盐酸苯氧丙酚胺(Isoxsuprine Hydrochloride) - 药物靶点：β2-adrenergic receptor_在研适应症：流产，炭疽，动脉硬化闭塞症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

Isoxsuprine、Isoxsuprine hydrochloride (JP17/USP)、异克舒令

+ [2]

靶点

β2-adrenergic receptor

作用机制

β2-adrenergic receptor激动剂(β2-肾上腺素能受体激动剂)

治疗领域

感染神经系统疾病心血管疾病+ [3]

在研适应症

流产炭疽动脉硬化闭塞症+ [7]

非在研适应症-

原研机构

Alfresa Pharma Corp.

在研机构

Alfresa Pharma Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (1963-03-14),

流产炭疽动脉硬化闭塞症+ [7]

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构

分子式C18H23NO3

InChIKeyBMUKKTUHUDJSNZ-UHFFFAOYSA-N

CAS号395-28-8

查看全部结构式(2)

关联

4

项与盐酸苯氧丙酚胺相关的临床试验

CTRI/2023/03/050935 / Not yet recruiting临床2/3期IIT

Study the comparative efficacy of Shwadanshtradi Yoga and Isoxsuprine in Garbhini Udarshoola: A randomized controlled clinical trial

开始日期2023-04-15

申办/合作机构-

NCT03752307 / Completed临床1/2期IIT

Double-blind, Placebo-controlled, Randomized Study of the Safety and Tolerability of Isoxsuprine HCL Combined With High Dose Steroid Treatment of Multiple Sclerosis (MS) Relapse

This is a proof of concept, randomized, double-blind, placebo-controlled, 2-arm, parallel group study of Isoxsuprine in MS subjects experiencing a typical relapse.
Evidence from preclinical stroke models and experimental allergic encephalomyelitis suggest that isoxsuprine hydrochloride may have neuroprotective activity and reduce disability in animal models. Given its potential neuroprotective effects in CNS injury models, the investigators propose to test it as a safe, tolerable add on treatment for acute relapses in patients with relapsing forms of MS.

开始日期2019-02-15

申办/合作机构

The University of New Mexico

CTRI/2018/04/013262 / Completed临床4期IIT

A Prospective, Single Center, Open-Label, Non-Comparative Study For Evaluation Of Efficacy And Safety Study Of Isoxsuprine Hydrochloride As Uterine Relaxant In Preterm Labor

开始日期2018-04-14

申办/合作机构-

100 项与盐酸苯氧丙酚胺相关的临床结果

登录后查看更多信息

100 项与盐酸苯氧丙酚胺相关的转化医学

登录后查看更多信息

100 项与盐酸苯氧丙酚胺相关的专利（医药）

登录后查看更多信息

443

项与盐酸苯氧丙酚胺相关的文献（医药）

2024-10-03·Journal of Microbiology and Biotechnology

Development of a New Isoxsuprine Hydrochloride-Based Hydroxylated Compound with Potent Antioxidant and Anti-Inflammatory Activities

Article

作者: Chang, Te-Sheng ; Wu, Jiumn-Yih ; Liu, Chun-Wei ; Ding, Hsiou-Yu ; Wu, Chien-Yu ; Wang, Tzi-Yuan

The scientific community actively pursuits novel compounds with biological activities. In this context, our study utilized the predicted data mining approach (PDMA), which can efficiently screen out biotransformable precursor candidates to produce new bioactive compounds. The PDMA was applied to Bacillus megaterium tyrosinase (BmTYR) to form new bioactive hydroxyl compounds from isoxsuprine hydrochloride (isoxsuprine). The results show that isoxsuprine could be biotransformed by BmTYR to form a new compound, 3''-hydroxyisoxsuprine. 3''-Hydroxyisoxsuprine exhibited 40- fold and 10-fold higher potent antioxidant and anti-inflammation activities than the precursor, isoxsuprine. The 3''-hydroxyisoxsuprine effectively mitigates the hyperimmune response in RAW 264.7 macrophages by inhibiting the upregulation of pro-inflammatory cytokine (IL-1β and IL-6) and inflammatory enzyme COX-2 gene expression triggered by LPS stimulation. This study illustrates that PDMA is an effective strategy for screening known natural and chemical compounds and for generating new bioactive compounds through biotransformation. Our newly produced compound has potential future applications in pharmacology and biotechnology.

2024-01-01·Animal Science Journal

Failure of isoxsuprine HCl to increase sheep fertility after cervical versus laparoscopic AI using chilled semen at different durations

Article

作者: Dayanıklı, Cemal ; Bülbül, Bülent ; Turan, Aydın ; Aksoy, Muhammet ; Şengül, Ebru ; Nur, Zekariya

AbstractTo improve the fertility of cervical artificial insemination (AI) in sheep, we investigated isoxsuprine HCl usage on the cervical passage during cervical AI. We also compared cervical and laparoscopic AI fertility results of using chilled semen at different durations. Semen was collected from rams and diluted as 20 × 106 or 400 × 106 spermatozoa/straw for laparoscopic and cervical AI, respectively, and chilled to 4°C within 2 h. Sheep were inseminated with chilled semen for 8 or 24 h via the laparoscopic or cervical AI method. Moreover, some of the cervical inseminated sheep were injected intramuscularly with 0.5 mg/kg of isoxsuprine HCl 15 min before AI. As a result, the use of isoxsuprine HCl did not affect cervical transit and fertility. In addition, fertility was affected by the storage duration of the semen; laparoscopic AI was more successful than cervical AI in terms of fertility; if cervical AI is performed, the duration between semen collection and AI should be less than 8 h after chilling the semen at 4°C, and if laparoscopic AI is performed, the time between semen collection and insemination can be up to 24 h after chilling the semen at 4°C. Longer storage periods should be studied.

2023-07-20·Cureus

Vaginal Drain to Prevent Ascending Infection in Preterm Premature Rupture of Membranes: A Novel Method

Article

作者: Samartharam, Hemmanoor ; Ila, Sai Samyuktha ; Vasudeva, Nagashree

BACKGROUNDNot to delay delivery for more than 24 hours after rupture of the membrane is the thumb rule in obstetrics. Ascending infection from the vagina results in dangerous chorioamnionitis, which threatens the lives of the baby and mother. We developed a novel method to prevent ascending infection by using a vaginal drain, which helps to continue pregnancies if the leak stops and buys some time for antenatal steroids to act if the leak doesn't stop.METHODIn this study, 20 uncomplicated singleton pregnant women with spontaneous preterm premature rupture of membranes at gestational ages <35 weeks were recruited. Under the speculum, vaginal epithelial debris and secretions were cleared by a saline wash. The tip of the Nelaton Catheter was kept in the posterior fornix and then strapped to the thigh. The outer end was connected to the collection bag system and allowed to hang down to the ground. The foot end of the cot was raised. Leaked amniotic fluid and amniotic fluid index (AFI) were measured daily. A daily AFOD estimation was done for leaked AF. Uterine activity was controlled with low-dose Isoxsuprine Hydrochloride rapid infusion tocolysis. Antenatal steroids (ANS) were given. The spread of infection was monitored by maternal pulse rate, fetal heart rate, TC, and CRP. Pregnancies were terminated when leaks didn't stop, AFI didn't raise, or mature AFOD was observed. The number of women in whom leaks stopped, the number of days pregnancies continued, neonatal respiratory distress (NRD), birth weights, and perinatal deaths were recorded. Results: Leaks stopped in eight (40%) women. Pregnancy continuation ranged from 7 to 74 days. In 12 women, the leak did not stop, but we could buy 2-5 days' time for ANS to act. All parameters of the infection were within normal limits. Thirteen babies developed mild NRD, and we lost one baby.CONCLUSIONBy using a vaginal drain for P(P)ROM, ascending infection can be prevented, leaks can be stopped in 40% of women, and can buy time for ANS to act.

100 项与盐酸苯氧丙酚胺相关的药物交易

登录后查看更多信息

外链

KEGG	Wiki	ATC	Drug Bank
D01748	盐酸苯氧丙酚胺	C04AA01	DB08941

研发状态

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
流产	日本	Alfresa Pharma Corp.	1963-03-14
炭疽	日本	Alfresa Pharma Corp.	1963-03-14
动脉硬化闭塞症	日本	Alfresa Pharma Corp.	1963-03-14
痛经	日本	Alfresa Pharma Corp.	1963-03-14
冻伤	日本	Alfresa Pharma Corp.	1963-03-14
早产	日本	Alfresa Pharma Corp.	1963-03-14
雷诺病	日本	Alfresa Pharma Corp.	1963-03-14
Reynolds综合征	日本	Alfresa Pharma Corp.	1963-03-14
血栓闭塞性血管炎	日本	Alfresa Pharma Corp.	1963-03-14
静脉血栓形成	日本	Alfresa Pharma Corp.	1963-03-14

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03752307 (CTgov)	临床1/2期	多发性硬化症	2	corticosteroid+Isoxsuprine Hydrochloride (Corticosteroid & Isoxsuprine HCL)	膚顧獵構壓構範鏇襯窪(憲艱淵選獵齋襯鹽觸鏇) = 窪壓壓積夢觸鑰廠鑰膚壓齋廠淵膚網蓋鏇鬱製 (鑰觸繭醖繭齋積餘餘觸, 顧糧構獵繭糧鹹廠範鏇 ~ 鑰鹽製鬱築鬱網糧網膚) 更多	-	2024-02-06
				corticosteroid (Corticosteroid & Placebo)	膚顧獵構壓構範鏇襯窪(憲艱淵選獵齋襯鹽觸鏇) = 鑰齋製築淵鹹鬱遞夢鑰壓齋廠淵膚網蓋鏇鬱製 (鑰觸繭醖繭齋積餘餘觸, 憲衊觸選顧醖艱淵遞鏇 ~ 壓艱醖壓蓋蓋壓窪餘鹽) 更多