预约演示
更新于：2025-03-22
Ibuprofen Lysine
布洛芬赖氨酸
更新于：2025-03-22
概要
基本信息
最高研发阶段批准上市 |
最高研发阶段(中国)- |
特殊审评孤儿药 (美国) |
登录后查看时间轴
结构/序列
分子式C19H32N2O4 |
InChIKeyIHHXIUAEPKVVII-ZSCHJXSPSA-N |
CAS号57469-77-9 |
关联
10
项与 布洛芬赖氨酸 相关的临床试验NCT05340582
Co-administration of Acetaminophen with Ibuprofen to Improve Duct-Related Outcomes in Extremely Premature Infants - the ACEDUCT Trial
IRCT20140527017880N8
Comparative evaluation of the effect of ibuprofen lysine & gelofen - acetaminophen on postoperative endodontic dental pain with irreversible pulpaitis
IRCT20130812014333N131
comparison of the effect of ibuprofen lysine with gelofen-acetaminophen on postoperative pain of mandibular third molars surgery
100 项与 布洛芬赖氨酸 相关的临床结果
登录后查看更多信息
100 项与 布洛芬赖氨酸 相关的转化医学
登录后查看更多信息
100 项与 布洛芬赖氨酸 相关的专利（医药）
登录后查看更多信息
25,100
项与 布洛芬赖氨酸 相关的文献（医药）2025-07-01SEPARATION AND PURIFICATION TECHNOLOGY
Enhancing electron transfer by amorphous FeOOH quantum dots during photocatalytic ozonation of ibuprofen
作者: Zhuang, Guanzheng ; Chen, Weirui ; Tian, Yingjing ; Bin, Liying ; Li, Ping ; Tang, Bing ; Yi, Yunqiang ; Fu, Siyou ; Li, Laisheng
Photocatalytic ozonation (PCO) process, as an effective water purification technol., was restrained by the low mass transfer and easy combination of photo-carriers (e-cb-h+vb) of conventional semiconductor catalysts.To these end, this study synthesized FeOOH quantum-dots (FeOOH QDs) and boosted the PCO activity by its amorphous structure with Ibuprofen (IBP) as model pollutant. 81.5 % IBP was removed by FeOOH QDs PCO, but it was 59.1 % and 61.2 % for α-FeOOH and β-FeOOH PCO, resp.FeOOH QDs PCO performed well at alk. environment but was easily inhibited by co-existing ions like SO2-4, HCO-3, NO-3, and Cl-.Compared with those of α-FeOOH and β-FeOOH, FeOOH QDs had the narrowest band gap and the lowest e-cb-h+vb recombination, therefore, its e-cb was more favorable to activate O3 into •OH.Tetrahedral Fe3+ and octahedral Fe3+ co-existed on FeOOH QDs and the tetrahedral Fe3+ was more conducive to the adsorption of O3 and contributed to its better PCO activity. •OH was the major reactive oxygen species accounting for IBP degradationDuring FeOOH QDs PCO process, 3 degradation routes were proposed basing on 13 kinds byproducts.T. E. S. T. result indicated that most of the intermediates were less toxic than IBP.This study is useful for developing catalysts for PCO process.
2025-07-01JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
Albumin amplifies the dioxetane (AMPPD) chemiluminescence triggered by alkaline phosphatase: Light emerging from protein cavities
作者: Morgon, Nelson Henrique ; de Souza, Aguinaldo Robinson ; Yoguim, Mauricio Ikeda ; Ximenes, Valdecir Farias ; Barison, Leonardo Almeida
AMPPD is an abbreviation for 3-(2′-spiroadamantyl)-4-methoxy-4-(3-phosphoryloxy)-phenyl-1,2-dioxetane, a thermally stable 1,2-dioxetane derivative widely used as a chemiluminescent probe in clin. laboratories for enzyme immunoassays.AMPPD is a substrate for alk. phosphatase (ALP), the enzyme that catalyzes the remotion of the phosphoryl group of AMPPD, triggering light emission.This study investigated the impact of albumins on the AMPPD:ALP system and found that human serum albumin (HSA) increases the light emission efficiency of AMPPD:ALP by around 100 times.The efficiency of light enhancement varied depending on the type of albumin, with bovine (BSA), porcine (PSA), and rabbit (RSA) serum albumins being less effective than HSA.We conducted experiments to demonstrate that once hydrolyzed by ALP, the dephosphorylated AMPPD diffuses to site I of HSA.By studying the photophys. properties of the phenol ester generated after AMPPD cleavage, we found that its complexation with HSA caused a significant increase in its fluorescent efficiency, which explains the amplification of the chemiluminescence.Resonance energy transfer from the excited phenol ester to coumarin-153 was detected, confirming the presence of both mols. in the protein cavity.Hence, introducing fluorescent acceptors into the reaction system can adjust the emission wavelength.Besides the first direct evidence of albumin as an enhancer for chemiluminescence, the results highlight the potential interference of albumins on AMPPD-mediated assays and new biotechnol. applications.
2025-07-01SEPARATION AND PURIFICATION TECHNOLOGY
Dynamic activation of PMS by CoNi-Zn(OH)2/MnO2 micromotors for efficient degradation of phenolic pollutants
作者: Li, Jia ; Lan, Ziwei ; Yang, Xiaohan ; Wang, Gui
CoNi-Zn(OH)2/MnO2 micromotors with high sp. surface area were synthesized by calcination, co-precipitation, hydrothermal, and ionic doping using the natural plant material ramie as a template.MnO2 in the micromotor catalyzed the H2O2 fuel to generate large amounts of O2, achieving a maximum velocity of 77.504 ± 5.19 μM S-1 for bubble driving.And H2O2 and peroxomonosulfate (PMS) were used as the catalytic substrates to generate hydroxyl radicals (·OH), superoxide radicals (O·-2), singlet-linear oxygen (1O2), and sulfate radicals (SO·-4), realizing the synergistic detection and degradation of phenolic pollutants.The high enzyme-like catalytic activity and autonomous motions of CoNi-Zn(OH)2/MnO2 micromotor together resulted in the detection limits of 3.9 x 10-7 M for catechol (CC) and 4.21 x 10-7 M for hydroquinone (HQ), resp.In addition, the degradation rates of CC and HQ by the micromotor could reach 98.0 % and 96.5 %, resp., within 30 min under neutral conditions (pH = 7).This system provides new insights into the construction of bubble-driven tubular CoNi-Zn(OH)2/MnO2 micromotor for the efficient and sensitive detection and degradation of phenolic pollutants in water.
100 项与 布洛芬赖氨酸 相关的药物交易
登录后查看更多信息
研发状态
10 条最早获批的记录, 后查看更多信息
登录
| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 动脉导管未闭 | 美国 | 2006-04-13 | |
| 关节炎 | 澳大利亚 | 2003-08-12 | |
| 背痛 | 澳大利亚 | 2003-08-12 | |
| 痛经 | 澳大利亚 | 2003-08-12 | |
| 头痛 | 澳大利亚 | 2003-08-12 | |
| 偏头痛 | 澳大利亚 | 2003-08-12 | |
| 肌肉骨骼疼痛 | 澳大利亚 | 2003-08-12 | |
| 紧张型头痛 | 澳大利亚 | 2003-08-12 | |
| 牙痛 | 澳大利亚 | 2003-08-12 |
登录后查看更多信息
临床结果
临床结果
适应症
分期
评价
查看全部结果
登录后查看更多信息
转化医学
使用我们的转化医学数据加速您的研究。
登录
或
药物交易
使用我们的药物交易数据加速您的研究。
登录
或
核心专利
使用我们的核心专利数据促进您的研究。
登录
或
临床分析
紧跟全球注册中心的最新临床试验。
登录
或
批准
利用最新的监管批准信息加速您的研究。
登录
或
特殊审评
只需点击几下即可了解关键药物信息。
登录
或
来和芽仔聊天吧
立即开始免费试用!
智慧芽新药情报库是智慧芽专为生命科学人士构建的基于AI的创新药情报平台，助您全方位提升您的研发与决策效率。
立即开始数据试用!
智慧芽新药库数据也通过智慧芽数据服务平台，以API或者数据包形式对外开放，助您更加充分利用智慧芽新药情报信息。
生物序列数据库
生物药研发创新
免费使用
化学结构数据库
小分子化药研发创新
免费使用