亚硒酸钠(Sodium Selenite) - 在研适应症：硒缺乏症，结肠癌，白内障_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ASELEND、アセレンド

靶点-

作用方式-

作用机制-

治疗领域

其他疾病肿瘤消化系统疾病+ [1]

在研适应症

硒缺乏症结肠癌白内障

非在研适应症-

原研机构

Fujimoto Pharmaceutical Corp.

在研机构

Illinois CollegeSenju Pharmaceutical Co., Ltd.

Fujimoto Pharmaceutical Corp.

非在研机构-

权益机构-

最高研发阶段批准上市

首次获批日期

日本 (2019-03-26),

硒缺乏症

最高研发阶段(中国)-

特殊审评-

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结构/序列

分子式H2Na2O3Se

InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N

CAS号10102-18-8

关联

15

项与亚硒酸钠相关的临床试验

NCT04296578

/ Withdrawn临床1期IIT

A Phase 1 Study Evaluating the Efficacy and Safety of Sodium Selenite in Combination With Abiraterone in Patients With Castrate Resistant Prostate Cancer Progressing on Abiraterone

The purpose of this study is to access the safety of combining sodium selenite with abiraterone and to see what doses of sodium selenite can be safely combined with abiraterone in treating castration resistant prostate cancer.

开始日期2020-10-01

申办/合作机构

Stanford University

NCT02393183

/ Withdrawn临床2/3期

The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease, a Placebo Controlled Randomized Clinical Trial

This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED:
β- Carotene (30 mg)
Vit C (100 mg)
Vit E (Alpha-Tocopherol Acetate): 60-200 IU
Calcium phosphate dihydrate (40 mg)
Zinc oxide (4 mg, elemental)
Copper gluconate (3.5 mg)
Sodium selenite 23 mg= Selenium 100 µg
Nicotinamide (a form of vit.B3) (10 mg)
in patients with mild Thyroid eye disease according to EUGOGO classification. To be given twice a day.

开始日期2019-07-15

申办/合作机构

Iran University of Medical Sciences & Health Services

IRCT20110123005670N28

/ Completed临床3期IIT

The effects of Na- selenite and Na- selenite -enriched yeast supplementation on glycemic status, lipid profile, oxidative and nitrosative stress in patients with coronary artery diseases.

开始日期2019-06-02

申办/合作机构

Tabriz University of Medical Sciences

100 项与亚硒酸钠相关的临床结果

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100 项与亚硒酸钠相关的转化医学

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100 项与亚硒酸钠相关的专利（医药）

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9,239

项与亚硒酸钠相关的文献（医药）

2025-12-31·Redox Report

Dietary supplementation of male mice with inorganic, organic or nanoparticle selenium preparations: evidence supporting a putative gut-thyroid-male fertility axis

Article

作者: Salah, W. ; Au, A. ; Witting, P. K. ; Mojadadi, A. ; Ortiz Cerda, T. ; Shao, J.-Y. ; Webb, J. ; Andersen, J. W. ; Ahmad, G. ; Harris, H. H. ; Bell-Anderson, K. ; O’Neil, T.

Selenium (Se) is linked to physiological homeostasis. Male mice (n = 8/group) were fed control (AIN93G) or diets enriched in sodium selenite (NaSe, 5.6 ppm), methylselenocysteine (Met, 4.7 ppm), diphenyl diselenide (DPDS, 14.2 ppm), or nanoselenium (NanoSe, 2.7 ppm); dietary Se ascertained by inductively-coupled plasma mass spectrometry. At 4 weeks testes, sperm, thyroids, blood and stool were collected to assess histoarchitecture, circulating hormones (thyroxine, T4; triiodothyronine, T3; thyroid stimulating hormone, TSH) and gut microbiome (16S rRNAV3-V4 amplicon sequencing). Supplemented NaSe, Met, and NanoSe increased plasma testosterone and testis glutathione peroxidases (GPx-1/4) while testicular superoxide dismutase and catalase increased slightly in the NanoSe group indicating a selective antioxidant response. Overall, NanoSe and NaSe enhanced male reproductive factors. All thyroids isolated from Se-supplemented mice contained marginal vacuoles and a lower follicle area vs control. Nano-Se enhanced thyroidiodothyronine deiodinase-1 (DIO1) expression however, thyroid GPx-1/4 remained unchanged. Supplemented NaSe and DPDSl increased plasma T3/T4 ratio, while plasma TSH was unchanged. Microbiome analyses showed that NanoSe was most efficacious in altering composition (judged by α-diversity, Shannon index and taxon richness) while the NaSe diet showed the greatest overall change in α-diversity. Dietary Se supplementation, particularly encapsulated NanoSe, may improve male fertility factors by enhancing the gut-thyroid-fertility axis.

2025-07-01·Biomaterials

Anaerobic probiotics-in situ Se nanoradiosensitizers selectively anchor to tumor with immuno-regulations for robust cancer radio-immunotherapy

Article

作者: Chen, Tianfeng ; Xu, Ligeng ; Yu, Yangyang ; Zhang, Jin ; Wang, Ying ; Ju, Zhenyu ; Jiang, Dan ; Jiang, Yalin ; Bu, Qingyue

Developing translational nanoradiosensitizers with multiple activities in sensitizing tumor cells and re-shaping tumor immunosuppressive microenvironments are urgently desired for addressing the poor therapeutic efficacy of radiotherapy in clinic. Inspired by the anaerobic and immunoagonist properties of the probiotic (bifidobacterium longum, BL), herein, a biomimetic Selenium nanoradiosensitizer in situ-formed on the surface of the probiotic (BL@SeNPs) is developed in a facile method to potentiate radiotherapy. BL@SeNPs selectively target to hypoxia regions of tumors and then anchor on the surface of tumor cells to inhibit its proliferation. Meanwhile, it also significantly promotes ROS generations to damage DNA and induces cell cycle arrest for enhancing the therapeutic efficacy of radiotherapy, which will induce immunogenic cell death to initiate antitumor immunities. In addition, BL@SeNPs nanoradiosensitizers can serve as immunoagonist to activate immune cells like dendritic cells (DCs) to further magnify the quality of the induced immune responses. More importantly, BL@SeNPs combining radiotherapy effectively reduce immunosuppressor cells (e.g. TAM, MDSC, TAN) infiltrating within tumors for shaping tumor microenvironments to effectively combat tumor progressions. This study provides a safe, effective and translational nanoradiosensitizer and its combination radiotherapy for clinical cancer treatment and shed lights for developing next generation of nanoradiosensitizers.

2025-06-01·Food Chemistry

Effect of steaming on the selenium form, structure, and bioavailability of selenopolysaccharides from Chlamys nobilis

Article

作者: Cai, Junting ; Yang, Junyang ; Zhu, Guoping ; Lin, Haisheng ; Cao, Wenhong ; Gao, Jialong ; Zheng, Huina ; Chen, Zhongqin ; Tan, Mingtang

To investigate the effect of steam processing on the form, structure and biological properties of selenopolysaccharides in the Chlamys nobilis, we conducted purification and compositional analysis of both raw and steamed samples. The results showed that the raw (SS-3) and steamed (SZ-3) groups had the highest selenium content in the purified fraction. Comparison of the structural characterization shows that selenium can exist in both O-Se-O and Se-O-C chemical bonds, but the absorption strength of the chemical bonds decreased after steam treatment, and steaming can convert β-type pyranose to α-type in selenopolysaccharides. In vitro simulation of gastrointestinal digestion, SZ-3 fractions showed a higher bioaccessibility compared to SS-3 fractions, and also the cellular transport and uptake rates of selenium SZ-3 > SS-3 > sodium selenite were significant in the Caco-2 cell model. In conclusion, steaming can alter the structure and selenium content of selenopolysaccharides without affecting their bioavailability.

100 项与亚硒酸钠相关的药物交易

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研发状态

批准上市

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适应症	国家/地区	公司	日期
硒缺乏症	日本	Fujimoto Pharmaceutical Corp.	2019-03-26

未上市

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适应症	最高研发状态	国家/地区	公司	日期
结肠癌	临床前	美国	Illinois College	2009-05-01
白内障	临床前	美国	Senju Pharmaceutical Co., Ltd.	2003-05-01

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00832039 (SISPCT, Pubmed \| JAMA Intern Med)	临床3期	脓毒症 \| 脓毒性休克	1,089	Sodium Selenite	襯夢齋積積夢鹹艱鹹鑰(壓壓淵廠願顧衊範製襯) = 蓋餘鬱繭夢遞窪憲觸顧鑰夢製衊鬱餘淵遞構鏇 (壓廠鏇艱鑰獵鬱獵憲壓, 24.5 ~ 32.3)	不佳	2016-09-01
				Placebo	襯夢齋積積夢鹹艱鹹鑰(壓壓淵廠願顧衊範製襯) = 觸範艱鏇積鹹範積製積鑰夢製衊鬱餘淵遞構鏇 (壓廠鏇艱鑰獵鬱獵憲壓, 21.8 ~ 29.4)
SECAR study (WCLC2013)	N/A	肿瘤	34	Sodiumselenite	(願網襯淵夢鹹夢壓蓋齋) = One patient had a complete remission 積構夢範醖簾選鬱鬱繭 (襯餘醖糧願襯齋餘醖鏇 ) 更多	-	2013-10-28
ASTRO2007	N/A	-	-	Sodium Selenite	窪艱醖獵製壓構餘遞壓(獵艱廠觸廠願製醖壓襯) = 構蓋選壓齋繭簾鏇膚醖壓構網齋簾衊願廠憲廠 (廠蓋淵構網淵鬱蓋餘製 ) 更多	-	2007-11-01
				Sodium Selenite (Observation)	窪艱醖獵製壓構餘遞壓(獵艱廠觸廠願製醖壓襯) = 顧憲願觸範壓鹽積夢構壓構網齋簾衊願廠憲廠 (廠蓋淵構網淵鬱蓋餘製 ) 更多
ASTRO2005	N/A	-	-	Sodium Selenite supplementation	(願鑰顧繭願繭衊觸構膚) = 壓鑰夢艱襯淵獵繭觸齋齋遞獵製範襯廠鑰醖願 (積膚築繭遞艱遞蓋顧齋 ) 更多	-	2005-10-01
				Sodium Selenite (Control group (no supplementation))	(願鑰顧繭願繭衊觸構膚) = 醖鏇繭醖鏇簾積製壓構齋遞獵製範襯廠鑰醖願 (積膚築繭遞艱遞蓋顧齋 ) 更多