This open level randomized controlled trial will be conducted in the department of medicine at Sir Salimullah Medical College and Mitford Hospital. Clinical severity will be assessed by the POP (Peradeniya Organophosphorus Poisoning) scale of admitted patients having a history of organophosphorus poisoning within 24 hours with clinical features and physical evidence of poisoning consumed. Only moderate severity (POP Scale score 4-7) of OPC (Organophosphorus compound) patients will be included in this study. Then one group of patients will be treated with atropine and pralidoxime and another group will be treated with atropine. The outcome will be noted as clinical improvement or recovery. hospital stay, requirement of ICU, death.

开始日期2022-06-01

申办/合作机构-

IRCT20170609034406N5

/ Recruiting临床3期IIT

Study of the efficacy of pralidoxime in the treatment of organophosphorus poisoning

开始日期2020-06-30

申办/合作机构

Tabriz University of Medical Sciences

IRCT20180613040087N1

/ Recruiting临床3期IIT

Comparison of continuous infusion versus intermittent bolus injection of Pralidoxime for the treatment of Organophosphate poisoning

开始日期2018-07-23

申办/合作机构

Shiraz University of Medical Sciences

100 项与氯解磷定相关的临床结果

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100 项与氯解磷定相关的转化医学

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100 项与氯解磷定相关的专利（医药）

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1,160

项与氯解磷定相关的文献（医药）

2025-05-01·The American Journal of Emergency Medicine

Cholinergic crisis in Lycoris radiata poisoning: A case of delayed onset and prolonged symptoms

Article

作者: Tsushima, Ryota ; Satoh, Fumiko ; Nogaki, Ayako ; Takahashi, Kohei ; Sasaki, Chizuko ; Yamagata, Hidehiro

Lycoris radiata, commonly known to contain alkaloids such as lycorine and galanthamine, is toxic and is easily accessible in East Asian countries, including Japan. Lycorine is a central nervous system and gastrointestinal irritant, whereas galanthamine, a carbamate, exhibits reversible acetylcholinesterase inhibition. Symptoms of Lycoris radiata poisoning are generally acute and resolve quickly. We present a case of an 83-year-old woman with impaired consciousness that presented to our hospital. The patient's presentation initially was not significant; however, a rapid progression of symptoms occurred eight hours after admission, including miosis, hypersalivation, increased airway secretions, vomiting, diarrhea, and myoclonus. A rapid hemodynamic and respiratory function deterioration necessitated vasopressor administration and mechanical ventilation. Given her toxidrome, we suspected a cholinergic crisis and measured her serum butyrylcholinesterase levels, which were considerably low. Initially presuming organophosphate poisoning with acetylcholinesterase inhibition, we administered pralidoxime. Her condition subsequently improved, allowing for de-escalation of support; which aligned with increasing serum butyrylcholinesterase levels. The patient disclosed ingestion of Lycoris radiata, and an analysis of her garden plants revealed lycorine and galanthamine, confirming the diagnosis. Acute Lycoris radiata poisoning can result in a severe clinical course. Furthermore, the onset of a cholinergic toxidrome may be delayed following ingestion, and the toxidrome may persist for a prolonged period.

2025-03-01·Journal of Family Medicine and Primary Care

Analyzing electrocardiographic, echocardiographic, and cardiac marker changes in organophosphorus poisoning cases at a tertiary care hospital of Jharkhand, India

Article

作者: Singh, Parul ; Agarwal, Krati ; Bodra, Diljeet ; Munda, Punam K.

ABSTRACTIntroduction:Organophosphorus insecticides, widely used worldwide, are a significant public health risk in developing countries, causing 3 million poisonings and 300,000 deaths annually. Despite a 20% fatality rate in Asia, improved care is reducing mortality. Improper storage and accessibility contribute to frequent suicides, especially among lower socio-economic groups. Cardiac complications, often fatal, are preventable with early treatment. This study examines 60 acute poisoning cases at RIMS, Ranchi, highlighting the need for improved management.Material and Methods:This prospective clinical study, conducted from May 2018 to November 2019, involved 60 patients with acute organophosphorus poisoning admitted within 24 hours of ingestion. Comprehensive management included gastric lavage, activated charcoal, antidotes (atropine and pralidoxime), and supportive measures. Clinical and biochemical assessments, including echocardiography, monitored patient progress and treatment outcomes.Results:In a study of 60 acute organophosphorus poisoning cases, common early symptoms included lacrimation, salivation, blurring vision, nausea, and vomiting. Pupil constriction was an early sign. Bradycardia occurred in 46.67% of patients. Despite intensive care, 6.67% succumbed, with causes including ventricular fibrillation, aspiration pneumonia, and non-cardiogenic pulmonary edema.Conclusion:Future studies should address the infrastructural gaps of this study, as acute organophosphate poisoning constitutes over 75% of hospital poisoning cases. Early recognition and prompt treatment of cardiac complications can prevent fatalities, highlighting the need for improved management protocols and healthcare infrastructure.

2025-02-01·Journal of Taibah University Medical Sciences

Outbreak of carbofuran and bifenthrin poisoning in siblings after ingestion of contaminated food in KSA: Clinical management and public health implications

Article

作者: Alyahya, Bader A ; Ali, Hajer F ; Al Aseri, Zohair A ; Alfaifi, Musa S ; Alasmari, Abrar K ; Alrougi, Hamoud M ; Assiri, Abdullah M ; Hamoud, Maged A ; Albogami, Hussein A ; Abdulalem, Nafaa A ; Altowairqi, Adel M ; Saqah, Rayyan M

BackgroundPesticide poisoning remains a major global health concern contributing to an estimated 371,594 deaths annually. Both accidental and deliberate pesticide exposure, particularly in developing countries, pose challenges to public health systems. In KSA, pesticide poisoning is prevalent, and insecticides such as carbamates and organophosphates are the primary culprits.Case presentationFour cases of acute poisoning caused by the ingestion of contaminated shawarma sandwiches containing carbofuran and bifenthrin, a carbamate and pyrethroid mixture, respectively, are described. The affected individuals, all siblings, exhibited varying degrees of cholinergic symptoms, including muscle fasciculations, excessive secretions, and respiratory distress. Despite their severe symptoms, three patients had normal or low-normal acetylcholinesterase levels, probably because of individual variability, delayed testing, or improper sample handling. One patient exhibited diminished acetylcholinesterase activity, thus suggesting severe inhibition; pancreatitis was a further complication that contributed to delayed recovery. Early clinical management included atropine, pralidoxime, and botulinum antitoxin, because of initial suspicion for botulism. Toxicological analysis confirmed carbofuran poisoning, and food safety investigations identified improper pesticide use in food preparation areas.ConclusionThe reported cases underscore the importance of timely toxicological consultation, proper testing, and appropriate sample handling to guide treatment of pesticide-related poisoning. These findings highlight the crucial need for adherence to WHO regulations and monitoring of pesticide use, as well as strict food safety practices to prevent future outbreaks. The successful multidisciplinary approach to managing these cases demonstrates the critical role of coordinated efforts between clinical teams and public health authorities in addressing such public health threats.

项与氯解磷定相关的新闻（医药）

2025-01-22

·FiercePharma

Kindeva unit Meridian Medical snares $129M to supply US with nerve agent antidote

St. Louis-based Kindeva snared a $129 million contract to supply the U.S. with the chemical nerve agent antidote autoinjector DuoDote. Meridian Medical Technologies, a unit of CDMO Kindeva, snared a $129 million contract to supply the United States with the chemical nerve agent antidote autoinjector DuoDote.The FDA-approved, dual-chamber autoinjector contains atropine and pralidoxime chloride and is used to counteract the effects of organophosphorus nerve agents and insecticides, the company said in a Jan. 16 press release.Kindeva, a CDMO focused on drug delivery devices, said the DuoDote autoinjectors will be produced and distributed from its fill-finish facility in St. Louis.“This contract underscores the ongoing importance of maintaining readiness against potential threats,” Milton Boyer, Kindeva’s chief executive, said in the release. “With our extensive experience in this space, we are proud to continue supporting the U.S. government’s efforts to protect public health and safety.”Kindeva operates manufacturing and R&D facilities in the U.S. and U.K. Last year, the company secured a 33 million pound sterling ($42.1 million at the time) contract from the U.K.’s Life Sciences Innovation Manufacturing Fund to boost its inhaler production and sustainability efforts.The grant was part of the country’s move to support the development and production of inhalers that utilize new propellants with lower global warming potential.

2025-01-16

·Pharmaceutical Technology

Meridian Medical wins $129m US gov contract for nerve agent antidote supply

Meridian Medical’s DuoDote will be stockpiled as part of the Strategic National Stockpile’s (SNS) CHEMPACK programme. Image credit: Lucky-photographer via Shutterstock. Kindeva Drug Delivery division Meridian Medical Technologies has won a new contract worth up to $129m from the US Government for the supply of its DuoDote chemical nerve agent antidote autoinjectors to the Strategic National Stockpile (SNS). Managed by the Administration for Strategic Preparedness and Response (ASPR) within the US Department of Health and Human Services (HHS), the SNS contains medicines and devices for lifesaving care, which are intended for use as stopgap buffers when the immediate supply of such materials may not be available or sufficient. The DuoDote dual-chamber autoinjector contains atropine and pralidoxime chloride and was approved by the US Food and Drug Administration (FDA) in 2006. It is indicated for the treatment of poisoning from organophosphorus nerve agents and organophosphorus insecticides. Perhaps the nerve agent most well-known to the general public, sarin has been in use since World War II and became infamous in more recent times for its 2013 use on civilians in Syria during the Bashar al-Assad regime. The DuoDote autoinjectors will be manufactured at Kindeva Drug Delivery’s facility in St Louis, Missouri. They will then be stockpiled and available for rapid deployment as part of the SNS CHEMPACK programme. SNS CHEMPACK is an ASPR initiative in which containers of nerve agent antidotes are placed in secure locations around the US to enable rapid response to chemical incidents. Kindeva CEO Milton Boyer commented: “As a trusted partner to the SNS, this contract underscores the ongoing importance of maintaining readiness against potential threats. “Our long-standing partnership with the SNS reflects our commitment to national preparedness and our ability to deliver crucial medical countermeasures when they are needed most. With our extensive experience in this space, we are proud to continue supporting the US Government’s efforts to protect public health and safety.” Kindeva recently partnered with Emervax to co-develop a vaccine delivery solution for viruses including mpox and yellow fever. Kindeva Drug Delivery was formerly known as 3M Drug Delivery Systems and rebranded itself in 2020, following its acquisition by Altaris Capital Partners in a deal valued at $650m.

上市批准疫苗并购

2023-12-02

·药闻康策

对短缺药进行集采，能解决“短缺”难题吗？

☝ 点击上方一键预约 ☝ 最新最热的医药健康新闻政策短缺药纳入集采名单，是国家重视短缺药的保障供应的重要举措。近年来，部分急救药品价格跳涨的事情时而出现。氯解磷定注射液（2ml:0.5g*1）的中标价曾从4.61元上涨至178元；西地兰（2ml:0.4mg*1）中标价曾从11元上涨至89元。价格与用量，是影响短缺药企业生产供应的决定性因素。造成短缺的原因有经济社会成本过高、原料生产成本上涨、人为垄断原材料、招采政策的更新迟缓等等一些难以控制的因素，短缺药这一“老大难”问题治理，亟需求变！01逐步纳入国家集采和地方集采政策治理翻开新篇章在刚结束的第九批国采中，用于催产的缩宫素注射剂等5种短缺药品和急抢救药品，均在品种目录覆盖范围内。无独有偶，10月27日，广州公共资源交易中心发布了《易短缺和急抢救药联盟集中带量采购文件》征求意见稿，将短缺药纳入集采。包括有酚妥拉明注射剂、苯巴比妥注射剂、呋塞米等18个临床必需易短缺类、急抢救类等化学药品和治疗用生物制品纳入集采范围。来源：《易短缺和急抢救药联盟集中带量采购文件》短缺药集采聚焦保供稳价。每个品种组别分别设置了最高有效申报价格。其中，最高有效申报价格和各产品的实际交易价格两者之间的低值简称为“P0”，各产品的申报价不高于P0的，视为有效报价。有专家学者表示，并非所有短缺药品种都适合集采，需要分析具体短缺的原因，对症下药。只有“真短缺”的药品才适合纳入集采，向企业明确需求量，提高行业集中度，利用成本规模提高利润，同时保障供应。02价稳量多，提振短缺药市场预期氨茶碱注射液市场销售额涨势厉害，个别品规的价格上浮较大。中康开思数据库显示，2023上半年氨茶碱注射液品种的等级医院销售同比增长165%，其中金耀药业的氨茶碱注射液（10ml:0.25mg*5）价格在上调明显，市场增长源于单价的上涨。来源：开思数据地高辛注射液等级医院市场上半年同比增长47%，品规单价是下调趋势。例如，西南药业的地高辛注射液（2ml:0.5mg*2）的单价从2021年底开始下调，2023年上半年销售额同比增长45%，是由销售量上升驱动。来源：开思数据药品是特殊商品，药品市场也是特殊市场，关系到民众的生命健康。解决药品短缺保供稳价问题，坚持“加强监测、分级应对、分类管理、清单制度、统筹联动、强化监管、保障供应”的原则，在运用市场机制、探索集中带量采购的同时，加强政府直接干预，加大市场监测调节，强化行政执法监管。（来源:新康界作者:牛果）药闻康策新媒体矩阵微信公众号点击下方一键关注【免责声明】1.“药闻康策”部分文章信息来源于网络转载是出于传递更多信息之目的，并不意味着赞同其观点或证实其内容的真实性。如对内容有疑议，请及时与我司联系。2.“药闻康策”致力于提供合理、准确、完整的资讯信息，但不保证信息的合理性、准确性和完整性，且不对因信息的不合理、不准确或遗漏导致的任何损失或损害承担责任。3.“药闻康策”所有信息仅供参考，不做任何商业交易或医疗服务的根据，如自行使用“药闻康策”内容发生偏差，我司不承担任何责任，包括但不限于法律责任，赔偿责任。欢迎转发分享、收藏、点赞、点在看

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100 项与氯解磷定相关的药物交易

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KEGG	Wiki	ATC	Drug Bank
D00469	氯解磷定	V03AB04	DBSALT000242

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适应症	国家/地区	公司	日期
肌肉无力	美国	BAXTER HEALTHCARE CORP ANESTHESIA AND CRITICAL CARE	1964-03-11
重症肌无力	美国	BAXTER HEALTHCARE CORP ANESTHESIA AND CRITICAL CARE	1964-03-11
有机磷中毒	美国	BAXTER HEALTHCARE CORP ANESTHESIA AND CRITICAL CARE	1964-03-11
呼吸功能不全	美国	BAXTER HEALTHCARE CORP ANESTHESIA AND CRITICAL CARE	1964-03-11