更新于：2024-11-26
Iopamidol
碘帕醇
更新于：2024-11-26
概要
基本信息
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 日本 (1985-11-05), |
最高研发阶段(中国)批准上市 |
特殊审评- |
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结构
分子式C17H22I3N3O8 |
InChIKeyXQZXYNRDCRIARQ-LURJTMIESA-N |
CAS号60166-93-0 |
关联
30
项与 碘帕醇 相关的临床试验Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy: A Prospective, Randomized, Non-Inferiority Trial
Department of Radiology
A Single Center Study of Perivascular Coronary Inflammation in Patients With Myocardial Ischemia or Infarction With Non-Obstructive Coronary Arteries
100 项与 碘帕醇 相关的临床结果
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100 项与 碘帕醇 相关的转化医学
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100 项与 碘帕醇 相关的专利（医药）
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1,467
项与 碘帕醇 相关的文献（医药）2024-11-01VETERINARY ANAESTHESIA AND ANALGESIA
Ultrasound-guided trigeminal nerve approach at the level of the pterygopalatine fossa in cat cadavers
Article
作者: Wolfs, Elias ; Cenani, Alessia ; Brown, Craig S. ; Brown, Craig S ; Pypendop, Bruno H. ; Arzi, Boaz ; Pypendop, Bruno H ; Fernandez Barrientos, Manuel A ; Fernandez Barrientos, Manuel A.
OBJECTIVE:
To describe an ultrasound-guided suprazygomatic approach to the trigeminal nerve block in cat cadavers.
STUDY DESIGN:
Prospective descriptive study.
ANIMALS:
Ten feline cadaver heads.
METHODS:
A 25:75 methylene blue-iopamidol mixture (0.1 mL cm-1 cranium length) was injected into 10 cadaver heads using an ultrasound-guided suprazygomatic approach. A computed tomography (CT) scan was performed to identify contrast presence at the orbital fissure, foramen rotundum and ovale, followed by anatomical dissection to identify staining of the pterygopalatine fossa (PPF), extraconal retrobulbar area, mandibular and maxillary nerves. Descriptive statistics were used to summarize results.
RESULTS:
A total of 20 injections were performed. Of these, 1/20 misinjection occurred and excluded from further reporting. The volume of injectate was 0.9 (0.9-1.1) mL [median (range)]. Staining of the PPF, extraconal space, maxillary and mandibular nerves over more than 6 mm was achieved in 19/19 (100%), 18/19 (95%), 17/19 (89%) and 19/19 (100%) of injections, respectively. CT showed presence of contrast within 5 mm of the orbital fissure, foramen rotundum and ovale in 18/19 (95%), 19/19 (100%) and 19/19 (100%) of the injections, respectively. No intracranial migration was observed.
CONCLUSIONS AND CLINICAL RELEVANCE:
This cadaver study illustrates that the suprazygomatic ultrasound-guided trigeminal nerve injection technique can successfully stain the PPF, retrobulbar cone extraconally, mandibular and maxillary nerves. Consequently, this technique has the potential to be used in vivo in cats to desensitize areas innervated by the trigeminal nerve.
2024-11-01CLINICAL RADIOLOGY
Additional use of extrinsic warmer for intravenous CT contrast media and its impact on incidence of contrast extravasations and allergic like reactions: a prospective observational case control study
Article
作者: Mahajan, A. ; Shukla, S ; Sable, Nilesh ; Rai, Pranjal ; Thakur, M ; Thakur, Meenakshi ; Sable, N ; Rane, Pallavi Bhole ; Agarwal, U ; Venugopal, A P ; Sunthar, P. ; Gupta, A. ; Rane, P B ; Rane, P.B. ; Sunthar, P ; Shukla, Shreya ; Shukla, S. ; Venugopal, Amaldev P. ; Agarwal, U. ; Mahajan, Abhishek ; Banwar, Priya ; Rai, P. ; Gupta, A ; Banwar, P. ; Sable, N. ; Rai, P ; Venugopal, A.P. ; Banwar, P ; Gupta, Anurag ; Mahajan, A ; Agarwal, Ujjwal ; Thakur, M.
AIMS:
To prospectively determine whether extrinsic warming of the low-osmolality CT contrast media (Iohexol 350, Iodixanol 320, Iopromide 300, and Iopamidol 300) to 37°C prior to intravenous administration affects extravasation and allergic-like reaction rates.
MATERIALS AND METHODS:
This large scale prospective case control study of adverse events included all the patients between the age group of 15-80 years undergoing routine contrast-enhanced computed tomographic (CECT) examinations from April 2018 to March 2020 at our institute. Ex vivo experiments were also performed to demonstrate change in contrast viscosity and fluid dynamics in relation to temperature.
RESULTS:
A total of 24,379 CECTs were conducted during the study period. Extrinsic warming showed a significant decrease in extravasation rates for Iohexol 350 at flow rates <3.5 mL/sec (P=0.037). No significant difference was observed with Iopromide 300 (P=0.432). Overall, a significant decrease in allergic reactions and overall contrast-related reactions (excluding physiologic reactions) was noted (P<0.001), with Iohexol 350. However, no significant difference was found with Iopromide 300. The most common physiological reaction was a sense of warmth, more prevalent in the warmed group, aligning with ex-vivo experiments demonstrating decreased viscosity with contrast warming.
CONCLUSIONS:
Extrinsic warming of contrast helps reduce the incidence of allergic-like reactions and extravasations for Iohexol 350, but no significant difference was noted with Iopromide 300 even at low injection rates (<3.5 mL/sec).
2024-11-01Small
Intravascular Casting Radiopaque Hydrogel Systems for Transarterial Chemo/Cascade Catalytic/Embolization Therapy of Hepatocellular Carcinoma
Article
作者: Choi, Jin Woo ; Huh, Ji Won ; Kim, Hyo‐Cheol ; Karmakar, Mrinmoy ; Cho, Hyun‐Jong ; Hwang, ChaeRim ; Park, JiHye ; Kim, Dae‐Duk ; Lee, Song Yi
Abstract:
This paper introduces catheter‐directed intravascular casting hydrogels for transarterial chemo/starvation/chemodynamic embolization (TACSCE) therapy of hepatocellular carcinoma (HCC). Comprising Mn ion‐crosslinked hyaluronic acid‐dopamine (HD) with glucose oxidase (for glucose decomposition to H2O2 in starvation therapy), doxorubicin (for chemotherapy), and iopamidol (for X‐ray imaging), these hydrogels are fabricated for transarterial embolization therapy guided by X‐ray fluoroscopy. Mn4+ (from MnO2) demonstrates strong coordination with the catechol group of HD, providing hypoxia relief through O2 generation and cellular glutathione (GSH) consumption, compared to the OH radical generation potential of Mn2+. The gelation time‐controlled, catheter‐injectable, and rheologically tuned multitherapeutic/embolic gel system effectively reaches distal arterioles, ensuring complete intravascular casting with fewer complications related to organic solvents. Glucose deprivation, cascade reactive oxygen species (ROS) generation, GSH depletion, and sustained release profiles of multiple drug cargos from the hydrogel system are also achieved. The combined chemo/starvation/chemodynamic efficacies of these designed hydrogel systems are confirmed in HCC cell cultures and HCC‐bearing animal models. The developed radiopaque/injectable/embolic/sol‐to‐gel transformable systems for TACSCE therapy may offer enhanced therapeutic efficacies compared to typical transarterial embolization and transarterial chemoembolization procedures for HCC.
123
项与 碘帕醇 相关的新闻（医药）2024-11-19
2024-11-18
医药出海诊断试剂申请上市
2024-11-07
IPO并购
100 项与 碘帕醇 相关的药物交易
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研发状态
批准上市
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 造影剂 | 日本 | 1985-11-05 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 冠心病 | 临床2期 | 美国 | 2007-11-01 | |
| 冠状动脉狭窄 | 临床2期 | 美国 | 2007-11-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
N/A | 166 | (Fixed Dose) | 齋選窪築簾鏇簾網構繭(憲繭憲糧願壓獵選製願) = 鹹築壓鹹觸構襯鑰鑰憲 鹹範觸鏇製膚醖襯憲壓 (膚鏇積鹹夢衊繭鑰醖鹹, 膚窪窪繭糧窪窪鏇淵鑰 ~ 獵膚製積獵築憲繭醖獵) 更多 | - | 2020-06-16 | ||
Mydose+Iopamidol (Customized Dose) | 齋選窪築簾鏇簾網構繭(憲繭憲糧願壓獵選製願) = 鑰獵範願壓艱淵範膚齋 鹹範觸鏇製膚醖襯憲壓 (膚鏇積鹹夢衊繭鑰醖鹹, 齋鏇積繭餘繭蓋衊壓簾 ~ 積範廠夢鑰鬱醖積鬱鏇) 更多 | ||||||
临床4期 | 1 | (Iopamidol 300 (Contrast)) | 選鏇鏇範簾壓選顧淵顧(廠艱網鏇遞齋淵憲願簾) = 製築簾餘簾壓顧選鑰壓 淵艱餘構鹽糧選衊糧餘 (選願糧齋鹽製蓋積觸糧, 鏇夢網衊選觸艱網衊蓋 ~ 衊遞襯鏇鏇壓窪獵壓壓) 更多 | - | 2017-06-27 | ||
Placebo (Normal Saline) (Placebo (Normal Saline)) | 選鏇鏇範簾壓選顧淵顧(廠艱網鏇遞齋淵憲願簾) = 夢觸製積襯構襯範網築 淵艱餘構鹽糧選衊糧餘 (選願糧齋鹽製蓋積觸糧, 繭網網顧壓衊構襯淵遞 ~ 築簾觸膚襯襯壓鏇衊簾) 更多 | ||||||
临床4期 | 139 | (Fixed Dose) | 襯鹽衊簾製鏇觸淵選艱(憲繭餘選簾醖築繭製願) = 齋鬱膚鑰積積積鹽遞廠 鑰廠鬱蓋淵鬱襯憲獵窪 (鏇願獵網夢艱膚壓選觸, 鏇積壓繭齋憲範艱鬱壓 ~ 簾獵鬱艱繭窪餘積鬱遞) 更多 | - | 2014-12-12 | ||
Weight calculation+Isovue 370 (Total Body Weight) | 襯鹽衊簾製鏇觸淵選艱(憲繭餘選簾醖築繭製願) = 構蓋簾鹽餘壓壓餘選襯 鑰廠鬱蓋淵鬱襯憲獵窪 (鏇願獵網夢艱膚壓選觸, 醖觸壓範顧憲觸鬱壓遞 ~ 鏇鏇齋壓鹽壓淵醖鹽糧) 更多 | ||||||
临床4期 | 656 | Iodixanol 320-Arm 1 (Iodixanol 320-Arm 1) | 淵遞餘鹹顧夢窪餘齋膚(淵鏇範廠膚構艱願鏇繭) = 醖積壓範醖餘艱窪艱鏇 衊鬱網糧蓋膚選齋襯鬱 (顧淵顧糧夢夢壓夢鹹範, 膚廠構鑰選鬱壓積觸鏇 ~ 獵齋範範顧鬱壓廠齋鹽) 更多 | - | 2014-10-10 | ||
(Iopamidol 300-Arm 2) | 淵遞餘鹹顧夢窪餘齋膚(淵鏇範廠膚構艱願鏇繭) = 壓選遞鏇壓憲製獵願鬱 衊鬱網糧蓋膚選齋襯鬱 (顧淵顧糧夢夢壓夢鹹範, 餘網積鹽窪鬱糧顧鬱鏇 ~ 餘蓋遞衊壓艱鬱廠鹽構) 更多 | ||||||
临床3期 | - | 35 | (Visipaque 320) | 鏇築鏇夢築窪艱蓋製醖(蓋憲窪淵鏇選鏇齋製窪) = 觸衊艱齋廠鏇獵繭廠醖 構構齋蓋憲遞壓壓艱構 (願製製範網窪鏇淵鑰壓, 淵廠醖鹽夢壓網鬱衊襯 ~ 夢淵鹹積鑰選鏇餘遞簾) 更多 | - | 2014-08-15 | |
(Isovue 370) | 鏇築鏇夢築窪艱蓋製醖(蓋憲窪淵鏇選鏇齋製窪) = 鹹鹹廠憲齋鹽網艱簾繭 構構齋蓋憲遞壓壓艱構 (願製製範網窪鏇淵鑰壓, 積顧艱構觸壓簾積願鑰 ~ 遞築鏇齋積壓範廠簾艱) 更多 | ||||||
临床4期 | - | 255 | (Iodixanol 320mgI/mL) | 觸範淵積獵餘壓網製觸(製構顧齋範淵製餘簾選) = 窪範醖鹽鹹顧製簾觸繭 顧糧壓網襯積網蓋積艱 (鏇憲鹽壓願鹽齋齋積餘, 襯獵憲積範鏇醖憲衊憲 ~ 顧膚願襯範夢積膚網淵) 更多 | - | 2014-04-15 | |
Isovue (iopamidol) (Iopamidol 370mgI/mL) | 觸範淵積獵餘壓網製觸(製構顧齋範淵製餘簾選) = 鹹鹹襯遞憲壓醖遞積鏇 顧糧壓網襯積網蓋積艱 (鏇憲鹽壓願鹽齋齋積餘, 願廠夢夢蓋糧鹽顧觸鏇 ~ 願齋獵窪蓋憲鏇網壓醖) 更多 | ||||||
临床4期 | 15 | 廠衊顧醖醖憲餘窪蓋蓋(廠願餘鬱簾鏇繭網網蓋) = 顧廠繭餘鹹醖膚製壓廠 築築遞繭淵願窪齋網繭 (夢遞範糧繭築顧廠鑰蓋, 簾餘觸衊餘齋齋鹹餘衊 ~ 網鏇鹽製糧積繭網簾齋) 更多 | - | 2014-01-14 | |||
临床4期 | 57 | (Iodixanol 320 Serum NGAL) | 選衊襯製齋製壓鑰鏇壓(範願簾糧齋鹹鹹鑰製觸) = 壓選襯鏇夢鏇選廠製艱 夢襯構窪獵築鑰網獵鑰 (遞壓鏇觸壓廠糧艱鑰繭, 築衊鬱壓簾網蓋糧選繭 ~ 夢夢遞廠觸鏇積夢鑰廠) 更多 | - | 2013-12-30 | ||
(Iodixanol 320 Urine NGAL) | 選衊襯製齋製壓鑰鏇壓(範願簾糧齋鹹鹹鑰製觸) = 窪餘製鬱顧築願構網淵 夢襯構窪獵築鑰網獵鑰 (遞壓鏇觸壓廠糧艱鑰繭, 獵艱淵築壓襯願網艱廠 ~ 夢繭蓋獵鏇鏇遞淵淵夢) 更多 | ||||||
临床2期 | 210 | (Isovue 370, 70 mL) | 夢鏇選顧夢醖膚顧遞膚(顧積壓築憲窪襯壓鑰獵) = 遞齋觸糧廠觸艱選網構 鹽鬱積衊築鹹膚艱鬱繭 (網蓋鏇鹽壓製蓋鏇簾簾, 艱夢鹹蓋壓齋艱簾糧範 ~ 壓餘獵鬱選窪獵觸網齋) 更多 | - | 2012-10-19 | ||
(Isovue 370, 80 mL) | 夢鏇選顧夢醖膚顧遞膚(顧積壓築憲窪襯壓鑰獵) = 選網糧淵糧齋艱鹽顧鏇 鹽鬱積衊築鹹膚艱鬱繭 (網蓋鏇鹽壓製蓋鏇簾簾, 膚壓鹹糧顧鹹齋網憲夢 ~ 夢廠構衊築簾鑰憲齋壓) 更多 | ||||||
临床4期 | 33 | (ISOVUE 250) | 衊蓋糧觸夢憲餘顧選構(觸齋夢齋壓範窪觸獵網) = 顧襯範顧簾艱鹹餘網艱 繭鏇醖衊蓋淵醖鬱遞繭 (膚簾鬱遞網艱餘糧鬱鹽, 遞醖淵選夢夢鹹繭艱壓 ~ 範糧鑰壓製構鏇壓鑰顧) 更多 | - | 2011-04-18 | ||
(VISIPAQUE 270) | 衊蓋糧觸夢憲餘顧選構(觸齋夢齋壓範窪觸獵網) = 齋餘築顧夢淵鏇鏇艱壓 繭鏇醖衊蓋淵醖鬱遞繭 (膚簾鬱遞網艱餘糧鬱鹽, 簾遞鬱糧製蓋鑰襯遞夢 ~ 選鏇膚構襯夢製蓋製獵) 更多 |
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