This study explains about case-report of 84-yr-old woman with xerostomia and left submandibular palpable masses without tenderness. The sagittal view of neck CT scan revealed tumor lesion with well circumscribed, fat-containing, submandibular, malignant tumor masquerading as benign lesion and diagnosed as adenoid cystic carcinoma with lipometaplasia. These glandular tumor cells with dual differentiation consisted of eosinophilic cuboidal ductal cells and surrounding myoepithelial cells with clear cytoplasm and basophilic angular and irregular nucleus. The present case is first description of lipometaplasia arising in adenoid cystic carcinoma and rare case of adenoid cystic carcinoma with lipometaplasia and validate pathogenesis of lipogenesis through morphoproteomic anal. MDM2 is strongly immunoreactive in nucleus of tumor cells, stromal cell, and adipocytes, all of which also demonstrate strong immunoreactivity for BMP9. EGFR and (E) c-Kit are only pos. in cytoplasm of tumor cells whereas beta-catenin is immunohistochem. expressed in cytoplasmic and membranous areas but not nuclear area of neoplastic cells, stromal cells, or adipocytes. Present case advances morphoproteomic insight into pathogenic etiol. of lipogenesis in adenoid cystic carcinoma and tumors like those in present case are expected to be considered as definite morphol. variant of adenoid cystic carcinoma. It is rare and unique pathol. principle which plays crucial role in improving clin. outcome and determining appropriate treatment of disease.