Sponge-Like Dressings Based on the Association of Chitosan and Sericin for the Treatment of Chronic Skin Ulcers. II. Loading of the Hemoderivative Platelet Lysate

3区 · 医学

Article

作者: Tenci, Marika ; Riva, Federica ; Rossi, Silvia ; Del Fante, Claudia ; Sandri, Giuseppina ; Caramella, Carla ; Ferrari, Franca ; Bonferoni, Maria C ; Nicoletti, Giovanni ; Mori, Michela

Platelet lysate (PL) was loaded into dressings based on chitosan glutamate (CSG) low and high molecular weight, sericin (Ser), and glycine (Gly). A synergic effect of Ser and PL on fibroblast proliferation was proved in vitro. Two different PL loading approaches were considered: the first provided to prepare dressings by freeze-drying a mixture of PL and CSG/Gly/Ser solution, the second approach consisted in the extemporarily loading of PL in the CSG/Gly/Ser freeze-dried dressings. As for the first approach, PL loading did not produce any variation in dressing mechanical properties. Such dressings absorbed a high amount (about 8-fold of dry weight) of phosphate-buffered saline (fluid mimicking wound exudate), forming a gel with pseudoplastic and elastic properties. Platelet-derived growth factor AB assay indicated that neither freeze-drying nor the excipients alter PL growth factor content. As for the second approach, mechanical and rheological properties of the gel formed upon PL absorption enabled to choose a PL loading of about 90 μL/cm(2). Upon contact with fibroblasts, all PL loaded formulations increased the number not only of viable cells but also of those in the proliferative phase. Histological studies effected on human skin strips pointed out the positive effect of PL loaded dressings on dermal matrix reconstruction.

2009-08-01·Cadernos de Saúde Pública4区 · 医学

Revisão sistemática da eficácia do interferon alfa (convencional, peguilado) e lamivudina para o tratamento da hepatite crônica B

4区 · 医学

ReviewOA

作者: Acurcio, Francisco de Assis ; Silva, Grazielle Dias ; Almeida, Alessandra Maciel ; Silva, Dirce Inês da ; Guerra Jr, Augusto Afonso

1987-12-01·Plant Cell Reports2区 · 生物学

Regeneration of plants from mesophyll protoplasts of the wild crucifer Eruca sativa Lam.

2区 · 生物学

Article

作者: Gouri Chatterjee ; S. K. Sen ; Samir R. Sikdar ; Srabani Das

Protoplasts isolated from mesophyll cells of Eruca sativa Lam., cultured on suitable medium, underwent sustained cell divisions to form calli. The plating efficiency was found to be 0.4%. The protoplast-derived calli subsequently produced plantlets through organogenesis (15.71%) and somatic embryogenesis (11.25%). Regenerated plants exhibited normal appearance. These results indicate potential to introgress desirable traits from this wild crucifer into important oilseed and cole Brassicas by protoplast fusion and hybrid recovery.

100 项与拉莫三嗪/盐酸舍曲林相关的药物交易

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适应症	最高研发状态	国家/地区	公司	日期
背痛	临床2期	罗马尼亚	Meditop Pharmaceutical Ltd.	2014-06-07

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


IAS2007	N/A	乙型肝炎 \| HIV感染	-	LAM/AZT/EFV Gp1LAM/AZT/EFV Gp1LAM/AZT/EFV Gp1	選鬱構鏇選範淵淵淵願(範願壓鏇觸鹹齋製顧艱) = 鬱憲選選窪構憲衊鏇糧簾觸簾願築壓選製網醖 (積顧窪積簾鏇繭繭餘顧 ) 更多	-	2007-01-01
				TDF/AZT/EFV Gp2TDF/AZT/EFV Gp2TDF/AZT/EFV Gp2	選鬱構鏇選範淵淵淵願(範願壓鏇觸鹹齋製顧艱) = 範夢醖壓醖鹽獵築築鹽簾觸簾願築壓選製網醖 (積顧窪積簾鏇繭繭餘顧 ) 更多
IAS2002	N/A	HIV感染	-	ADV 10mg	(餘醖鹽積獵淵窪觸構鑰) = 簾壓餘艱醖齋鬱願獵夢顧壓構艱鹹蓋鬱艱鬱齋 (艱衊願網網顧廠獵積憲 ) 更多	-	2002-01-01
				LAM	(餘醖鹽積獵淵窪觸構鑰) = 憲築醖襯膚艱觸鏇鹽遞顧壓構艱鹹蓋鬱艱鬱齋 (艱衊願網網顧廠獵積憲 ) 更多