A Phase III Single-center, Randomized, Double-Blinded, Parallel-group, Active Controlled Study to Evaluate the Efficacy and Safety of a Single Dose of Emodepside Compared to Multiple Doses of Mebendazole in Adolescent and Adult Participants With Soil-transmitted Helminthiasis

This study aims to assess the efficacy and safety of emodepside compared to mebendazole in adults and adolescents infected with T. trichiura, either as single infection or co-infections with hookworm and/or A. lumbricoides.

开始日期2026-01-01

申办/合作机构

Swiss Tropical & Public Health Institute

[+3]

NCT06736691

/ Not yet recruiting临床3期IIT

A Phase III Single-center, Randomized, Double-blinded, Parallel-group, Active-controlled Study to Evaluate the Efficacy and Safety of a Single Dose of Emodepside Compared to Multiple Doses of Mebendazole in Adolescent and Adult Participants With Soil-transmitted Helminthiasis

开始日期2025-10-01

申办/合作机构

Swiss Tropical & Public Health Institute

[+3]

NCT06373835

/ Completed临床2期IIT

Efficacy, Safety and Pharmacokinetics of Ascending Dosages of Emodepside and in Comparison to Ivermectin Against Strongyloidiasis Stercoralis in Adults: Randomized Stage II Seamless Adaptive Controlled Trials

Efficacy, safety and pharmacokinetics of ascending dosages of emodepside and in comparison to ivermectin against Strongyloidiasis stercoralis in adults: randomized stage II seamless adaptive controlled trials

开始日期2024-05-20

申办/合作机构

Swiss Tropical & Public Health Institute

100 项与 Emodepside 相关的临床结果

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100 项与 Emodepside 相关的转化医学

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100 项与 Emodepside 相关的专利（医药）

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187

项与 Emodepside 相关的文献（医药）

2025-12-01·BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of the new active ingredient tigolaner, an allosteric modulator of the GABA-gated chloride channel for use as a spot-on ectoparasiticide in animal health

Article

作者: Turberg, Andreas ; Raming, Klaus ; Mencke, Norbert ; Hallenbach, Werner ; Lösel, Peter ; Ebbinghaus-Kintscher, Ulrich ; Köbberling, Johannes ; Schwarz, Hans-Georg ; Bretschneider, Thomas ; Maue, Michael ; Neumann, Julia Hahn ; Hübsch, Walter ; Adamczewski, Martin ; Lindner, Niels ; Fischer, Reiner ; Décor, Anne ; Görgens, Ulrich ; Ilg, Kerstin ; Wölfel, Katharina

Parasiticides play a crucial role in animal health. The need for innovative ectoparasiticides for companion animals has been growing, driven by the risks posed by parasites to both animals and humans. We detail here the discovery pathway of tigolaner, an ectoparasiticide, offering up to 13 weeks protection against fleas and ticks to cats. Felpreva® employs this active ingredient for ectoparasite control together with the endoparasiticides emodepside and praziquantel. It was approved by the European Medicines Agency in November 2021. The discovery of tigolaner resulted from research at Bayer focused on finding novel molecules inhibiting GABA-gated chloride channels (GABA-Cls), with an improved toxicological profile and resistance-breaking potential when compared to dieldrin and fipronil. A high-throughput in vitro screening campaign on GABA-Cls, followed by a "mix-match" synthetic approach, led to the identification of several lead compounds acting as allosteric modulators. The GABA lead class compounds showed a different binding site when compared to fipronil. They have a unique chemotype based on a pyrazole moiety. Further variations of the central ring led to the discovery of tigolaner. Selected structure-activity relationships from the project are presented. Some synthetic pathways for tigolaner and its analogs are also described. This publication also outlines the efficacy of tigolaner against various parasites, making it a key compound of the Felpreva® product.

2025-11-01·LANCET INFECTIOUS DISEASES

Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial

Article

作者: Many, Sysouphanh ; Jeanguenat, Hannah ; Taylor, Lyndsay ; Hattendorf, Jan ; Sayasone, Somphou ; Keiser, Jennifer

BACKGROUND:

Strongyloidiasis is a pernicious, sometimes fatal, infectious disease caused by the parasitic nematode Strongyloides stercoralis and infects millions of people worldwide. Ivermectin is the only recommended single-dose treatment option available, but concerns of drug resistance are rightly founded, therefore driving the demand for efficacious alternatives. Emodepside, an anthelmintic recently repurposed from the veterinary field, is currently under clinical development for the treatment of onchocerciasis and soil-transmitted helminthiasis. We aimed to identify the most efficacious and safe dose of emodepside against S stercoralis infections.

METHODS:

We conducted a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial. Recruitment took place in 17 endemic villages in the Champhone district of Laos. Adults aged 18-60 years who provided three stool samples with a mean number of S stercoralis larvae per g of at least 0·75, as assessed by sextuplicate Baermann assays, were invited to participate. Clinically eligible participants were randomly assigned (1:1:1:1:1:1:1:1) to receive a single oral dose of placebo, ivermectin (200 μg/kg), or emodepside at doses 5 mg, 10 mg, 15 mg, 20 mg, 25 mg, or 30 mg. The participants, laboratory technicians, study nurses, and physicians were masked to the treatment assignments; study investigators were not masked. Participants providing at least one sample during follow-up were included in the primary outcome analysis, whereby efficacy was estimated by cure rate (defined as the proportion of participants who became S stercoralis negative 14-21 days after treatment). Treated patients were assessed for adverse events at 3-h, 24-h, 72-h, and 14 days post-treatment. This trial is registered at ClinicalTrials.gov (NCT06373835) and is completed.

FINDINGS:

Between May 20, 2024, and Aug 14, 2024, 820 individuals were screened for S stercoralis infection and, of these, 202 individuals (108 male and 94 female) were randomly allocated to treatment groups and treated. 25 participants were treated with ivermectin, 25 with placebo, 25 participants with emodepside at 5 mg, 15 mg, 25 mg, or 30 mg dose, and 26 participants with emodepside at 10 mg or 20 mg dose. 5 mg emodepside had a predicted cure rate of 78·3% (95% CI 59·4-89·9), which was higher than the observed cure rate in the placebo treatment group (0%; 0·0-13·7; 0 of 25 participants). The dose-response curve plateaued at 15 mg, with a predicted cure rate of 89·1% (81·6-93·7). The observed cure rate in the ivermectin treatment group was 88·0% (68·8-97·5; 22 of 25 participants). The most common adverse event in all treatment groups was somnolence at 3-h post-treatment (ranging from nine [36%] of 25 participants in the emodepside 15 mg group to 17 [68%] of 25 in the 30 mg group). Other common adverse events included vision blur (two [8%] of 25 participants in the ivermectin group to 11 [44%] of 25 in the emodepside 30 mg group at 3-h post-treatment), vision impairment (three [4%] of 26 in the 10 mg group to eight [32%] of 25 in the emodepside 30 mg group), and dizziness (two [8%] of 25 participants in the emodepside 5 mg group to seven [28%] of 25 in the emodepside 30 mg group) at 3-h post-treatment. Adverse events were predominantly mild in nature and no serious adverse events occurred.

INTERPRETATION:

At all doses tested, emodepside was efficacious and well tolerated in individuals infected with S stercoralis. The broad-spectrum weight-independent dose and robust safety profile positions emodepside as a promising new candidate for strongyloidiasis treatment.

FUNDING:

European Research Council and the Uniscientia Foundation.

2025-10-01·LANCET INFECTIOUS DISEASES

Emodepside for strongyloidiasis: insights from parasite genetics

Letter

作者: Jin, Xuemin ; Liu, Mingyuan ; Liu, Xiaolei

项与 Emodepside 相关的新闻（医药）

2025-10-26

·道道之道

【本周医刊】2025年第43周医学期刊更新

2025年第43周（2025.10.19-2025.10.25）重要医学期刊论著更新如下： 1.综合期刊 LANCET 题目：Ibrutinib and rituximab versus immunochemotherapy in patients with previously untreated mantle cell lymphoma (ENRICH): a randomised, open-label, phase 2/3 superiority trial 翻译：伊布替尼联合利妥昔单抗对比免疫化疗治疗初治套细胞淋巴瘤患者（ENRICH研究）：一项随机、开放标签、2/3期优效性试验题目：Prognostic accuracy of clinical markers of postpartum bleeding in predicting maternal mortality or severe morbidity: a WHO individual participant data meta-analysis 翻译：产后出血临床标志物预测孕产妇死亡或严重并发症的预后准确性：一项世界卫生组织（WHO）个体参与者数据荟萃分析题目：Sultiame once per day in obstructive sleep apnoea (FLOW): a multicentre, randomised, double-blind, placebo-controlled, dose-finding, phase 2 trial 翻译：每日一次舒噻美治疗阻塞性睡眠呼吸暂停（FLOW研究）：一项多中心、随机、双盲、安慰剂对照、剂量探索2 期试验题目：Assessment of malnutrition in preschool-aged children by mid-upper arm circumference in the Gaza Strip (January, 2024–August, 2025): a longitudinal, cross-sectional, surveillance study 翻译：加沙地带通过上臂中围评估学龄前儿童营养不良状况（2024年1 月—2025年8 月）：一项纵向横断面监测研究 NEW ENGLAND JOURNAL OF MEDICINE 题目：Hypertonic Saline or Carbocisteine in Bronchiectasis 翻译：支气管扩张症中的高渗盐水或羧甲司坦题目：Aspirin in Patients with Chronic Coronary Syndrome Receiving Oral Anticoagulation 翻译：阿司匹林在接受口服抗凝治疗的慢性冠状动脉综合征患者中的作用题目：Common Diseases in Clinical Cohorts — Not Always What They Seem 翻译：临床队列中的常见疾病——并非总是看起来那样题目：Sotatercept for Pulmonary Arterial Hypertension within the First Year after Diagnosis 翻译：索他西普用于诊断后第一年内的肺动脉高压题目：Association of 2024–2025 Covid-19 Vaccine with Covid-19 Outcomes in U.S. Veterans 翻译：2024-2025 年新冠疫苗与美国退伍军人新冠病毒感染结局的关联 BMJ-BRITISH MEDICAL JOURNAL 题目：Exposure to sugar rationing in first 1000 days after conception and long term cardiovascular outcomes 翻译：受孕后前 1000 天糖配给暴露与长期心血管结局题目：Anti-CD38 monoclonal antibody CM313 for primary immune thrombocytopenia 翻译：抗 CD38 单克隆抗体CM313 用于原发性免疫性血小板减少症 JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 题目：Everolimus and Low-Dose Tacrolimus After Heart Transplant in Children: A Randomized Clinical Trial 翻译：儿童心脏移植后使用依维莫司和低剂量他克莫司的随机临床试验题目：Remote Screening for Asymptomatic Atrial Fibrillation: The AMALFI Randomized Clinical Trial 翻译：无症状性心房颤动的远程筛查：AMALFI 随机临床试验 NATURE MEDICINE 题目：Cardiotropic AAV gene therapy for heart failure: a phase 1 trial 翻译：心力衰竭的亲心肌腺相关病毒（AAV）基因疗法：一项1 期试验题目：Safety and pharmacokinetics of SARS-CoV-2 DNA-encoded monoclonal antibodies in healthy adults: a phase 1 trial 翻译：SARS-CoV-2 DNA 编码的单克隆抗体在健康成年人中的安全性和药代动力学：一项1 期试验题目：Plasma proteome adaptations during feminizing gender-affirming hormone therapy 翻译：女性化性别确认激素治疗期间的血浆蛋白质组适应性变化题目：Myelin injury precedes axonal injury and symptomatic onset in multiple sclerosis 翻译：在多发性硬化症中，髓鞘损伤先于轴突损伤和症状发作题目：Circulating tumor DNA-guided adjuvant therapy in locally advanced colon cancer: the randomized phase 2/3 DYNAMIC-III trial 翻译：循环肿瘤 DNA 指导的局部晚期结肠癌辅助治疗：随机2/3 期DYNAMIC-III 试验题目：YAP/TEAD inhibitor VT3989 in solid tumors: a phase 1/2 trial 翻译：YAP/TEAD 抑制剂VT3989 用于实体瘤：一项1/2 期试验 LANCET DIGITAL HEALTH（本周无更新） NPJ DIGITAL MEDICINE 题目：Evaluating human-in-the-loop strategies for artificial intelligence-enabled translation of patient discharge instructions: a multidisciplinary analysis 翻译：评估人工智能辅助的患者出院指导翻译中人工介入策略：一项多学科分析题目：Active remote monitoring of long-term conditions with mobile devices: a systematic review of cost-effectiveness analyses 翻译：使用移动设备对长期病症进行主动远程监测：成本效益分析的系统综述题目：Real-time detection of respiratory circuit events in mechanical ventilation using deep learning 翻译：基于深度学习的机械通气中呼吸回路事件的实时检测题目：HONeYBEE: enabling scalable multimodal AI in oncology through foundation model-driven embeddings 翻译：HONeYBEE：通过基础模型驱动的嵌入在肿瘤学中实现可扩展的多模态人工智能题目：Location and amount of joint involvement differentiates rheumatoid arthritis into different clinical subsets 翻译：关节受累的部位和程度将类风湿关节炎分为不同的临床亚组题目：Streamlined machine learning model for early sepsis risk prediction in burn patients 翻译：用于烧伤患者早期败血症风险预测的简化机器学习模型题目：A deep learning based automatic report generator for retinal optical coherence tomography images 翻译：基于深度学习的视网膜光学相干断层扫描图像自动报告生成器 2.肿瘤学 CA-A CANCER JOURNAL FOR CLINICIANS（本周无更新） ANNALS OF ONCOLOGY 题目：Neoadjuvant trastuzumab deruxtecan alone or followed by paclitaxel, trastuzumab, and pertuzumab for high-risk HER2-positive early breast cancer (DESTINY-Breast11): a randomised, open-label, multicentre, phase 3 trial 翻译：曲妥珠单抗德鲁替康单药或序贯紫杉醇、曲妥珠单抗和帕妥珠单抗用于高危HER2 阳性早期乳腺癌（DESTINY-Breast11）：一项随机、开放标签、多中心的3 期试验题目：Improved survival and rising incidence: insights from the largest retrospective study on leptomeningeal metastases in patients with NSCLC 翻译：生存率提高与发病率上升：来自非小细胞肺癌脑膜转移最大规模回顾性研究的见解题目：Patient-reported outcomes in the SERENA-6 trial of camizestrant plus CDK4/6 inhibitor in patients with advanced breast cancer and emergent ESR1 mutations during first-line endocrine-based therapy 翻译：在 SERENA-6 试验中，卡米司琼联合CDK4/6 抑制剂治疗一线内分泌治疗期间出现ESR1 突变的晚期乳腺癌患者的患者报告结局题目：The evolving landscape of leptomeningeal metastases from NSCLC: an international, contemporary, multicenter cohort study 翻译：非小细胞肺癌脑膜转移的演变格局：一项国际性、当代、多中心队列研究题目：Capivasertib plus abiraterone in PTEN-deficient metastatic hormone-sensitive prostate cancer: CAPItello-281 Phase III study 翻译：Capivasertib 联合阿比特龙用于PTEN 缺陷型转移性激素敏感性前列腺癌：CAPItello-281 3 期研究 JOURNAL OF CLINICAL ONCOLOGY（本周无更新） LANCET ONCOLOGY（本周无更新） NATURE CANCER 题目：Engineering T cells with a membrane-tethered version of SLP-76 overcomes antigen-low resistance to CAR T cell therapy 翻译：用膜结合型 SLP-76 改造T 细胞可克服CAR-T 细胞疗法对低抗原的耐药性题目：MEF2D-expressing cancer precursors reprogram tissue-resident macrophages to support liver tumorigenesis 翻译：表达 MEF2D 的癌前细胞重编程组织驻留巨噬细胞以支持肝脏肿瘤发生 JAMA ONCOLOGY（本周无更新） CANCER RESEARCH（本周无更新） CLINICAL CANCER RESEARCH（本周无更新） JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE（本周无更新） 3.内分泌学与代谢 LANCET DIABETES & ENDOCRINOLOGY（本周无更新） 4.呼吸病学 LANCET RESPIRATORY MEDICINE（本周无更新） 5.心血管病学 EUROPEAN HEART JOURNAL 题目：Efficacy of aficamten in patients with obstructive hypertrophic cardiomyopathy and mild symptoms: results from the SEQUOIA-HCM trial 翻译：阿凡卡坦治疗症状轻微的梗阻性肥厚型心肌病患者的疗效：SEQUOIA-HCM试验结果题目：Cardiac amyloidosis detection from a single echocardiographic video clip: a novel artificial intelligence-based screening tool 翻译：从单个超声心动图视频片段检测心脏淀粉样变性：一种新型的基于人工智能的筛查工具题目：Empagliflozin enhances metabolic efficiency and improves left ventricular hypertrophy in a hypertrophic cardiomyopathy mouse model 翻译：恩格列净在肥厚型心肌病小鼠模型中提高代谢效率并改善左心室肥厚 CIRCULATION 题目：Ivabradine in Patients Undergoing Noncardiac Surgery: A Randomized Controlled Trial 翻译：伊伐布雷定在非心脏手术患者中的应用：一项随机对照试验题目：Sacubitril/Valsartan and Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy: The PRADA II Randomized Clinical Trial 翻译：沙库巴曲缬沙坦与辅助乳腺癌治疗期间心脏功能障碍的预防：PRADA II 随机临床试验题目：PYGM Protects Against Myocardial Infarction by Enhancing Glycogenolysis and Facilitating Autophagic Flux 翻译：PYGM 通过增强糖原分解和促进自噬流来预防心肌梗死 JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 题目：Effect of Intensive Blood Pressure Lowering Treatment on Retinal Microvasculature: Secondary Analysis From ESPRIT 翻译：强化降压治疗对视网膜微血管的影响：ESPRIT研究的二次分析题目：Modest Effects of Intensive Blood Pressure–Lowering on Quality of Life in Patients at High Cardiovascular Risk: The ESPRIT Trial 翻译：强化降压对高心血管风险患者生活质量的适度影响：ESPRIT试验题目：Effect of Intensive Blood Pressure Control on Stroke: A Prespecified Secondary Analysis of the ESPRIT Trial 翻译：强化血压控制对中风的影响：ESPRIT 试验的预先指定二次分析题目：Intensive Blood Pressure Control in Older Patients With Hypertension: 6-Year Results of the STEP Trial 翻译：老年高血压患者的强化血压控制：STEP 试验的6 年结果题目：Using PREVENT Equations to Compare Intensive vs Standard Systolic Blood Pressure Control for Primary Prevention in SPRINT 翻译：使用 PREVENT 方程比较SPRINT 研究中强化与标准收缩压控制用于一级预防的效果 6.传染病学 LANCET INFECTIOUS DISEASES 题目：Olorofim for the treatment of invasive fungal diseases in patients with few or no therapeutic options: a single-arm, open-label, phase 2b study 翻译：奥洛非芬用于治疗几乎无治疗选择或无治疗选择的侵袭性真菌病患者：一项单臂、开放标签的2b 期研究题目：Effectiveness and impact of nirsevimab in Chile during the first season of a national immunisation strategy against RSV (NIRSE-CL): a retrospective observational study 翻译：智利全国呼吸道合胞病毒（RSV）免疫策略首个季节中尼塞韦单抗的有效性及影响（NIRSE-CL研究）：一项回顾性观察研究题目：Incidence of health-care-associated infections in long-term care facilities in nine European countries: a 12-month, prospective, longitudinal cohort study 翻译：欧洲 9 个国家长期护理机构中医院相关性感染的发生率：一项为期12 个月的前瞻性纵向队列研究题目：Sutezolid in combination with bedaquiline, delamanid, and moxifloxacin for pulmonary tuberculosis (PanACEA-SUDOCU-01): a prospective, open-label, randomised, phase 2b dose-finding trial 翻译：舒他唑利联合贝达喹啉、德拉马尼与莫西沙星治疗肺结核（PanACEA-SUDOCU-01研究）：一项前瞻性、开放标签、随机的2b 期剂量探索试验题目：Delpazolid in combination with bedaquiline, delamanid, and moxifloxacin for pulmonary tuberculosis (PanACEA-DECODE-01): a prospective, randomised, open-label, phase 2b, dose-finding trial 翻译：地帕唑利联合贝达喹啉、德拉马尼与莫西沙星治疗肺结核（PanACEA-DECODE-01研究）：一项前瞻性、随机、开放标签的2b 期剂量探索试验题目：Efficacy, immunogenicity, and safety of a next-generation mRNA-1283 COVID-19 vaccine compared with the mRNA-1273 vaccine (NextCOVE): results from a phase 3, randomised, observer-blind, active-controlled trial 翻译：新一代 mRNA-1283 新冠疫苗与mRNA-1273 疫苗的有效性、免疫原性及安全性对比（NextCOVE研究）：一项3 期、随机、观察者设盲、活性对照试验结果题目：Extended nirmatrelvir–ritonavir treatment durations for immunocompromised patients with COVID-19 (EPIC-IC): a placebo-controlled, randomised, double-blind, phase 2 trial 翻译：延长奈玛特韦 - 利托那韦治疗免疫功能低下新冠患者的疗程（EPIC-IC研究）：一项安慰剂对照、随机、双盲的2 期试验题目：Efficacy and safety of ascending doses of emodepside in comparison with ivermectin in adults infected with Strongyloides stercoralis in Laos: a phase 2a, dose-ranging, randomised, parallel-group, placebo-controlled, single-blind clinical trial 翻译：老挝地区感染粪类圆线虫的成人中，递增剂量的依莫帕米与伊维菌素的有效性及安全性对比：一项2a 期、剂量范围探索、随机、平行组、安慰剂对照、单盲临床试验 CLINICAL MICROBIOLOGY AND INFECTION 题目：Survival and quality-of-life in mucormycosis: a multicentric ambispective cohort study 翻译：毛霉菌病患者的生存率与生活质量：一项多中心双向性队列研究题目：Humoral and cellular immune responses in people living with HIV following successive COVID-19 vaccine booster doses 翻译：人类免疫缺陷病毒（HIV）感染者接种多剂新冠疫苗加强针后的体液与细胞免疫应答题目：Characterization of post-acute multi-organ sequelae following dengue infection 翻译：登革热感染后急性后期多器官后遗症的特征分析题目：Methenamine hippurate as prophylaxis for recurrent urinary tract infections in older women—a triple-blind, randomised, placebo-controlled, phase IV trial (ImpresU) 翻译：马尿酸乌洛托品用于老年女性复发性尿路感染的预防——一项三盲、随机、安慰剂对照的IV 期试验（ImpresU研究）题目：Clinical performance of a genotyping assay based on a hybrid capture technique in cervical cancer screening in China: a prospective population-based multicentre cohort study 翻译：基于杂交捕获技术的基因分型检测在中国宫颈癌筛查中的临床性能：一项基于人群的前瞻性多中心队列研究题目：Multicentre evaluation of a EUCAST-based agar-screening method for terbinafine and itraconazole susceptibility of Trichophyton spp 翻译：基于欧洲抗菌药物敏感性试验委员会（EUCAST）标准的琼脂筛查法用于毛癣菌属对特比萘芬和伊曲康唑敏感性检测的多中心评价题目：Enterobacteralesgut colonization and late-onset sepsis in neonates: a multicentre prospective study across 18 neonatal intensive care units in six countries 翻译：新生儿肠道肠杆菌目细菌定植与晚发性败血症：一项涵盖6 国18 个新生儿重症监护室的多中心前瞻性研究题目：Effectiveness of COVID-19 vaccination among dialysis and kidney transplant patients compared with matched controls—a nationwide cohort study 翻译：透析与肾移植患者新冠疫苗接种的有效性：一项与匹配对照人群对比的全国性队列研究题目：Screening and targeted prophylaxis for Clostridioides difficile infection 翻译：艰难梭菌感染的筛查与靶向预防 7.胃肠肝病学 LANCET GASTROENTEROLOGY & HEPATOLOGY（本周无更新） JOURNAL OF HEPATOLOGY（本周无更新） GASTROENTEROLOGY 题目：Barrett’s Oesophagus Surveillance Versus Endoscopy at Need Study (BOSS): A Randomized Controlled Trial 翻译：巴雷特食管监测与按需内镜检查研究（BOSS）：一项随机对照试验题目：Cost-Effectiveness of Regular Surveillance Versus Endoscopy at Need for Patients With Barrett’s Esophagus: Economic Evaluation Alongside the Barrett’s Oesophagus Surveillance Study (BOSS) Randomized Controlled Trial 翻译：巴雷特食管患者定期监测与按需内镜检查的成本效益：基于巴雷特食管监测研究（BOSS）随机对照试验的经济学评价题目：Blood-Based T-Cell Diagnosis of Celiac Disease 翻译：基于血液的 T 细胞检测诊断乳糜泻题目：Glucagon-Like Peptide-1 Receptor Agonists and Gastrointestinal Adverse Events: A Systematic Review and Meta-Analysis 翻译：胰高血糖素样肽 - 1 受体激动剂与胃肠道不良事件：一项系统评价与荟萃分析题目：An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease 翻译：炎症性肠病临床试验中糖皮质激素合理使用的国际共识 GUT 题目：Characteristics of an antibody profile associated with protection against hepatitis C virus reinfection in a high-risk cohort 翻译：高危队列中与丙型肝炎病毒再感染保护相关的抗体谱特征题目：SIRT6 promotes intrahepatic cholangiocarcinoma development by reprogramming glutamine metabolism via enhanced GLUL 翻译：SIRT6 通过增强GLUL 重编程谷氨酰胺代谢，从而促进肝内胆管癌发生发展题目：First genome-wide association study reveals immune-mediated aetiopathology in idiopathic achalasia 翻译：首项全基因组关联研究揭示特发性贲门失弛缓症的免疫介导发病机制题目：iPSC-induced multilineage liver organoids, small intestinal organoids and brain organoids sustain pangenotype hepatitis E virus propagation 翻译：诱导多能干细胞（iPSC）构建的多谱系肝类器官、小肠类器官及脑类器官可支持全基因型戊型肝炎病毒增殖题目：PDE5A+cancer-associated fibroblasts enhance immune suppression in gastric cancer 翻译：表达 PDE5A 的癌相关成纤维细胞增强胃癌中的免疫抑制 HEPATOLOGY（本周无更新） CLINICAL GASTROENTEROLOGY AND HEPATOLOGY 题目：Efficacy and Safety of Budesonide Orodispersible Tablets for Eosinophilic Esophagitis up to 3 Years: An Open-Label Extension Study 翻译：布地奈德口崩片治疗嗜酸性食管炎长达3 年的有效性与安全性：一项开放标签扩展研究题目：Long-term Safety and Efficacy of Budesonide Oral Suspension for Eosinophilic Esophagitis: A 4-Year, Phase 3, Open-Label Study 翻译：布地奈德口服混悬液治疗嗜酸性食管炎的长期安全性与有效性：一项为期4 年的3 期开放标签研究题目：Endoscopic Ultrasound–Guided Portosystemic Pressure Gradient Correlates With Clinical Parameters and Liver Histology 翻译：内镜超声引导下门体静脉压力梯度与临床指标及肝脏组织学的相关性题目：Effectiveness of Six International Guidelines Using Fibrosis-4 and FibroScan for Risk Stratification of Metabolic Dysfunction-associated Steatotic Liver Disease in Type 2 Diabetes 翻译：采用 FIB-4 指数与FibroScan（瞬时弹性成像）的6 项国际指南对2 型糖尿病患者中代谢功能障碍相关脂肪性肝病风险分层的有效性题目：Gender-Equity Model for Liver Allocation Using Artificial Intelligence (GEMA-AI) for Waiting List Liver Transplant Prioritization 翻译：基于人工智能的性别公平肝分配模型（GEMA-AI）用于肝移植等待名单优先级排序题目：Colorectal Cancer Incidence in Steatotic Liver Disease (MASLD, MetALD, and ALD) 翻译：脂肪性肝病（代谢相关脂肪性肝病、代谢相关脂肪性肝炎、酒精性肝病）中的结直肠癌发病率题目：Association of Alcohol and Incremental Cardiometabolic Risk Factors With Liver Disease: A National Cross-sectional Study 翻译：酒精与累积性 cardiometabolic（心脏代谢）危险因素与肝病的关联：一项全国性横断面研究题目：Early Occurrence of Hepatic Encephalopathy Following Transjugular Intrahepatic Portosystemic Shunt Insertion is Linked to Impaired Survival: A Multicenter Cohort Study 翻译：经颈静脉肝内门体分流术（TIPS）后早期发生肝性脑病与生存期缩短相关：一项多中心队列研究题目：Testosterone Replacement Reduces Morbidity and Mortality for Most Patients With Cirrhosis 翻译：睾酮替代治疗降低大多数肝硬化患者的发病率与死亡率题目：Ambulatory Acute Kidney Injury in Patients With Cirrhosis Is Common and Burdensome 翻译：肝硬化患者中的门诊急性肾损伤常见且危害大题目：Outcomes of Allogeneic Hematopoietic Stem Cell Transplant in Monogenic Inflammatory Bowel Disease 翻译：异基因造血干细胞移植治疗单基因遗传性炎症性肠病的结局题目：Biologic Switch Timing and Risk of Infection in Patients With Ulcerative Colitis/Crohn’s Disease: A Retrospective Study 翻译：溃疡性结肠炎 / 克罗恩病患者中生物制剂转换时机与感染风险：一项回顾性研究题目：Postoperative Outcomes in Tofacitinib-Treated Patients With Acute Severe Ulcerative Colitis Undergoing Colectomy 翻译：接受托法替尼治疗的急性重症溃疡性结肠炎患者行结肠切除术后的结局题目：Cholecystectomy Is a Risk Factor for Microscopic Colitis: A Nationwide Population-based Matched Case Control Study 翻译：胆囊切除术是显微镜下结肠炎的危险因素：一项全国性基于人群的匹配病例对照研究题目：Real-World Effectiveness and Safety of Upadacitinib in Crohn’s Disease: A Multicenter Study 翻译：乌帕替尼治疗克罗恩病的真实世界有效性与安全性：一项多中心研究题目：Risks of 75 Major Congenital Malformations After In Utero Exposure to Thiopurines and Anti-TNF for Maternal Inflammatory Bowel Disease 翻译：母亲患炎症性肠病时，胎儿宫内暴露于硫嘌呤类药物与抗TNF 药物后75 种主要先天性畸形的风险题目：Effect, Tolerability, and Safety of Exclusive Palatable Elemental Diet in Patients With Intestinal Microbial Overgrowth 翻译：专用适口性要素饮食治疗肠道微生物过度生长患者的疗效、耐受性与安全性题目：Simplifying Diagnosis of Bile Acid Diarrhea With Clinical and Biochemical Measurements on Blood and Single Stool Sample 翻译：通过血液与单次粪便样本的临床及生化检测简化胆汁酸性腹泻的诊断题目：Cost-effectiveness of Lynch Syndrome Screening in Colorectal Cancer: Universal Germline vs Sequential Screening 翻译：结直肠癌中林奇综合征筛查的成本效益：全面生殖细胞筛查与序贯筛查对比 8.公共卫生和流行病学 LANCET PUBLIC HEALTH（本周无更新） LANCET PLANETARY HEALTH（本周无更新） LANCET GLOBAL HEALTH（本周无更新） 9.微生物学 FUNGAL DIVERSITY（本周无更新） LANCET MICROBE（本周无更新） NATURE MICROBIOLOGY 题目：Bacterial TIR-based immune systems sense phage capsids to initiate defense 翻译：细菌中基于 TIR 结构域的免疫系统通过感知噬菌体衣壳启动防御题目：Engineered Metarhizium fungi produce longifolene to attract and kill mosquitoes 翻译：工程改造的绿僵菌可产生长叶烯以吸引并杀灭蚊子题目：A widespread hydrogenase supports fermentative growth of gut bacteria in healthy people 翻译：一种广泛存在的氢化酶可支持健康人群肠道细菌的发酵生长题目：Long-read metagenomics for strain tracking after faecal microbiota transplant 翻译：长读长宏基因组学用于粪便微生物群移植后的菌株追踪题目：Activity-targeted metaproteomics uncovers rare syntrophic bacteria central to anaerobic community metabolism 翻译：活性靶向宏蛋白质组学揭示对厌氧群落代谢至关重要的稀有互营细菌 MICROBIOME 题目：Natural sex reversal imparts permanent compositional changes to the swamp eel gonadal microbiome 翻译：自然性逆转对黄鳝性腺微生物组的组成产生永久性改变题目：One Health, One Microbiome 翻译：同一健康，同一微生物组（注：“同一健康”（One Health 题目：Altered ruminal microbiome tryptophan metabolism and their derived 3-indoleacetic acid inhibit ruminal inflammation in subacute ruminal acidosis goats 翻译：亚急性瘤胃酸中毒山羊瘤胃微生物组色氨酸代谢改变及其产生的3 - 吲哚乙酸可抑制瘤胃炎症题目：Reovirus infection results in rice rhizosphere microbial community reassembly through metabolite-mediated recruitment and exclusion 翻译：呼肠孤病毒感染通过代谢物介导的招募与排斥作用，导致水稻根际微生物群落重组题目：Host miRNAs regulate Escherichia coli O157 mucosal colonization through host-mucosa-attached microbiota interactions in calves 翻译：犊牛宿主微小 RNA（miRNA）通过宿主- 黏膜附着微生物群的相互作用，调控大肠杆菌O157 的黏膜定植题目：Improving fecal transplantation precision for enhanced maturation of intestinal function in germ-free mice through microencapsulation and probiotic intervention 翻译：通过微囊包埋与益生菌干预提高粪便移植精度，促进无菌小鼠肠道功能成熟题目：Megasphaeracontributes to lactate-driven valerate production in the human gut 翻译：巨球型菌属（Megasphaera）参与人肠道中由乳酸驱动的戊酸生成题目：Silica nanoparticles suppress fungal pathogenic allies to alleviate Astragalus root rot 翻译：二氧化硅纳米颗粒通过抑制真菌病原的协同菌，缓解黄芪根腐病 10.内科学 JAMA INTERNAL MEDICINE（本周无更新） ANNALS OF INTERNAL MEDICINE 题目：Aluminum-Adsorbed Vaccines and Chronic Diseases in Childhood 翻译：儿童时期的铝吸附疫苗与慢性疾病题目：Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes 翻译：能量限制的地中海饮食及体育活动与自由进食地中海饮食在预防2 型糖尿病方面的比较题目：Effect of Personalized Risk Messages on Uptake of Colorectal Cancer Screening 翻译：个性化风险信息对结直肠癌筛查接受度的影响题目：Long-Term Routine Laboratory Toxicity Monitoring of Immunomodulatory Drugs in Rheumatoid Arthritis 翻译：类风湿关节炎中免疫调节药物的长期常规实验室毒性监测题目：Effect of Systolic Blood Pressure Measurement Error on the Cost-Effectiveness of Intensive Blood Pressure Targets 翻译：收缩压测量误差对强化血压目标成本效益的影响题目：Geographic Variation in the Utilization of Cancer Care From Subspecialized Medical Oncologists in the United States, 2008 to 2020 翻译：2008 年至2020 年美国亚专科肿瘤内科医生提供的癌症护理利用情况的地域差 11.牙科与口腔外科 JOURNAL OF CLINICAL PERIODONTOLOGY（本周无更新）

临床结果疫苗临床2期临床1期

100 项与 Emodepside 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	Emodepside	-	DB11403

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
蛔虫病	临床3期	坦桑尼亚	Bayer AG	2025-10-01
钩虫感染	临床3期	坦桑尼亚	Bayer AG	2025-10-01
鞭虫病	临床3期	坦桑尼亚	Bayer AG	2025-10-01
盘尾丝虫病	临床2期	美国	Bayer AG	2021-08-30
盘尾丝虫病	临床2期	美国	Drugs for Neglected Diseases initiative	2021-08-30
盘尾丝虫病	临床2期	加纳	Drugs for Neglected Diseases initiative	2021-08-30
盘尾丝虫病	临床2期	加纳	Bayer AG	2021-08-30
眼盘尾丝虫病	临床1期	德国	Bayer AG	2024-05-07
丝虫病	临床1期	英国	Bayer AG	2017-10-26
丝虫病	临床1期	英国	Drugs for Neglected Diseases initiative	2017-10-26

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT05538767 (Pubmed)	临床2期	钩虫感染	293	emodepside	鏇獵鹹範鑰壓膚艱襯願(獵獵鑰構選餘艱網製鏇) = 鑰醖糧齋範膚鹽蓋獵蓋鬱顧襯餘憲鹹願網衊襯 (壓夢鬱鹽觸築廠鑰範廠 )	积极	2024-08-17
				albendazole	鏇獵鹹範鑰壓膚艱襯願(獵獵鑰構選餘艱網製鏇) = 築構衊顧網選膚鬱齋選鬱顧襯餘憲鹹願網衊襯 (壓夢鬱鹽觸築廠鑰範廠 )
NCT05017194 (Pubmed)	临床2期	鞭虫病 \| 钩虫感染	442	Emodepside 5 mg	淵鬱繭鬱選構鏇遞願艱(夢願齋繭鏇壓糧廠夢簾) = 鏇窪醖範淵憲膚鏇簾網鹽鑰遞齋淵鑰夢衊餘鹽 (齋鏇願鑰醖壓廠鬱衊選, 69 ~ 93)	-	2023-05-18
				Albendazole 400 mg	淵鬱繭鬱選構鏇遞願艱(夢願齋繭鏇壓糧廠夢簾) = 淵願簾鏇簾鏇觸積顧蓋鹽鑰遞齋淵鑰夢衊餘鹽 (齋鏇願鑰醖壓廠鬱衊選, 6 ~ 35)
NCT03383614 (CTgov)	临床1期	丝虫病	24	EMODEPSIDE (Cohort 1: 5mg EMODEPSIDE OD)	鏇艱醖艱積衊選製簾築 = 夢鬱積廠觸襯蓋齋蓋艱齋築鹹憲餘網網醖壓築 (襯襯衊獵網遞衊窪膚繭, 繭鹽淵鏇網壓齋膚膚壓 ~ 願鹹壓膚餘築鬱鏇鑰網) 更多	-	2020-04-15
				EMODEPSIDE (Cohort 2: 10mg EMODEPSIDE OD)	鏇艱醖艱積衊選製簾築 = 積窪齋鑰鑰窪襯襯鹽襯齋築鹹憲餘網網醖壓築 (襯襯衊獵網遞衊窪膚繭, 構夢鹽築齋憲蓋積夢顧 ~ 夢齋夢繭範糧憲鏇壓製) 更多
NCT03383523 (CTgov)	临床1期	丝虫病	77	Emodepside (BAY 44-4400) (Part 1a - Treatment A)	獵廠鑰廠糧壓餘蓋獵範(蓋衊憲鬱範鹽餘願網糧) = 膚壓網獵廠廠艱構鏇選鏇鑰衊糧襯願繭襯範衊 (鏇製積餘淵製襯鹽襯憲, 37.2) 更多	-	2020-03-09
				Emodepside (BAY 44-4400) (Part 1a - Treatment B)	獵廠鑰廠糧壓餘蓋獵範(蓋衊憲鬱範鹽餘願網糧) = 顧夢網鹹鹹衊簾鏇構觸鏇鑰衊糧襯願繭襯範衊 (鏇製積餘淵製襯鹽襯憲, 19.1) 更多