更新于：2024-06-29
Hydrochlorothiazide/Telmisartan
替米沙坦氢氯噻嗪
更新于：2024-06-29
概要
基本信息
药物类型 小分子化药 |
别名 Telmisartan and Hydrochlorothiazide、TELMISARTAN/HYDROCHLOROTHIAZIDE、Telmisartan/Hydrochlorothiazide + [14] |
作用机制 AT1R拮抗剂(血管紧张素II-1型受体拮抗剂)、NCC抑制剂(噻嗪类敏感氯化钠协同转运蛋白抑制剂) |
治疗领域 |
非在研适应症- |
非在研机构- |
最高研发阶段批准上市 |
首次获批日期 美国 (2000-11-17), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构
分子式C40H38ClN7O6S2 |
InChIKeyOZCVMXDGSSXWFT-UHFFFAOYSA-N |
CAS号485391-74-0 |
关联
46
项与 替米沙坦氢氯噻嗪 相关的临床试验替米沙坦氢氯噻嗪片在中国成年健康受试者中的一项随机、开放、空腹和餐后单次给药、两制剂、三序列、三周期交叉的生物等效性研究
健康受试者空腹/餐后用药，单中心、随机、开放、2制剂、3周期、3序列、部分重复（仅重复参比制剂）的替米沙坦氢氯噻嗪片的平均生物等效性试验
替米沙坦氢氯噻嗪片在健康受试者中单中心、随机、开放、两制剂、单次给药、三周期、三序列、部分重复交叉空腹/餐后生物等效性试验
100 项与 替米沙坦氢氯噻嗪 相关的临床结果
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100 项与 替米沙坦氢氯噻嗪 相关的转化医学
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100 项与 替米沙坦氢氯噻嗪 相关的专利（医药）
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4
项与 替米沙坦氢氯噻嗪 相关的文献（医药）2012-09-01Journal of the renin-angiotensin-aldosterone system : JRAAS4区 · 医学
Efficacy and safety of a single-pill fixed-dose combination of high-dose telmisartan/hydrochlorothiazide in patients with uncontrolled hypertension
4区 · 医学
ArticleOA
作者: Shimizu, Tomohiko ; Kuwano, Takashi ; Mitsutake, Ryoko ; Shiga, Yuhei ; Saku, Keijiro ; Nagata, Itsuki ; Shirotani, Tetsuro ; Fujisawa, Kazuaki ; Miura, Shin-ichiro ; Uehara, Yoshinari ; Norimatsu, Kenji ; Arimura, Tadaaki ; Inoue, Asao ; Matsunaga, Eiyu ; Morii, Joji
Objective::
Many patients still have high blood pressure (BP) after treatment with high-dose angiotensin II type 1 receptor blockers (ARBs) or Preminent® (medium-dose of losartan (50 mg/day)/hydrochlorothiazide (HCTZ) (12.5 mg/day)). Therefore, we analyzed whether Micombi®BP (high-dose telmisartan (80 mg/day)/HCTZ (12.5 mg/day)) could provide better results with regard to efficacy and safety for patients with uncontrolled hypertension.
Methods::
In total, 44 hypertensive patients (22 males, age 71±14 years) who showed uncontrolled BP despite the use of high-dose ARBs or Preminent® were enrolled in this study. We used a changeover design in which the patients were switched from high-dose ARBs or Preminent® to Micombi®BP. We analyzed BP, heart rate (HR), and biochemical parameters before and after treatment for 3 months.
Results::
Systolic BP and diastolic BP significantly decreased (125±15/69±11 mmHg) and 85% of the patients achieved their target BP at 3 months after changeover. Patients who switched from ARBs and those who switched from Preminent® showed similar BP-lowering effects. In addition, the reductions in BP after 3 months in patients with or without chronic kidney disease and in those with or without metabolic syndrome (MetS) were also similar. There were no significant changes in HR during the study period. Although blood levels of potassium, hemoglobin A1c and uric acid (UA) significantly increased after 3 months for all of the patients, none of the patients showed serious adverse effects.
Conclusion::
High-dose telmisartan/HCTZ therapy was associated with a significant reduction in BP and helped patients achieve their target BP.
2008-01-01Drugs1区 · 医学
Telmisartan/Hydrochlorothiazide
1区 · 医学
Review
作者: White, William B. ; Plosker, Greg L.
Fixed-dose combinations of telmisartan and hydrochlorothiazide (HCTZ) [Micardis Plus, Micardis HCT, PritorPlus] are available in many countries for the treatment of patients with essential hypertension. Combining the angiotensin II receptor antagonist (angiotensin II receptor blocker [ARB]) telmisartan with the thiazide diuretic HCTZ provides antihypertensive therapy with complementary mechanisms of action. In the US and EU, telmisartan/HCTZ is approved for patients whose hypertension is not adequately controlled with telmisartan monotherapy; US labelling for the fixed-dose combination also includes inadequate control of blood pressure (BP) with HCTZ monotherapy.The antihypertensive efficacy of once-daily telmisartan/HCTZ has been demonstrated in several large, randomized trials in patients with stages 1 and 2 hypertension. The addition of HCTZ to telmisartan achieved significant reductions in BP in nonresponders to telmisartan monotherapy, and the antihypertensive efficacy of telmisartan/HCTZ was similar to or significantly greater than that of various comparator agents. Moreover, in studies that used ambulatory BP monitoring, telmisartan/HCTZ provided consistent 24-hour BP reductions throughout morning, daytime and night-time periods. The BP-lowering efficacy over the entire 24-hour dose administration interval is consistent with the pharmacokinetic profile of telmisartan, which has the longest elimination half-life among currently available ARBs and a unique chemical structure. Adverse events with telmisartan/HCTZ in clinical trials were typically mild and transient, and no unexpected events occurred that had not been previously reported with either telmisartan or HCTZ. Extensive tolerability data are available for telmisartan, in particular from the ONTARGET study, the largest clinical outcomes trial with an ARB. As such, fixed-dose combinations of telmisartan/HCTZ provide an effective, rational and generally well tolerated treatment option for the management of patients with hypertension.
2003-09-01Revue medicale de Liege
[Kinzalkomb, a fixed telmisartan-hydrochlorothiazide combination for the treatment of hypertension].
Review
作者: Kulbertus, H
Kinzalkomb marketed in Belgium by Bayer is a fixed combination of telmisartan 80 mg and hydrochlorothiazide 125 mg for the treatment of hypertension. New guidelines for the treatment of hypertension were recently released both in Europe and the United States (see article by J.M. Krzesinski in this issue). They offer the choice of using a fixed biotherapy even as first line treatment. Hydrochlorothiazide at low dose is a frequent component of such biotherapies: it is efficacious and secure. Telmisartan is a highly selective blocker of angiotensin II AT1 receptors ("sartans"); it is at least as effective as the classical antihypertensive agents; thanks to its half-life, the longest of all sartans', it provides adequate antihypertensive coverage throughout the whole 24-hour postdose interval and particularly over the last 6 hours of the dosage interval. Its tolerability profile is equivalent to placebo. The combination telmisartan-hydrochlorothiazide is more effective than each agent alone at lowering blood pressure; furthermore telmisartan possesses a potassium-sparing effect that when the two drugs are coadministered attenuates the kaliuretic effect of hydrochlorothiazide. Various large trials are currently under way (ONTARGET, TRANSCEND, PROFESS, PROTECTION, DETAIL). These studies which together involve some 50,000 patients will hopefully help to further specify the role of telmisartan in condition which require an intervention on the renin-angiotensin system.
100 项与 替米沙坦氢氯噻嗪 相关的药物交易
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外链
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 原发性高血压 | 欧盟 | 2002-04-19 | |
| 原发性高血压 | 欧盟 | 2002-04-19 | |
| 原发性高血压 | 冰岛 | 2002-04-19 | |
| 原发性高血压 | 冰岛 | 2002-04-19 | |
| 原发性高血压 | 列支敦士登 | 2002-04-19 | |
| 原发性高血压 | 列支敦士登 | 2002-04-19 | |
| 原发性高血压 | 挪威 | 2002-04-19 | |
| 原发性高血压 | 挪威 | 2002-04-19 | |
| 高血压 | 美国 | 2000-11-17 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床3期 | 132 | (Telmisartan + HCTZ + Amlodipine) | 顧遞蓋鑰鑰構選醖構鏇(鑰鏇顧構積繭製積醖壓) = 憲憲網鏇窪醖築淵遞衊 蓋製鹹願顧鏇簾願網膚 (醖築築願顧鬱壓窪觸顧, 醖鑰構淵選簾廠襯壓簾 ~ 廠積願齋鹽範襯獵願夢) 更多 | - | 2016-03-28 | ||
placebo+telmisartan + HCTZ (Telmisartan + HCTZ + Placebo) | 顧遞蓋鑰鑰構選醖構鏇(鑰鏇顧構積繭製積醖壓) = 願網膚簾製鏇觸齋膚壓 蓋製鹹願顧鏇簾願網膚 (醖築築願顧鬱壓窪觸顧, 鏇繭築糧廠築繭憲築觸 ~ 醖製築衊艱襯壓窪願網) 更多 | ||||||
临床3期 | - | 639 | 觸築艱構築製膚蓋獵齋(窪鏇壓構憲築鬱積範網) = occurred in 29 (4.5%) patients 顧廠夢鑰艱夢蓋繭艱醖 (範獵鹹築簾襯簾繭艱壓 ) | - | 2009-02-01 |
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