预约演示
更新于：2025-07-15
Amorolfine Hydrochloride
盐酸阿莫罗芬
更新于：2025-07-15
概要
基本信息
非在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1991-12-18), |
最高研发阶段(中国)批准上市 |
特殊审评- |
登录后查看时间轴
结构/序列
分子式C21H36ClNO |
InChIKeyXZKWIPVTHGWDCF-KUZYQSSXSA-N |
CAS号78613-38-4 |
关联
15
项与 盐酸阿莫罗芬 相关的临床试验NCT06689852
MULTICENTRIC, RANDOMIZED, EVALUATOR BLINDED CLINICAL INVESTIGATION for the EVALUATION of EFFICACY and SAFETY of TWO PRODUCTS for the TREATMENT of ONYCHOMYCOSIS
ChiCTR2300074178
Q-switched Nd:YAG laser versus Amorolfine Hydrochloride Cream in treatment of Distal lateral subungual onychomycosis in older adults
NCT05482763
Pilot Study on the Evaluation of the Efficacy, Tolerability and Safety of Topical and Oral Antifungals in the Treatment of Onychomycosis and Creation of a Library of Dermatological Clinical Isolates
100 项与 盐酸阿莫罗芬 相关的临床结果
登录后查看更多信息
100 项与 盐酸阿莫罗芬 相关的转化医学
登录后查看更多信息
100 项与 盐酸阿莫罗芬 相关的专利（医药）
登录后查看更多信息
485
项与 盐酸阿莫罗芬 相关的文献（医药）2025-06-01ENVIRONMENTAL RESEARCH
Torrefaction of sewage sludge: An approach to nutrient recycling and contaminant reduction in agriculture
Article
作者: Pierdonà, Lorenzo ; Paul, Chandra Sekhar ; Košnář, Zdeněk ; Doležal, Petr ; Nang, Sreynet ; Mercl, Filip ; Tlustoš, Pavel
The disposal of sewage sludge, a byproduct of wastewater treatment, presents both opportunities and challenges in agricultural applications due to its rich nutrient content and potential pollutant load. This study investigates the effects of torrefaction, a low-temperature thermochemical treatment, on the elemental composition and organic pollutant content of sewage sludge and its impact on maize (Zea mays L.). Sewage sludge from a municipal wastewater treatment plant was torrefied at 320 C for 3 h, then applied to soil in a field experiment. The torrefaction process concentrated mineral nutrients such as phosphorus and potassium but reduced nitrogen and sulfur content. The content of available phosphorus and potassium decreased by only 28 % and 24 %, respectively. Importantly, torrefaction significantly decreased the concentrations of pharmaceuticals, synthetic musk compounds, and endocrine-disrupting compounds in the sludge, with reductions of over 90 % for most compounds. Persistent organic pollutants, including polychlorinated biphenyls and organochlorine pesticides, also showed significant reductions (99 and 95 %, respectively), although polycyclic aromatic hydrocarbons (PAHs) increased by 20 % due to torrefaction. Despite this, the PAH content in torrefied sludge (Σ16 PAH <3 mg/kg) remained below regulatory limits set for soil application. At higher application doses, the effect of torrefied sludge on agronomic performance of maize did not differ from that of dried sewage sludge. Torrefaction has demonstrated promising results in improving the safety and efficacy of sewage sludge as a fertilizer by reducing organic contaminants and increasing phosphorus and potassium contents without significantly diminishing their availability. However, the limited effectiveness of torrefaction in reducing PAH content must be carefully considered when evaluating its suitability for soil applications. Furthermore, the condensate produced during the torrefaction process was not analyzed in this study and may represent a potentially hazardous by-product due to its pollutant content.
2025-06-01Case Studies in Chemical and Environmental Engineering
Untargeted metabolomic LC-HRMS combined with chemometric reveal metabolites change from sorghum flakes affected by food processing
作者: Anggraeni, Ayu Septi ; Suratno ; Noviana, Ika Mulawati Purwanti ; Utami, Indrawati Dian ; Nurfahmi, Laely ; Khasanah, Yuniar ; Alam, Lucky Prabowo Miftachul ; Windarsih, Anjar
A non-targeted UHPLC-HRMS metabolomics approach combined with chemometric anal. was employed to assess the change in metabolite profiles of sorghum flakes based on food processing techniques.The result showed that fatty acids were the most abundant metabolites, followed by lipids, amino acids, alkaloids, amines, and polyphenols, representing key metabolic markers influenced by food processing in sorghum flakes.Specific metabolites, including 15S-Hydroxyeicosatrienoic acid (15S-HETrE), terminaline, vitamin E acetate, furan fatty acid F6, all-trans-retinal, and fingolimod, exhibited increased concentrations during oven processing compared to raw sorghum, likely due to their thermal stability.This study provides valuable insights into effect of food processing effect on metabolites profiles.
2025-05-01Annales Pharmaceutiques Francaises
Amorolfine hydrochloride loaded solid lipid nanoparticles: Preparation, characterization and ex vivo nail permeation study to treat onychomycosis
Article
作者: Ahmed, Tasleem ; Mahato, Arun Kumar ; Shanthi, Nithya
Onychomycosis is a disease of the nail plate caused by fungi, leading to the progressive defacing of the nail. The infection requires a longer period of treatment orally and topically. The treatment with the topical route is difficult due to the low availability of drugs across the infected nail. This failure in topical treatment is the drawback of the conventional drug delivery system (DDS), particularly drug penetration issues across the nail plate. The solid lipid nanoparticle (SLN) approach was used to overcome such issues. The drug amorolfine hydrochloride (AOF) was incorporated into SLN by using the micro-emulsion cold dilution method. Monostrearin and stearic acid were used as solid lipids in the formulation of drug-loaded SLNs. The nanoparticle formulation was optimized by varying the type of solid lipids and bile salts. Sodium taurocholate (STC) and sodium tauroglycholate (STG) are the bile salts used as biosurfactants in the formulation. The SLNs prepared with stearic acid and STG demonstrated higher drug encapsulation efficiency (71.73%) and drug loading efficiency (13.03%) than monostearin. Bile salts have affected the particle size range and STG was found to produce smaller size particles with stearic acid (406nm) than STC. Process parameter homogenization speed was also optimized and 403 relative centrifugal force (RCF) was optimal to produce smaller-size particles (406nm). The drug permeation through the nail plate and anti-fungal studies were also performed for AOF-SLNs loaded cream and marketed cream (Amfocin). The SLNs have improved the permeation (1.63-fold) and anti-fungal activity (2.50-fold) of AOF. Transmission electron microscopy (TEM) images revealed a spherical shape of SLNs with no aggregation. The physical stability was performed and SLNs have higher stability at refrigeration storage. The SLNs were incorporated in cream for the final application for onychomycosis. The analytical method of high-performance liquid chromatography (HPLC) was used for the quantification of AOF in the formulations.
100 项与 盐酸阿莫罗芬 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 传染性皮肤病 | 中国 | 2000-04-10 | |
| 皮肤念珠菌病 | 日本 | 1993-10-01 | |
| 银屑病 | 日本 | 1993-10-01 | |
| 足癣 | 日本 | 1993-10-01 | |
| 白癜风 | 日本 | 1993-10-01 | |
| 真菌病 | 日本 | 1991-12-18 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
临床4期 | 50 | (Loceryl NL+Cosmetic Varnish) | 築鏇糧鹹齋淵獵廠選範(窪糧餘廠糧選鑰範顧鹽) = 積製廠構齋範鑰簾鹹鏇 構鹽餘獵範齋選築鏇築 (構鹹選積糧壓鬱壓蓋製, 9.1) 更多 | - | 2018-10-09 | ||
(Loceryl NL 12 Weeks) | 築鏇糧鹹齋淵獵廠選範(窪糧餘廠糧選鑰範顧鹽) = 鑰構鹽觸鬱憲膚壓鏇膚 構鹽餘獵範齋選築鏇築 (構鹹選積糧壓鬱壓蓋製, 6.2) 更多 | ||||||
临床4期 | 20 | (Loceryl NL) | 淵網糧壓窪觸觸衊醖廠 = 餘夢鹹範窪艱觸獵顧積 艱夢廠鹹鹽範艱網醖窪 (壓襯壓選憲顧網膚壓醖, 膚遞蓋膚構艱糧齋壓獵 ~ 醖襯壓鹽糧齋製窪範廠) 更多 | - | 2018-10-03 | ||
(Ciclopirox NL) | 淵網糧壓窪觸觸衊醖廠 = 艱廠蓋蓋網鹽範簾鏇構 艱夢廠鹹鹽範艱網醖窪 (壓襯壓選憲顧網膚壓醖, 積淵衊鑰淵齋蓋鬱膚遞 ~ 廠範獵構願憲廠遞壓襯) 更多 |
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
Eureka LS:
全新生物医药AI Agent 覆盖科研全链路，让突破性发现快人一步
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用