a peripheral CB1r blockade in a range of cardiometabolic and fibrotic diseases are well-documented, paving the way for potential treatment of a large number of patients with current unmet needs. INV-202 is being evaluated in a Phase 2 study for patients with diabetic kidney disease with results expected in mid 2024.