Primary Objective will be to evaluate the use of Ga-67 citrate as an alternative radiopharmaceutical for CSF imaging.
Secondary Objective will be to evaluate the biodistribution, pharmacokinetics and radiation dosimetry of In 111 DTPA and gallium-67 after intrathecal injection during remission of leptomeningeal metastasis (LM) and during LM occurrence, remission and recurrence.

开始日期2007-05-01

申办/合作机构

The University of Texas MD Anderson Cancer Center

100 项与枸橼酸镓[67Ga] 相关的临床结果

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100 项与枸橼酸镓[67Ga] 相关的转化医学

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100 项与枸橼酸镓[67Ga] 相关的专利（医药）

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118,906

项与枸橼酸镓[67Ga] 相关的文献（医药）

2025-12-31·Green Chemistry Letters and Reviews

State-of-the-art mean centering of ratio spectra and HPLC methodologies for comprehensive analysis of some dry eyes drugs: investigation of white and green practices

作者: Alsehli, Bandar R. ; Mohamed, Mahmoud A. ; Saleh, Sayed M. ; Allam, Ahmed A. ; Rudayni, Hassan A. ; Alminderej, Fahad M. ; Alwaili, Maha A.

White and green chem. contribute significantly to improving the sustainability of the chem. industry.Based on green and white metrics, ten sustainability tools have been developed.Several tools were used to evaluate how environmentally friendly, innovative as well as forthright RP-HPLC and mean centering of ratio spectra (MCR) techniques were used to simultaneously analyze and sep. sodium hyaluronate (SDH) and benzalkonium chloride (BNZ) in eye drops.An HPLC study utilizing 0.07 M sodium sulfate adjusted to pH 3.0 and Ethanol (90:10, volume/volume) with 205 nm UV detection used an isocratic approach.The experiment used a Partisil Hichrom SCX column (150 mm x 4.6 mm, 5μm), 20μL injection volume, and a 0.8 mL/min flow rate.The column oven was set at 25°C for each sequence.With the aid of the MCR spectral method, the overlapping of the medication' spectral parameters was efficiently resolved.This technique enabled SDH and BNZ to distinguish at 222.1 and 215 nm wavelengths.HPLC and MCR calibration curves revealed a correlation coefficient exceeding 0.999 for all medications between 10-200μg/mL and 5-30μg/mL.The approach produces good recovery results with 98% to 102%.The proposed approach has been validated following ICH principles.

2025-12-31·Environmental Pollutants and Bioavailability

Comprehensive toxicity assessment of selected pharmaceuticals (ciprofloxacin, amoxicillin, and levofloxacin) on freshwater microalgae Scenedesmus obliquus : effect of media composition

作者: Chandrsekaran, Natarajan ; Bhattacharya, Bikramjit ; Poddar, Bikram ; Mandal, Sanmitra ; Mukherjee, Amitava ; Rex M, Camil

Antibiotics are widely used in health care to treat various infections.Excessive use and poor waste management make antibiotics a serious threat to aquatic ecosystems.Most of the ecotoxicol. assessments on freshwater microalgae are evaluated in the defined culture medium, which lacks environmental relevance.Hence, this study aimed to evaluate the toxicity of amoxicillin, ciprofloxacin, and levofloxacin on the freshwater microalga Scenedesmus obliquus in both lake water medium (LWM) and Blue green-11 medium (BG-11 M).Results indicated that levofloxacin exhibited the highest toxicity, followed by amoxicillin and ciprofloxacin in both LWM and BG-11 M.Pearson correlation and cluster heat map analyses revealed that oxidative stress generation was directly linked to reduced photosynthetic activity and cell viability.These findings suggest toxicity assessments conducted in defined culture media may modulate the toxicity levels compared to environmentally relevant media, like lake water.

2025-12-31·Acta Agriculturae Scandinavica, Section B — Soil & Plant Science

Association between agronomic traits and metabolite profiles on yield response and water use efficiency in newly developed wheat populations under drought stressed conditions

作者: Madala, Ntakadzeni E. ; Mutanda, Maltase ; Shimelis, Hussein ; Figlan, Sandiswa ; Chaplot, Vincent

Multiple trait selection guides the deployment of wheat varieties with high grain yield (GY) and water-use efficiency (WUE).The study aimed to determine the degree and trend of association between agronomic traits and major metabolites to identify influential traits and metabolites optimized by wheat genotypes for improved GY, WUE and drought tolerance.One hundred wheat genotypes were evaluated under drought-stressed (DS) and non-stressed (NS) using a 5 x 20 alpha-lattice design with two replications.The recorded agronomic traits included GY, shoot biomass (SB), root biomass (RB) and plant biomass (PB).The WUE in relation to GY (WUEgy) was computed based on GY produced under DS and NS.The grain of 10 wheat genotypes with high GY under DS were assayed for their metabolic responses to DS.The WUEgy showed significant correlations with PB, RB and SB under DS and NS conditions.Citric acid was strongly correlated with GY and WUEgy than other metabolites under DS.The SB had high pos. direct effects on GY under both treatments, while PB had high and pos. direct effects on WUEgy under DS.Therefore, selection based on SB, PB and citric acid is effective when selecting wheat ideotypes for drought tolerance and WUE.

100 项与枸橼酸镓[67Ga] 相关的药物交易

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外链

KEGG	Wiki	ATC	Drug Bank
-	枸橼酸镓[67Ga]	V09HX01	DB06784

研发状态

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适应症	国家/地区	公司	日期
炎症	日本	Nihon Medi-Physics Co., Ltd.	1975-12-18
肿瘤	日本	Nihon Medi-Physics Co., Ltd.	1975-12-18

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研究	分期	人群特征	评价人数	分组	结果	评价	发布日期


ASN2017	N/A	常染色体显性多囊肾病 \| 多囊肾 \| 感染	5	67-Gallium Citrate (67-Gallium-citrate SPECT/CT)	窪顧築鹹齋願壓夢淵獵(鬱糧遞齋膚窪獵製憲遞) = The most frequent presenting symptoms of cyst infection were fever (n=5) and abdominal pain (n=4) 淵鏇蓋餘夢淵襯願積鏇 (範鹹襯蓋觸網構簾夢繭 ) 更多	积极	2017-10-31
				67-Gallium Citrate (Ultrasound (US))