This study is a two-arm placebo controlled randomized clinical trial, to assess the effect of a 12-week EGCG intervention on physical frailty compared to placebo in pre-frail older cancer survivors.

开始日期2024-07-01

申办/合作机构

University of Rochester

NCT06398405 / Recruiting临床2期IIT

Efficacy and Safety of Epigallocatechin-3-gallate, an Important Polyphenolic That Originates From Tea, in Patients With Esophageal Squamous Cancer: A Phase II Trial

The investigators conduct this phase II study to evaluate safety and effectiveness of EGCG in patients with dysphagia. Swallowing-related dysphagia and pain scores were recorded using the numerical rating scale (NRS) daily . Barium meal radiography was utilized to measure the luminal size and the length of the lesion area both before and after a week of EGCG treatment. The scales are translated into Chinese and guides in Chinese are developed instructing how to use the scales and perform the assessments.

开始日期2024-04-22

申办/合作机构

山东省肿瘤医院

NCT06265532 / Recruiting临床1期IIT

Collagen-targeted PET Imaging for Assessment of EGCG Effect

The primary purpose of this substudy is to determine if collagen-targeted PET using the type 1 collagen-targeted PET probe, Gallium-68 (68Ga)-labeled collagen binding probe 8 (CBP8) can inform as to drug effect of EGCG and assist in dose selection.

开始日期2024-02-07

申办/合作机构

The University of California, San Francisco

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100 项与表没食子儿茶素没食子酸酯相关的临床结果

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100 项与表没食子儿茶素没食子酸酯相关的转化医学

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100 项与表没食子儿茶素没食子酸酯相关的专利（医药）

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9,017

项与表没食子儿茶素没食子酸酯相关的文献（医药）

2024-12-31·Journal of enzyme inhibition and medicinal chemistry

Identification of potential inhibitors against Staphylococcus aureus shikimate dehydrogenase through virtual screening and susceptibility test

Article

作者: Zhu, Mengfan ; Qu, Jinfeng ; Deng, Qi

Staphylococcus aureus shikimate dehydrogenase (SaSDH) plays a crucial role in the growth of Staphylococcus aureus (S. aureus), but absent in mammals and therefore a potential target for antibacterial drugs to treat drug-resistant S. aureus infection. In this study, a 3D model of SaSDH was constructed by homology modelling and inhibitors of SaSDH were screened through virtual screening. (-)-Gallocatechin gallate and rhodiosin were identified as inhibitors with K_is of 2.47 μM and 73.38 μM, respectively. Molecular docking and isothermal titration calorimetry showed that both inhibitors interact with SaSDH with a K_D of 44.65 μM for (-)-gallocatechin gallate and 16.45 μM for rhodiosin. Both inhibitors had antibacterial activity, showing MICs of 50 μg/mL for (-)-gallocatechin gallate and 250 μg/mL for rhodiosin against S. aureus. The current findings have the potential for identification of drugs to treat S. aureus infections by targeting SaSDH.

2024-12-01·Molecular biology reports

Regulation of gene expression by modulating microRNAs through Epigallocatechin-3-gallate in cancer

Review

作者: Dharshini, Loganathan Chandramani Priya ; Mandal, Abul Kalam Azad

Cancer is an intricate ailment that has a higher death rate globally and is characterized by aberrant cell proliferation and metastasis in nature. Since the beginning of healthcare, natural products, especially those derived from plants, have been utilized to support human health. Green tea contains an essential catechin called epigallocatechin gallate, which has anti-proliferative, anti-mutagenic, anti-inflammatory, and antioxidative properties. The anticancer properties of EGCG have been extensively studied using pre-clinical cell culture and animal model systems. Dysregulated miRNA may be a biomarker since it influences the different characteristics of cancer like upholding proliferative signaling, cell death, invasiveness, metastasis, and angiogenesis. EGCG either elevates or lowers the expression of dysregulated miRNAs in cancer. Nonetheless, due to its anticancer properties, greater attention has been paid towards the development of efficient strategies for utilizing EGCG in cancer chemotherapy. This review summarizes the modifying effect of EGCG on miRNAs in cancer after briefly discussing the anticancer mechanisms of EGCG and the function of miRNAs in cancer.

2024-12-01·Molecular biology reports

Oxidative stress in Alzheimer’s disease: current knowledge of signaling pathways and therapeutics

Review

作者: Sharma, Prajjwal ; Singh, Sunil K ; Dhapola, Rishika ; HariKrishnaReddy, Dibbanti ; Beura, Samir K

Alzheimer's disease's pathophysiology is still a conundrum. Growing number of evidences have elucidated the involvement of oxidative stress in the pathology of AD rendering it a major target for therapeutic development. Reactive oxygen species (ROS) generated by altered mitochondrial function, dysregulated electron transport chain and other sources elevate aggregated Aβ and neurofibrillary tangles which further stimulating the production of ROS. Oxidative stress induced damage to lipids, proteins and DNA result in neuronal death which leads to AD. In addition, oxidative stress induces apoptosis that is triggered by the modulation of ERK1/2 and Nrf2 pathway followed by increased GSK-3β expression and decreased PP2A activity. Oxidative stress exaggerates disease condition by interfering with various signaling pathways like RCAN1, CREB/ERK, Nrf2, PP2A, NFκB and PI3K/Akt. Studies have reported the role of TNF-α in oxidative stress stimulation that has been regulated by drugs like etanercept increasing the level of anti-oxidants. Other drugs like pramipexole, memantine, carvedilol, and melatonin have been reported to activate CREB/RCAN1 and Nrf2 pathways. In line with this, epigallocatechin gallate and genistein also target Nrf2 and CREB pathway leading to activation of downstream pathways like ARE and Keap1 which ameliorate oxidative stress condition. Donepezil and resveratrol reduce oxidative stress and activate AMPK pathway along with PP2A activation thus promoting tau dephosphorylation and neuronal survival. This study describes in detail the role of oxidative stress in AD, major signaling pathways involving oxidative stress induced AD and drugs under development targeting these pathways which may aid in therapeutic advances for AD.

项与表没食子儿茶素没食子酸酯相关的新闻（医药）

2024-04-07

·PRNewswire

Nucific Invites You To Nuture Your Gut Microbiome and Celebrate World Health Day with Nucific Bio-X4

Enjoy a Slimmer Waistline, More Energy, Smoother Digestion, and Boosted Confidence with 4-in-1 Probiotic Support LOS ANGELES, April 7, 2024 /PRNewswire/ -- World Health Day, observed annually on April 7th, serves as a global platform to raise awareness about pressing health issues and advocate for universal healthcare access. It aims to mobilize individuals and communities to take proactive steps towards maintaining and improving their health. Continue Reading Nucific Bio-X4 is a groundbreaking weight support formula made from science-backed ingredients chosen to help boost metabolism, fight unhealthy cravings, and help you achieve your weight loss goals.†* Renowned nutritionist and Nucific® founder, Dr. Amy Lee stresses the significance of nurturing your microbiome as the cornerstone of overall health. Gut health is pivotal in digestion, nutrient absorption, and immune function. Additionally, the gut microbiome impacts various health aspects, such as mental well-being, weight management, and healthy skin. In reality, supporting your good gut bacteria is key for supporting every aspect of health. Nucific's Dr. Amy Lee recommends taking care of your gut health in honor of World Health Day with supplements like Nucific BIO-X4. Nucific Bio-X4 is a groundbreaking weight support formula that contains advanced probiotics, which flood your gut with healthy slimming power. These probiotics work synergistically to help boost metabolism, combat unhealthy cravings, and assist you in achieving your weight loss goals.† By prioritizing gut health with probiotic-rich supplements like Nucific Bio-X4, individuals can take proactive steps towards achieving a healthy weight, renewed youthful vitality and youthful-looking skin.†* What is Nucific BIO-X4? Nucific BIO-X4 offers a comprehensive approach to weight management and gut health with its 4-in-1 probiotic formula. Your gut health consists of 4 key factors: Your microbiome, digestive enzymes, metabolism, and appetite. Nucific BIO-X4 is uniquely formulated to support all of these systems for smoother digestion, better nutrient absorption, faster fat-burning, and fewer junk food cravings — all in one easy-to-use blend.†* To support optimal digestion and promote a slimmer body, NucificBio-X4 combines four key ingredient blends: green tea extract (EGCG), Caralluma Fimbriata, potent probiotics, and digestive enzymes. By supporting gut health with Nucific Bio-X4, individuals can experience not only a leaner physique but also more energy, sharper focus, a younger appearance, and renewed vitality.†* Nucific Bio-X4 Key Ingredients Probiotics: A potent blend of five powerful bacterial strains, including Lactobacillus and Bifidobacterium, to support smooth digestion and easier weight management. These strains work together to soothe the gut and contribute to overall digestive comfort, helping promote a healthier digestive tract.†* EGCG: Derived from green tea, EGCG is a natural compound known for its metabolism-boosting properties. Numerous studies have shown its ability to support metabolic rate, helping users achieve a slimmer physique while providing the energy to enjoy each day to the fullest.†* Caralluma Fimbriata: This edible cactus high in fiber aids in curbing unhealthy food cravings, a significant step towards achieving desired body goals. By helping users resist tempting snacks and unhealthy foods, this compound supports dietary discipline and assists in maintaining a healthy waistline.†* Digestive Enzymes (Amylase, Lipase, Bromelain): A blend of digestive enzymes to efficiently break down foods, unlocking their nutrients and alleviating digestive issues. Amylase, lipase, and bromelain work synergistically to enhance nutrient absorption, promoting overall well-being from head to toe.†* Where to Purchase Nucific Bio-X4 Nucific BIO-X4 is available for sale on the Nucific website for the price of $99 with a 90-day purchase price refund guarantee. Discounts are also periodically available for Nucific email subscribers and text club members. About Nucific Nucific believes great nutrition is the key to a healthy mind and body. This has led the wellness brand and its creators to develop some of the most advanced supplements on the market. Backed by Dr. Amy Lee, the Nucific product line helps people from all walks of life look and feel their best. The brand's other whole-body health support formulas include Carb-C6, Deep Cell Activator, and Nighttime Slimming Complex. Nucific's products contain premium ingredients that are third-party tested for quality. For more information, visit or @nucific on Instagram. About Dr. Amy Lee Dr. Amy Lee is a member of the National Board of Physician Nutrition Specialists and board certified by the American Board of Internal Medicine. Serving as the Chief Medical Officer in more than 30 nutrition clinics, Dr. Lee creates optimized diet plans for her patients, helping them achieve their weight goals and supporting their overall well-being. She is also co-author of the recent book, Access: Addressing the Obesity Crisis. Dr. Lee is a nutritional expert in the media as well appearing in outlets like Forbes, Yahoo!, The Healthy, Healthline, and so much more. Her continued research allows her to create innovative nutritional supplements to help people across the world look and feel their absolute best. For more information visit, dramylee.com and follow @dramy_lee on Instagram. †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. *All individuals are unique. Your results can and will vary. Press Contact: Laura Baumgartner - Asylum PR [email protected] SOURCE Nucific

2024-04-01

·CPHI制药在线

Online Expo丨2024制药产业主题展-天然提取物专场正式上线！

数字经济的发展使产业数字化成必然趋势。作为高成效、低成本的获客方式，数字化营销受到了众多企业欢迎，医药行业也纷纷选择加大投入。为促进制药行业数字经济发展，通过线上贸易对接，达成买卖双方合作，2024年，制药在线将携手CPHI & PMEC China推出制药产业线上主题展。主题展贯穿全年，覆盖天然提取物、维生素类、生命科学与生物医药、制粒干燥、玻璃药包、反应设备6大主题，旨在为制药行业带来全年不落幕的展会体验。2024年4月1日至30日，首场制药产业线上主题展正式上线。此次线上展将聚焦天然提取物产业，旨在为350+天然提取物厂家提供供需对接、贸易撮合等服务。同时，线上展期间还将陆续推出药食同源、保健品原料应用等相关主题直播以及对企业高层的采访，共话行业新风向，共谋产业新发展。活动亮点抢先看01主题直播/企业专访探讨前沿技术，对话企业高层📌时间：4月1日 14:00-15:30天然提取物空中学苑—药食同源专场讲师：朱秀敏邢台学院生物科学与工程学院教授；营养与食品安全研究中心主任於洪建天津科技大学新农村发展研究院副院长；合肥和晨生物总经理📌时间：4月10日企业专访演讲人：王婷婷部长大连医诺生物股份有限公司品牌与市场部📌时间：4月15日 14:00-14:45天然食品资源高值化利用的技术创新与实践讲师：张连富江南大学食品学院教授，工学博士，博士生导师🎉🎉🎉更多采访敬请期待🔍二维码预约观看02线上展厅350+源头工厂，8000+优质产品部分推荐厂家及产品盘锦天源药业有限公司公司是2004年新建的符合GMP要求的，以水飞蓟提取物为主导产品的国家高新技术企业。主要产品为水飞蓟系列产品：水飞蓟素（丙酮提取、乙酸乙酯提取、乙醇提取）、水溶性水飞蓟素、水飞蓟宾、水飞蓟籽油、保健食品水飞蓟胶囊、蓟葛五灵颗粒以及外用制剂等。主营产品：水飞蓟素、水飞蓟提取物、水飞蓟宾…浙江得乐康食品股份有限公司得乐康成立于1994年，在米糠、银杏叶、茶叶这三种原料的开发和利用上精益求精，分别推出谷维素、阿魏酸、米糠油、植物甾醇、糠甾醇；银杏叶提取物、莽草酸、奎宁酸、银杏内酯；绿茶提取物、茶氨酸、茶黄素、EGCG、EC、ECG、EGC等产品。不断追求品质提升，同时降低生产成本，为客户提供高性价比产品是我们的追求和骄傲。主营产品：银杏叶提取物、绿茶提取物、天然茶氨酸、EGCG、谷维素、阿魏酸、莽草酸、奎宁酸、米糠油…吉林省宏久生物科技股份有限公司吉林省宏久生物科技股份有限公司于1998年创建于中国长白山脚下，是一家专业从事天然产品种植、研发、生产与销售的民营股份制高新技术企业。其天然植物提取物产品广泛应用于全球功能性食品饮料、保健品、化妆品、膳食补充剂和制药等领域。主营产品：人参茎叶总皂苷、红参浸膏、人参浸膏、西洋参提取物、人参提取物…杭州双马生物科技股份有限公司双马生物是一家以食品、医药原料中间体、医药保健品等的研发、生产及销售为核心业务的高新技术企业。公司生产销售的红曲、功能性红曲（粉）、红曲胶囊系列保健品，畅销全国二十多个省市，远销美国、欧洲、东南亚及南美等国家和地区。公司作为国内较早从事功能性红曲研发生产的企业之一，在该领域拥有高知名度和影响力。主营产品：红曲粉、功能性红曲粉、红曲米…陕西华晨生物科技有限公司陕西华晨生物科技有限公司是一家专注于植物、动物提取物的研究、生产及销售的高科技企业。公司在杨凌设立工厂，年处理原材料 800吨，并先后取得了SC、ISO22000、HALAL等认证，公司自成立以来，始终坚持以人才为本、诚信立业的经营原则，荟萃业界精英，将先进的生产技术、管理方法及企业经验与本公司的具体实际相结合，始终为客户提供好的产品和技术支持以及健全的售后服务。使企业在激烈的市场竞争中始终保持竞争力，实现公司快速、稳定地发展。公司主打产品有：富里酸，芦丁，锯叶棕提取物，番泻叶提取物，紫草提取物。主营产品：喜来芝提取物，黑姜提取物，东革阿里…惠州市康维健生物科技有限公司惠州市康维健生物科技有限公司位于广东省惠州市三和经济开发区，致力于为全球食品、化妆品原料、保健食品原料、药用辅料、动物营养提供安全、优质的产品和服务。公司是一家具有生物合成技术的国家高新技术企业，拥有自主研发的酯类酶法合成工艺技术平台（拥有专利16项，技术秘密100余项），实现了抗坏血酸棕榈酸酯的环保生产，工厂产能3300吨/年。基于酯类酶法合成工艺技术，还有多款产品可进行商业化生产。包括酶法生产植物甾醇酯、抗坏血酸硬脂酸酯、维生素A棕榈酸酯、抗坏血酸油酸酯、抗坏血酸亚油酸酯、抗坏血酸亚麻。主营产品：抗坏血酸棕榈酸酯、抗坏血酸硬脂酸酯、抗坏血酸…湖南禹健生物科技有限公司湖南禹健生物科技有限公司是一家以纯天然植物提取物为主，适用于健康食品，膳食补充，食品饮料，保健品复方等专业领域的高科技创新型企业。公司集研发、生产、销售于一体，主要产品有速溶玫瑰花提取物，速溶茶提取物及名贵菌类提取物等。公司严格按照GMP操作标准生产管理，已取得Organic Kosher，Halal，IS09001等一系列国内外的品质证书及管理资质。主营产品：灵芝提取物，蝶豆花提取物，速溶玫瑰花提取物…🔍下方二维码浏览更多产品及厂家信息03热门活动活动时间: 2024年4月1-30日《天然提取物精选厂家名录》免费下载参与方式：STEP1-登陆/注册制药在线买家会员账号STEP2-点击下载发询盘享CPHI & PMEC China VIP观众权益惊喜福利：1. 自主询盘3个，定制咖啡杯1个2. 自主询盘3个以上，小米双肩包1个扫描下方二维码参与活动活动咨询活动联系：李女士 021-33392269买家客服：姚女士 021-3339225404线下展联动CPHI China 2024 天然提取物线下展🔍6月14日前完成观众登记，省100元现场门票费！2024年6月19-21日，由Informa Markets、中国医药保健品进出口商会主办，上海博华国际展览有限公司协办的“第二十二届世界制药原料中国展”将在上海浦东新国际博览中心盛大召开。“天然提取物展区”作为CPHI China的特色展区之一，将在展示新产品、新思路、新技术的同时，持续关注政策最新动向、聚焦市场发展趋势，助力企业打开产品创新路径，推动天然提取物上下游产业共同实现转型升级。还等什么立即扫码参与活动吧！活动咨询活动联系：李女士 021-33392269买家客服：姚女士 021-33392254👇👇点击“阅读原文”限时免费领取参观门票！

医药出海带量采购

2023-09-11

·Science Daily

Ceramic tea set glazing affects health benefits of tea, finds new study

Tea contains flavonoids such as catechins, which have numerous health benefits. Now, researchers reveal that the glazing on ceramic tea sets plays a crucial role in retaining the beneficial components of tea. By examining the effects of different glazes on the catechin content in green tea, they find that the choice of glaze materials affects the concentration of these compounds, as well as the color and flavor of tea. Tea contains flavonoids such as catechins, which have numerous health benefits. Now, researchers from Nagoya Institute of Technology, Japan, reveal that the glazing on ceramic tea sets plays a crucial role in retaining the beneficial components of tea. By examining the effects of different glazes on the catechin content in green tea, they find that the choice of glaze materials affects the concentration of these compounds, as well as the color and flavor of tea. Introduced as a medicinal drink around 2700 B.C., tea has grown to be the one of the most popular beverages worldwide. One of the key reasons for its popularity is its rich content of flavonoids and polyphenols, which contribute to the antioxidant property, flavor, and aroma of tea, offering various potential health benefits. These compounds are extracted from tea leaves during brewing and can be influenced by several factors, such as water temperature, brewing time, and the materials used in tea preparation vessels. Recently, researchers from Nagoya Institute of Technology (NITech) in Japan have revealed, for the first time, that the choice of glazing on ceramic tea sets used to prepare tea plays a key role in the retention of catechin flavonoids. In their study published online in the journal Scientific Reports on June 28, 2023, Associate Professor Takashi Shirai, along with Dr. Yunzi Xin, Mr. Sota Shido, and Dr. Kunihiko Kato from the Advanced Ceramics Research Center at NITech, examined the impact of four different typical Japanese commercial glazes -- Oribe, Namako, Irabo, and Toumei -- on the content of catechins, the most abundant flavonoid found in green tea. While glaze coatings primarily consist of feldspar minerals, such as silicon, aluminum, sodium, and calcium oxides, they also contain distinct metal oxide species that impart a unique appearance and texture to the ceramic vessel. Oribe glaze predominantly contains copper (Cu) oxides and imparts a vibrant green color, while Namako glaze contains cobalt (Co) oxides for a dark blue appearance. Irabo glaze contains iron (Fe) oxides that impart orange tones, while Toumei glaze has a high titanium (Ti) content, providing a transparent finish. To examine the effect of the glaze on tea catechins, the researchers brewed a green tea solution using ion-exchanged water at 80°C for three minutes. The tea leaves were separated, and the supernatant (liquid lying above solid residue) was mixed with glaze powders coated on ceramic tiles. The glaze-tea mixture was then allowed to react for six hours, followed by the removal of the glaze powder through centrifugation and filtration. The researchers observed that the pristine tea solution had a clear bright yellow color, but after six hours of degradation, it turned into a yellowish-brown color. In contrast, the tea solutions degraded by different glazes exhibited darker black or brown colors. In other words, the extent of color change depended significantly on the type of glaze. Additionally, the researchers also observed a selective reduction in the amount of altered catechins in tea. The tea solutions mixed with Oribe, Namako, and Irabo glazes showed significantly lower concentrations of epicatechin, epicatechin gallate, epigallocatechin, and epigallocatechin gallate, while the Toumei glaze selectively degraded epigallocatechin gallate. The reduction in catechin concentration and the resulting color change can be attributed to the oxidation process of catechins, which forms brownish thearubigins and reddish-orange theaflavin and its oxide pigments. "During the degradation process, Cu-, Co-, Fe-, and Ti-oxides in glaze powders can act as a Lewis acid catalyst and promote the oxidation of catechin molecules to ortho-quinones, followed by further reaction to form thearubigins and/or theaflavin and its oxides. Another oxidation route is through the polymerization of intermediate free radical catechins," explains Dr. Shirai. "And it is very interesting that thearubigins and theaflavins are the main components of fermented tea like black tea. In other words, green tea brewed by specific ceramic tea sets can be turned into black tea." In summary, this study highlights that the choice of glaze materials used in ceramic tea sets can significantly affect the concentration of beneficial compounds such as catechins in tea. "The specific function of glazes on the degradation of catechins not only provides principal information for the design and development of functional materials but can also impact daily tea drinking and long-term human health-related issues," concludes Dr. Shirai.

临床结果

100 项与表没食子儿茶素没食子酸酯相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	表没食子儿茶素没食子酸酯	-	DB12116

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
杜氏肌营养不良症	临床3期	德国	Charité - Universitätsmedizin Berlin	2010-12-30
阿尔茨海默症	临床3期	德国	Charité - Universitätsmedizin Berlin	2009-10-01
多发性硬化症	临床3期	-	Charité - Universitätsmedizin Berlin	-
肝细胞癌	临床2期	-	The University of Texas Southwestern Medical Center	2024-08-01
肝硬化	临床2期	-	The University of Texas Southwestern Medical Center	2024-08-01
炎症	临床2期	美国	University of Rochester	2024-07-01
肿瘤	临床2期	美国	University of Rochester	2024-07-01
吞咽障碍	临床2期	中国	山东省肿瘤医院	2024-04-22
食管鳞状细胞癌	临床2期	中国	山东省肿瘤医院	2024-04-22
免疫球蛋白轻链淀粉样变性	临床2期	德国	-	2013-04-01

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05758571 (Phase I/II clinical trial of efficacy and safety of EGCG oxygen nebulization inhalation in the treatment of COVID-19 pneumonia patients with cancer, Pubmed)	临床1/2期	新型冠状病毒感染	60	EGCG nebulization 1760-8817umol/L	網選獵夢淵夢範選繭憲(糧鹹齋鹹廠遞遞範糧齋) = 壓積餘顧獵醖獵顧鏇壓範築積淵淵觸製齋廠醖 (衊鏇簾鏇憲積壓憲遞襯 )	积极	2024-04-17
NCT02008721 (CTgov)	临床3期	多系统萎缩	92	EGCG as putative neuroprotective agent (EGCG as Putative Neuroprotective Agent)	製顧鏇顧膚淵範製鏇醖(窪網遞顧壓廠積構膚觸) = 製廠淵觸鑰構鹹範醖鬱顧簾艱鬱襯繭壓繭製憲 (遞蓋餘構窪願窪顧憲鹹, 襯鹽觸構遞簾膚壓網廠 ~ 醖襯構憲鹽築簾鬱膚顧) 更多	-	2024-03-12
NCT02008721 (CTgov)	临床3期	多系统萎缩	92	Placebo (Placebo)	製顧鏇顧膚淵範製鏇醖(窪網遞顧壓廠積構膚觸) = 蓋艱廠襯獵淵廠願淵廠顧簾艱鬱襯繭壓繭製憲 (遞蓋餘構窪願窪顧憲鹹, 顧鏇餘願遞膚獵淵淵鬱 ~ 鑰繭膚艱鹹範壓蓋網壓) 更多	-	2024-03-12
NCT02580279 (Pubmed)	临床1期	肿瘤 \| 皮炎	19	EGCG solution	夢構鹽範製鑰網鹽築築(簾齋醖齋願餘鬱鏇壓餘) = significant relief can be observed in burning sensation after 15 days of EGCG treatment 築廠鬱觸憲糧壓觸顧壓 (窪鏇獵顧窪積製糧製繭 ) 更多	-	2023-08-24
NCT03928847 (CTgov)	早期临床1期	特发性肺纤维化	35	Epigallocatechin-3-gallate (EGCG) (EGCG PK in Healthy Volunteers 450 mg)	醖簾糧築鏇衊選餘糧鏇(遞廠糧窪鏇蓋廠壓鹽築) = 簾鹹鏇膚淵選襯艱構製鬱鬱鬱繭顧鹹鹹齋獵鹽 (夢憲繭鏇蓋淵膚窪醖壓, 襯醖鏇淵願壓顧繭襯衊 ~ 淵遞選膚衊醖廠繭壓鬱) 更多	-	2022-12-22
NCT03928847 (CTgov)	早期临床1期	特发性肺纤维化	35	Epigallocatechin-3-gallate (EGCG) (EGCG PK in Healthy Volunteers 750 mg)	醖簾糧築鏇衊選餘糧鏇(遞廠糧窪鏇蓋廠壓鹽築) = 淵願顧製淵膚蓋鏇廠網鬱鬱鬱繭顧鹹鹹齋獵鹽 (夢憲繭鏇蓋淵膚窪醖壓, 壓膚獵製夢窪積積壓範 ~ 襯構餘鬱簾窪網蓋憲鏇) 更多	-	2022-12-22
ChiCTR2000029831 (Pubmed \| BMC Oral Health)	早期临床1期	慢性牙周炎	20	SRP plus EGCG medication	選襯構壓窪艱遞觸憲蓋(壓淵醖憲繭壓積鏇艱膚) = 願艱網觸製鑰夢積選膚膚壓窪醖選蓋獵鬱憲鏇 (鏇廠選繭簾鬱獵廠膚觸 ) 更多	-	2021-02-18
NCT01928485 (CTgov)	临床2期	前列腺癌	6	active surveillance (Arm A (Active Surveillance))	鬱鹹鏇觸壓夢鬱艱醖築(憲積遞鹽壓鬱鹹衊淵鑰) = 積齋鹹壓淵淵壓構積鹽鏇鏇鏇遞糧鹹簾願蓋膚 (積範夢蓋顧膚選繭糧鹽, 簾齋鬱齋淵獵艱壓糧襯 ~ 艱獵艱淵積顧鏇廠顧齋) 更多	-	2020-03-03
NCT01928485 (CTgov)	临床2期	前列腺癌	6	laboratory biomarker analysis+Sunphenon (Arm B (Sunphenon))	鬱鹹鏇觸壓夢鬱艱醖築(憲積遞鹽壓鬱鹹衊淵鑰) = 醖糧獵積糧淵齋餘齋範鏇鏇鏇遞糧鹹簾願蓋膚 (積範夢蓋顧膚選繭糧鹽, 艱夢遞遞齋獵蓋壓廠簾 ~ 蓋製衊鏇範積築襯構膚) 更多	-	2020-03-03
PROMESA (MDS2018)	临床2/3期	多系统萎缩	127	EGCG	鹽積遞鹹繭網鏇遞壓鏇(淵餘膚窪製觸餘顧壓遞) = Individual cases of hepatotoxicity in the EGCG group show that the limit of maximal tolerable doses was reached 醖齋蓋艱糧網遞壓範憲 (襯衊繭選觸襯憲鑰糧艱 ) 更多	不佳	2018-10-05
MP259 (ERA2017)	N/A	肾脏毒性 proteinuria \| nitric oxide \| malondialdehyde	20	EPIGALLOCATECHIN GALLATE	築糧鏇淵鹹夢築鑰範簾(齋選淵襯網觸願鏇膚願) = 鑰糧範膚淵積獵餘簾蓋選願繭鑰築鏇鹽鬱鹽鬱 (鑰觸鑰鹽構餘範餘醖鑰, 5.4)	积极	2017-05-26
MP259 (ERA2017)	N/A	肾脏毒性 proteinuria \| nitric oxide \| malondialdehyde	20	EPIGALLOCATECHIN GALLATE	築糧鏇淵鹹夢築鑰範簾(齋選淵襯網觸願鏇膚願) = 選遞艱餘鹹選廠願夢鑰選願繭鑰築鏇鹽鬱鹽鬱 (鑰觸鑰鹽構餘範餘醖鑰, 9.9)	积极	2017-05-26
AAAAI2017	临床1期	HIV感染 IgE	22	PolyphenonE 800mg	鬱範醖鏇夢夢積憲鑰觸(網積簾繭網齋憲選願衊) = 憲顧願願鏇餘壓憲網鑰遞簾積範願簾鹽醖網鹽 (顧築窪簾鹹鏇齋選積築, 229) 更多	积极	2017-02-01
NCT02147041 (Pubmed \| Clin Nutr)	临床2/3期	体重下降	115	High-dose green tea extract	繭鹽蓋繭鬱鬱夢壓糧衊(蓋鏇選簾願網製壓艱積) = 築鑰範遞夢鏇簾餘淵襯遞選顧壓壓製鏇淵製顧 (顧餘繭範範壓簾簾齋蓋 ) 更多	积极	2016-06-01