D-塔格糖(D-tagatose) - 在研适应症：普拉德-威利综合症，2型糖尿病，I型高脂蛋白血症_专利_临床

概要

基本信息

药物类型

小分子化药

别名

(3S,4S,5R)-1,3,4,5,6-pentahydroxyhexan-2-one、D-lyxo-hex-2-ulose、D-lyxo-hexulose

+ [4]

靶点-

作用方式-

作用机制

铁螯合剂

治疗领域

神经系统疾病遗传病与畸形内分泌与代谢疾病+ [1]

在研适应症

普拉德-威利综合症2型糖尿病I型高脂蛋白血症

非在研适应症-

原研机构

Chromadex Corp.

在研机构

Biospherics.net, Inc.Chromadex Corp.

非在研机构

Dominari Holdings, Inc.

最高研发阶段临床3期

首次获批日期-

最高研发阶段(中国)-

特殊审评孤儿药 (美国)

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结构/序列

分子式C6H12O6

InChIKeyBJHIKXHVCXFQLS-PQLUHFTBSA-N

CAS号87-81-0

关联

5

项与 D-塔格糖相关的临床试验

NCT06230900

/ Active, not recruitingN/AIIT

Assessment of Mass Balance of Orally Administered [14C] (3S,4S,5R)-1,3,4,5,6-pentahydroxy-hexan-2-one in Healthy Volunteers Using a Microtracer Approach

Worldwide almost 40% of the adult population is overweight (including >10% obese), and more than 350 million children (up to the age of 19) are overweight. Overweight and obesity are significant problems and important risk factors for several lifestyle-related diseases, such as cardiovascular disease, certain cancers, non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). Excessive consumption of glucose/sucrose is a major contributor to overweight and obesity. Alternative, low-calorie sweeteners could reduce daily energy intake and thus slow down the development of these conditions and related diseases. (3S,4S,5R)-1,3,4,5,6-pentahydroxy-hexan-2-one is a sweetener that may be suitable for use as a sugar substitute; it is only partially digested in the small intestine and as a result has a lower energy density than more traditional sweeteners such as sucrose. However, it is not yet known to what extent (3S,4S,5R)-1,3,4,5,6-pentahydroxy-hexan-2-one is used in the body and then excreted.
The aim of this study is to measure the metabolic utilization (the 'mass balance') of a single dose of 14C-labelled (3S,4S,5R)-1,3,4,5,6-pentahydroxy-hexan-2-one and AMS technology. Based on clinical data of excretion (urine and faeces) and CO2 production (expired air), the mass balance can be derived. These generated results will be used to map the metabolic pathways (3S,4S,5R)-1,3,4,5,6-pentahydroxy-hexan-2-one undergoes during the digestion process. In addition, it will provide insight into the use of AMS technology to investigate the relationship between diet and health.

开始日期2024-02-05

申办/合作机构

Wageningen University

[+2]

JPRN-UMIN000026233

/ CompletedN/AIIT

A study of the effects on oral bacteria with D-Tagatose chewing gum - A study with D-Tagatose chewing gum

开始日期2015-08-06

申办/合作机构-

NCT00961662

/ Completed临床2期

Dose Ranging Effects of Three Low-doses of Naturlose™ (Tagatose) on Glycemic Control and Safety of Naturlose™ (Tagatose) Over Six Months in Subjects With Mild Type 2 Diabetes Mellitus Under Control With Diet and Exercise.

This study is a six-month, prospective, randomized, multicenter, single- blind, controlled clinical study to evaluate the effect of three low-doses of Naturlose (Tagatose) on glycemic control and safety in subjects with Type 2 diabetes under diet control and exercise. The subjects were randomized in one of the 3 arms receiving 2.5, 5 or 7.5 gm of Tagatose.

开始日期2008-02-01

申办/合作机构

University of Kentucky

100 项与 D-塔格糖相关的临床结果

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100 项与 D-塔格糖相关的转化医学

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100 项与 D-塔格糖相关的专利（医药）

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1,921

项与 D-塔格糖相关的文献（医药）

2025-03-12·Journal of Agricultural and Food Chemistry

Activating the d-Tagatose Production Capacity of Escherichia coli with Structural Insights into C4 Epimerase Specificity

Article

作者: Taylor, Jayce E. ; Palur, Dileep Sai Kumar ; Didzbalis, John ; Denish, Pamela R. ; Gannalo, Trevor ; Atsumi, Shota ; Luu, Bryant ; Siegel, Justin B. ; Skorka, Bryan A. ; Anderson, Ian C. ; Arredondo, Augustine

d-Tagatose, a rare low-calorie sweetener, is ideal for beverages due to its high solubility and low viscosity. Current enzymatic production methods from d-galactose or d-galactitol are limited by reaction reversibility, affecting the yield and purity. This study demonstrates that Escherichia coli harbors a thermodynamically favorable pathway for producing d-tagatose from d-glucose via phosphorylation-epimerization-dephosphorylation steps. GatZ and KbaZ, annotated as aldolase chaperones, exhibit C4 epimerization activity, converting d-fructose-6-phosphate to d-tagatose-6-phosphate. Structural analysis reveals active site differences between these enzymes and class II aldolases, indicating functional divergence. By exploiting the strains' inability to metabolize d-tagatose, carbon starvation was applied to remove sugar byproducts. The engineered strains converted 45 g L^-1 d-glucose to d-tagatose, achieving a titer of 7.3 g L^-1 and a productivity of 0.1 g L^-1 h^-1 under test tube conditions. This approach highlights E. coli as a promising host for efficient d-tagatose production.

2025-03-01·Food Hydrocolloids

Improvement of quercetin bioaccessibility by whey protein isolate/D-tagatose conjugates: Effect on the structural characterization through simultaneous rheological and FTIR techniques

作者: Meng, Yao ; Lin, Yujie ; Liu, Fei ; Ban, Qingfeng ; Chen, Feifei

To improve the performance of whey protein isolates (WPI) as an encapsulation agent in the food industry, we investigated the formation mechanism of WPI and D-tagatose (DT) conjugates using simultaneous rheol. and Fourier-Transform IR spectroscopy (FTIR) techniques, and analyzed its effects in encapsulating quercetin (Que).The degree of glycosylation of the conjugates increased to 18% after heating treatment, whereas particle size and potential decreased to 64 nm and -39 mV, with WPI/D10 showing the lowest value.Simultaneous rheol. and Fourier transform IR analyses showed that the structure of the WPI/DT complexes changed, and the gel properties were much better than those of WPI.Several new peaks appeared at 2961, 1525, 1450, 1392, and 1236 cm-1, indicating that adding DT affected the structure of WPI.DT promoted secondary structural changes in WPI by increasing the degree of hydrocarbon chain, O-H group vibration, and C-O stretching.The WPI/DT conjugates increased the solubility of Que to 60.74% and ABTS clearance to 73.98%.The study may offer a theor. foundation for using WPI/DT-encapsulated Que in food industry.

2025-03-01·Agriculture, Ecosystems & Environment

Pseudostellaria heterophylla cultivar mixtures driven changes in rhizosphere metabolites to suppress soil-borne Fusarium disease

作者: Wang, Xingyue ; Zhang, Jiaoyang ; Wu, Hongmiao ; Zhang, Zhongyi ; Li, Zhong ; Malacrino, Antonino ; Rensing, Christopher ; Zhang, Zhen ; Lin, Wenxiong ; Zhang, Yixuan ; Dang, Panpan ; Liu, Yuting

Crop diversification contributes to a decrease in soil-borne crop diseases, as well as an increase in agricultural productivity.However, few studies have investigated the changes in the composition of the rhizosphere microbial communities and rhizosphere metabolites, as well as their suppressive effect on soil-borne diseases under different crop cultivar mixture regimes.We carried out a series of experiments to assess changes in the rhizosphere microbial community and metabolites profile under different Pseudostellaria heterophylla cultivar mixture cultivation in consecutive monoculture fields by employing amplicon metagenomics (16S rRNA, ITS, and 18S rRNA) and non-targeted metabolomics.The impact of key metabolites on pathogenic Fusarium oxysporum, crop growth, and soil microorganisms was assessed under controlled conditions.Our study indicated that the cultivar mixtures improved the P. heterophylla performance, increased the fresh root biomass by 81.9-115.4% and the heterophyllin B content by 35% compared to the consecutive monoculture, resp.Cultivar mixtures increased the abundance of beneficial bacteria (Lactobacillus, Pseudomonas, Nitrosospira) and consumer protists, and decreased the abundance of pathogenic fungal genera (Fusarium, Alternaria, Curvularia, Stemphylium, Gibberella).The qPCR results indicated that the cultivar mixtures significantly decreased the abundance of pathogenic F. oxysporum by 64.0-84.3% compared to the consecutive monoculture treatment.Non-targeted metabolomics anal. showed that the cultivar mixtures significantly altered the soil metabolite profiles, and increased the contents of d-galactose, galactinol, d-sorbitol, glycerol, melibiose, D-fructose and D-tagatose.Subsequently, the key upregulated metabolites (glycerol, d-fructose, gluconic acid, quinic acid, and l-valine), identified through the random forest anal., significantly inhibited the growth of F. oxysporum.The crucial metabolites in the presence of a pathogen (F. oxysporum) and single metabolite treatment significantly increased the biomass, SOD and CAT activity and decreased the POD and MAD activity of P. heterophylla compared to FOP (F. oxysporum treatment).Furthermore, the crucial metabolites under pathogen treatment significantly lowered the abundance of total fungi and F. oxysporum and increased the abundance of Pseudomonas spp. compared to FOP.Therefore, our study was able to emphasize the efficacy of using cultivar mixtures to combat soil-borne Fusarium disease through the modulation of rhizosphere metabolites.

100 项与 D-塔格糖相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	D-塔格糖	-	DB04936

研发状态

10 条进展最快的记录,

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适应症	最高研发状态	国家/地区	公司	日期
2型糖尿病	临床3期	-	Chromadex Corp.	-
I型高脂蛋白血症	临床3期	-	Chromadex Corp.	-
普拉德-威利综合症	临床3期	-	Chromadex Corp.	-

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临床结果

适应症

分期

评价

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


NCT00955747 (NEET, CTgov)	临床3期	2型糖尿病	494	Sugar Substitute Splenda (Sugar Substitute Splenda)	構簾艱觸餘壓齋憲壓網(艱築蓋醖醖夢糧襯膚範) = 鬱範壓觸醖衊夢網鏇壓壓遞淵繭構簾窪簾窪鏇 (壓願餘廠鹹餘鏇築蓋窪, 鹽艱糧築糧簾鹹獵廠衊 ~ 鑰鹹憲選鬱齋鹹鏇窪選) 更多	-	2014-11-19
				Tagatose (Tagatose)	構簾艱觸餘壓齋憲壓網(艱築蓋醖醖夢糧襯膚範) = 糧艱鏇願選壓鬱觸獵簾壓遞淵繭構簾窪簾窪鏇 (壓願餘廠鹹餘鏇築蓋窪, 鬱鏇齋廠範憲獵艱選願 ~ 淵廠窪願觸網憲遞簾製) 更多
NCT00961662 (CTgov)	临床2期	2型糖尿病	161	D-Tagatose (2.5 Active)	獵獵鹽願簾廠獵壓齋簾(觸廠獵鬱淵顧觸繭積簾) = 鹹網衊廠衊顧鬱願簾鬱醖積壓廠範醖淵遞齋鬱 (製網構製鬱廠鹽窪淵蓋, 鏇夢廠醖範淵衊繭繭構 ~ 糧繭衊艱鹽獵選構鹹襯) 更多	-	2014-11-06
				D-Tagatose (5.0 Mid Dose)	獵獵鹽願簾廠獵壓齋簾(觸廠獵鬱淵顧觸繭積簾) = 齋夢窪鹽膚鑰鏇願範鑰醖積壓廠範醖淵遞齋鬱 (製網構製鬱廠鹽窪淵蓋, 艱鬱鹹窪鹽鬱壓壓獵繭 ~ 廠窪餘築鹽製醖衊壓醖) 更多