更新于：2024-06-20
CM-101 (Chemomab)
更新于：2024-06-20
概要
基本信息
原研机构 |
在研机构 |
非在研机构- |
最高研发阶段临床2期 |
首次获批日期- |
最高研发阶段(中国)- |
特殊审评快速通道 (美国)、孤儿药 (美国)、孤儿药 (欧盟) |
关联
9
项与 CM-101 (Chemomab) 相关的临床试验A Phase 2, Multicenter, Randomized, Double-Blind, Proof of Biology Study to Evaluate the Safety, Tolerability, and Activity of CM-101 in Patients With Systemic Sclerosis
This study is designed to assess the safety and tolerability of the anti-human CCL24 monoclonal antibody CM-101 in adult patients with systemic sclerosis (SSc). Approximately 45 patients at approximately 40 sites will be randomized in a 2:1 ratio to receive either 10 mg/kg CM-101 or placebo.
开始日期2024-09-01 |
申办/合作机构 |
A Phase 2a, Randomized, Double-Blind, Placebo-Controlled, Clinical Trial Evaluating the Safety and Efficacy of CM-101 in Subjects with Primary Sclerosing Cholangitis - The SPRING study
开始日期2022-01-20 |
申办/合作机构 |
Phase 2A Multi-Center, Double-Blind, Randomized, Placebo-Controlled Study of CM-101 in Patients With Non-Alcoholic Steatohepatitis (NASH)
This phase 2a study is a multi-center, double-blind randomized, placebo-controlled study. The study is designed to determine the safety and tolerability of the anti-human CCL24 monoclonal antibody CM-101 in adult patients with non-cirrhotic nonalcoholic steatohepatitis (NASH) patients with stage 1c, 2 or 3 fibrosis. The patients will be randomized to 1 of 2 treatment groups: 5 mg/kg CM-101 or placebo.
开始日期2021-02-24 |
申办/合作机构 |
100 项与 CM-101 (Chemomab) 相关的临床结果
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100 项与 CM-101 (Chemomab) 相关的转化医学
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100 项与 CM-101 (Chemomab) 相关的专利（医药）
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10
项与 CM-101 (Chemomab) 相关的文献（医药）2004-01-01·Restorative neurology and neuroscience
Macrophage stimulation using a group B-streptococcus exotoxin (CM101) leads to axonal regrowth in the injured optic nerve.
Article
作者: Hellerqvist, Carl G ; Ohlsson, Marcus ; Mattsson, Per ; Svensson, Mikael ; Wamil, Barbara D
PURPOSE:
A group B-streptococcus exotoxin (CM101) was administered following optic nerve injury in adult rats in order to analyze putative effects on macrophages, glial scar formation and regrowth of axons in the lesioned optic nerve.
METHODS:
After a standardized intraorbital optic nerve crush, animals were randomized to treatment with CM101 (30 microm/kg body weight, iv, repeated every other day) or vehicle alone. Morphology (semithin sections) and immunohistochemistry directed towards macrophages (ED1), neurofilament (NF), astrocytes (GFAP) and regenerative sprouts (GAP43) were employed at different time-points up to 28 dpi.
RESULTS:
A significant increase of ED1-positive macrophages (p < 0.05) was observed at 7, 14 and 28 dpi in treated animals compared to untreated, indicative of macrophage stimulation. Less degenerative structures were found in sections distal to the injury in treated animals, seemingly due to a pro-phagocytic effect. Reactive gliosis was significantly (p < 0.05) less pronounced in CM101-treated animals. The presence of GAP43-positive sprouts and neurofilament-positive neurites distal to the lesion in treated animals indicate regrowth of axons crossing the glial scar.
CONCLUSION:
Treatment with group B-streptococcus exotoxin leads to macrophage stimulation, increased phagocytosis of inhibitory debris, and a less dense reactive gliosis, which in turn allows for regrowth of axons through the glial scar.
2001-12-01·Clinical cancer research : an official journal of the American Association for Cancer Research
Identification of a novel membrane protein, HP59, with therapeutic potential as a target of tumor angiogenesis.
Article
作者: Shi, E ; Wang, Y ; Carter, C ; Cetateanu, N D ; Lloyd, R S ; Fu, C ; Mernaugh, R L ; Wamil, B D ; Page, D L ; Yakes, F M ; Venkov, C ; Hellerqvist, C G ; Yan, H P ; Bardhan, S
CM101, a polysaccharide isolated from the culture medium of Group B streptococcus, a neonatal pathogen, targets pathological angiogenesis and inhibits tumor growth in mice and humans. CM101 also targets neonatal lung and adult sheep lung endothelial cells. A gene encoding a transmembrane protein that interacts with CM101 was isolated from a sheep lung endothelial cell cDNA library. The gene, termed sp55, encodes a 495-amino acid polypeptide. COS-7 cells transfected with a vector containing sp55 express the SP55 protein-bound CM101 in a concentration-dependent manner. Stably transfected CHO cells also bound CM101. The corresponding human gene, hp59, was isolated from a human fetal lung cDNA library and had a predicted identity to SP55 of 86% over 495 amino acids. HP59 protein was shown by immunohistochemistry to be present in the pathological tumor vasculature of the lung, breast, colon, and ovary, but not in the normal vasculature, suggesting that the protein may be critical to pathological angiogenesis. The hp59 gene and/or the HP59 protein was not expressed in a variety of normal tissues, but was significantly expressed in human fetal lung, consistent with the pathophysiology of Group B streptococcus infections in neonates. Mice immunized with HP59 and SP55 peptides showed significant attenuation of tumor growth. Immunization effectively inhibited both the tumor angiogenesis and vasculogenesis processes, as evidenced by lack of both HP59- and CD34-positive vessels. These results and the immunohistochemistry data suggest a therapeutic potential for the CM101 target protein HP59 both as a drug target and as a vaccine against pathoangiogenesis.
2001-01-01·Angiogenesis1区 · 医学
CM101 stimulates cutaneous wound healing through an anti-angiogenic mechanism.
1区 · 医学
Article
作者: Lillian B. Nanney ; Jeffrey Whitsitt ; Nancy L. Cardwell ; Carl G. Hellerqvist ; He-Ping Yan ; Jeffrey M. Davidson ; Barbara D. Wamil
CM101, an anti-pathoangiogenic polysaccharide derived from group B streptococcus, has been shown to inhibit inflammatory angiogenesis and accelerate wound healing in a mouse model and minimize scarring/gliosis following spinal cord injury. To evaluate the in vivo effects of CM101 on cutaneous wound healing in the pig, intravenously delivered CM101 or placebo vehicle was given 1 h after cutaneous wounding and again at 72 h after injury. Tissues from partial-thickness and full-thickness excisions were collected at days 4 and 7 after wounding and evaluated for a variety of standard healing parameters. Both types of CM101-treated wounds showed significantly less evidence of inflammatory angiogenesis when assessed by macroscopic photography of the wound surface, qualitative histological observations, laser doppler perfusion imaging, and quantitative morphometric analysis of microvessel area from endothelium selectively immunostained for factor VIII. Resurfacing was accelerated in partial-thickness and full-thickness excisions that received two doses of CM101 as compared to the placebo-treated excisional wounds. Neodermal thickness was increased in CM101-treated wounds at day 4 and was slightly reduced in comparison with placebo by day 7. New collagen accumulation appeared to be unaffected by the CM101 treatment. Immunohistochemical staining using a polyclonal antisera directed against the anti-pathoangiogenic CM101 target protein HP59 on day 7 indicated a strong immunoreactivity on the microvessels present in the control wounds but not in wounds of the CM101-treated animals. In summary, the immunolocalization HP59 in the microvessels of the cutaneous wound bed in control but not in CM101 treated wounds suggests that CM101 inhibits the pathologic inflammatory angiogenesis accompanying the normal granulation processes. The net biological effect of inhibited inflammatory pathoangiogenesis is a diminished, suggested and purely physiologic, microvascular bed which translates into an enhanced rate of epithelial resurfacing and therefore an overall accelerated rate of wound repair.
41
项与 CM-101 (Chemomab) 相关的新闻（医药）2024-06-18
—Proteomic Analysis of Patient Samples Further Confirms that CCL24 is Associated with Primary Sclerosing Cholangitis (PSC) Severity and Progression, Highlighting the Potential of Chemomab’s CCL24-Neutralizing Antibody CM-101 as a Promising Therapy for PSC—
—CM-101 Phase 2 PSC Trial Topline Data Readout Expected Midyear 2024—
TEL AVIV, Israel, June 18, 2024 (GLOBE NEWSWIRE) -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB) (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today announced a new scientific publication that further confirms the important role of the soluble protein CCL24 in the pathologies underlying the rare fibrotic liver disease primary sclerosing cholangitis (PSC). The new study reinforces the extensive evidence showing the potential of Chemomab’s CCL24-neutralizing antibody, CM-101, to interrupt the biological processes driving PSC disease progression and severity. The study, “Machine Learning Identifies Key Proteins in Primary Sclerosing Cholangitis Progression and Links High CCL24 to Cirrhosis”1 has been published in the current online version of the peer-reviewed International Journal of Molecular Science.
The study applied machine learning to proteomic profiles of PSC patient sera to assess the involvement of CCL24 and to identify markers of disease presence, severity and cirrhosis. The pathway analysis underscored the importance of both fibrosis-related pathways and pathways associated with immune response and inflammation in PSC. Notably, the analysis showed that enrichment for PSC-related biological pathways was associated with high levels of CCL24 and that patients with cirrhosis had higher levels of CCL24, providing further evidence for the role of CCL24 in disease progression and severity. The authors also noted that the biomarkers identified in this study have significant translational importance, offering potential advancements in the monitoring of disease progression in clinical settings.
“These proteomic analyses add to the large body of data showing that CCL24 is a major driver of PSC disease progression and severity. They also confirm the importance of both fibrotic and inflammation/immune-related pathways in PSC, highlighting the relevance of the dual anti-fibrotic and anti-inflammatory activity of CM-101,” said Adi Mor, PhD, co-founder, Chief Executive Officer and Chief Scientific Officer of Chemomab. “We look forward to our CM-101 PSC Phase 2 topline data readout in the coming weeks, which has the potential to provide the first significant clinical proof-of-concept of CM-101’s therapeutic activity in this lethal disease with no FDA approved therapies.”
A second study published in the online edition of the journal Drug Safety, Targeting CCL24 in Inflammatory and Fibrotic Diseases: Rationale and Results from Three CM-101 Phase 1 Studies,2 summarized the findings of three Phase 1 studies3 of CM-101. It concluded that CM-101 successfully neutralizes CCL24, a key factor linked to inflammatory and fibrotic diseases. Phase 1a studies of intravenous (IV) and subcutaneous (SC) administration of CM-101 in healthy participants demonstrated rare and mild adverse events. In Phase 1b studies in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), both IV and SC administered CM-101 exhibited good tolerability, with a notable reduction in serum levels of inflammatory, fibrotic and collagen turnover biomarkers, suggesting its therapeutic potential in addressing inflammatory and fibrotic conditions.
About Primary Sclerosing Cholangitis
PSC is a rare, progressive liver disease characterized by inflammation and fibrosis (scarring) of the bile ducts that can lead to cirrhosis of the liver, liver failure and death. PSC also increases the risk of various cancers, which account for about half of PSC-related mortality. PSC affects an estimated 30,000 patients in the U.S. and about 80,000 worldwide. The underlying cause of PSC is unknown, but about 75% of patients also have inflammatory bowel disease. Liver transplantation is common in advanced cases, but even then, PSC re-occurs in about 20% of transplanted patients. With no approved therapies, there is a high unmet need for new drugs to address the symptoms of PSC and slow or stop the progression of this devastating illness.
1 Snir, T.; Greenman, R.; Aricha, R.; Frankel, M.; Lawler, J.; Saffioti, F.; Pinzani, M.; Thorburn, D.; Mor, A.; Vaknin, I. Machine Learning Identifies Key Proteins in Primary Sclerosing Cholangitis Progression and Links High CCL24 to Cirrhosis. Int. J. Mol. Sci. 2024, 25, 6042.
2 Mor, A., Friedman, S., Hashmueli, S. et al. Targeting CCL24 in Inflammatory and Fibrotic Diseases: Rationale and Results from Three CM-101 Phase 1 Studies. Drug Saf (2024).
3 Clinical trial retrospective registration NCT06025851, NCT06037577, and NCT06044467. Date of registration: September 2023
Forward Looking Statements
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act. These forward-looking statements include, among other things, the clinical development pathway for CM-101; the expectation that Chemomab will report topline data from the PSC clinical trial by mid-year 2024; the length, duration and impact of the war in Israel on Chemomab’s business and operations; the future operations of Chemomab and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones; the nature, strategy and focus of Chemomab; the development and commercial potential and potential benefits of any product candidates of Chemomab; and that the product candidates have the potential to address high unmet needs of patients with serious fibrosis-related diseases and conditions. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon Chemomab's current expectations. Forward-looking statements involve risks and uncertainties. Because such statements deal with future events and are based on Chemomab's current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Chemomab could differ materially from those described in or implied by the statements in this presentation, including those found under the caption "Risk Factors" and elsewhere in Chemomab's filings and reports with the SEC. Chemomab expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Chemomab's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based, except as required by law.
About Chemomab Therapeutics Ltd.
Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique and pivotal role of CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody that neutralizes CCL24 activity. In clinical and preclinical studies, CM-101 appears safe, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported positive results from three clinical trials of CM-101 in patients, including a Phase 2a liver fibrosis trial in NASH patients and an investigator-initiated study in patients with severe lung injury. A Phase 2 trial in primary sclerosing cholangitis has completed patient enrollment, with topline data expected midyear 2024. Chemomab’s CM-101 program for the treatment of systemic sclerosis is Phase 2-ready with an open U.S. IND. For more information about Chemomab, visit chemomab.com.
Contacts:
Media & Investors:
Chemomab Therapeutics
Barbara Lindheim
Consulting Vice President
Investor & Public Relations,
Strategic Communications
Phone: +1 917-355-9234
barbara.lindheim@chemomab.com
IR@chemomab.com
临床结果临床2期临床1期
2024-06-06
—Ex Vivo Studies Using Clinical Samples from Patients with Liver Fibrosis Reinforce the Anti-Fibrotic Activity of CM-101 by Showing the Drug’s Direct Interference with Liver Fibroblast Activation—
—New Translational Data Further Confirms CM-101’s Disease Modifying Activity in Primary Sclerosing Cholangitis—
TEL AVIV, Israel, June 06, 2024 (GLOBE NEWSWIRE) -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB) (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today reported that it presented two scientific posters supporting the clinical rationale for the company’s primary sclerosing cholangitis (PSC) program at EASL 2024, the Annual Congress of the European Association for the Study of the Liver, which is taking place June 5-8, 2024 in Milan, Italy. Chemomab also announced a poster presentation at the Gordon Research Conference on Chemotactic Cytokines, held June 2-7, 2024 in Portland, Maine.
The presentations cover a range of topics, from new preclinical studies further elucidating the roles of the novel soluble protein target CCL24 and Chemomab’s CCL24-neutralizing antibody CM-101 in fibro-inflammatory liver disorders, to translational research supporting the clinical development of CM-101 for PSC, a rare and often fatal liver disease.
The first EASL poster describes an ex vivo-developed translational assay designed to further characterize the anti-fibrotic activity of CM-101 in patients with liver disease.1 This study was selected for an EASL 2024 Poster Tour highlighting presentations of special interest. Using a serum-based ex vivo hepatic stellae cell (HSC) activation assay derived from patients with liver fibrosis due to metabolic dysfunction-associated steatohepatitis (MASH), the study showed that sera from these patients directly activates HSCs and that HSC activation levels were significantly reduced in the sera of patients treated with CM-101. Importantly, a protein signature generated from CCL24-activated HSCs was able to predict PSC disease and its severity. These findings support CM-101’s mode of action in liver fibrosis and are expected to help in characterizing its anti-fibrotic drug effects by serving as a translational tool in PSC clinical trials.
In a second poster2, researchers presented a comprehensive proteomic profiling study of patients with PSC, which was combined with machine learning-based methods to develop a protein signature model that successfully predicted the presence and severity of PSC when combined with proteins correlated with the Enhanced Liver Function (ELF) biomarker score. The machine learning analysis was also able to identify key proteins associated with PSC progression. Additionally, the model showed that high CCL24 levels were associated with cirrhosis in patients with PSC. The findings emphasize the value of targeting CCL24 in PSC treatment.
“As we approach the topline readout of our CM-101 Phase 2 PSC trial, we welcome the opportunity to highlight important new data at EASL 2024 and at a prestigious Gordon Research Conference,” noted Adi Mor, PhD, co-founder, Chief Executive Officer and Chief Scientific Officer of Chemomab. “We are especially excited about the novel translational work from our R&D team included in two presentations at EASL. In one, an ex vivo translational assay we developed confirmed that serum from patients with liver fibrosis activates HSCs, a key driver of PSC pathology, and that administration of CM-101 significantly reduces this HSC activation, indicating that inhibition of CCL24 is sufficient to attenuate HSC activation. The second study presented a proteomics and machine learning-based PSC protein signature model developed by Chemomab researchers that has potential as a biomarker for monitoring and assessing drug activity in current and future clinical trials of CM-101.”
The Gordon Conference presentation3 highlighted preclinical studies that provide further evidence of the key role of CCL24 in driving fibro-inflammatory pathways in liver diseases such as primary sclerosing cholangitis, as well as the ability of Chemomab’s CCL24-neutralizing antibody CM-101 to block these effects and attenuate inflammation and fibrosis.
The posters will be available post-conference on the Chemomab website at .
1 - Ex-vivo translational assay of hepatic stellate cells using patient-derived serum characterizes the anti-fibrotic activity of CM-101, J Amer, A Salhab, R Greenman, A Katav, T Snir, R Aricha, M Frankel, J Lawler, F Saffioti, D Thorburn, M Pinzani, I Vaknin, A Mor and R Safadi, June 6, 2024, Fibrosis/Stellate cell biology session, EASL abstract #380
2 - Machine learning-driven identification of serum protein signature for primary sclerosing cholangitis and enhanced liver fibrosis score, T Snir, R Greenman, A Katav, R Aricha, M Frankel, J Lawler, F Saffioti, D Thorburn, M Pinzani, I Vaknin, A Mor, June 6, 2024, Immune-mediated and cholestatic: Experimental and pathophysiology session, EASL abstract #1032
3 - Attenuating liver fibrosis and inflammation: blocking CCL24 inhibits recruitment of hepatic stellate cells, monocytes and neutrophils and modulates hepatic stellate cell activation, R Greenman, O Hay, I Mishalian, I Vaknin, M Pinzani, D Thorburn, J Amer, A Salhab, R Safadi, A Mor, A Peled, June 2-7, 2024, Gordon Research Conference on Chemotactic Cytokines
Forward Looking Statements
This press release contains "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act. These forward-looking statements include, among other things, the clinical development pathway for CM-101; the expectation that Chemomab will report topline data from the PSC clinical trial by mid-year 2024; the length, duration and impact of the war in Israel on Chemomab’s business and operations; the future operations of Chemomab and its ability to successfully initiate and complete clinical trials and achieve regulatory milestones; the nature, strategy and focus of Chemomab; the development and commercial potential and potential benefits of any product candidates of Chemomab; and that the product candidates have the potential to address high unmet needs of patients with serious fibrosis-related diseases and conditions. Any statements contained in this communication that are not statements of historical fact may be deemed to be forward-looking statements. These forward-looking statements are based upon Chemomab's current expectations. Forward-looking statements involve risks and uncertainties. Because such statements deal with future events and are based on Chemomab's current expectations, they are subject to various risks and uncertainties and actual results, performance or achievements of Chemomab could differ materially from those described in or implied by the statements in this presentation, including those found under the caption "Risk Factors" and elsewhere in Chemomab's filings and reports with the SEC. Chemomab expressly disclaims any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in Chemomab's expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based, except as required by law.
About Chemomab Therapeutics Ltd.
Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique and pivotal role of CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody that neutralizes CCL24 activity. In clinical and preclinical studies, CM-101 appears safe, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported positive results from three clinical trials of CM-101 in patients, including a Phase 2a liver fibrosis trial in NASH patients and an investigator-initiated study in patients with severe lung injury. A Phase 2 trial in primary sclerosing cholangitis has completed patient enrollment, with topline data expected midyear 2024. Chemomab’s CM-101 program for the treatment of systemic sclerosis is Phase 2-ready with an open U.S. IND. For more information about Chemomab, visit chemomab.com.
Contacts:
Media & Investors:
Chemomab Therapeutics
Barbara Lindheim
Consulting Vice President
Investor & Public Relations,
Strategic Communications
Phone: +1 917-355-9234
barbara.lindheim@chemomab.com
IR@chemomab.com
临床2期临床结果
2024-05-17
TEL AVIV, Israel, May 17, 2024 (GLOBE NEWSWIRE) -- Chemomab Therapeutics Ltd. (Nasdaq: CMMB) (Chemomab), a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need, today announced upcoming scientific presentations at the Gordon Research Conference on Chemotactic Cytokines and at EASL 2024, the Annual Congress of the European Association for the Study of the Liver. The presentations cover a range of topics, from new preclinical studies further elucidating the roles of the soluble protein target CCL24 and Chemomab’s CCL24 neutralizing antibody CM-101 in fibro-inflammatory disease, to novel translational research designed to support the ongoing clinical development of CM-101 for primary sclerosing cholangitis, a rare and often fatal fibrotic liver disease. The presentations will be made available and described in greater detail post embargo. Gordon Research Conference: Chemotactic Cytokines - Portland, Maine, USA, June 2-7, 2024 Date:June 2-7, 2024Format:Poster presentation: Attenuating liver fibrosis and inflammation: blocking CCL24 inhibits recruitment of hepatic stellate cells, monocytes and neutrophils and modulates hepatic stellate cell activationPresenter:Prof. Amnon Peled, Hadassah University Hospital; Faculty of Medicine, Hebrew UniversityInformation:2024 Chemotactic Cytokines Conference GRC EASL Congress 2024 – Milan, Italy, June 5-8, 2024 Date:June 6, 2024Time:8:30-18:00 CESTFormat:Poster presentation: Ex-vivo translational assay of hepatic stellate cells using patient- derived serum characterizes the anti-fibrotic activity of CM-101Presenter:Revital Aricha, PhD, Vice President, Translational Science, Chemomab TherapeuticsSession:Poster - Fibrosis/Stellate cell biology, Abstract #380 Date:June 6, 2024Time:8:30-17:00 CESTFormat:Poster presentation: Machine learning-driven identification of serum protein signature for primary sclerosing cholangitis and enhanced liver fibrosis scorePresenter: Ilan Vaknin, PhD, Vice President, R&D, Chemomab TherapeuticsSession:Immune-mediated and cholestatic: Experimental and pathophysiology, Abstract #1032 Date:June 7, 2024Time:12:25-13:45 CESTFormat:Poster Tour: Ex-vivo translational assay of hepatic stellate cells using patient-derived serum characterizes the anti-fibrotic activity of CM-101Presenter:Ilan Vaknin, PhD, Vice President, R&D, Chemomab TherapeuticsSession:Fibrosis/Stellate Cell Biology Poster Tour, Abstract #380Location:Basic Science Track HubInformation:EASL Congress 2024 In addition, Chemomab Corporate Development will be in San Diego June 3-6, 2024, participating in the BIO International Convention’s One-on-One Partnering™ event. Registered attendees can click here to log in and schedule a meeting with Chemomab. About Chemomab Therapeutics Ltd.Chemomab is a clinical stage biotechnology company developing innovative therapeutics for fibro-inflammatory diseases with high unmet need. Based on the unique and pivotal role of CCL24 in promoting fibrosis and inflammation, Chemomab developed CM-101, a monoclonal antibody that neutralizes CCL24 activity. In clinical and preclinical studies, CM-101 appears safe, with the potential to treat multiple severe and life-threatening fibro-inflammatory diseases. Chemomab has reported positive results from three clinical trials of CM-101 in patients, including a Phase 2a liver fibrosis trial in NASH patients and an investigator-initiated study in patients with severe lung injury. A Phase 2 trial in primary sclerosing cholangitis has completed patient enrollment, with topline data expected midyear 2024. Chemomab’s CM-101 program for the treatment of systemic sclerosis is Phase 2-ready with an open U.S. IND. For more information about Chemomab, visit chemomab.com. Contacts: Media & Investors:Chemomab TherapeuticsBarbara LindheimConsulting Vice PresidentInvestor & Public Relations, Strategic CommunicationsPhone: +1 917-355-9234barbara.lindheim@chemomab.com IR@chemomab.com
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 系统性硬皮病 | 临床2期 | 美国 | 2023-02-21 | |
| 非酒精性脂肪性肝炎 | 临床2期 | 以色列 | 2021-02-24 | |
| 原发性硬化性胆管炎 | 临床2期 | 美国 | 2020-10-01 | |
| 原发性硬化性胆管炎 | 临床2期 | 德国 | 2020-10-01 | |
| 原发性硬化性胆管炎 | 临床2期 | 以色列 | 2020-10-01 | |
| 原发性硬化性胆管炎 | 临床2期 | 西班牙 | 2020-10-01 | |
| 原发性硬化性胆管炎 | 临床2期 | 英国 | 2020-10-01 |
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| 研究 | 分期 | 人群特征 | 评价人数 | 分组 | 结果 | 评价 | 发布日期 |
|---|
临床2期 | 23 | 鑰膚鬱鑰艱憲廠簾顧範(選餘鹹艱壓簾願餘鹹餘) = significant reduction 網鹽觸遞壓膚顧淵遞範 (鹽鬱醖獵簾鹽壓觸壓築 ) 更多 | 积极 | 2023-11-13 | |||
placebo | |||||||
临床2期 | 23 | 餘觸選窪鬱範繭築顧糧(淵糧衊構膚顧艱鹹憲顧) = 鏇鹹繭鹽鹽鑰餘鑰鏇製 鹽積簾遞鏇鬱夢繭衊網 (膚鹹選範齋構鹽壓夢觸 ) | - | 2023-06-21 | |||
Placebo | 餘觸選窪鬱範繭築顧糧(淵糧衊構膚顧艱鹹憲顧) = 鏇簾鹹獵窪壓壓積網鬱 鹽積簾遞鏇鬱夢繭衊網 (膚鹹選範齋構鹽壓夢觸 ) |
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