亚硒酸钠(Sodium Selenite) - 在研适应症：硒缺乏症，结肠癌，白内障_专利_临床

概要

基本信息

药物类型

小分子化药

别名

ASELEND、アセレンド

靶点-

作用机制-

治疗领域

其他疾病肿瘤消化系统疾病+ [1]

在研适应症

硒缺乏症结肠癌白内障

非在研适应症-

原研机构

Fujimoto Pharmaceutical Corp.

在研机构

Illinois CollegeSenju Pharmaceutical Co., Ltd.

Fujimoto Pharmaceutical Corp.

非在研机构-

最高研发阶段批准上市

首次获批日期

日本 (2019-03-26),

硒缺乏症

最高研发阶段(中国)-

特殊审评-

登录后查看时间轴

结构/序列

分子式H2Na2O3Se

InChIKeyCQRWCHXOXPSKFW-UHFFFAOYSA-N

CAS号10102-18-8

关联

7

项与亚硒酸钠相关的临床试验

NCT02393183

/ Withdrawn临床2/3期IIT

The Effect of a New Antioxidant Combination (ASTED) on Mild Thyroid Eye Disease, a Placebo Controlled Randomized Clinical Trial

This randomized clinical trial is designed to evaluate the effect of selected antioxidant vitamins and minerals supplement named as ASTED:
β- Carotene (30 mg)
Vit C (100 mg)
Vit E (Alpha-Tocopherol Acetate): 60-200 IU
Calcium phosphate dihydrate (40 mg)
Zinc oxide (4 mg, elemental)
Copper gluconate (3.5 mg)
Sodium selenite 23 mg= Selenium 100 µg
Nicotinamide (a form of vit.B3) (10 mg)
in patients with mild Thyroid eye disease according to EUGOGO classification. To be given twice a day.

开始日期2019-07-15

申办/合作机构

Iran University of Medical Sciences & Health Services

IRCT20110123005670N28

/ Completed临床3期IIT

The effects of Na- selenite and Na- selenite -enriched yeast supplementation on glycemic status, lipid profile, oxidative and nitrosative stress in patients with coronary artery diseases.

开始日期2019-06-02

申办/合作机构

Tabriz University of Medical Sciences

NCT03081949

/ Completed临床4期IIT

Peripartum Cardiomyopathy in Nigeria (PEACE) A Registry to Study the Demographics, Social and Clinical Characteristics, Pathophysiology and Outcomes of Peripartum Cardiomyopathy in Nigeria

Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world. Unfortunately, much about the disease including its aetiology, epidemiology and treatment is not yet well described. This will be a prospective, national, multicenter cohort study, conducted in centres in Nigeria. It is expected that approximately 500 patients with PPCM and 500 apparently healthy pregnant women will be recruited over a 6-month period with follow-up at 3-monthly intervals for 18 months.

开始日期2017-06-12

申办/合作机构-

100 项与亚硒酸钠相关的临床结果

登录后查看更多信息

100 项与亚硒酸钠相关的转化医学

登录后查看更多信息

100 项与亚硒酸钠相关的专利（医药）

登录后查看更多信息

2,817

项与亚硒酸钠相关的文献（医药）

2025-03-01·Food Chemistry

Characterization of the effect of low-concentration sodium selenite on the microstructure and quality of yeast-leavened steamed bread using X-ray computed tomography

Article

作者: Chen, Xiong ; Dai, Jun ; Ding, Wenping ; Chen, Xuan ; Zhuang, Kun ; Yao, Lan

Dough fermentation is an effective method for selenium conversion. This study investigated the effects of low Na₂SeO₃ concentrations on the morphology, texture, fermentation properties, Se species, Se bioaccessibility, and antioxidant capacity of two types of yeast-leaved steamed bread. The results indicated that Na₂SeO₃ did not significantly affect the specific volume; but it did result in increased hardness. X-ray computed tomography revealed that the center of steamed bread became denser owing to Na₂SeO₃, and the porosity was reduced by approximately half at the highest addition level, although the cell number remained relatively unchanged. The fermentation property test demonstrated that Na₂SeO₃ reduced the gas production rate in dough. The conversion rate of seleno-amino acids increased with the addition of Na₂SeO₃, reaching a maximum of over 7 %, as did the antioxidant capacity, although the Se bioaccessibility decreased. In conclusion, this Se-enriched steamed bread reveals its potential functional benefits as a staple food.

2025-02-01·International Journal of Biological Macromolecules

Effect of combination of polyphenols, polysaccharide, and sodium selenite on bortezomib anti-cancer action

Article

作者: Rani, Sarita ; Tejavath, Kiran Kumar ; Gupta, Shruti ; Gupta, Umesh

Combinatorial drug delivery has shown promising results over single drug for cancer therapy. Here, we aimed to explore combination of proteasome inhibitor; bortezomib (BTZ) with natural antioxidants (AOs); polyphenols like caffeic acid (CFA), resveratrol (RES), fucoidan (FD), and synthetic AO; sodium selenite (Na₂SeO₃) for cellular cytotoxicity in breast cancer cell lines; MCF-7 and MDA MB-231. The combination of RES + BTZ, FD + BTZ, and Na₂SeO₃ + BTZ showed synergism while CFA showed antagonism with BTZ. The EC₅₀ values of different combinations were found to be significantly less than the individual AOs in ABTS and DPPH assay. Furthermore, the effect of combination of drugs on migratory properties of MCF-7 cells were evaluated by in-vitro wound healing assay, resulting in the reduction of such behavior. In support of this, RT-qPCR was performed to analyze differential gene expressions of apoptotic and Epithelial-Mesenchymal Transition (EMT) markers with and without treatment. In results, the combination of Na₂SeO₃ + BTZ reduced the expression of Bcl-XL and N-Cad causing cytotoxicity and suggested that the combination of Na₂SeO₃ + BTZ (IC₅₀ = 1.40 ± 0.45 μM) could be a better option among other combinations for breast cancer therapy. Overall, the outcome indicates that the combination of BTZ with AOs may yield potential therapeutic benefit.

2025-01-01·Poultry Science

Sodium selenite antagonizes trimethyl tin-induced chicken hepatotoxic hepatitis through the RNS/NF-κB/NLRP3 pathway

Article

作者: Lin, Xu ; Chen, Xinzhang

Trimethyl tin (TMT) is a good stabilizer for plastic products but is also a toxic environmental pollutant. Selenium has good antioxidant and anti-inflammatory properties and has been widely used in the poultry industry. However, it has not been reported whether selenium enrichment can antagonize TMT-induced viral hepatitis in poultry. To fill this gap, AA broiler models exposed to TMT for 42 d were established and fed a Se-enriched diet at the same time. H&E staining showed that selenium could significantly alleviate TMT-induced liver inflammation. Further analysis of the underlying mechanism revealed that TMT induced nitrosation stress (RNS), increased NO content and iNOS expression, which in turn activated the NF-κB/NLRP3 pathway and induced pyroptosis. However, selenium enrichment can reverse this situation, that is, reduce the occurrence of RNS, reduce the degree of pyroptosis, and thus alleviate the occurrence of inflammation. In our study, we demonstrated for the first time that TMT could induce hepatotoxicity other than neurotoxicity in poultry and that selenium could antagonize TMT-induced hepatotoxic hepatitis in chickens through the RNS/NF-κB/NLRP3 pathway.

100 项与亚硒酸钠相关的药物交易

登录后查看更多信息

研发状态

批准上市

10 条最早获批的记录,

登录

后查看更多信息

适应症	国家/地区	公司	日期
硒缺乏症	日本	Fujimoto Pharmaceutical Corp.	2019-03-26

未上市

10 条进展最快的记录,

登录

后查看更多信息

适应症	最高研发状态	国家/地区	公司	日期
结肠癌	临床前	美国	Illinois College	2009-05-01
白内障	临床前	美国	Senju Pharmaceutical Co., Ltd.	2003-05-01

登录后查看更多信息

临床结果

适应症

分期

评价

查看全部结果

研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


WCO_IOF_ESCEO2023	N/A	-	120	Sodium Benzoate 500 mg/kg	襯積積範製鏇簾壓網範(築願築憲顧築構鏇窪鏇) = 醖醖衊鹽鹽淵憲網鑰夢鏇顧築構餘選構衊窪鹹 (鏇範膚齋膚獵繭獵糧餘 ) 更多	积极	2023-05-04
				Sodium Benzoate 1000 mg/kg	襯積積範製鏇簾壓網範(築願築憲顧築構鏇窪鏇) = 網顧淵簾範蓋觸醖網鬱鏇顧築構餘選構衊窪鹹 (鏇範膚齋膚獵繭獵糧餘 ) 更多
SECAR study (WCLC2013)	N/A	肿瘤	34	Sodiumselenite	(獵觸顧願製顧遞築顧艱) = One patient had a complete remission 襯顧廠鏇鹽艱願齋觸繭 (願構鏇鏇蓋憲構夢醖夢 ) 更多	-	2013-10-28
ASTRO2007	N/A	-	-	Sodium Selenite	遞襯範鑰蓋壓構壓範衊(網衊醖蓋夢築製製積壓) = 顧簾糧襯觸廠範廠獵鹽鹹齋願蓋鏇糧衊壓淵鏇 (鏇憲鏇餘繭獵醖觸顧鏇 ) 更多	-	2007-11-01
				Sodium Selenite (Observation)	遞襯範鑰蓋壓構壓範衊(網衊醖蓋夢築製製積壓) = 廠製鬱鑰廠範夢廠齋選鹹齋願蓋鏇糧衊壓淵鏇 (鏇憲鏇餘繭獵醖觸顧鏇 ) 更多
ASTRO2005	N/A	-	-	Sodium Selenite supplementation	(齋積襯遞繭壓獵積蓋網) = 簾選願壓築鬱衊範齋壓齋膚鹽壓遞鑰顧簾願獵 (襯糧憲願廠壓艱製網繭 ) 更多	-	2005-10-01
				Sodium Selenite (Control group (no supplementation))	(齋積襯遞繭壓獵積蓋網) = 淵遞顧壓艱蓋醖鹹選淵齋膚鹽壓遞鑰顧簾願獵 (襯糧憲願廠壓艱製網繭 ) 更多