预约演示
更新于：2025-04-26
Dexibuprofen
右布洛芬
更新于：2025-04-26
概要
基本信息
原研机构- |
在研机构 |
最高研发阶段批准上市 |
首次获批日期 奥地利 (2000-07-27), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C13H18O2 |
InChIKeyHEFNNWSXXWATRW-JTQLQIEISA-N |
CAS号51146-56-6 |
关联
23
项与 右布洛芬 相关的临床试验ChiCTR2500097383
A multi-center, randomized, and positive-drug parallel controlled prospective clinical study to evaluate the efficacy and safety of dexibuprofen in the treatment of children with fever caused by influenza
ChiCTR2400093489
Evaluation of the safety and efficacy of dexibuprofen in improving fever symptoms in children aged 6 months to 3 years: a multicenter post marketing clinical study
CTR20242540
JC002餐后比较药代动力学临床试验
100 项与 右布洛芬 相关的临床结果
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100 项与 右布洛芬 相关的转化医学
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100 项与 右布洛芬 相关的专利（医药）
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1,924
项与 右布洛芬 相关的文献（医药）2025-04-17ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Desymmetrization/Kinetic Resolution of Planar Chiral [2.2]Paracyclophanes by Bioinspired Peptide‐Iminophosphorane Catalysis
Article
作者: Wei, Xin ; Wang, Tianli ; Wu, Zhengdong ; He, Jiajia ; Liu, Zanjiao ; Fang, Siqiang ; Che, Jixing ; Su, Zhishan
Abstract:
Planar chiral [2.2]paracyclophanes, particularly pseudo‐disubstituted derivatives, are privileged scaffolds for chiral ligands and catalysts in asymmetric synthesis and have widespread applications in materials science. However, catalytic asymmetric approaches for the enantioselective synthesis of pseudo‐disubstituted [2.2]paracyclophanes remain underexplored. In this study, we introduce a novel class of peptide‐iminophosphorane organosuperbases to induce planar chirality in spatially stacked [2.2]paracyclophanes. This efficient protocol enables the enantioselective synthesis of a diverse array of structurally distinct pseudo‐gem, pseudo‐ortho, and pseudo‐para [2.2]paracyclophanes, achieving high yields and excellent enantioselectivities via desymmetrization or kinetic resolution. Moreover, the products can be readily diversified through various functional group transformations. Mechanistic investigations provide valuable insights into the unique stereocontrol exhibited by this peptide‐iminophosphorane catalytic system.
2025-04-01Science China-Chemistry
Tandem asymmetric propargylic amination/carboxylative cyclization reaction to chiral 5-methylidene-2-oxazolidinones using CO2 as C1 synthon
作者: Zhou, Jian ; Zhang, Zheng ; Sun, Ying ; Tang, Yun-Hao ; Yang, Yi-Zhuo ; Zhang, Zhi-Hao ; Zhou, Feng
We report a tandem asym. Cu-catalyzed propargylic amination (ACPA)/Ag-catalyzed carboxylative cyclization (SCC) with CO2 to 5-methylidene-2-oxazolidinones, even with tetrasubstituted stereocenters.By varying pyridine bisoxazoline (PYBOX) ligands, a general and highly enantioselective ACPA of unprecedentedly broad scope of secondary propargylic acetates and primary amines is achieved.Both α-aryl and α-aliphatic propargylic acetates could react with either aromatic or aliphatic primary amines to give the corresponding N-aryl or N-aliphatic ethynylamines with α-aliphatic or α-aryl groups in over 90% ee for use in the next step.The key to developing this one-pot sequence is to use a chelator triethylenetetramine (TETA) to mask the copper ion, to avoid its neg. effect on Ag-catalyzed cyclization, while releasing PYBOX to activate the silver catalyst.With the methylidene moiety, these oxazolidinones can be readily elaborated.The value of the sequence is further shown by the catalytic enantioselective total synthesis of (-)-cytoxazone and the potent ezetimibe analog.
2025-03-28ORGANIC LETTERS
Unveiling Heavier Dihydropyridine Chalcogenol Esters in Metallaphotoredox Catalyst-Enabled Regioselective Hydrothio(seleno)carbonylation
Article
作者: Bera, Anshuman ; Bag, Sandip ; Vennapusa, Sivaranjana Reddy ; Sahoo, Basudev ; Vijayan, Sariga Mangalamundackal ; Pal, Amit
Herein, aromaticity-driven thio(seleno)ester group transfer from novel 1,4-dihydropyridine thio(seleno)esters to alkene feedstocks is disclosed by merging palladium and photoredox catalysis. In this process, photoactivation of dihydropyridine thio(seleno)esters is integrated with regioselective hydrometalation of alkenes, avoiding photoinduced Pd-C bond homolysis of organopalladium intermediates. Additionally, a regioselective hydroselenocarbonylation of an alkene is accomplished for the first time using a bench-stable selenoester reagent. The activation mode of novel dihydropyridine thioesters has been illustrated by detailed mechanistic studies, spectroscopic analysis, intermediate trapping, and isotope labeling experiments.
100 项与 右布洛芬 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 炎症 | 韩国 | 2007-12-31 | |
| 发热 | 中国 | 2001-01-01 | |
| 骨关节炎 | 中国 | - | 2001-01-01 |
| 类风湿关节炎 | 中国 | - | 2001-01-01 |
| 疼痛 | 奥地利 | 2000-07-27 | |
| 疼痛 | 意大利 | 2000-07-27 |
未上市
10 条进展最快的记录, 后查看更多信息
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床2期 | 中国 | 2021-07-13 | |
| 镇痛 | 临床2期 | 中国 | 2021-07-13 | |
| 麻醉 | 临床2期 | 中国 | 2020-11-16 | |
| 麻醉 | 临床2期 | 中国 | 2020-11-16 | |
| 急性疼痛 | 临床2期 | 美国 | 2018-01-12 | |
| 肌痛 | 临床2期 | 美国 | 2015-01-01 | |
| 痛经 | 临床1期 | 中国 | 2023-05-17 |
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临床结果
临床结果
适应症
分期
评价
查看全部结果
临床2期 | 251 | (Active Arm) | 糧衊蓋衊餘襯壓鏇願觸(簾糧範糧遞網窪鑰獵顧) = 鑰艱構壓醖觸夢願壓製 糧廠觸鬱廠糧遞觸鏇夢 (餘夢築壓顧淵夢遞簾壓, 31.311) 更多 | - | 2022-01-25 | ||
Vehicle (Placebo Arm) | 糧衊蓋衊餘襯壓鏇願觸(簾糧範糧遞網窪鑰獵顧) = 廠壓餘遞糧顧醖糧醖製 糧廠觸鬱廠糧遞觸鏇夢 (餘夢築壓顧淵夢遞簾壓, 29.763) 更多 | ||||||
临床3期 | 263 | 襯鹽鏇鹹淵獵醖窪艱鑰(選獵衊齋簾壓遞鑰齋積) = 齋製鏇簾鹹膚製製壓遞 壓遞淵膚鹹願鹽夢鹽壓 (憲襯遞憲餘衊窪顧簾獵 ) | - | 2018-06-23 | |||
襯鹽鏇鹹淵獵醖窪艱鑰(選獵衊齋簾壓遞鑰齋積) = 鹽顧獵衊構膚鬱繭鏇壓 壓遞淵膚鹹願鹽夢鹽壓 (憲襯遞憲餘衊窪顧簾獵 ) |
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