预约演示
更新于：2025-08-02
Pazufloxacin Mesilate
甲磺酸帕珠沙星
更新于：2025-08-02
概要
基本信息
非在研机构- |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (2002-04-11), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C17H19FN2O7S |
InChIKeyUDHGFPATQWQARM-FJXQXJEOSA-N |
CAS号163680-77-1 |
关联
10
项与 甲磺酸帕珠沙星 相关的临床试验NCT03696342
Clinical Study of the Efficacy of the Ophthalmic Solution of Pazufloxacin 0.6% (PRO-157) for the Treatment of Acute Bacterial Conjunctivitis, Compared to the Ophthalmic Solution of Gatifloxacin 0.3%.
NCT03675841
A Phase I，Pazufloxacin Mesilate Ear Drops in Patients With Chronic Suppurative Otitis Media
NCT02592096
A Single Dose Phase I Clinical Study of Pazufloxacin Mesilate Ear Drops for the Patients With Otitis Media
100 项与 甲磺酸帕珠沙星 相关的临床结果
登录后查看更多信息
100 项与 甲磺酸帕珠沙星 相关的转化医学
登录后查看更多信息
100 项与 甲磺酸帕珠沙星 相关的专利（医药）
登录后查看更多信息
676
项与 甲磺酸帕珠沙星 相关的文献（医药）2025-08-01SEPARATION AND PURIFICATION TECHNOLOGY
Environmentally friendly synthesis of quasi-MIL-100(Fe) with modulation defects for efficient photo-Fenton degradation of ciprofloxacin
作者: Ma, Xianyun ; Zhang, Sanbing ; Liu, Yajia ; Miao, Chang-qing ; Zhu, Bowen ; Wang, Min ; Li, Zuopeng
Defect engineering is a promising approach for constructing highly efficient catalytic activity based on metal-organic frameworks (MOFs).In this study, a defective MOFs, referred to as quasi-MIL-100(Fe), was synthesized by moderate synthesis method and then careful thermal treatment at an atm. ranging from 150 to 450°C, linking crystalline materials and the associated metal oxides.MIL-100(Fe) heat-treated at 250°C (referred to as M-250) partially breaks coordination bonds, resulting in a crystalline-to-amorphous transformation, increased porosity, and elimination of ligands.Compared to pristine MIL-100(Fe), M-250 possessed more reactive sites and exhibited the highest photo-Fenton degradation of ciprofloxacin with 95.6% removal efficiency in 90 min, despite the unfavorable photo properties for photo-Fenton performance due to the destruction of the crystal structure.Addnl., d. functional theory (DFT) calculations, combined with free radical quenching and mass spectrometry anal., elucidated the catalytic mechanism.These findings highlight the significant potential of quasi-MOFs for applications in the photo-Fenton reaction.
2025-06-01CHEMICAL ENGINEERING JOURNAL
Ratiometric FRET encoding Zr-MOF@Au-FAM/TAMRA nano assemblies based on tetrahedral framework nucleic acid-functionalized magnetic beads and DNA walker for ultrasensitive quantifying enrofloxacin and ciprofloxacin
作者: Yang, Junsong ; Jiang, Hongtao ; Wang, Zhouping ; Qi, Shuo ; Dong, Xiaoze ; Ang, Beijun ; Khan, Imran Mahmood
Quinolone-antibiotic residues pose serious threat to food safety and ecol. environmental health.Therefore, we have developed a ratiometric FRET encoding Zr-MOF@Au-FAM/TAMRA (ZAFT) nano assemblies based on tetrahedral framework nucleic acid-functionalized magnetic beads (W/Apt-Tet-MB) and DNA walker for ultrasensitive quantification of two typical quinolone antibiotics (enrofloxacin and ciprofloxacin).Firstly, a simple and stable satellite nano assembly (Zr-MOF@AuNPs) was synthesized.DNA hairpin H1-L@FAM was coupled with Zr-MOF@AuNPs to form Zr-MOF@Au@FAM (ZAF) nano assembly.Furthermore, the W/Apt-Tet-MB demonstrated excellent capturing capability for ENR and CIP due to the efficient integration of group-specific aptamer in the DNA tetrahedra.In addition to capturing targets, the walker DNA (W) was released, triggering the opening of DNA H1 on the ZAF.Supported by fuel DNA H2 and entropy-driven mechanisms, the newly exposed ssDNA region within H1 then reacted with H2 and reporter DNA (modified with Tamra) through nucleic acid hybridization to form ZAFT and release W again.Subsequently, the released W opened other nearby H1 and continuously initiated a new round of DNA walker reaction.Thus, ZAFT was generated in large quantities.Meanwhile, significant ratiometric fluorescence signals (F585/F519) were generated and pos. correlated with the amounts of targets employing the localized surface plasmon resonance (LSPR) activities of prepared Zr-MOF@AuNPs.The developed aptasensor demonstrated good linearity in the 0.001-100 ng/mL range, with a LOD of 0.24 and 0.31 pg/mL towards ENR and CIP.Importantly, the aptasensor was successfully applied to quantify ENR/CIP in real samples with satisfactory recoveries, manifesting its prospective application in environmental monitoring and food safety.
2025-04-21JOURNAL OF DRUG TARGETING
Artificial intelligence-based molecular property prediction of photosensitising effects of drugs
Article
作者: Hofmann, Amun G. ; Agibetov, Asan ; Weber, Benedikt ; Ibbotson, Sally
Drug-induced photosensitivity is a potential adverse event of many drugs and chemicals used across a wide range of specialties in clinical medicine. In the present study, we investigated the feasibility of predicting the photosensitising effects of drugs and chemical compounds via state-of-the-art artificial intelligence-based workflows. A dataset of 2200 drugs was used to train three distinct models (logistic regression, XGBoost and a deep learning model (Chemprop)) to predict photosensitising attributes. Labels were obtained from a list of previously published photosensitisers by string matching and manual validation. External evaluation of the different models was performed using the tox21 dataset. ROC-AUC ranged between 0.8939 (Chemprop) and 0.9525 (XGBoost) during training, while in the test partition it ranged between 0.7785 (Chemprop) and 0.7927 (XGBoost). Analysis of the top 200 compounds of each model resulted in 55 overlapping molecules in the external validation set. Prediction scores in fluoroquinolones within this subset corresponded well with culprit substructures such as fluorinated aryl halides suspected of mediating photosensitising effects. All three models appeared capable of predicting photosensitising effects of chemical compounds. However, compared to the simpler model, the complex models appeared to be more confident in their predictions as exhibited by their distribution of prediction scores.
100 项与 甲磺酸帕珠沙星 相关的药物交易
登录后查看更多信息
研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 感染 | 中国 | 2004-01-01 | |
| 细菌感染 | 日本 | 2002-04-11 |
未上市
10 条进展最快的记录, 后查看更多信息
登录
| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 慢性化脓性中耳炎 | 临床1期 | 中国 | 2015-07-24 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 46 | (PRO-157) | 構構範襯選鑰鑰鑰淵製 = 齋齋衊遞鑰齋選鬱鏇觸 鹽壓餘淵廠憲襯廠簾積 (網製鬱鏇壓襯繭鬱醖襯, 觸繭築衊膚齋蓋繭夢膚 ~ 艱衊鹽簾範夢鏇醖積糧) 更多 | - | 2021-08-24 | ||
(Zymar) | 構構範襯選鑰鑰鑰淵製 = 齋鬱襯衊糧蓋網蓋積築 鹽壓餘淵廠憲襯廠簾積 (網製鬱鏇壓襯繭鬱醖襯, 構淵蓋齋遞餘鏇憲憲選 ~ 願壓鏇築願壓淵鑰膚顧) 更多 | ||||||
临床2期 | 150 | (PRO-157 BID (2 Times Per Day)) | 襯糧鹽餘顧鑰製鏇顧範 = 願繭範憲醖餘窪獵齋憲 艱憲廠鬱築蓋繭鬱製鹽 (鏇餘網壓網鬱鏇餘夢構, 襯積鑰顧觸淵網夢選壓 ~ 衊築蓋廠糧積鹹醖鏇醖) 更多 | - | 2019-02-15 | ||
(PRO-157 TID (3 Times Per Day)) | 襯糧鹽餘顧鑰製鏇顧範 = 壓鑰網蓋齋簾積網簾積 艱憲廠鬱築蓋繭鬱製鹽 (鏇餘網壓網鬱鏇餘夢構, 夢鏇鏇壓艱選廠淵鏇艱 ~ 廠蓋鹹壓淵網願範觸鬱) 更多 | ||||||
临床2期 | 300 | Pazufloxacin 0.09% BID | 顧壓顧鑰遞選齋蓋觸衊(鬱選襯鹹餘窪襯壓顧憲) = 鹹簾願製簾蓋鬱範遞觸 繭積壓鹹網鏇願壓獵鹽 (製夢願簾築製醖遞蓋鹽 ) | 积极 | 2017-05-07 | ||
Pazufloxacin 0.09% TID | 顧壓顧鑰遞選齋蓋觸衊(鬱選襯鹹餘窪襯壓顧憲) = 蓋壓選餘觸鏇範繭憲鹹 繭積壓鹹網鏇願壓獵鹽 (製夢願簾築製醖遞蓋鹽 ) |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用