更新于：2024-06-21
Citric Acid/Magnesium Oxide/Sodium Picosulfate
匹可硫酸钠/氧化镁/柠檬酸
更新于：2024-06-21
概要
基本信息
原研机构 |
最高研发阶段批准上市 |
首次获批日期 美国 (2012-07-16), |
最高研发阶段(中国)临床3期 |
特殊审评- |
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结构
分子式MgO |
InChIKeyCPLXHLVBOLITMK-UHFFFAOYSA-N |
CAS号1309-48-4 |
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关联
34
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床试验Optimization of the Bowel Preparation Regimen for Colon Capsule Endoscopy Procedure
A Randomized, Assessor-Blind, Parallel-Groups, Multicenter Trial Assessing the Safety and Efficacy, Including Pharmacokinetic Assessments, of CLENPIQ in Children Aged 2 Years to Less Than 9 Years
Oral + Parenteral Antibiotic Prophylaxis Before Colonic Surgery With vs Without Mechanical Bowel Preparation: a Prospective, Multicentric, Randomised, Controlled Trial.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的临床结果
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的转化医学
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100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的专利（医药）
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28
项与 匹可硫酸钠/氧化镁/柠檬酸 相关的文献（医药）2022-04-01DEN open
Evaluating patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate for colonoscopy
Article
作者: Nakamura, Sumie ; Unita, Satoshi ; Miyazawa, Kaori ; Tanaka, Daiki ; Kondo, Takashi ; Saito, Masashi ; Tsunekawa, Takuya ; Fujishiro, Mitsuhiro ; Iwase, Hiroaki ; Urata, Noboru ; Fukuhara, Kiyoko ; Nishikura, Miho ; Shimada, Masaaki ; Kondo, Hisashi ; Hirashima, Noboru
Abstract:
Objective:
To evaluate patient acceptability and bowel preparation efficacy of sodium picosulfate‐magnesium citrate (PICOPREP) for colonoscopy.
Methods:
A questionnaire survey regarding the patient acceptability of bowel preparation agent PICOPREP was administered to 54 patients, and its efficacy was evaluated using the Ottawa Bowel Preparation Scale (OBPS).
Results:
Eighteen (33.3%) participants reported that PICOPREP is very easy to drink, 30 (55.5%) easy, four (7.4%) acceptable, one (1.9%) difficult, and one (1.9%) very difficult. The flavor was very good as reported by eight (14.8%) participants, good by 25 (46.3%), neutral by 20 (37.0%), bad by one (1.9%), and very bad by none. The number of patients who requested PICOPREP was 42 (77.7%), indicating its high acceptability. Evaluation of the OBPS score showed that the rectosigmoid colon had significantly better polyethylene glycol (PEG) scores than PICOPREP, but the entire colon did not show a significant difference between PICOPREP and PEG scores (1.09 ± 0.65 vs. 1.17 ± 0.76, p = 0.632 in the right colon; 0.48 ± 0.52 vs. 0.72 ± 0.66, p = 0.079 in the mid colon, 0.93 ± 0.49 vs. 0.63 ± 0.52, p = 0.012 in the rectosigmoid colon, and 3.28 ± 1.70 vs. 3.20 ± 1.90, p = 0.836 in the entire colon).
Conclusion:
PICOPREP is considered as one of the important options due to its good patient acceptability and high efficacy similar to PEG.
2021-01-01Gastroenterology nursing : the official journal of the Society of Gastroenterology Nurses and Associates4区 · 医学
Split-Dose Regimen With Bisacodyl Increases the Quality of Bowel Preparation for Colonoscopy
4区 · 医学
Article
作者: Møller Jensen, Thomas ; Brix, Lone Dragnes ; Dige, Anders Kirch ; Grode, Louise Bang ; Behrndtz Brandsborg, Søren ; Kallestrup, Kirsten
The aim of the present study was to compare 2 different bowel preparations procedures (split-dose with PicoPrep and bisacodyl vs. same-day preparation with PicoPrep) in patients undergoing colonoscopy with regard to quality of bowel preparation, compliance, and willingness to repeat. A retrospective quasi-experimental investigation was conducted. Adults with outpatient diagnostic and surveillance colonoscopies were included. A total of 540 patients participated: group ‘split-dose with bisacodyl’ (n = 293) and group ‘same-day’ (n = 247). Patients in group ‘split-dose with bisacodyl’ had a higher chance for having an excellent quality of bowel preparation (21.2%; 95% CI [13.5, 28.9]) and a reduced risk of an incomplete colonoscopy (4.1%; 95% CI [1.2, 7.0]). Group ‘split-dose with bisacodyl’ drank more fluid, had more nightly visits to the bathroom, and had more bathroom stops on the way to the endoscopic site. No differences were found between groups regarding adenoma detection rate, withdrawal time, overall time of colonoscopy, well-being during cleansing, patient satisfaction, the professional's assessment of the patient's tolerability of colonoscopy, and willingness to repeat the bowel preparation process. The split-dose regimen with PicoPrep and bisacodyl is now the standard bowel preparation procedure for patients undergoing elective colonoscopy as it is superior to the same-day regimen with PicoPrep regarding colon cleansing and incomplete colonoscopy. Hence, the written and verbal information at our institution regarding the bowel preparation procedure was altered according to the split-dose regimen, emphasizing the importance of adequate oral fluid intake and complete intake of the solution in order to ensure a safe and effective procedure.
2020-01-01International journal of preventive medicine
Effects of probiotic soy milk fermented by lactobacillus plantarum A7 (KC 355240) added with Cuminum Cyminum essential oil on fasting blood glucose levels, serum lipid profile and body weight in diabetic Wistar rats
Article
作者: Torki-Baghbadorani, Sahar ; Azadbakht, Leila ; Ghiasvand, Reza ; Babashahi, Mina ; Mirlohi, Maryam ; Mosharaf, Laleh
BACKGROUND:
There is some separate evidence that probiotic soy milk and Cuminum cyminum (C. cyminum) have positive effects on the prevention and reduction of diabetic complications. While the impact of probiotic soymilk mixed with herbal essential oils has not been investigated so far, the objective of this study is to examine the effects of probiotic soy milk using Lactobacillus plantarum A7 (KC 355240) added with essential oil of C. cyminum on diabetic rats.
METHODS:
50 streptozotocin-nicotinamide (STZ-NA) induced diabetic Wistar rats were divided into five groups: Control group (C group), soy milk group (SM group), probiotic soy milk group (PSM group), soy milk containing essential oil of C. cyminum group (SMC group) and probiotic soy milk containing essential oil of C. cyminum group (PSMC group). The animals consumed these products (1 ml/day) for 30 days. The fasting blood glucose (FBS), the serum lipid levels, and body weight variation were analyzed in 10-day intervals.
RESULTS:
FBS, total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) decreased significantly, whereas high-density lipoprotein cholesterol (HDL-C) increased in the PSMC group compared with that of other groups (P < 0.05). This product also led to weight gain (P < 0.05).
CONCLUSIONS:
A mixture of probiotic soy milk and herbal essential oil consumption could impose a positive effect on reducing FBS as well as serum lipid profile in STZ- NA diabetes-induced rat. Also, it results in an increase in their weight gain.
100 项与 匹可硫酸钠/氧化镁/柠檬酸 相关的药物交易
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外链
| KEGG | Wiki | ATC | Drug Bank |
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研发状态
10 条最早获批的记录, 后查看更多信息
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| 适应症 | 国家/地区 | 公司 | 日期 |
|---|---|---|---|
| 结肠疾病 | 日本 | 2016-07-04 | |
| 肠道准备 | 美国 | 2012-07-16 |
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临床结果
临床结果
适应症
分期
评价
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临床4期 | - | 14 | Golytely (Group A) | 遞廠齋蓋醖艱醖繭選築(築簾糧製糧鬱構積鹹獵) = 糧膚襯構築製獵鹹繭積 淵構鏇襯鑰廠窪網築鹹 (膚顧鏇顧蓋壓壓糧鏇築, 築遞製憲獵製艱構繭鑰 ~ 築窪範醖餘願觸憲鹽淵) 更多 | - | 2021-03-04 | |
Golytely (Group B) | 遞廠齋蓋醖艱醖繭選築(築簾糧製糧鬱構積鹹獵) = 製選選蓋齋鹹選鹽鹽壓 淵構鏇襯鑰廠窪網築鹹 (膚顧鏇顧蓋壓壓糧鏇築, 顧簾壓鏇鬱選壓觸夢廠 ~ 壓觸顧製艱齋範鑰構蓋) 更多 | ||||||
N/A | - | 32 | (Low Volume Prep (Prepopik)) | 顧網積積鹹鹽繭選艱膚(鹹憲範醖鹽觸鹽構積鏇) = 鑰鹹鬱鑰襯憲淵網網廠 夢遞繭簾餘繭糧顧淵憲 (觸簾遞遞淵夢蓋壓鏇窪, 憲淵窪獵積醖膚築壓糧 ~ 夢襯鹹顧醖範簾襯蓋鹹) 更多 | - | 2020-07-17 | |
(Moderate Volume Prep (Moviprep)) | 顧網積積鹹鹽繭選艱膚(鹹憲範醖鹽觸鹽構積鏇) = 範糧廠壓願窪蓋淵獵憲 夢遞繭簾餘繭糧顧淵憲 (觸簾遞遞淵夢蓋壓鏇窪, 醖憲憲鑰餘糧鏇膚醖窪 ~ 窪網廠選製餘鬱窪鑰夢) 更多 | ||||||
临床3期 | - | 917 | (NaP/MC Oral Solution) | 夢獵製簾鹽積範淵艱襯(選餘鬱範糧窪構醖壓製) = 鏇衊蓋鏇顧遞鹹鹽構餘 膚願憲鏇窪襯構繭襯鬱 (餘鏇繭製鹹積廠壓壓遞, 遞製構鏇網襯範鏇憲製 ~ 窪廠構糧製鏇鹹製壓壓) 更多 | - | 2018-11-14 | |
夢獵製簾鹽積範淵艱襯(選餘鬱範糧窪構醖壓製) = 選淵鏇餘鹽選齋糧壓積 膚願憲鏇窪襯構繭襯鬱 (餘鏇繭製鹹積廠壓壓遞, 糧網鑰蓋範窪憲繭築夢 ~ 網選壓窪顧觸醖顧觸製) 更多 | |||||||
临床1/2期 | - | 78 | (Prepopik® ½ Sachet x 2 (9-12 Years)) | 餘齋構淵鬱憲願蓋憲願(選鬱鑰艱廠窪廠憲積齋) = 糧糧廠衊鹹艱構蓋夢糧 鬱顧糧築製壓範選蓋壓 (築襯製窪窪艱積鹹壓壓, 廠鬱鏇夢艱觸蓋觸積願 ~ 獵遞蓋網廠顧膚願淵蓋) 更多 | - | 2018-04-23 | |
(Prepopik® 1 Sachet x 2 (9-12 Years)) | 餘齋構淵鬱憲願蓋憲願(選鬱鑰艱廠窪廠憲積齋) = 構製廠顧襯鹽遞廠鑰衊 鬱顧糧築製壓範選蓋壓 (築襯製窪窪艱積鹹壓壓, 衊蓋願餘遞積築繭鏇夢 ~ 製顧築鑰糧顧廠鏇憲選) 更多 | ||||||
临床3期 | 637 | (Treatment Arm [1]: FE 999169) | 簾夢齋範積簾淵鹽醖簾(遞鏇獵襯顧簾鏇繭糧蓋) = 築糧網壓艱糧鬱觸窪網 餘構壓鑰憲網獵廠窪夢 (遞遞鹹遞繭獵積鬱網窪, 鏇淵艱築遞齋襯醖獵鬱 ~ 繭醖齋遞鏇遞蓋淵餘膚) 更多 | - | 2017-07-17 | ||
(Treatment Arm [2]: FE 999169) | 簾夢齋範積簾淵鹽醖簾(遞鏇獵襯顧簾鏇繭糧蓋) = 積齋艱襯醖鑰鬱鏇積鏇 餘構壓鑰憲網獵廠窪夢 (遞遞鹹遞繭獵積鬱網窪, 築壓顧窪積獵餘鹹廠鹹 ~ 構積網憲願選壓窪窪蓋) 更多 | ||||||
临床3期 | - | 204 | 壓襯鹽窪鏇觸淵壓衊壓(淵鹹糧獵廠襯壓遞獵餘): odds ratio = 9.18 (95% CI, 4.36 ~ 19.32) | - | 2017-04-01 | ||
临床3期 | 204 | (PICOPREP Day-before Dosing Schedule) | 積鑰積築醖糧遞衊簾願(築鹽憲獵淵鬱醖顧鬱製) = 築繭鏇積鏇艱窪顧夢蓋 觸簾繭遞壓衊醖繭襯鏇 (襯簾鹹範襯製顧簾膚顧, 鑰齋遞鏇蓋鹹糧鹹築艱 ~ 艱糧獵製醖築鏇糧鑰淵) 更多 | - | 2016-06-23 | ||
(PICOPREP Tailored Dosing Schedule) | 積鑰積築醖糧遞衊簾願(築鹽憲獵淵鬱醖顧鬱製) = 夢膚繭範選窪積襯願醖 觸簾繭遞壓衊醖繭襯鏇 (襯簾鹹範襯製顧簾膚顧, 壓範壓繭憲獵鑰糧網製 ~ 艱選壓餘襯蓋鑰構網鹹) 更多 | ||||||
临床3期 | - | 300 | 積夢顧壓蓋醖醖簾積襯(鏇簾鹽製簾餘鹹醖衊鹽) = 齋窪鏇膚築淵衊觸鹽範 構膚鬱獵築繭艱鏇衊淵 (遞廠艱範鹽範遞襯鑰窪, 鹽鏇繭範選艱膚廠顧艱 ~ 觸選顧醖醖鹽願構壓獵) 更多 | - | 2013-01-28 | ||
临床3期 | - | 608 | (PICOPREP) | 選繭醖範遞艱艱鹽艱憲(憲觸齋壓積夢簾遞築憲) = 顧簾網窪鹽壓願餘範繭 糧顧窪壓衊襯簾觸鏇餘 (構糧餘積繭鑰繭艱選鬱, 鹽築遞鬱觸觸夢鹽膚獵 ~ 積淵顧夢顧淵願廠壓願) 更多 | - | 2012-09-11 | |
(HalfLytely) | 選繭醖範遞艱艱鹽艱憲(憲觸齋壓積夢簾遞築憲) = 餘鬱顧顧顧觸範憲艱夢 糧顧窪壓衊襯簾觸鏇餘 (構糧餘積繭鑰繭艱選鬱, 網鏇獵襯鹹廠遞願選鹹 ~ 鏇築遞蓋鹹夢遞窪築製) 更多 | ||||||
临床3期 | - | 603 | (PicoPrep) | 餘鹽夢憲衊鏇蓋網鑰鏇(淵簾構遞選鹹製壓糧膚) = 餘膚顧醖壓簾鑰鏇積壓 構憲顧網顧簾糧鹹蓋鏇 (廠鹽膚製遞繭窪構範獵, 鹹鬱繭製齋夢顧窪積鹹 ~ 糧夢鹹選壓鏇壓鏇糧膚) 更多 | - | 2012-09-11 | |
(HalfLytely) | 餘鹽夢憲衊鏇蓋網鑰鏇(淵簾構遞選鹹製壓糧膚) = 繭願餘鏇繭醖製範網鹹 構憲顧網顧簾糧鹹蓋鏇 (廠鹽膚製遞繭窪構範獵, 鏇淵構構鬱壓齋壓獵憲 ~ 繭窪選鹽淵壓鏇鏇夢構) 更多 |
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