预约演示
更新于：2025-05-16
Dexibuprofen
右布洛芬
更新于：2025-05-16
概要
基本信息
原研机构- |
在研机构 |
权益机构- |
最高研发阶段批准上市 |
首次获批日期 奥地利 (2000-07-27), |
最高研发阶段(中国)批准上市 |
特殊审评优先审评 (中国) |
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结构/序列
分子式C13H18O2 |
InChIKeyHEFNNWSXXWATRW-JTQLQIEISA-N |
CAS号51146-56-6 |
关联
26
项与 右布洛芬 相关的临床试验ChiCTR2500101700
Efficacy and Safety of Dexibuprofen Oral Suspension for Fever Treatment in Children with Acute Lower Respiratory Tract Infections: A Multicenter, Randomized Controlled Trial
ChiCTR2500097383
A multi-center, randomized, and positive-drug parallel controlled prospective clinical study to evaluate the efficacy and safety of dexibuprofen in the treatment of children with fever caused by influenza
ChiCTR2400093489
Evaluation of the safety and efficacy of dexibuprofen in improving fever symptoms in children aged 6 months to 3 years: a multicenter post marketing clinical study
100 项与 右布洛芬 相关的临床结果
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100 项与 右布洛芬 相关的转化医学
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100 项与 右布洛芬 相关的专利（医药）
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1,934
项与 右布洛芬 相关的文献（医药）2025-08-01DYES AND PIGMENTS
Tetraphenylethylene based chiral AIEgen for enantioselective detection of chiral acids
作者: Wei, Keyue ; Feng, Hai-Tao ; Zhang, Wangyan ; Li, Qingyang ; Zhang, Xiuhua ; Chen, Miao-Miao ; Qi, Chunxuan ; Zhao, Weiwei
Enantioselective recognition is crucial in pharmaceutical anal. and life sciences but remains a significant challenge.Herein, we constructed two chiral probes named (1R, 2R)-CHDA-2TPE and (1S, 2S)-CHDA-2TPE, which exhibit typical aggregation-induced emission (AIE) properties.The chiral probes show high enantioselectivity to 11 kinds of chiral reagents.Notably, the fluorescence intensity ratio of the probe with L- and D-glutamic acid was up to 88.8.The 1H NMR titration results suggested that the hydrogen bond is response for the recognition.These findings implied that the synthesized probes are promising candidates for analyzing chiral compounds
2025-06-01CHINESE JOURNAL OF CHEMISTRY
Enantioselective Synthesis of Planar/Multiple Chiral [n]Cyclophanes through Asymmetric Allylation
作者: Li, Xin ; Zheng, Hanliang ; Zhang, Xin‐Xin ; Sun, Yidan ; Wang, Ziyang
Comprehensive Summary:
Planar‐chiral cyclophanes with carbon‐centered chirality are important targets in natural products and pharmaceuticals. However, synthesizing such planar chiral cyclophanes with two stereogenic elements via a one‐step asymmetric reaction remains a formidable challenge. Herein, we present an efficient kinetic resolution method for synthesizing planar‐chiral [n]cyclophanes with carbon‐centered chirality. This is achieved through the enantioselective allylation of racemic aldehyde [n]cyclophanes catalyzed by Bi(OAc)3 and chiral phosphoric acid. The reaction delivers planar‐chiral [n]cyclophanes and multiple chiral [n]cyclophanes with high yields and excellent enantioselectivities, showcasing remarkable kinetic resolution efficiency (s factor up to 292). The broad substrate scope, scalability, and potential for derivatization highlight the value of this methodology. DFT calculations have also been performed to provide insights into the origin of the experimentally observed diastereo‐ and enantioselectivity for this reaction.
2025-06-01Sustainable Chemistry and Pharmacy
Enantioselective extraction of ibuprofen enantiomers using quinine-terminated tetra-arm PEGs as a recyclable chiral selector
作者: Lu, Qiang ; Hu, Gang ; Yang, Kedi ; Ge, Li ; Qin, Shufen ; Mao, Xiaolu
A novel chiral quinine-terminated tetra-arm PEGs (Quin@4-arm PEGs) was synthesized from tetra-arm PEGs and natural quinine, demonstrating significant chiral recognition of ibuprofen enantiomers, as confirmed by NMR anal.We have developed a biphasic chiral extraction system to sep. the two enantiomers of ibuprofen using the as-prepared Quin@4-arm PEGs as the chiral selector.We explored several extraction parameters, including pH, chiral selector concentration, initial ibuprofen concentration, and temperature, to evaluate their influence on the enantiomeric excess and distribution behavior of the two enantiomers.The optimal conditions for the enantioselective extraction of ibuprofen enantiomers were determined using response surface methodol.The results showed that a single chiral extraction could achieve an enantiomeric excess of up to 54 % and a yield exceeding 80 % for S-ibuprofen at the initial ibuprofen concentration of 0.09 mg·mL-1, with 2.22 % Quin@4-arm PEGs, a pH of 7.6 and a temperature of 18.0 °C.In addition, back-extraction experiments demonstrated the effective recycling of the chiral selector in this chiral extraction system, achieving similar enantioselective extraction results over seven cycles.This work provides an effective method for separating ibuprofen enantiomers using quinine-terminated tetra-arm PEGs as a recyclable chiral selector.
100 项与 右布洛芬 相关的药物交易
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研发状态
批准上市
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 炎症 | 韩国 | 2007-12-31 | |
| 发热 | 中国 | 2001-01-01 | |
| 骨关节炎 | 中国 | - | 2001-01-01 |
| 类风湿关节炎 | 中国 | - | 2001-01-01 |
| 疼痛 | 奥地利 | 2000-07-27 | |
| 疼痛 | 意大利 | 2000-07-27 |
未上市
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| 适应症 | 最高研发状态 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|---|
| 镇痛 | 临床2期 | 中国 | 2021-07-13 | |
| 镇痛 | 临床2期 | 中国 | 2021-07-13 | |
| 麻醉 | 临床2期 | 中国 | 2020-11-16 | |
| 麻醉 | 临床2期 | 中国 | 2020-11-16 | |
| 急性疼痛 | 临床2期 | 美国 | 2018-01-12 | |
| 肌痛 | 临床2期 | 美国 | 2015-01-01 | |
| 痛经 | 临床1期 | 中国 | 2023-05-17 |
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临床结果
临床结果
适应症
分期
评价
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临床2期 | 251 | (Active Arm) | 艱憲餘簾齋鹹鹹築網鹹(襯壓積選鹽顧夢鏇糧簾) = 繭淵簾鹽鹹鬱餘鑰繭衊 窪壓築廠壓選獵膚網醖 (鹹鏇鏇網鬱窪遞遞簾積, 31.311) 更多 | - | 2022-01-25 | ||
Vehicle (Placebo Arm) | 艱憲餘簾齋鹹鹹築網鹹(襯壓積選鹽顧夢鏇糧簾) = 醖觸鹹鏇鏇廠顧積窪製 窪壓築廠壓選獵膚網醖 (鹹鏇鏇網鬱窪遞遞簾積, 29.763) 更多 | ||||||
临床3期 | 263 | 醖遞襯範淵觸醖範膚餘(顧衊膚顧膚蓋顧齋鏇餘) = 鏇網壓範淵醖範願鹽鏇 廠廠顧窪鹽願齋糧獵鹽 (衊鏇齋鹹鑰鏇鹽製廠鑰 ) | - | 2018-06-23 | |||
醖遞襯範淵觸醖範膚餘(顧衊膚顧膚蓋顧齋鏇餘) = 廠窪簾製範廠選顧憲窪 廠廠顧窪鹽願齋糧獵鹽 (衊鏇齋鹹鑰鏇鹽製廠鑰 ) |
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