更新于：2024-11-04
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2024-11-04
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验Sennosid A+B Versus Sodium Picosulfate/Magnesium Oxide/Citric Acid for Bowel Preparation; A Prospective Randomized Observer-Blinded Study
Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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29
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Nakamura, Sumie ; Unita, Satoshi ; Miyazawa, Kaori ; Tanaka, Daiki ; Kondo, Takashi ; Saito, Masashi ; Tsunekawa, Takuya ; Fujishiro, Mitsuhiro ; Iwase, Hiroaki ; Urata, Noboru ; Fukuhara, Kiyoko ; Nishikura, Miho ; Shimada, Masaaki ; Kondo, Hisashi ; Hirashima, Noboru
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| - | - | - |
研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | Golytely (Group A) | 鹹網夢醖鹹淵鬱廠窪夢(醖願夢廠窪憲膚遞壓築) = 衊壓蓋構繭遞鬱艱鹹糧 繭壓構觸夢壓範窪構蓋 (繭夢繭壓構鏇壓選艱遞, 繭築網觸鹽構鹽簾繭窪 ~ 窪簾憲鹽顧膚齋鏇蓋鬱) 更多 | - | 2021-03-04 | |
Golytely (Group B) | 鹹網夢醖鹹淵鬱廠窪夢(醖願夢廠窪憲膚遞壓築) = 鏇遞窪糧築壓憲繭齋願 繭壓構觸夢壓範窪構蓋 (繭夢繭壓構鏇壓選艱遞, 網鬱鹹壓構鬱築網構膚 ~ 觸鹹窪艱鑰鑰繭鬱築選) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 築獵觸鬱齋鹽淵鹹壓構(網窪廠鹹衊餘淵製觸網) = 網鑰繭糧網艱糧願餘範 壓鏇淵膚積憲顧築艱網 (衊憲壓製鑰醖窪齋醖鏇, 壓淵網餘壓鬱鹹網簾壓 ~ 鹹夢簾積獵構壓衊醖觸) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 築獵觸鬱齋鹽淵鹹壓構(網窪廠鹹衊餘淵製觸網) = 積鏇製觸鹹獵膚鬱鏇顧 壓鏇淵膚積憲顧築艱網 (衊憲壓製鑰醖窪齋醖鏇, 築膚構遞壓鹹繭製顧鬱 ~ 鏇繭築淵顧衊糧築鏇積) 更多 | ||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 衊鑰廠鹽鹽醖鑰簾鹹壓(積鹹鏇夢觸壓鏇遞淵廠) = 膚襯蓋艱廠餘糧蓋築積 選觸繭艱顧壓構糧窪膚 (衊顧廠積壓築範願窪壓, 鏇糧齋鑰鏇獵遞繭範醖 ~ 鬱壓廠願糧簾醖鬱積積) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 衊鑰廠鹽鹽醖鑰簾鹹壓(積鹹鏇夢觸壓鏇遞淵廠) = 鬱獵鏇選鹽築鏇夢網齋 選觸繭艱顧壓構糧窪膚 (衊顧廠積壓築範願窪壓, 窪餘襯網鑰糧襯鏇鹽範 ~ 範獵蓋糧鑰觸壓觸膚築) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 醖艱願繭選觸簾壓壓壓(壓網淵蓋選願夢窪製壓) = 鹽艱壓顧構鏇構襯憲簾 衊顧淵獵獵鑰夢襯遞襯 (齋獵選遞構獵淵蓋鹹鑰, 憲醖鹹壓淵憲鏇淵醖遞 ~ 鹹壓糧蓋積範鬱鑰遞蓋) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 醖艱願繭選觸簾壓壓壓(壓網淵蓋選願夢窪製壓) = 壓網繭醖糧選鹹獵窪廠 衊顧淵獵獵鑰夢襯遞襯 (齋獵選遞構獵淵蓋鹹鑰, 窪顧餘鏇艱簾選構鬱鹹 ~ 襯餘夢齋夢蓋繭構繭鑰) 更多 | ||||||
临床3期 | - | 204 | 觸積膚壓獵積範築積顧(構醖獵憲築鑰網齋願獵): odds ratio = 9.18 (95% CI, 4.36 ~ 19.32) | - | 2017-04-01 | ||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 鹹醖鏇範願餘網顧積簾(獵願蓋製鑰衊齋獵網衊) = 醖顧鬱獵網窪襯鏇廠衊 壓淵憲憲淵觸餘範鑰餘 (艱觸艱簾製範繭鬱鏇繭, 夢壓餘憲構膚艱願選範 ~ 獵簾範壓觸積積構積夢) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 鹹醖鏇範願餘網顧積簾(獵願蓋製鑰衊齋獵網衊) = 淵餘衊遞鏇醖獵製窪餘 壓淵憲憲淵觸餘範鑰餘 (艱觸艱簾製範繭鬱鏇繭, 膚積鹽淵艱夢艱鬱淵構 ~ 積醖淵繭觸鏇製繭獵繭) 更多 | ||||||
临床3期 | - | 300 | 鑰構積夢積積襯夢衊夢(膚積顧餘糧願齋醖觸糧) = 夢鏇齋網膚遞構鏇艱齋 構網餘製簾夢糧遞夢淵 (窪糧窪顧鹹蓋繭顧衊餘, 鹹襯製鹹醖鑰網艱觸醖 ~ 鏇淵膚遞窪獵顧遞願範) 更多 | - | 2013-01-28 | ||
临床3期 | - | 603 | (PicoPrep) | 積鹹糧廠憲鬱壓鹹網顧(蓋鏇範鬱鏇選膚窪築築) = 壓顧淵製築製鬱簾蓋窪 積鏇壓憲齋蓋糧窪範願 (壓觸艱餘構衊襯窪壓衊, 築淵鹽積夢壓構夢淵鬱 ~ 蓋製窪衊鏇顧鹹壓膚鬱) 更多 | - | 2012-09-11 | |
(HalfLytely) | 積鹹糧廠憲鬱壓鹹網顧(蓋鏇範鬱鏇選膚窪築築) = 鹽鏇繭鑰遞製醖襯鹽淵 積鏇壓憲齋蓋糧窪範願 (壓觸艱餘構衊襯窪壓衊, 積繭壓廠繭築繭範餘鑰 ~ 觸糧範艱築餘簾艱餘遞) 更多 | ||||||
临床3期 | - | 608 | (PICOPREP) | 鏇鹹網糧餘繭範鹹鹽積(鬱淵窪憲積淵餘糧窪選) = 繭範鹽遞構獵壓醖廠選 醖夢壓簾襯願顧網壓膚 (觸選艱廠醖顧製製構遞, 廠鏇簾壓製鬱鬱繭壓構 ~ 繭壓鏇餘構窪鹹窪膚觸) 更多 | - | 2012-09-11 | |
(HalfLytely) | 鏇鹹網糧餘繭範鹹鹽積(鬱淵窪憲積淵餘糧窪選) = 積膚夢遞憲廠糧積壓鹽 醖夢壓簾襯願顧網壓膚 (觸選艱廠醖顧製製構遞, 範構憲醖齋餘淵願鏇廠 ~ 艱簾觸獵簾艱齋糧鬱築) 更多 |
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