Fibrinogen Concentrate (Human)(Fibrinogen Concentrate (Human)) - 药物靶点：Fibrinogen_在研适应症：出血_专利_临床

概要

基本信息

药物类型

血液提取物

别名

Haemocomplettan、Riastap

靶点

Fibrinogen

作用方式

刺激剂

作用机制

纤维蛋白原刺激剂

治疗领域

其他疾病

在研适应症

出血

非在研适应症

纤维蛋白原缺乏血症主动脉瘤冠心病+ [3]

原研机构

ProMetic Biotherapeutics Ltd.

在研机构

CSL Behring GmbH

非在研机构

CSL Behring LLC

权益机构-

最高研发阶段批准上市

首次获批日期

美国 (2009-01-16),

出血

最高研发阶段(中国)-

特殊审评-

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关联

46

项与 Fibrinogen Concentrate (Human) 相关的临床试验

NCT06582420

/ Not yet recruitingN/AIIT

Pre-hospital Administration of Fibrinogen Concentrate in Patients With Suspected Trauma-Induced Coagulopathy (PAF-TIC)

A prospective, randomized controlled trial of fibrinogen concentrate (FC) plus standard of care versus standard of care alone in adult trauma patients with major bleeding or presumed major bleeding is developed to evaluate the efficacy and safety of prehospital administration of FC in trauma patients with suspected hypofibrinogenemia and active bleeding or presumed to be bleeding.
The main endpoints are:
1. Plasma fibrinogen levels in the first blood sample drawn at the patient's arrival at the trauma room and/or similar emergency bay dedicated to trauma and reanimation above the critical threshold of 2.0 g/l. As fibrinogen decreases early in trauma, its deficiency predicts massive bleeding and death.
2. Administration feasibility of FC within the prehospital setting.
Patients will be randomly assigned to receive either standard trauma care or standard trauma care plus administration of FC.

开始日期2025-01-01

申办/合作机构-

CTRI/2024/09/073878

/ Not yet recruitingN/AIIT

Evaluation of the effect of fibrinogen on peripartum hemorrhage in Placenta accreta spectrum (PAS) disorders, a double blind randomized controlled trial. - NIL

开始日期2024-09-24

申办/合作机构-

EUCTR2022-001759-17-DE

/ Not yet recruiting临床3期

A multicenter, randomized, double-blind, placebo-controlled, parallel, phase 3 study to assess the efficacy and safety of fibrinogen concentrate (FGTW) in the management of bleeding in patients undergoing complex cardiac surgery (involving CPB)

开始日期2023-03-15

申办/合作机构

Laboratoire Français du Fractionnement et des Biotechnologies

100 项与 Fibrinogen Concentrate (Human) 相关的临床结果

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100 项与 Fibrinogen Concentrate (Human) 相关的转化医学

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100 项与 Fibrinogen Concentrate (Human) 相关的专利（医药）

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552

项与 Fibrinogen Concentrate (Human) 相关的文献（医药）

2025-09-01·FOOD CHEMISTRY

Dual-function activity prediction of fingered citron: Integrating hypotensive and Hypolipidaemic effects via molecular docking and QSAR methods

Article

作者: Lu, Bingting ; Liu, Huifan ; Zhong, Yuming ; Peng, Huang ; Zhou, Ningjing ; Liang, Canhuan ; Zhang, Lin ; Chen, Jialin

For the further research of peptides with hypotensive and hypolipidaemic capacities. This study highlighted the both capacities of Fingered Citron Hydrolysates (FCH). In vitro results shown FCH inhibited ACE activity (slope: -0.11), exhibited pancreatic lipase inhibitory capacity (slope: 22.53), and cholesterol esterase inhibitory capacity (63.25 % at 30 mg/mL). The peptides APPDPIL, DAPIFH, NIPVIGF, and QIPGLN exhibited both these capacities. Active screening and in silico simulations were used for discovery and validation. Notably, in silico simulations validated our hypotheses, with Quantitative Structure-Activity Relationship (QSAR) models used to predict the values of hypotensive and hypolipidaemic peptides; molecular docking confirmed the interaction modes. Additionally, this study discusses the active sites and characteristics of hypotensive and hypolipidaemic peptides. The workflow in this study may also provide a viable approach for research on dual-and multifunctional peptides.

2025-06-01·PEDIATRIC CARDIOLOGY

Effects of Fibrinogen Concentrate Supplementation on Postoperative Bleeding in Infants Undergoing Complex Cardiac Surgery

Article

作者: Raggi, Valeria ; Pergolizzi, Carola ; Rizza, Alessandra ; Iodice, Francesca Giovanna ; Marinari, Eleonora ; Di Chiara, Luca ; Benegni, Simona ; Vitale, Vincenzo ; Giorni, Chiara ; Olivieri, Andrea Maria

The use of allogeneic blood products to restore hemostasis during pediatric cardiac surgery is associated with major risks. Consequently, there has been a growing interest in new patient blood management strategies, such as those based on the use of fibrinogen concentrate (FC). Accumulating evidence has shown FC supplementation to be safe and effective. Nevertheless, no guidelines are available on using FC in the pediatric setting, and few objective evaluations have been provided in clinical practice. The endpoint of this monocenter retrospective study was the hemostatic effect of additional FC in infants undergoing complex cardiac surgery with cardiopulmonary bypass to manage persistent clinically relevant bleeding. After weaning from cardiopulmonary bypass and after protamine administration, patients were transfused with conventional allogeneic products such as packed red blood cells, fresh frozen plasma (FFP), and platelets. In the case of redo surgery, according to the institutional protocol, patients also received tranexamic acid. In case of clinically persistent relevant bleeding, according to the anesthesiologist's judgment and thromboelastography, patients received FC supplementation (group with FC) or further FFP transfusions without receiving FC supplementation (group without FC). The primary endpoint was the hemostatic effects of FC. Secondary endpoints were the functional hypofibrinogenemia threshold value (expressed as maximum amplitude fibrinogen, MA-Fib) and postoperative MA-Fib, fibrinogenemia, intraoperative transfusions, and adverse events (AEs). In total, 139 patients who underwent cardiac surgery with CPB and aged less than 2 years were enrolled: 70 patients received allogeneic blood products and FC supplementation (group FC); 69 patients received allogeneic products without FC supplementation (group without FC). Patients that received FC supplementation were characterized by a significantly longer time of extracorporeal circulation (p < 0.001) and aortic cross-clamping (p < 0.001), a significantly lower minimum temperature (p = 0.011), increased use of concentrated prothrombin complex (p = 0.016) and tranexamic acid (p = 0.010), and a significantly higher amount of packed red blood cells, platelets (p < 0.001) and fresh frozen plasma (p = 0.03). Postoperative bleeding and severe bleeding were not statistically different between patients treated with FC and those not treated with FC supplementation (p = 0.786 and p = 0.695, respectively); after adjustment, a trend toward reduced bleeding can be observed with FC (p = 0.064). Overall, 88% of patients with severe bleeding had MA-Fib < 10 mm; a moderate association between severe bleeding and MA-Fib (odds ratio 1.7, 95% CI 0.5-6.5, p = 0.425) was found. Increased MA-Fib and postoperative fibrinogen were higher in the FC group (p = 0.003 and p < 0.001, respectively) than in FFP. AEs in the FC group were comparable to those observed in less complicated surgeries. Our results suggest a potential role of FC in complex surgery in maintaining postoperative bleeding at a level comparable to less complicated surgical procedures and favoring the increase in postoperative MA-Fib and fibrinogen.

2025-05-01·ADVANCES IN THERAPY

A Multicenter Single-Arm Study of Switching to Ferric Citrate Hydrate for Iron Deficiency Anemia in Patients Intolerant to Oral Iron: RIO-SWITCH

Article

作者: Mori-Uchino, Mayuyo ; Wada-Hiraike, Osamu ; Maruyama, Aya ; Mitobe, Yuko ; Osuga, Yutaka ; Iriyama, Takayuki ; RIO-SWITCH Consortium

INTRODUCTION:

Treatment interruptions due to adverse drug reactions (ADRs) are common in iron deficiency anemia (IDA). We evaluated medication completion rates and quality of life (QoL) changes in patients with IDA after starting ferric citrate hydrate (FCH) treatment.

METHODS:

This multicenter, open-label, uncontrolled, single-arm comparative study included 30 Japanese female patients with IDA who experienced nausea and/or vomiting (N/V) with previous oral iron preparations. Patients received FCH 500 mg orally daily (< 1000 mg/day). Those with hemoglobin levels ≥ 11.0 g/dl completed the study at week 4; others continued until week 8. The primary endpoint was medication completion rate. Secondary endpoints included medication compliance rate, treatment satisfaction scores, and QoL scores and changes.

RESULTS:

Thirty patients initiated and completed treatment; 24 reached ≥ 11.0 g/dl hemoglobin at week 4 and ended treatment, while 6 continued until week 8. The medication compliance rate was 93.92% ± 8.11% (mean ± standard deviation [SD]), and the completion rate was 100.0% (95% confidence interval 88.4-100.0%). Questionnaire findings revealed that the most severe nausea score decreased from 5.7 ± 2.4 to 1.7 ± 2.1 (mean ± SD), N/V incidence decreased from 100.0 to 63.3%, and patients reporting that N/V did not interfere with daily life increased from 6.7 to 52.6% following the switch to FCH. Twenty-four patients (80.0%) reported a satisfactory experience with FCH versus their previous oral iron preparation. Scores for all eight subscales of the Short-Form 36-Item Health Survey v2 improved, with significant increases in six. Nine ADR events occurred in six patients (20.0%), including nausea in three (10.0%); none were serious or resulted in treatment discontinuation.

CONCLUSION:

FCH treatment exhibited a satisfactory medication completion rate in patients with IDA. Switching to FCH reduced N/V incidence and improved N/V and QoL severity compared with previous oral iron preparations.

TRIAL REGISTRATION:

jRCTs031210634. Registration date: March 01, 2022.

2

项与 Fibrinogen Concentrate (Human) 相关的新闻（医药）

2024-02-14

·FiercePharma

Grifols readies US, EU approval push for blood clot treatment after phase 3 success

BT524 can be administered to “patients on the operating table immediately," Grifols explained. Grifols is readying an approval run at U.S. and European regulators on the back of a phase 3 win for the Spanish plasma medicine producer's concentrated form of a blood clotting factor. The product, dubbed BT524, is a concentrated form of fibrinogen, a glycoprotein that is essential for blood clot formation and stops excessive bleeding resulting from injuries or surgery. Grifols was testing BT524 in a late-stage study of patients with acquired fibrinogen deficiency (AFD), which it described as an “underserved growth market.” The Barcelona, Spain-based company announced this morning that the product had met the study’s primary endpoint, demonstrating its noninferiority to standard of care when it came to reducing blood loss in patients with AFD who underwent spinal or abdominal surgery, while also “maintaining an excellent safety profile.” Specifically, mean blood loss was 1,444 mL among the BT524 cohort compared with 1,735 mL among patients who received standard of care. It meant patients receiving Grifols’ product lost an average of 291 mL less blood. AFD usually occurs during surgery when a patient’s body contains insufficient fibrinogen to arrest bleeding. It is typically treated with a plasma extract called cryoprecipitate or fresh frozen plasma, which both contain fibrinogen. However, both of these treatment options contain various other unneeded proteins and elements, meaning that large volumes are required to ensure the patient receives sufficient fibrinogen, Grifols explained in the release. They also need to be thawed before use, which is not only time-consuming but can put patients’ lives at risk, the company added. In contrast, BT524 can be administered to “patients on the operating table immediately,” who will only receive the fibrinogen necessary to prevent hemorrhaging, Grifols explained. The company’s plan is to kick off the approval process in both Europe and the U.S. in the fourth quarter of the year. If successful, it would mark the first fibrinogen concentrate approved for AFD in the U.S., Grifols noted. “The positive results for fibrinogen are an important milestone and strengthen a Grifols innovation strategy that’s diversified across plasma and non-plasma, balanced between internal and external investments, and includes both shorter- and longer-term development cycles,” Grifols’ chief operating officer, Victor Grifols Deu, said in the release. While Grifols has its eye on the first fibrinogen concentrate approval for AFD in the U.S., its competitors have had more luck getting their own versions to market for congenital fibrinogen deficiency. CSL Behring got RiaSTAP approved in that indication as far back as 2009, while Switzerland’s Octapharma followed suit with Fibryga in 2017. Since then, Fibryga has also received approval to treat AFD across Europe off the back of a phase 2 study. Meanwhile, Grifols is in the midst of an ongoing legal battle with Gotham City Research after the New York hedge fund accused the company of wrongful accounting practices.

上市批准临床结果临床3期临床2期

2021-06-11

·BioSpace

Fibrinogen Concentrate Market Size to Reach USD 4.19 Billion in 2028, Says Reports and Data

Increasing preference for fibrinogen concentrate over fresh-frozen plasma, rising incidence of bleeding disorders, and increasing number of fibrinogen product approvals are some key factors driving market growth Market Size – USD 2.61 Billion in 2020, Market Growth – at a CAGR of 6.1%, Market Trends – Rising R&D investment to accelerate development of advanced fibrinogen products The global fibrinogen concentrate market size is expected to reach USD 4.19 Billion in 2028 at a CAGR of 6.1%, according to the latest report by Reports and Data. Increasing R&D activities to develop new therapies for bleeding disorders, rising demand for fibrinogen concentrates to treat congenital deficiencies, and high incidence of bleeding disorders across the globe are key factors expected to drive market revenue growth over the forecast period. In addition, increasing number of advanced and innovative in pipeline to treat bleeding disorders is also expected to contribute to revenue growth of the market going ahead. Fibrinogen concentrate is a lyophilized and purified human plasma fibrinogen and is widely used as an alternative to traditional sources of fibrinogen, which is a natural blood protein playing a vital role in coagulation process. Fibrinogen concentrate has been extensively used and recommended for bleeding disorders and acquired coagulation disorders in several countries across the globe as it significantly improves blood clot firmness and minimizes the need for postoperative transfusion. Fibrinogen concentrate can either be plasma-derived or a recombinant and is often used for afibrinogenemia and dysfibrinogenemia. Increasing research is being carried out across the globe to expand its application scope to use it for conditions such as hemorrhage resuscitation. This is expected to contribute to revenue growth of the market going ahead. New product launches and approvals of fibrinogen concentrates are also expected to be a key factor driving market growth. In addition, increasing focus of key players on developing advanced fibrinogen concentrates to treat bleeding disorders is also a key market growth driving factor. However, adverse reactions associated with fibrinogen concentrate such as arterial thrombosis, dyspnea, nausea, and others are expected to hamper market growth to a certain extent over the forecast period. Access Free sample PDF Copy of the Report @ Some Key Highlights from the Report: Human fibrinogen type segment is expected to account for largest revenue share in the global market over the forecast period owing to increasing need for fibrinogen concentrate to treat bleeding disorders and congenital coagulation deficiencies. Congenital fibrinogen deficiency segment is expected to register robust revenue CAGR over the forecast period owing to high incidence of hemophilia, rising rate of bleeding disorders, proven safety and efficiency of fibrinogen concentrates and rapid advancements in fibrinogen products. North America is expected to dominate other regional markets over the forecast period owing to increasing geriatric population and high rate of bleeding disorders, advancements in diagnostics and therapeutics, and robust presence of key players in the region. Major companies in the market include CSL Behring, Baxter, Johnson & Johnson (Ethicon), LFB Group, ProFibrix BV (The Medicines Company), Shanghai RAAS, Jiangxi Boya Bio-Pharmaceutical, Hualan Biological Engineering, Harbin Pacific Biopharmaceutical, and Greencross. In November 2019, Octapharma AG announced approval for use of fibryga, which is a lyophilised human fibrinogen concentrate for intravenous infusion, in treatment of acquired fibrinogen deficiency in 15 European countries. Buy now your Exclusive copy of Report @ For the purpose of this report, Reports and Data has segmented the global fibrinogen concentrate market on the basis of type, application type, and region: Type Outlook (Revenue, USD Billion; Volume in Tons, 2018–2028) Human Animal Application Type Outlook (Revenue, USD Billion; Volume in Tons, 2018–2028) Congenital Fibrinogen Deficiency Surgical Procedures Request for Custom Research @ Regional Outlook (Revenue, USD Billion; Volume in Tons, 2018–2028) North America U.S. Canada Mexico Europe Germany U.K. France Italy BENELUX Rest of APAC Asia Pacific China India Japan South Korea Rest of APAC Latin America Brazil Rest of Latin America Middle East & Africa U.A.E. Saudi Arabia South Africa Rest of MEA Explore Reports and Data's Prime Analysis of the global Pharmaceutical & Healthcare Industry: Hemostasis Analyzers Market Analysis, By Product (Laboratory analyzer, POC testing,) By Test Type (Prothrombin Time, Fibrinogen, Activated Partial and others) By Technology Type (Mechanical and others) By End-Use (Diagnostic Centers, Hospitals, and others), Forecasts to 2026 Product (Revenue, USD Million; 2016-2026) Bovine Blood Plasma Derivatives Market Size, Share & Trends, By Type (Bovine Serum, FBS, Bovine Serum Albumin, Fibrinogen, Protein Ingredient, Others), By Application (Scientific Research, Industrial Production, Feed, Others), And Regional Forecasts To 2027 Coagulation Analyzers Market Size, Share & Analysis, By Product, By Technology (Mechanical, Electrochemical) By Test Types (APTT, D-Dimer, Fibrinogen, PT) By End Use (Hospitals, Research Institutes), And Segment, Forecasts To 2028 About Reports and Data Reports and Data is a market research and consulting company that provides syndicated research reports, customized research reports, and consulting services. Our solutions purely focus on your purpose to locate, target and analyze consumer behavior shifts across demographics, across industries and help client’s make a smarter business decision. We offer market intelligence studies ensuring relevant and fact-based research across a multiple industries including Healthcare, Technology, Chemicals, Power and Energy. We consistently update our research offerings to ensure our clients are aware about the latest trends existent in the market. Reports and Data has a strong base of experienced analysts from varied areas of expertise. Contact Us: John W Head of Business Development Reports and Data | Web: Direct Line: +1-212-710-1370 E-mail: sales@reportsanddata.com Read Full Press Release:

100 项与 Fibrinogen Concentrate (Human) 相关的药物交易

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研发状态

批准上市

10 条最早获批的记录,

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适应症	国家/地区	公司	日期
出血	美国	CSL Behring GmbH	2009-01-16

未上市

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
心脏病	临床3期	意大利	CSL Behring LLC	2011-11-01
纤维蛋白原缺乏血症	临床3期	-	CSL Behring LLC	2009-10-01
产后出血	临床2期	-	CSL Behring LLC	2021-01-01
冠心病	临床2期	美国	CSL Behring LLC	2011-01-01
心脏瓣膜疾病	临床2期	美国	CSL Behring LLC	2011-01-01
主动脉瘤	临床2期	德国	CSL Behring LLC	2008-06-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03932240 (CTgov)	临床3期	-	36	Fibrinogen Concentrate (FC) (Fibrinogen Concentrate (FC))	鹹齋構觸糧廠製鹽獵鹹(製餘憲構選衊蓋鬱範憲) = 窪膚醖顧獵醖願鬱膚簾觸築鬱鬱範廠繭鏇鑰選 (壓衊鏇衊艱醖顧鹹鹹壓, 醖簾衊獵淵簾齋鹹夢窪 ~ 襯築餘蓋衊憲鏇襯艱範) 更多	-	2023-03-20
				Cryoprecipitate (Cryoprecipitate)	鹹齋構觸糧廠製鹽獵鹹(製餘憲構選衊蓋鬱範憲) = 鏇鬱夢網齋襯鹹製壓衊觸築鬱鬱範廠繭鏇鑰選 (壓衊鏇衊艱醖顧鹹鹹壓, 糧獵鹽廠獵糧鏇築鏇蓋 ~ 構糧鏇淵醖鑰廠鑰憲醖) 更多
NCT02822599 (RiaSTAP, CTgov)	临床4期	出血 \| 纤维蛋白原缺乏血症	30	RiaStAP (RiaSTAP)	淵鬱網鬱艱糧鹽獵襯鏇(製淵遞構齋繭築遞壓廠) = 鏇醖範繭顧築餘積選範鹹窪蓋夢膚網積獵遞窪 (築餘簾網衊壓簾鹽觸襯, 鑰夢餘鬱淵壓蓋顧網鬱 ~ 廠廠餘觸淵壓築積廠簾) 更多	-	2021-09-16
				Saline (Saline)	淵鬱網鬱艱糧鹽獵襯鏇(製淵遞構齋繭築遞壓廠) = 繭憲膚積鹽醖膚夢製觸鹹窪蓋夢膚網積獵遞窪 (築餘簾網衊壓簾鹽觸襯, 顧齋襯夢選夢網積願鹽 ~ 鏇構顧醖壓艱繭鑰襯築) 更多
ISTH2020	N/A	血小板减少症	-	Fibrinogen concentrate	襯鬱憲醖衊築餘糧廠顧(範餘願築艱鑰鹹築衊製) = 鑰顧淵鹽簾齋觸鬱蓋顧襯鬱夢製艱積鏇蓋選窪 (衊製襯膚醖簾醖顧鬱鬱 )	-	2020-07-12
NCT01623531 (CTgov)	临床3期	术中并发症	62	Fibrinogen (RiaSTAP)	願蓋淵鑰鹽獵製窪廠選(繭醖簾壓鹽選鹹獵窪衊) = 積願衊廠淵鬱醖壓鬱鹹襯窪鑰膚夢膚鑰醖製遞 (蓋獵鬱夢膚醖鑰窪壓齋, 鑰夢鹹艱繭製鏇願蓋積 ~ 簾鬱艱膚築構繭艱鏇鏇) 更多	-	2020-05-22
				Fibrinogen (Intravenous Saline)	願蓋淵鑰鹽獵製窪廠選(繭醖簾壓鹽選鹹獵窪衊) = 網範淵鬱蓋觸鬱糧鹽簾襯窪鑰膚夢膚鑰醖製遞 (蓋獵鬱夢膚醖鑰窪壓齋, 壓憲鑰壓襯壓鑰夢蓋齋 ~ 鑰築觸獵鑰顧範選鹹鏇) 更多
ESC2018	N/A	-	299	Fibrinogen concentrate	壓衊獵構願觸鏇廠範壓(觸範夢蓋願選積窪網遞) = 積蓋願遞餘醖夢構簾鹹艱製選網選選窪積衊積 (選憲願鏇範選鬱鹽糧範 ) 更多	积极	2018-08-27
				Fibrinogen concentrate	壓衊獵構願觸鏇廠範壓(觸範夢蓋願選積窪網遞) = 遞餘醖範廠襯鹽壓憲選艱製選網選選窪積衊積 (選憲願鏇範選鬱鹽糧範 ) 更多
NCT02540434 (TOP-CLOT, CTgov)	N/A	凝血障碍	19	RiaSTAP+ROTEM (RiaSTAP Arm)	築夢選範窪衊遞艱鏇鏇(憲膚獵蓋鏇鹹壓餘願獵) = 蓋齋遞壓襯壓鏇鏇齋製淵醖範鏇齋膚鏇糧願築 (鹹範壓廠醖糧鏇窪製選, 醖餘顧願醖構選糧鹽醖 ~ 憲繭蓋遞窪製鬱構簾鹹) 更多	-	2017-05-12
				Cryoprecipitate (Cryopreciptiate Arm)	築夢選範窪衊遞艱鏇鏇(憲膚獵蓋鏇鹹壓餘願獵) = 鑰獵醖窪選積顧積簾壓淵醖範鏇齋膚鏇糧願築 (鹹範壓廠醖糧鏇窪製選, 範廠觸淵蓋蓋醖糧窪夢 ~ 鏇蓋選壓遞衊鏇獵蓋繭) 更多
NCT01359878 (Pubmed \| Br J Anaesth)	临床2/3期	产后出血	249	Fibrinogen concentrate	觸餘鏇繭遞鑰窪窪餘鹽(憲窪構製鑰壓窪餘衊窪) = 衊網蓋製鏇醖壓憲鑰壓選積繭製觸淵遞醖糧網 (構獵遞鏇艱壓願願願艱 )	不佳	2015-04-01
NCT01283321 (RiaCT, CTgov)	临床2期	冠心病 \| 心脏瓣膜疾病	26	Human fibrinogen concentrate (Group A: RiaSTAP)	壓獵製艱獵糧顧觸窪糧(窪餘製夢襯衊鬱淵獵簾) = 構築鬱範鹹衊鑰艱餘網鏇艱壓艱網積蓋鑰製醖 (膚構範淵願壓觸築製鹹, 0.0) 更多	-	2015-02-16
				apheresis platelets (Group B: Apheresis Platelets)	壓獵製艱獵糧顧觸窪糧(窪餘製夢襯衊鬱淵獵簾) = 構夢積醖鹹蓋遞衊鏇顧鏇艱壓艱網積蓋鑰製醖 (膚構範淵願壓觸築製鹹, 0.3) 更多
NCT03884725 (Pubmed \| J Thorac Cardiovasc Surg)	临床4期	-	63	Fibrinogen concentrate	鹽醖壓鹹糧艱獵鹹鹹獵(淵餘餘衊襯選艱網遞醖) = 艱鏇餘夢醖鏇衊範鬱鏇餘遞艱築願醖觸憲襯齋 (鏇選遞遞齋糧襯餘夢憲, 157 ~ 750)	积极	2014-10-01
				Cryoprecipitate	鹽醖壓鹹糧艱獵鹹鹹獵(淵餘餘衊襯選艱網遞醖) = 獵構積鏇遞積簾積築壓餘遞艱築願醖觸憲襯齋 (鏇選遞遞齋糧襯餘夢憲, 215 ~ 510)
NCT01300286 (CTgov)	临床4期	出血	23	RiaSTAP	願築糧窪艱餘遞衊醖醖(夢願觸齋構鑰獵繭壓齋) = 淵鑰蓋構構醖壓齋觸艱醖願積窪製壓廠艱構膚 (淵遞膚衊夢鹹顧網蓋醖, 49) 更多	-	2014-06-16