凯托卡因(Ketocaine) - _专利_临床

概要

基本信息

药物类型

小分子化药

别名-

靶点-

作用机制-

治疗领域

肿瘤神经系统疾病

在研适应症-

非在研适应症

肿瘤疼痛原发性痛经

原研机构

Recordati SpA

AstraZeneca PLC

在研机构-

非在研机构

University of Lund

Alma Mater Studiorum - Università di Bologna

University of Oulu

最高研发阶段无进展临床前

首次获批日期-

最高研发阶段(中国)-

特殊审评-

结构

分子式C18H29NO2

InChIKeyUXAWFWFJXIANHZ-UHFFFAOYSA-N

CAS号1092-46-2

关联

100 项与凯托卡因相关的临床结果

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100 项与凯托卡因相关的转化医学

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100 项与凯托卡因相关的专利（医药）

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32

项与凯托卡因相关的文献（医药）

1984-08-01·Journal of pharmaceutical sciences3区 · 医学

Potential Antitumor Agents X: Synthesis and Antitumor Activity of Two Nitrogen Mustard Derivatives Related to Ketocaine

3区 · 医学

Article

作者: Daniela Bonazzi ; Rosaria Bossa ; Mirella Rambaldi ; Aldo Andreanix ; Iraklis Galatulas

The synthesis of two nitrogen mustard derivatives (VIII and IX) related to the well-known local anesthetic ketocaine (III) is reported. These compounds were tested in mice implanted with Ehrlich ascites tumor cells, and the antitumor activity was compared with that of two previously synthesized analogues (I and II) lacking the nitro group and with that of doxorubicin. The monofunctional compound IX was inactive, but the bifunctional compound VIII showed potent antitumor activity (%T/C greater than 254 at 20 mg/kg).

1984-01-01·Archiv der Pharmazie4区 · 医学

Potential Antitumor Agents, XXII. Alkylating Agents from p‐Hydroxypropiophenone and p‐Hydroxyacetophenone

4区 · 医学

Article

作者: Daniela Bonazzi ; Rosaria Bossa ; Giovanna Lelli ; Mirella Rambaldi ; Aldo Andreani ; Iraklis Galatulas

Abstract:

The synthesis of the alkylating agents 18–25 from p‐hydroxypropiophenone, p‐hydroxyacetophenone and their nitro derivatives 14–17 is reported. The antitumor activities of these new compounds are compared to those of the previously reported analogs 2–13 of the local anesthetic ketocaine (1).

1983-07-01·Journal of pharmaceutical sciences3区 · 医学

Potential Antitumor Agents IX: Synthesis and Antitumor Activity of Two Analogues of Ketocaine

3区 · 医学

Article

作者: Rosaria Bossa ; Giancarlo Scapini ; Aldo Andreanix ; Iraklis Galatulas

The reaction between o-hydroxybutyrophenone and tris(2-chloroethyl)amine gave two analogues (II, V) of the well-known local anesthetic ketocaine (I). Compounds II and V showed interesting antitumor activity in mice implanted with Ehrlich ascites tumor cells (% T/C = 149 at 5 mg/kg and 171 at 50 mg/kg, respectively). Further studies on the pharmacological behavior of these new compounds are in progress.

100 项与凯托卡因相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	凯托卡因	-	-

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
肿瘤	临床前	意大利	Alma Mater Studiorum - Università di Bologna	1984-08-01
疼痛	临床前	芬兰	University of Oulu	1983-01-01
原发性痛经	临床前	瑞典	University of Lund	1980-01-01