预约演示
更新于：2025-02-15
Dexibuprofen
右布洛芬
更新于：2025-02-15
概要
基本信息
原研机构- |
最高研发阶段批准上市 |
首次获批日期 瑞士 (1998-04-28), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C13H18O2 |
InChIKeyHEFNNWSXXWATRW-JTQLQIEISA-N |
CAS号51146-56-6 |
关联
22
项与 右布洛芬 相关的临床试验ChiCTR2400093489
Evaluation of the safety and efficacy of dexibuprofen in improving fever symptoms in children aged 6 months to 3 years: a multicenter post marketing clinical study
CTR20242540
JC002餐后比较药代动力学临床试验
CTR20240968
JC002比较药代动力学临床试验
100 项与 右布洛芬 相关的临床结果
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100 项与 右布洛芬 相关的转化医学
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100 项与 右布洛芬 相关的专利（医药）
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1,922
项与 右布洛芬 相关的文献（医药）2025-03-01COLLOIDS AND SURFACES B-BIOINTERFACES
Dexibuprofen loaded into nanoemulsion based gel for topical application – In vitro characterization and in vivo anti-inflammatory evaluation
Article
作者: Irfan, Muhammad ; Khalid, Ikrima ; Shah, Pervaiz Akhtar ; Asghar, Sajid ; Munir, Muhammad Rehan ; Asif, Muhammad ; Khan, Ikram Ullah ; Albekairi, Norah A ; Munir, Rabia ; Khalid, Syed Haroon ; Kamal, Yousaf ; Alshammari, Abdulrahman
Arthritic disease is one of the most common diseases in adults and a leading cause of joint degeneration. Dexibuprofen (DEX) is routinely used for the treatment of rheumatoid arthritis, acute postoperative pain, primary dysmenorrheal, and in lower back pain. However, it is poorly water soluble with compromised bioavailability, and hence has limited therapeutic activity. In order to overcome these issues, we studied the formulation and characterization of nanoemulsion based system i.e nanoemulgel of DEX. This study aimed to prepare topical nanoemulgel containing 2 % DEX and solubility-enhanced DEX via ternary inclusion complexation (DEX-SE-T) and to compare it with commercially available 5 % Ibuprofen gel as there is no topical formulation of DEX is available in the market currently. A pseudoternary phase diagram was constructed using the spontaneous water titration method. Blank and drug-loaded nanoemulgel were prepared using a high-speed homogenization method. All the formulations were evaluated in terms of particle size, pH, conductivity, viscosity, zeta potential, and ex vivo drug permeation. DEX loaded nanoemulgel yield enhanced in vitro skin permeation than the commercially available 5 % ibuprofen gel. The optimized nanoemulgel formulation (DEX-SE-T) was tested in in vivo anti-inflammatory models including cotton pellets-induced abdominal granuloma (chronic inflammation) and carrageenan-induced paw edema (acute inflammation). DEX-SE-T loaded nanoemulgel has improved in vivo anti-inflammatory activity as compared to ibuprofen gel. DEX-SE-T could be a promising option for effective topical treatment of inflammatory conditions.
2025-02-04ADVANCED SYNTHESIS & CATALYSIS
Photocatalytic Silylation of Aryl Alkynoates: Synthesis of Silylated Coumarins
作者: Selvakumar, Sermadurai ; Ladumor, Ravikumar ; Samanta, Sourav
Abstract:
Herein, we report the photocatalytic synthesis of 3‐silyl coumarins using hydrosilanes as the silyl radical source with aryl alkynoates. Readily prepared N‐aminopyridinium salts act as hydrogen atom transfer reagents for generating silyl radicals under photoredox catalysis. The reaction proceeds through a silyl radical addition to alkyne followed by radical cascade cyclization/migration with subsequent oxidation and aromatization to give the desired 3‐silyl coumarins in 34–89% yield.
2025-01-21ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Copper‐Catalyzed Asymmetric Hydrogenation of Unsymmetrical ortho‐Br Substituted Benzophenones
Article
作者: Luo, Yicong ; Guan, Jing ; Chen, Jianzhong ; Wang, Qiyuan ; Zhang, Wanbin
Abstract:
The asymmetric hydrogenation of benzophenones, catalyzed by low‐activity earth‐abundant metal copper, has hitherto remained a challenge due to the substrates equipped with two indistinguishably similar aryl groups. In this study, we demonstrated that the prochiral carbon of the ortho‐bromine substrate exhibits the highest electrophilicity and high reactivity among the ortho‐halogen substituted benzophenones, as determined by the Fukui function (f+) analysis and hydrogenation reaction. Considering that the enantiodirecting functional bromine group can be easily derivatized and removed in the products, we successfully achieved a green copper‐catalyzed asymmetric hydrogenation of ortho‐bromine substituted benzophenones. This method yielded a series of chiral benzhydrols with excellent results. The utility of this protocol has been validated through a gram‐scale reaction and subsequent product transformations. Independent gradient model based on Hirshfeld partition (IGMH) and energy decomposition analysis (EDA) indicate that the CH⋅⋅⋅HC multiple attractive dispersion interactions (MADI) effect between the catalyst and substrate enhances the catalyst's activity.
100 项与 右布洛芬 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 炎症 | 韩国 | 2007-12-31 | |
| 头痛 | 阿根廷 | - | 2007-04-16 |
| 背痛 | 阿根廷 | - | 2007-04-02 |
| 肌肉骨骼疼痛 | 阿根廷 | - | 2007-04-01 |
| 痛经 | 英国 | - | 2007-03-14 |
| 发热 | 中国 | 2001-01-01 | |
| 骨关节炎 | 中国 | - | 2001-01-01 |
| 类风湿关节炎 | 中国 | - | 2001-01-01 |
| 疼痛 | 瑞士 | - | 1998-05-21 |
| 风湿性疾病 | 瑞士 | - | 1998-04-28 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床2期 | 中国 | 2021-07-13 | |
| 镇痛 | 临床2期 | 中国 | 2021-07-13 | |
| 麻醉 | 临床2期 | 中国 | 2020-11-16 | |
| 麻醉 | 临床2期 | 中国 | 2020-11-16 | |
| 急性疼痛 | 临床2期 | 美国 | 2018-01-12 | |
| 肌痛 | 临床2期 | 美国 | 2015-01-01 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 251 | (Active Arm) | 衊網積淵膚壓鹹糧鏇醖(構淵夢鹽窪糧糧壓製膚) = 選選襯醖憲繭夢鬱鹹範 夢遞鏇積製鬱糧顧繭窪 (簾夢選鹹鏇鹽簾蓋簾醖, 顧蓋餘淵壓醖遞廠顧觸 ~ 簾遞顧簾憲壓窪蓋觸獵) 更多 | - | 2022-01-25 | ||
Vehicle (Placebo Arm) | 衊網積淵膚壓鹹糧鏇醖(構淵夢鹽窪糧糧壓製膚) = 餘夢壓鏇製鏇積夢鏇憲 夢遞鏇積製鬱糧顧繭窪 (簾夢選鹹鏇鹽簾蓋簾醖, 觸齋簾醖觸願製夢構構 ~ 繭簾鏇窪鹽製願築襯艱) 更多 | ||||||
临床3期 | 263 | 憲憲觸淵製鹽積衊廠鏇(築壓鑰選遞範艱夢窪繭) = 衊獵壓製範膚艱簾夢積 糧餘鹹壓膚膚鹽蓋鬱鏇 (衊壓壓餘鑰顧製淵積淵 ) | - | 2018-06-23 | |||
憲憲觸淵製鹽積衊廠鏇(築壓鑰選遞範艱夢窪繭) = 獵製築夢艱膚鹹壓獵鏇 糧餘鹹壓膚膚鹽蓋鬱鏇 (衊壓壓餘鑰顧製淵積淵 ) |
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