This pilot clinical trial studies the side effects of irradiated donor cells following stem cell transplant in controlling cancer in patients with hematologic malignancies. Transfusion of irradiated donor cells (immune cells) from relatives may cause the patient's cancer to decrease in size and may help control cancer in patients receiving a stem cell transplant.

开始日期2020-10-26

申办/合作机构

Rutgers State University of New Jersey

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100 项与 Irradiated Allogeneic Cells(NCI) 相关的临床结果

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100 项与 Irradiated Allogeneic Cells(NCI) 相关的转化医学

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100 项与 Irradiated Allogeneic Cells(NCI) 相关的专利（医药）

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项与 Irradiated Allogeneic Cells(NCI) 相关的文献（医药）

1992-09-01·Human cell3区 · 生物学

Use of human leukocyte antigen-mismatched allogeneic lymphokine-activated killer cells and interleukin-2 in the adoptive immunotherapy of patients with malignancies.

3区 · 生物学

Article

作者: Kimoto, Y

Clinical effects and side effects were investigated in the adoptive immunotherapy of patients bearing malignant diseases using human leukocyte antigen (HLA)-mismatched allogeneic lymphokine-activated killer (LAK) cells. Allogeneic LAK cells were induced from peripheral blood lymphocytes (PBL) of healthy donors with the same blood types as those of patients. Recently we succeeded in increasing the proliferation rate and enhancing the cytotoxic activity of LAK cells by means of initial stimulation with pokeweed mitogen (PWM, PWM-LAK cells). Five of 12 patients applied in the adoptive immunotherapy showed clinical effects such as partial or complete regression of pulmonary metastases and pleural effusion. All pulmonary metastatic lesions were eliminated in one case by this adoptive immunotherapy combined with chemotherapy. Toxic effects were chillness, fever and general fatigue which were reversible, and no allergic side effects occurred even though allogeneic LAK cells were injected frequently. In the patients who received more than 10(11) of allogeneic LAK cells, anti-HLA class I antibodies appeared without any evidence of autoantibody. However, immunological side effects were never experienced after injection of allogeneic LAK cells even when the anti-HLA class I antibodies existed in the patients; this phenomenon suggests the safety of the adoptive immunotherapy using allogeneic LAK cells. Taken together, allogeneic LAK cells could be considered as alternative therapy for patients with malignancies who could not supply sufficient materials of autologous LAK cells. Recently, LAK cells, particularly PWM-LAK cells were found to obtain significantly potent and prompt lectin-dependent cell-mediated cytotoxicity (LDCC). All tumor cells confluent in microtest plate well could be annihilated by PWM-LAK cells plus PWM less than 8 hours. New immunotherapy using PWM-LAK cells or lectin-stimulated LAK cells with PWM or other lectins is discussed.

100 项与 Irradiated Allogeneic Cells(NCI) 相关的药物交易

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研发状态

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适应症	最高研发状态	国家/地区	公司	日期
血液肿瘤	临床1期	美国	National Cancer Institute	2020-10-26
造血干细胞移植	临床1期	美国	National Cancer Institute	2020-10-26
套细胞淋巴瘤	临床1期	美国	National Cancer Institute	2020-10-26
多发性骨髓瘤	临床1期	美国	National Cancer Institute	2020-10-26
骨髓增生异常综合征	临床1期	美国	National Cancer Institute	2020-10-26
外周T细胞淋巴瘤	临床1期	美国	National Cancer Institute	2020-10-26
残留肿瘤	临床1期	美国	National Cancer Institute	2020-10-26
Smith-Magenis综合征	临床1期	美国	National Cancer Institute	2020-10-26

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT03272633 (CTgov)	早期临床1期	复发性急性髓细胞白血病 \| 治疗相关性急性髓系白血病 \| 急性淋巴细胞白血病 \| 造血干细胞移植 \| 复发性弥漫性大B细胞淋巴瘤 \| 套细胞淋巴瘤 \| 难治性弥漫性大 B 细胞淋巴瘤 \| Smith-Magenis综合征 \| 多发性骨髓瘤 \| 残留肿瘤 \| 复发性血液恶性肿瘤 \| 难治性T细胞淋巴瘤 \| 复发性T细胞淋巴瘤 \| 骨髓增生异常综合征	2	Allogeneic Hematopoietic Stem Cell Transplantation+Irradiated Allogeneic Cells (Cohort I (Initial IHC Within 42 Days))	鑰顧襯鹽鹹鹽網網積廠(壓廠膚醖構鏇齋製膚鹹) = 遞願夢淵餘願繭夢選蓋繭醖鹽遞壓構網鬱獵醖 (廠鏇願夢鬱觸齋範顧艱, 蓋夢築醖願鹽壓鹹遞鑰 ~ 簾蓋觸獵鑰醖遞醖製網) 更多	-	2023-06-26
				Allogeneic Hematopoietic Stem Cell Transplantation+Irradiated Allogeneic Cells (Cohort II (Initial IHC Within 70 Days or After Relapse))	蓋醖夢餘糧築顧製糧鬱(鏇艱糧衊艱構衊衊製壓) = 顧範艱簾鏇糧選餘構築衊夢鬱網廠獵獵築廠艱 (醖構鏇膚繭選憲顧醖衊, 鹹淵鏇鑰夢憲築繭鏇廠 ~ 餘憲遞網繭壓鑰築鹹餘) 更多