洋葱提取物(Onion extract) - 在研适应症：瘢痕疙瘩_专利_临床

概要

基本信息

药物类型

中药

别名

Compound Heparin Sodium and Allantoin Gel、复方肝素钠尿囊素凝胶、Contractubex

靶点-

作用机制-

治疗领域

皮肤和肌肉骨骼疾病

在研适应症

瘢痕疙瘩

非在研适应症-

原研机构

Merz Pharma GmbH & Co. KGaA

在研机构

Merz Pharmaceuticals GmbH

非在研机构-

最高研发阶段批准上市

首次获批日期

中国 (2020-12-01),

瘢痕疙瘩

最高研发阶段(中国)批准上市

特殊审评-

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关联

4

项与洋葱提取物相关的临床试验

ChiCTR2400079689 / Suspended早期临床1期IIT

Efficacy and safety of the topical triple regimen of spreadable SHS-mediated low-dose 5-fluorouracil transdermal delivery combined with compound heparin sodium allantoin gel for hypertrophic scars treatment: A Prospective, Randomized Controlled clinical trial

开始日期2024-02-01

申办/合作机构-

ChiCTR2400087948 / Completed早期临床1期IIT

Efficacy and safety of compound heparin sodium Allantoin gel in the treatment of rosacea

开始日期2023-04-26

申办/合作机构

西安交通大学第二附属医院

NCT02180022 / Completed临床4期IIT

Effect of Onion Peel Extract on Endothelial Function and Endothelial Progenitor Cells in Overweight and Obese Subjects

Acute or chronic intake of polyphenol-rich foods has been reported to improve endothelial function. Quercetin, found abundantly in onion, is a potent antioxidant flavonoid. This study was designed to investigate whether consumption of onion peel extract (OPE) improves endothelial function in healthy overweight and obese subjects.

开始日期2013-04-01

申办/合作机构

Kyunghee University Medical Center

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100 项与洋葱提取物相关的临床结果

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100 项与洋葱提取物相关的转化医学

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100 项与洋葱提取物相关的专利（医药）

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87

项与洋葱提取物相关的文献（医药）

2024-10-01·Journal of Craniofacial Surgery

Comparison of the Cosmetic Efficacy of Extractum Cepae and Silicone-Based Gel in Upper Blepharoplasty

Article

作者: Çelik, Seda ; Özer, Ömer ; Güçlü, Emin Serbülent ; Eröz, Pinar ; Baysal, Zeki

Background:Upper eyelid blepharoplasty is one of the most common surgeries performed worldwide. However, an important problem after surgery is scar formation. The authors aimed to compare the efficacy of extractum cepae and silicone-based gels on postoperative scar appearance in patients undergoing upper eyelid blepharoplasty.Methods:After suture removal, patients were divided into 3 groups: group 1 [n=82, extractum cepae, sodium heparin, and allantoin mixture, Contractubex Gel (Merz Pharmaceuticals, Frankfurt, Germany)], group 2 [n=81, silicone-based gel (Dermatix Ultra Silicone Gel, Menarini, Singapore)], and group 3 (n=77, no additional treatment). Patients used the topical gels twice daily. All evaluations were performed on color photographs by 2 physicians during the postoperative first and third months.Results:The mean visual analog scale scores were significantly higher in all 3 groups in the postoperative first month (4.39±2.03, 4.41±2.57, and 4.33±2.46, respectively) compared with the postoperative third month (2.22±1.24, 2.15±1.38, and 2.29±1.47, respectively) (P=0.014, 0.037, and 0.026, respectively). The “Is the scar more stiff” score was higher in the postoperative first month compared with the third month.Conclusions:In conclusion, blepharoplasty scars improved up to the postoperative third month, but the topical gels used did not significantly improve the cosmetic appearance of blepharoplasty scars compared with the control group.

2024-01-01·Clinical Case Reports

Effect of Contractubex phonophoresis on postsurgical scar of carpal tunnel release: A case report

作者: Bokaee, Fateme

Key Clinical MessageContractubex phonophoresis can be used in clinical setting to manage postsurgical scar after carpal tunnel release. Contractubex phonophoresis can improve pliability, height, and tenderness of the scar.AbstractScar is one of the most common complications after open release of carpal tunnel. Scars are mentally and physically disturbing, and they can result into itching and pain. Scar after release of carpal tunnel can lead to compression of median nerve and failure of surgery. Various treatments are suggested for scar management. topical drugs are one of these treatments. Phonophoresis of topical drugs can enhance delivery of topical drugs. In present case, author report the effect of phonophoresis of Contractubex on postsurgical scar after carpal tunnel release. Result indicated that phonophoresis of Contractubex can be effective in scar management.

2023-12-01·Clinical Nutrition ESPEN

Onion supplementation and health metabolic parameters: A systematic review and meta-analysis of randomized controlled trials

Review

作者: Hejazi, Najmeh ; Ghalandari, Hamid ; Askarpour, Moein ; Nouri, Mehran

INTRODUCTIONFunctional foods, such as onions, have been the center of many recent investigations. In this systematic-review and meta-analysis, we aimed to gather up the existing information with regard to the impact of onion supplementation on anthropometric measurements/indices, lipid profile, indices of glycemic control and hepatic health, systolic and diastolic blood pressures (SBP and DBP), and adiponectin and leptin.METHODSAll major online datasets (PubMed, Web of Science, Cochrane, and Scopus) were thoroughly searched from inception up to October 2022. Relevant randomized controlled trials (RCTs) were obtained using the eligibility criteria. Weighted mean differences (WMDs) were calculated and reported. Statistical significance was set as p-values <0.05.RESULTSAmong all the retrieved data, 14 RCTs were eligible to be included. The results of the crude analysis showed that onion supplementation significantly improved body fat percentage (BFP), low-density lipoprotein-cholesterol (LDL-c), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), systolic blood pressure, adiponectin, and aspartate aminotransferase (AST). Subgroup analysis revealed that interventions lasting more than 12 weeks can significantly alter weight, waist circumference (WC), body mass index (BMI), BFP, LDL-c, TC, SBP, and DBP. Moreover, the intake of dosages of >300 mg/day of onion supplementation could significantly improve weight, WC, BMI, BFP, LDL-c, HDL-C, TC, AST, ALT, SBP and DBP.CONCLUSIONIt seems that the intake of onion supplementation can improve health metabolic parameters. We observed that with either longer follow-up periods or higher dosages of onion supplementation, improvements in cardio-metabolic parameters could be expected.

100 项与洋葱提取物相关的药物交易

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